Health Consequences of Circadian Disruption in Humans and Animal Models
Abstract
Daily rhythms in behavior and physiology are programmed by a hierarchical collection of biological clocks located throughout the brain and body, known as the circadian system. Mounting evidence indicates that disruption of circadian regulation is associated with a wide variety of adverse health consequences, including increased risk for premature death, cancer, metabolic syndrome, cardiovascular dysfunction, immune dysregulation, reproductive problems, mood disorders, and learning deficits. Here we review the evidence for the pervasive effects of circadian disruption in humans and animal models, drawing from both environmental and genetic studies, and identify questions for future research.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Circadian oscillations are ubiquitous in cells throughout the brain and body and their coordinated daily activity is essential for normal health.
“Circadian oscillations are ubiquitous in cells throughout the brain and body and their coordinated daily activity is essential for normal health1–3.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [2]
Chronic circadian disruptions, as in shift work or frequent travel across time zones, cause long term physiological and neurological health to deteriorate.
“However, when circadian disruptions are chronic, as in shift work or frequent travel across time zones, long term physiological and neurological health deteriorate2, 5.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [2]
Cites
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
Zuckerman, A. J. (1995) · Journal of Clinical Pathology · doi:10.1136/jcp.48.7.691-a · Cited by 8,761 · see citing works
Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351 · see citing works
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265 · see citing works
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166 · see citing works
Neurocognitive consequences of sleep deprivation
Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154 · see citing works
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135 · see citing works
Stephan, F. K., & Zucker, I. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1583 · Cited by 2,039 · see citing works
Molecular components of the mammalian circadian clock
Ko, C. H., & Takahashi, J. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl207 · Cited by 1,657 · see citing works
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621 · see citing works
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611 · see citing works
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525 · see citing works
Plant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage
Dodd, A. N., Salathia, N. S., Hall, A. J. W., Kevei, É., Tóth, R., Nagy, F., Hibberd, J. M., Millar, A. J., & Webb, A. A. R. (2005) · Science · doi:10.1126/science.1115581 · Cited by 1,489 · see citing works
Roenneberg, T., Allebrandt, K. V., Merrow, M., & Vetter, C. (2012) · Current Biology · doi:10.1016/j.cub.2012.03.038 · Cited by 1,407 · see citing works
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature · doi:10.1038/19323 · Cited by 1,402 · see citing works
Positional Cloning of the Mouse Circadian Gene
King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382 · see citing works
Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,256 · see citing works
Health disorders of shift workers
Knutsson, A. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg048 · Cited by 1,218 · see citing works
Kondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V., & Antoch, M. P. (2006) · Genes & Development · doi:10.1101/gad.1432206 · Cited by 1,188 · see citing works
Actions of Melatonin in the Reduction of Oxidative Stress
Reiter, R. J., Tan, D. X., Osuna, C., & Gitto, E. (2000) · Journal of Biomedical Science · doi:10.1007/bf02253360 · Cited by 1,182 · see citing works
Zeitzer, J. M., Dijk, D., Kronauer, R. E., Brown, E. N., & Czeisler, C. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00695.x · Cited by 1,175 · see citing works
Circadian control of the immune system
Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3386 · Cited by 1,135 · see citing works
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works
Physiological significance of a peripheral tissue circadian clock
Lamia, K. A., Storch, K.-F., & Weitz, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806717105 · Cited by 1,048 · see citing works
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
Cho, H., Zhao, X., Hatori, M., Yu, R. T., Barish, G. D., Lam, M. T., Chong, L.-W., DiTacchio, L., Atkins, A. R., Glass, C. K., et al. (2012) · Nature · doi:10.1038/nature11048 · Cited by 1,037 · see citing works
Circadian timing of food intake contributes to weight gain
Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H., & Turek, F. W. (2009) · Obesity · doi:10.1038/oby.2009.264 · Cited by 953 · see citing works
Cajochen, C., Münch, M., Kobialka, S., Kräuchi, K., Steiner, R., Oelhafen, P., Orgül, S., & Wirz-Justice, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0957 · Cited by 939 · see citing works
Buxton, O. M., Cain, S. W., O’Connor, S. P., Porter, J. H., Duffy, J. F., Wang, W., Czeisler, C. A., & Shea, S. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003200 · Cited by 932 · see citing works
Karlsson, B., Knutsson, A., & Lindahl, B. (2001) · Occupational and Environmental Medicine · doi:10.1136/oem.58.11.747 · Cited by 924 · see citing works
Peroxiredoxins are conserved markers of circadian rhythms
Edgar, R. S., Green, E. W., Zhao, Y., Gerben Van Ooijen, A., Olmedo, M., Qin, X., Xu, Y. Q., Pan, M., Valekunja, U. K., Feeney, K. A., et al. (2012) · Nature · doi:10.1038/nature11088 · Cited by 915 · see citing works
Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock
Bae, K., Jin, X., Maywood, E. S., Hastings, M. H., Reppert, S. M., & Weaver, D. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00302-6 · Cited by 900 · see citing works
Shift Work Sleep Disorder: Prevalence and Consequences Beyond that of Symptomatic Day Workers
