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The Impact of Rotating Shift Work on the Prevalence of Irritable Bowel Syndrome in Nurses
Open accessAbstract
OBJECTIVES: Shift work has been associated with gastrointestinal symptoms such as abdominal pain, constipation, and diarrhea. These symptoms overlap with those reported by patients with functional bowel disorders. Because shift work will lead to misalignment between the endogenous circadian timing system and the external 24 h environment, we hypothesized that nurses participating in shift work will have a higher prevalence of functional bowel disorders when compared with nurses participating in day shifts. METHODS: Nurses engaged in patient care were invited to complete Rome III, irritable bowel syndrome-quality of life measure (IBS-QOL) and modified Sleep-50 questionnaires. Respondents were classified as working day, night, or rotating shifts. The prevalence of IBS, functional constipation, functional diarrhea, and individual gastrointestinal symptoms was determined. RESULTS: Data were available for 399 nurses (214 day shift, 110 night shift, and 75 rotating shift workers). Rotating shift nurses had a significantly higher prevalence of IBS compared to day shift nurses (48% vs. 31%, P<0.01). Multivariable logistic regression correcting for age, gender, and sleep quality proved this association robust. IBS-QOL scores among groups were similar. Prevalence of functional constipation and functional diarrhea was similar between groups. Rotating shift nurses had a significantly higher prevalence of abdominal pain compared to day shift (81% vs. 54%, P<0.0001) and night shift workers (61%, P=0.003). CONCLUSIONS: Participation in shift work, especially rotating shift work, is associated with the development of IBS and abdominal pain that is independent of sleep quality. Circadian rhythm disturbances may have a function in the pathogenesis of IBS and abdominal pain.
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“Disrupted rhythmicity in the gut microbiome may be involved in an immediate and frequently reported, yet hitherto poorly understood, effect of shift work, namely, gastrointestinal discomfort [42,43].”
From Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being (2017) · cites this paper as [43]
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Scheiermann, C., Gibbs, J. E., Ince, L. M., & Loudon, A. S. I. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0008-4 · Cited by 574
Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being
James, S. M., Honn, K. A., Gaddameedhi, S., & Van Dongen, H. P. A. (2017) · Current Sleep Medicine Reports · doi:10.1007/s40675-017-0071-6 · Cited by 517
Health Consequences of Circadian Disruption in Humans and Animal Models
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Gut clock: implication of circadian rhythms in the gastrointestinal tract.
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Metadata
- Authors
- Nojkov, B., Rubenstein, J. H., Chey, W. D., & Hoogerwerf, W. A.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Hoogerwerf, Willemijntje A
- Venue
- American Journal of Gastroenterology
- Published
- 2010-04
- Volume
- 105
- Issue
- 4
- Pages
- 842-847
- ISSN
- 0002-9270 (ISSN-L)
- PMC
- PMC2887235
- OpenAlex
- W2152771831
- Cited by
- 226
- References
- 24
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 16 · 2023: 18 · 2022: 20 · 2021: 17 · 2020: 13 · 2019: 10 · 2018: 14 · 2017: 9 · 2016: 19 · 2015: 11 · 2014: 16 · 2013: 10 · 2012: 13
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r21dk074477-02)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21 DK-074477, K23DK079291)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- irritable bowel syndrome, rotating shifts, shift work, nurses, circadian rhythm disruption, abdominal pain, functional constipation, functional diarrhea, sleep quality, IBS quality of life, night shift work
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Nurses, Quality of Life, Surveys and Questionnaires, Sleep Wake Disorders, Work Schedule Tolerance, Prevalence, Chi-Square Distribution, Logistic Models, Irritable Bowel Syndrome
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