Health disorders of shift workers
Abstract
The effects of shift work on physiological function through disruption of circadian rhythms are well described. However, shift work can also be associated with specific pathological disorders. This article reviews the evidence for a relationship between specific medical disorders and working at night or on shift systems. The strongest evidence exists for an association with peptic ulcer disease, coronary heart disease and compromised pregnancy outcome.
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Disrupted rhythmicity in the gut microbiome may be involved in the immediate, frequently reported but poorly understood gastrointestinal discomfort of shift work.
“Disrupted rhythmicity in the gut microbiome may be involved in an immediate and frequently reported, yet hitherto poorly understood, effect of shift work, namely, gastrointestinal discomfort [42,43].”
From Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being (2017) · cites this paper as [42]
Multiple studies, opinions, and guidelines have suggested melatonin as primary therapy for improved health and sleep of shift workers.
“Multiple studies, opinions, and guidelines have suggested melatonin as primary therapy for improved health and sleep of shift workers [69,70,71].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [69]
Circadian disruption and sleep deprivation are not uncommon in the modern world and constitute an increasing health concern.
“this is important because circadian disruption (CD; eg, shift work and jet lag) and sleep deprivation are not uncommon in the modern world and constitute an increasing health concern.19,20”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [20]
Shift work and short-turnaround time for air crews on trans-meridianal flights have health and cognitive effects that could be ameliorated by work policies.
“For example, shift work 201 and short-turn around time for air crews on trans-meridianal flights 202 have health and cognitive effects that could be ameliorated by work policies.”
From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [201]
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- Authors
- Knutsson, A.
- Affiliations
- Mid Sweden University (SE)
- Corresponding author
- Knutsson, A.
- Venue
- Occupational Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-03-01
- Volume
- 53
- Issue
- 2
- Pages
- 103-108
- ISSN
- 0962-7480 (ISSN-L)
- 1471-8405
- OpenAlex
- W2135303822
- Cited by
- 1,218
- References
- 40
- Citations by year
- 2026: 20 · 2025: 26 · 2024: 29 · 2023: 46 · 2022: 38 · 2021: 51 · 2020: 55 · 2019: 70 · 2018: 57 · 2017: 63 · 2016: 72 · 2015: 70 · 2014: 77 · 2013: 71 · 2012: 68
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Occupational Medicine (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
- Keywords
- shift work, circadian rhythm disruption, health disorders, peptic ulcer, coronary artery disease, pregnancy outcomes, night work, occupational health
- MeSH terms
- Cardiovascular Diseases, Circadian Rhythm, Diabetes Mellitus, Female, Gastrointestinal Diseases, Humans, Longevity, Metabolic Diseases, Neoplasms, Occupational Diseases, Pregnancy, Pregnancy Complications, Work Schedule Tolerance
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