Drake, C. L., Roehrs, T., Richardson, G., Walsh, J. K., & Roth, T. (2004) · Sleep · doi:10.1093/sleep/27.8.1453 · Cited by 860 · see citing works
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau
Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000) · Science · doi:10.1126/science.288.5465.483 · Cited by 860 · see citing works
Night-Shift Work and Risk of Colorectal Cancer in the Nurses' Health Study
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I. I., Fuchs, C. S., & Colditz, G. A. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.11.825 · Cited by 837 · see citing works
Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in Women
Pan, A., Schernhammer, E. S., Sun, Q., & Hu, F. B. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001141 · Cited by 805 · see citing works
Mania-like behavior induced by disruption of <i>CLOCK</i>
Roybal, K., Theobold, D., Graham, A., DiNieri, J. A., Russo, S. J., Krishnan, V., Chakravarty, S., Peevey, J., Oehrlein, N., Birnbaum, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609625104 · Cited by 803 · see citing works
Light at night increases body mass by shifting the time of food intake
Fonken, L. K., Workman, J. L., Walton, J. C., Weil, Z. M., Morris, J. S., Haim, A., & Nelson, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008734107 · Cited by 796 · see citing works
Shift work, safety and productivity
Folkard, S. (2003) · Occupational Medicine · doi:10.1093/occmed/kqg047 · Cited by 774 · see citing works
A Mutation of the Circadian System in Golden Hamsters
Ralph, M. R., & Menaker, M. (1988) · Science · doi:10.1126/science.3413487 · Cited by 700 · see citing works
Gibbs, J. E., Blaikley, J., Beesley, S., Matthews, L. C., Simpson, K. D., Boyce, S., Farrow, S. N., Else, K. J., Singh, D., Ray, D. W., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106750109 · Cited by 671 · see citing works
Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658 · see citing works
Goldberg, R. B. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2534 · Cited by 645 · see citing works
Shift work and chronic disease: the epidemiological evidence
Wang, X.-S., Armstrong, M. E. G., Cairns, B. J., Key, T. J., & Travis, R. C. (2011) · Occupational Medicine · doi:10.1093/occmed/kqr001 · Cited by 640 · see citing works
Sleep loss and fatigue in shift work and shift work disorder
Åkerstedt, T., & Wright, K. P. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.03.001 · Cited by 639 · see citing works
Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Cauter, E. V., Polonsky, K. S., & Scheen, A. J. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.5.0317 · Cited by 611 · see citing works
Roles of Circadian Rhythmicity and Sleep in Human Glucose Regulation
Van Cauter, E. (1997) · Endocrine Reviews · doi:10.1210/er.18.5.716 · Cited by 608 · see citing works
Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance
Dijk, D., Duffy, J. F., & Czeisler, C. A. (1992) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1992.tb00021.x · Cited by 602 · see citing works
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590 · see citing works
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons
LeGates, T. A., Altimus, C. M., Wang, H., Lee, H.-K., Yang, S., Zhao, H., Kirkwood, A., Weber, E. T., & Hattar, S. (2012) · Nature · doi:10.1038/nature11673 · Cited by 577 · see citing works
Dose-response relationships for resetting of human circadian clock by light
Boivin, D. B., Duffy, J. F., Kronauer, R. E., & Czeisler, C. A. (1996) · Nature · doi:10.1038/379540a0 · Cited by 559 · see citing works
Crawley, J. N., & Paylor, R. E. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1382 · Cited by 551 · see citing works
Disruption of circadian clocks has ramifications for metabolism, brain, and behavior
Karatsoreos, I. N., Bhagat, S., Bloss, E. B., Morrison, J. H., & McEwen, B. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018375108 · Cited by 547 · see citing works
Strange vision: ganglion cells as circadian photoreceptors
Berson, D. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00130-9 · Cited by 546 · see citing works
Dysregulation of inflammatory responses by chronic circadian disruption
Castanon-Cervantes, O., Wu, M., Ehlen, J. C., Paul, K., Gamble, K. L., Johnson, R. L., Besing, R. C., Menaker, M., Gewirtz, A. T., & Davidson, A. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001026 · Cited by 542 · see citing works
Self-citationShimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., Hayashi, M., Wada, T., Aoyagi, T., & Tezuka, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502383102 · Cited by 536 · see citing works
Depression scores associate with chronotype and social jetlag in a rural population
Levandovski, R., Dantas, G., Fernandes, L. C., Caumo, W., Torres, I., Roenneberg, T., Hidalgo, M. P. L., & Allebrandt, K. V. (2011) · Chronobiology International · doi:10.3109/07420528.2011.602445 · Cited by 527 · see citing works
Prospective study of shift work and risk of coronary heart disease in women
Kawachi, I., Colditz, G. A., Stampfer, M. J., Willett, W. C., Manson, J. E., Speizer, F. E., & Hennekens, C. H. (1995) · Circulation · doi:10.1161/01.cir.92.11.3178 · Cited by 524 · see citing works
PER3 polymorphism predicts sleep structure and waking performance
Viola, A. U., Archer, S. N., James, L. M., Groeger, J. A., Lo, J. C. Y., Skene, D. J., von Schantz, M., & Dijk, D.-J. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.073 · Cited by 520 · see citing works
Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic functionPreprint
Bugge, A. K., Feng, D., Everett, L. J., Briggs, E. R., Mullican, S. E., Wang, F., Jager, J., & Lazar, M. A. (2012) · Genes & Development · doi:10.1101/gad.186858.112 · Cited by 503 · see citing works
Haus, E. L., & Smolensky, M. H. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.08.003 · Cited by 499 · see citing works
PER2 controls lipid metabolism by direct regulation of PPARγ
Grimaldi, B., Bellet, M. M., Katada, S., Astarita, G., Hirayama, J., Amin, R. H., Granneman, J. G., Piomelli, D., Leff, T., & Sassone-Corsi, P. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.10.005 · Cited by 489 · see citing works
Cocaine sensitization and reward are under the influence of circadian genes and rhythm
Abarca, C., Albrecht, U., & Spanagel, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142039099 · Cited by 472 · see citing works
Dijk, D., Duffy, J. F., Riel, E., Shanahan, T. L., & Czeisler, C. A. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0611v.x · Cited by 467 · see citing works
Obesity in mice with adipocyte-specific deletion of clock component Arntl
Paschos, G. K., Ibrahim, S., Song, W.-L., Kunieda, T., Grant, G., Reyes, T. M., Bradfield, C. A., Vaughan, C. H., Eiden, M., Masoodi, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2979 · Cited by 465 · see citing works
Increased risk of ischaemic heart disease in shift workers
Knutsson, A., Jonsson, B., Akerstedt, T., & Orth-Gomer, K. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91619-3 · Cited by 459 · see citing works
Circadian Disruption Leads to Insulin Resistance and Obesity
Shi, S.-Q., Ansari, T. S., McGuinness, O. P., Wasserman, D. H., & Johnson, C. H. (2013) · Current Biology · doi:10.1016/j.cub.2013.01.048 · Cited by 452 · see citing works
The circadian basis of winter depression
Lewy, A. J., Lefler, B. J., Emens, J. S., & Bauer, V. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602425103 · Cited by 451 · see citing works
Masking: History, Definitions, and Measurement
Mrosovsky, N. (1999) · Chronobiology International · doi:10.3109/07420529908998717 · Cited by 449 · see citing works
Bright light effects on body temperature, alertness, EEG and behavior
Badia, P., Myers, B. L., Boecker, M. R., Culpepper, J., & Harsh, J. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90549-4 · Cited by 437 · see citing works
Blask, D. E., Brainard, G. C., Dauchy, R. T., Hanifin, J. P., Davidson, L. K., Krause, J. A., Sauer, L. A., Rivera-Bermudez, M. A., Dubocovich, M. L., Jasser, S. A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1945 · Cited by 431 · see citing works
Doi, M., Takahashi, Y., Komatsu, R., Yamazaki, F., Yamada, H., Haraguchi, S., Emoto, N., Okuno, Y., Tsujimoto, G., Kanematsu, A., et al. (2010) · Nature Medicine · doi:10.1038/nm.2061 · Cited by 431 · see citing works
Chronic jet-lag increases mortality in aged mice
Davidson, A. J., Sellix, M. T., Daniel, J., Yamazaki, S., Menaker, M., & Block, G. D. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.058 · Cited by 427 · see citing works
Self-citationCircadian clock protein cryptochrome regulates the expression of proinflammatory cytokines
Narasimamurthy, R., Hatori, M., Nayak, S. K., Liu, F., Panda, S., & Verma, I. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209965109 · Cited by 421 · see citing works
Deregulated expression of the PER1 , PER2 and PER3 genes in breast cancers
Chen, S., Choo, K., Hou, M., Yeh, K., Kuo, S., & Chang, J. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi075 · Cited by 419 · see citing works
Regulation of Monoamine Oxidase A by Circadian-Clock Components Implies Clock Influence on Mood
Hampp, G., Ripperger, J. A., Houben, T., Schmutz, I., Blex, C., Perreau‐Lenz, S., Brunk, I., Spanagel, R., Ahnert‐Hilger, G., Meijer, J. H., et al. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.012 · Cited by 419 · see citing works
Effects of Chronic Jet Lag on Tumor Progression in Mice
Filipski, E., Delaunay, F., King, V. M., Wu, M., Claustrat, B., Gréchez‐Cassiau, A., Guettier, C., Hastings, M. H., & Lévi, F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0674 · Cited by 416 · see citing works
Host Circadian Clock as a Control Point in Tumor Progression
Filipski, E. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.9.690 · Cited by 413 · see citing works
Shift work, sleep, and sleepiness – differences between shift schedules and systems
Sallinen, M., & Kecklund, G. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2900 · Cited by 412 · see citing works
Woon, P. Y., Kaisaki, P. J., Bragança, J., Bihoreau, M., Lévy, J., Farrall, M., & Gauguier, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703247104 · Cited by 410 · see citing works
Constant light desynchronizes mammalian clock neurons
Ohta, H., Yamazaki, S., & McMahon, D. G. (2005) · Nature Neuroscience · doi:10.1038/nn1395 · Cited by 405 · see citing works
Kubo, T., Ozasa, K., Mikami, K., Wakai, K., Fujino, Y., Watanabe, Y., Miki, T., Nakao, M., Hayashi, K., Suzuki, K. A. O., et al. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj232 · Cited by 403 · see citing works
Rotating shift work and the metabolic syndrome: a prospective study
De Bacquer, D., Van Risseghem, M., Clays, E., Kittel, F., De Backer, G., & Braeckman, L. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyn360 · Cited by 394 · see citing works
Andrews, J. L., Zhang, X., McCarthy, J. J., McDearmon, E. L., Hornberger, T. A., Russell, B., Campbell, K. S., Arbogast, S., Reid, M. B., Walker, J. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014523107 · Cited by 389 · see citing works
A Time to Work: Recent Trends in Shift Work and Flexible Schedules
McMenamin, T. M. (2007) · Monthly labor review · Cited by 389 · see citing works
Circadian Clock Mutation Disrupts Estrous Cyclicity and Maintenance of Pregnancy
Miller, B. H., Olson, S. L., Turek, F. W., Levine, J. E., Horton, T. H., & Takahashi, J. S. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.055 · Cited by 377 · see citing works
The Adaptive Value of Circadian Clocks
Woelfle, M. A., Ouyang, Y., Phanvijhitsiri, K., & Johnson, C. H. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.023 · Cited by 375 · see citing works
The Circadian<i>Clock</i>Mutation Alters Sleep Homeostasis in the Mouse
Naylor, E., Bergmann, B. M., Krauski, K., Zee, P. C., Takahashi, J. S., Vitaterna, M. H., & Turek, F. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08138.2000 · Cited by 367 · see citing works
Genetic Control of Melatonin Synthesis in the Pineal Gland of the Mouse
Ebihara, S., Marks, T. N., Hudson, D. J., & Menaker, M. (1986) · Science · doi:10.1126/science.3941912 · Cited by 354 · see citing works
Re-entrainment of circadian rhythms after phase-shifts of the Zeitgeber.
Aschoff, J., Hoffmann, K. H., Pohl, H. H., & Wever, R. A. (1975) · PubMed · Cited by 352 · see citing works
Guilding, C., & Piggins, H. D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05581.x · Cited by 348 · see citing works
Shimba, S., Ogawa, T., Hitosugi, S., Ichihashi, Y., Nakadaira, Y., Kobayashi, M., Tezuka, M., Kosuge, Y., Ishige, K., Ito, Y., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025231 · Cited by 347 · see citing works
Di Lorenzo, L., De Pergola, G., Zocchetti, C., L'Abbate, N., Basso, A., Pannacciulli, N., Cignarelli, M., Giorgino, R., & Soleo, L. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802419 · Cited by 346 · see citing works
Light-at-night, circadian disruption and breast cancer: assessment of existing evidence
Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345 · see citing works
Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man
SCOTT, E. M., Carter, A. M., & Grant, P. J. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803778 · Cited by 344 · see citing works
Lo, J. C., Groeger, J. A., Santhi, N., Arbon, E. L., Lazar, A. S., Hasan, S., von Schantz, M., Archer, S. N., & Dijk, D.-J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045987 · Cited by 342 · see citing works
Genome-wide Expression Analysis of Mouse Liver Reveals CLOCK-regulated Circadian Output Genes
Oishi, K., Miyazaki, K., Kadota, K., Kikuno, R. F., Nagase, T., Atsumi, G.-I., Ohkura, N., Azama, T., Mesaki, M., Yukimasa, S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304564200 · Cited by 341 · see citing works
Night Shift Work and the Risk of Endometrial Cancer
Viswanathan, A. N., Hankinson, S. E., & Schernhammer, E. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2485 · Cited by 338 · see citing works
Folkard, S. (2008) · Chronobiology International · doi:10.1080/07420520802106835 · Cited by 335 · see citing works
Chronic 'jet lag' produces temporal lobe atrophy and spatial cognitive deficits
Cho, K. (2001) · Nature Neuroscience · doi:10.1038/88384 · Cited by 332 · see citing works
Core circadian protein CLOCK is a positive regulator of NF-κB–mediated transcription
Spengler, M. L., Kuropatwinski, K. K., Comas, M., Gasparian, A. V., Fedtsova, N. G., Gleiberman, A. S., Gitlin, I. I., Artemicheva, N. M., Deluca, K. A., Gudkov, A. V., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206274109 · Cited by 331 · see citing works
Sleep and Cardiovascular Disease
Wolk, R. A., Gami, A. S., García‐Touchard, A., & Somers, V. K. (2005) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2005.07.002 · Cited by 327 · see citing works
Pilcher, J. J., Lambert, B. J., & Huffcutt, A. I. (2000) · SLEEP · doi:10.1093/sleep/23.2.1b · Cited by 325 · see citing works
Esquirol, Y., Bongard, V., Mabile, L., Jonnier, B., Soulat, J., & Perret, B. (2009) · Chronobiology International · doi:10.1080/07420520902821176 · Cited by 324 · see citing works
Salgado-Delgado, R., Angeles-Castellanos, M., Saderi, N., Buijs, R. M., & Escobar, C. (2010) · Endocrinology · doi:10.1210/en.2009-0864 · Cited by 323 · see citing works
Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters
Martino, T. A., Oudit, G. Y., Herzenberg, A. M., Tata, N., Koletar, M. M., Kabir, G. M., Belsham, D. D., Backx, P. H., Ralph, M. R., & Sole, M. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00829.2007 · Cited by 317 · see citing works
Metabolic disturbances in male workers with rotating three-shift work. Results of the WOLF study
Karlsson, B. H., Knutsson, A., Lindahl, B., & Alfredsson, L. S. (2003) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-003-0440-y · Cited by 316 · see citing works
Sadacca, L. A., Lamia, K. A., deLemos, A. S., Blum, B., & Weitz, C. J. (2011) · Diabetologia · doi:10.1007/s00125-010-1920-8 · Cited by 314 · see citing works
Circadian Systems: Longevity as a Function of Circadian Resonance in Drosophila melanogaster
Pittendrigh, C. S., & Minis, D. H. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1537 · Cited by 303 · see citing works
Rotating Night Shift Work and the Risk of Ischemic Stroke
Brown, D. L., Feskanich, D., Sanchez, B. N., Rexrode, K. M., Schernhammer, E. S., & Lisabeth, L. D. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp056 · Cited by 297 · see citing works
Vascular Disease in Mice With a Dysfunctional Circadian Clock
Anea, C. B., Zhang, M., Stepp, D. W., Simkins, G. B., Reed, G. L., Fulton, D. J., & Rudic, R. D. (2009) · Circulation · doi:10.1161/circulationaha.108.827477 · Cited by 292 · see citing works
Rüger, M., Gordijn, M. C. M., Beersma, D. G. M., de Vries, B., & Daan, S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00121.2005 · Cited by 286 · see citing works
Gastrointestinal disorders among shift workers
Knutsson, A., & Bøggild, H. (2010) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.2897 · Cited by 286 · see citing works
Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice
Lee, S., Donehower, L. A., Herron, A. J., Moore, D. D., & Fu, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010995 · Cited by 286 · see citing works
Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation
Altimus, C. M., Güler, A. D., Villa, K. L., McNeill, D. S., LeGates, T. A., & Hattar, S. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808312105 · Cited by 286 · see citing works
Antiphase Oscillation of the Left and Right Suprachiasmatic Nuclei
de la, H. O., Iglesia, Meyer, J. L., Carpino, A., & Schwartz, W. J. (2000) · Science · doi:10.1126/science.290.5492.799 · Cited by 286 · see citing works
Åkerstedt, T., Fredlund, P., Gillberg, M., & Jansson, B. (2002) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2002.00287.x · Cited by 285 · see citing works
Alvarez, J. D., Hansen, A. G., Ord, T. S., Bębas, P., Chappell, P. E., Giebultowicz, J. M., Williams, C. J., Moss, S., & Sehgal, A. (2008) · Journal of Biological Rhythms · doi:10.1177/0748730407311254 · Cited by 285 · see citing works
Molecular Circadian Rhythms in Central and Peripheral Clocks in Mammals
Dardente, H., Dardente, H., & Cermakian, N. (2007) · Chronobiology International · doi:10.1080/07420520701283693 · Cited by 284 · see citing works
Shiftwork and Metabolic Risk Factors of Cardiovascular Disease
Ha, M., & Park, J. (2005) · Journal of Occupational Health · doi:10.1539/joh.47.89 · Cited by 276 · see citing works
The Significance of Circadian Organization for Longevity in the Golden Hamster
Hurd, M. W., & Ralph, M. R. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098129000255 · Cited by 275 · see citing works
Molecular clock is involved in predictive circadian adjustment of renal function
Zuber, A. M., Centeno, G., Pradervand, S., Nikolaeva, S., Maquelin, L., Cardinaux, L., Bonny, O., & Firsov, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904890106 · Cited by 274 · see citing works
An Abrupt Shift in the Day/Night Cycle Causes Desynchrony in the Mammalian Circadian Center
Nagano, M., Adachi, A. A., Nakahama, K., Nakamura, T., Tamada, M., Meyer-Bernstein, E. L., Sehgal, A., & Shigeyoshi, Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-14-06141.2003 · Cited by 273 · see citing works
Phase relations between a circadian rhythm and its zeitgeber within the range of entrainment
Aschoff, J., & Pohl, H. H. (1978) · Die Naturwissenschaften · doi:10.1007/bf00440545 · Cited by 269 · see citing works
Hoogerwerf, W. A., Hellmich, H. L., Cornélissen, G., Franz Halberg, A., Shahinian, V. B., Bostwick, J., Savidge, T., & Cassone, V. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.009 · Cited by 268 · see citing works
The role of mPer2 clock gene in glucocorticoid and feeding rhythms
Yang, S., Liu, A., Weidenhammer, A., Cooksey, R. C., McClain, D., Kim, M. K., Aguilera, G., Abel, E. D., & Chung, J. H. (2009) · Endocrinology · doi:10.1210/en.2008-0705 · Cited by 263 · see citing works
A longitudinal study on the effect of shift work on weight gain in male Japanese workers.
Suwazono, Y., Dochi, M., Sakata, K., Okubo, Y., Oishi, M., Tanaka, K., Kobayashi, E., Kido, T., & Nogawa, K. (2008) · Obesity · doi:10.1038/oby.2008.298 · Cited by 259 · see citing works
Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork
Barclay, J. L., Husse, J., Bode, B., Naujokat, N., Meyer-Kovac, J., Schmid, S. M., Lehnert, H., & Oster, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037150 · Cited by 259 · see citing works
Light Affects Morning Salivary Cortisol in Humans
Scheer, F. A. J. L., & Buijs, R. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.9.6102 · Cited by 258 · see citing works
Light-induced suppression of endogenous circadian amplitude in humans
Jewett, M. E., Kronauer, R. E., & Czeisler, C. A. (1991) · Nature · doi:10.1038/350059a0 · Cited by 253 · see citing works
Circadian misalignment in major depressive disorder
Emens, J., Lewy, A., Kinzie, J. M., Arntz, D., & Rough, J. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2009.04.009 · Cited by 253 · see citing works
Shift work and disturbed sleep/wakefulness
Åkerstedt, T. (1998) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(98)90004-1 · Cited by 252 · see citing works
Mukherjee, S., Coque, L., Cao, J., Kumar, J., Chakravarty, S., Asaithamby, A., Graham, A., Gordon, E., Enwright, J. F., Dileone, R., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.031 · Cited by 249 · see citing works
An analysis of the “eveningness–morningness” dimension in “depressive” college students
Chelminski, I., Ferraro, F. R., Petros, T. V., & Plaud, J. J. (1999) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00051-2 · Cited by 243 · see citing works
Impaired Cued and Contextual Memory in NPAS2-Deficient Mice
Garcia, J. A., Zhang, D., Estill, S. J., Michnoff, C. H., Rutter, J. P., Reick, M., Scott, K., Diaz-Arrastia, R. R., & McKnight, S. L. (2000) · Science · doi:10.1126/science.288.5474.2226 · Cited by 242 · see citing works
Mutation of the Circadian Clock Gene Per2 Alters Vascular Endothelial Function
Viswambharan, H., Carvas, J. M., Antic, V., Marecic, A., Jud, C., Zaugg, C. E., Ming, X., Montani, J., Albrecht, U., & Yang, Z. (2007) · Circulation · doi:10.1161/circulationaha.106.653303 · Cited by 242 · see citing works
Shift work and cancer – considerations on rationale, mechanisms, and epidemiology
Costa, G., Haus, E., & Stevens, R. (2010) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.2899 · Cited by 241 · see citing works
Crowley, S. J., Lee, C., Tseng, C. Y., Fogg, L. F., & Eastman, C. I. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403258422 · Cited by 238 · see citing works
Forced Desynchronization of Dual Circadian Oscillators within the Rat Suprachiasmatic Nucleus
de la Iglesia, H. O., Cambras, T., Schwartz, W. J., & Dı́ez-Noguera, A. (2004) · Current Biology · doi:10.1016/j.cub.2004.04.034 · Cited by 236 · see citing works
Chronic Jet Lag Produces Cognitive Deficits
Cho, K., Ennaceur, A., Cole, J. C., & Suh, C. K. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-06-j0005.2000 · Cited by 236 · see citing works
Hippocampal-dependent learning requires a functional circadian system
Ruby, N. F., Hwang, C. E., Wessells, C., Fernandez, F., Zhang, P., Sapolsky, R., & Heller, H. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808259105 · Cited by 234 · see citing works
Effects of circadian disruption on the cardiometabolic system
Rüger, M., & Scheer, F. A. J. L. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9122-8 · Cited by 232 · see citing works
Liu, J., Mankani, G., Shi, X., Meyer, M., Cunningham-Runddles, S., Ma, X., & Sun, Z. S. (2006) · Infection and Immunity · doi:10.1128/iai.00287-06 · Cited by 226 · see citing works
The Impact of Rotating Shift Work on the Prevalence of Irritable Bowel Syndrome in Nurses
Nojkov, B., Rubenstein, J. H., Chey, W. D., & Hoogerwerf, W. A. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.48 · Cited by 226 · see citing works
Rotating Shift Work and Risk of Prostate Cancer
Conlon, M., Lightfoot, N., & Kreiger, N. (2006) · Epidemiology · doi:10.1097/01.ede.0000249519.33978.31 · Cited by 225 · see citing works
A Prospective Cohort Study of Shift Work and Risk of Ischemic Heart Disease in Japanese Male Workers
Fujino, Y., Iso, H., Tamakoshi, A., Inaba, Y., Koizumi, A., Kubo, T., & Yoshimura, T. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj185 · Cited by 225 · see citing works
Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons
Wang, T. A., Yu, Y. V., Govindaiah, G., Ye, X., Artinian, L. R., Coleman, T. P., Sweedler, J. V., Cox, C. L., & Gillette, M. U. (2012) · Science · doi:10.1126/science.1222826 · Cited by 221 · see citing works
Duration of shiftwork related to body mass index and waist to hip ratio
van Amelsvoort, L., Schouten, E., & Kok, F. J. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0801028 · Cited by 221 · see citing works
Shiftwork and Cardiovascular Disease: Review of Disease Mechanisms
Knutsson, A., & Bøggild, H. (2000) · Reviews on Environmental Health · doi:10.1515/reveh.2000.15.4.359 · Cited by 220 · see citing works
Reddy, A. B., Field, M. D., Maywood, E. S., & Hastings, M. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07326.2002 · Cited by 220 · see citing works
The clock gene Per2 links the circadian system to the estrogen receptor
Gery, S., Virk, R. K., Chumakov, K., Yu, A., & Koeffler, H. P. (2007) · Oncogene · doi:10.1038/sj.onc.1210585 · Cited by 218 · see citing works
Penev, P. D., Kolker, D. E., Zee, P. C., & Turek, F. W. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.6.h2334 · Cited by 216 · see citing works
The impact of the circadian timing system on cardiovascular and metabolic function
Morris, C. J., Yang, J. N., & Scheer, F. A. J. L. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00019-8 · Cited by 215 · see citing works
The effects of depression and age on the Horne-Ostberg morningness-eveningness score
Drennan, M. D., Klauber, M. R., Kripke, D. F., & Goyette, L. M. (1991) · Journal of Affective Disorders · doi:10.1016/0165-0327(91)90096-b · Cited by 215 · see citing works
Entrainment of the human circadian pacemaker to longer-than-24-h days
Gronfier, C., Wright, K. P., Kronauer, R. E., & Czeisler, C. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702835104 · Cited by 215 · see citing works
Metabolic Syndrome in Permanent Night Workers
Biggi, N., Consonni, D., Galluzzo, V., Sogliani, M., & Costa, G. (2008) · Chronobiology International · doi:10.1080/07420520802114193 · Cited by 213 · see citing works
Circadian and wakefulness-sleep modulation of cognition in humans
Wright, K. P., Lowry, C. A., & LeBourgeois, M. K. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00050 · Cited by 209 · see citing works
Shift Work, Jet Lag, and Female Reproduction
Mahoney, M. M. (2010) · International Journal of Endocrinology · doi:10.1155/2010/813764 · Cited by 209 · see citing works
Influence of light at night on murine anxiety- and depressive-like responses
Fonken, L. K., Finy, M. S., Walton, J. C., Weil, Z. M., Workman, J. L., Ross, J., & Nelson, R. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.07.001 · Cited by 209 · see citing works
Shift Work at Young Age Is Associated with Elevated Long-Term Cortisol Levels and Body Mass Index
Manenschijn, L., van Kruysbergen, R., de Jong, F. H., Koper, J. W., & van Rossum, E. F. C. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1551 · Cited by 209 · see citing works
Shiftwork and myocardial infarction: a case-control study.
Knutsson, A., Hallquist, J., Reuterwall, C., Theorell, T., & Åkerstedt, T. (1999) · Occupational and Environmental Medicine · doi:10.1136/oem.56.1.46 · Cited by 208 · see citing works
Progressive arthropathy in mice with a targeted disruption of theMop3/Bmal-1 locus
Bunger, M. K., Walisser, J. A., Sullivan, R., Manley, P. A., Moran, S. M., Kalscheur, V. L., Colman, R. J., & Bradfield, C. A. (2005) · genesis · doi:10.1002/gene.20102 · Cited by 207 · see citing works
Postprandial hormone and metabolic responses amongst shift workers in Antarctica
Lund, J., Arendt, J., Hampton, S., English, J., & Morgan, L. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1710557 · Cited by 206 · see citing works
Circadian Phase Variation in Bipolar I Disorder
Mansour, H. A., Wood, J., Chowdari, K. V., Dayal, M., Thase, M. E., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L. (2005) · Chronobiology International · doi:10.1081/cbi-200062413 · Cited by 204 · see citing works
Cellular Circadian Clocks in Mood Disorders
McCarthy, M. J., & Welsh, D. K. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412456367 · Cited by 203 · see citing works
Dim nighttime light impairs cognition and provokes depressive-like responses in a diurnal rodent
Fonken, L. K., Kitsmiller, E., Smale, L., & Nelson, R. J. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412448324 · Cited by 203 · see citing works
Wang, L. M.-C., Dragich, J. M., Kudo, T., Odom, I. H., Welsh, D. K., O’Dell, T. J., & Colwell, C. S. (2009) · ASN NEURO · doi:10.1042/an20090020 · Cited by 201 · see citing works
Effects of light and food schedules on liver and tumor molecular clocks in mice
Filipski, E., Innominato, P. F., Wu, M., Li, X.-M., Iacobelli, S., Xian, L.-J., & Levi, F. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji083 · Cited by 200 · see citing works
Costa, G. (1997) · Chronobiology International · doi:10.3109/07420529709001147 · Cited by 199 · see citing works
Gibson, E. M., Wang, C., Tjho, S., Khattar, N., & Kriegsfeld, L. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015267 · Cited by 196 · see citing works
Visual impairment and circadiam rhythm disorders
Lockley, S. W., Arendt, J., & Skene, D. J. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.3/slockley · Cited by 196 · see citing works
Effect of shift work on body mass index and metabolic parameters
Morikawa, Y., Nakagawa, H., Miura, K., Soyama, Y., Ishizaki, M., Kido, T., Naruse, Y., Suwazono, Y., & Nogawa, K. (2007) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.1063 · Cited by 194 · see citing works
CLOCK in Breast Tumorigenesis: Genetic, Epigenetic, and Transcriptional Profiling Analyses
Hoffman, A. E., Yi, C., Zheng, T., Stevens, R. G., Leaderer, D., Zhang, Y., Holford, T. R., Hansen, J., Paulson, J., & Zhu, Y. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3798 · Cited by 192 · see citing works
Loss of cryptochrome reduces cancer risk in p53 mutant mice
Öztürk, N., Lee, J. H., Gaddameedhi, S., & Sancar, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813028106 · Cited by 192 · see citing works
Sleep and wakefulness out of phase with internal biological time impairs learning in humans
Wright, K. P., Hull, J. T., Hughes, R. J., Ronda, J. M., & Czeisler, C. A. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.4.508 · Cited by 191 · see citing works
Chronic exposure to dim light at night suppresses immune responses in Siberian hamsters
Bedrosian, T. A., Fonken, L. K., Walton, J. C., & Nelson, R. J. (2011) · Biology Letters · doi:10.1098/rsbl.2010.1108 · Cited by 190 · see citing works
Prematurity and work in pregnancy.
McDonald, A. D., McDonald, J. C., Armstrong, B., Cherry, N., Nolin, A. D., & Robert, D. (1988) · Occupational and Environmental Medicine · doi:10.1136/oem.45.1.56 · Cited by 185 · see citing works
Temporal dynamics of mouse hippocampal clock gene expression support memory processing
Jilg, A., Lesny, S., Peruzki, N., Schwegler, H., Selbach, O., Dehghani, F., & Stehle, J. H. (2009) · Hippocampus · doi:10.1002/hipo.20637 · Cited by 184 · see citing works
Dubrovsky, Y. V., Samsa, W. E., & Kondratov, R. V. (2010) · Aging · doi:10.18632/aging.100241 · Cited by 184 · see citing works
Measurement of, and Some Reasons for, Differences in Eating Habits Between Night and Day Workers
Waterhouse, J. M., Buckley, P., Edwards, B., & Reilly, T. P. (2003) · Chronobiology International · doi:10.1081/cbi-120025536 · Cited by 182 · see citing works
The Circadian Clock Interacts with Metabolic Physiology to Influence Reproductive Fitness
Xu, K., DiAngelo, J. R., Hughes, M. E., Hogenesch, J. B., & Sehgal, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.001 · Cited by 181 · see citing works
Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis
Wood, P. A., Yang, X., Taber, A., Oh, E.-Y., Ansell, C. M., Ayers, S. E., Al-Assaad, Z., Carnevale, K. A., Berger, F. G., Peña, M. M. O., et al. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0196 · Cited by 181 · see citing works
Cryptochrome, Circadian Cycle, Cell Cycle Checkpoints, and Cancer
Gauger, M. A., & Sancar, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1119 · Cited by 181 · see citing works
Periaqueductal gray matter projections to midline and intralaminar thalamic nuclei of the rat
Krout, K. E., & Loewy, A. D. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20000814)424:1 · Cited by 180 · see citing works
Monje, F. J., Cabatic, M., Divisch, I., Kim, E.-J., Herkner, K. R., Binder, B. R., & Pollak, D. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1537-11.2011 · Cited by 178 · see citing works
Hasler, B. P., Buysse, D. J., Kupfer, D. J., & Germain, A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.04.027 · Cited by 177 · see citing works
EFFECTS OF SHIFTWORK ON SLEEP AND MENSTRUAL FUNCTION IN NURSES
Labyak, S. E., Lava, S., Turek, F. W., & Zee, P. C. (2002) · Health Care For Women International · doi:10.1080/07399330290107449 · Cited by 177 · see citing works
Developmental and reproductive performance in circadian mutant mice
Dolatshad, H., Campbell, E. A., O’Hara, L., Maywood, E. S., Hastings, M. H., & Johnson, M. H. (2005) · Human Reproduction · doi:10.1093/humrep/dei313 · Cited by 176 · see citing works
Wood, J. A., Birmaher, B. B., Axelson, D., Ehmann, M., Kalas, C., Monk, K., Turkin, S. R., Kupfer, D. J., Brent, D. A., Monk, T. H., et al. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.03.003 · Cited by 176 · see citing works
Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF-α
Hashiramoto, A., Yamane, T., Tsumiyama, K., Yoshida, K., Komai, K., Yamada, H., Yamazaki, F., Doi, M., Okamura, H., & Shiozawa, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0903284 · Cited by 174 · see citing works
Period3 Structural Variation: A Circadian Biomarker Associated with Breast Cancer in Young Women
Zhu, Y. L., Brown, H. N., Zhang, Y., Stevens, R. G., & Zheng, T. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.268.14.1 · Cited by 173 · see citing works
Revised Limit Cycle Oscillator Model of Human Circadian Pacemaker
Jewett, M. E., Forger, D. B., & Kronauer, R. E. (1999) · Journal of Biological Rhythms · doi:10.1177/074873049901400608 · Cited by 171 · see citing works
Light and Diurnal Cycle Affect Human Heart Rate: Possible Role for the Circadian Pacemaker
Scheer, F. A. J. L., van Doornen, L. J. P., & Buijs, R. M. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000614 · Cited by 170 · see citing works
Rotating Shift Work and Menstrual Cycle Characteristics
Lawson, C. C., Whelan, E. A., Hibert, E. N. L., Spiegelman, D. L., Schernhammer, E. S., & Rich-Edwards, J. W. (2011) · Epidemiology · doi:10.1097/ede.0b013e3182130016 · Cited by 168 · see citing works
Shift Work, Nitrous Oxide Exposure and Subfertility among Swedish Midwives
Ahlborg, G., Axelsson, G., & Bodin, L. (1996) · International Journal of Epidemiology · doi:10.1093/ije/25.4.783 · Cited by 168 · see citing works
Chappell, P. E., White, R. S., & Mellon, P. L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11202.2003 · Cited by 168 · see citing works
Bedrosian, T. A., Fonken, L. K., Walton, J. C., Haim, A., & Nelson, R. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.01.004 · Cited by 167 · see citing works
Chronic Shift-Lag Alters the Circadian Clock of NK Cells and Promotes Lung Cancer Growth in Rats
Logan, R. W., Zhang, C., Murugan, S., O’Connell, S., Levitt, D., Rosenwasser, A. M., & Sarkar, D. K. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102715 · Cited by 166 · see citing works
Impaired Steroidogenesis and Implantation Failure in Bmal1−/− Mice
Ratajczak, C. K., Boehle, K. L., & Muglia, L. J. (2008) · Endocrinology · doi:10.1210/en.2008-1021 · Cited by 162 · see citing works
Yang, X., Wood, P. A., Oh, E.-Y., Du‐Quiton, J., Ansell, C. M., & Hrushesky, W. J. M. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0133-z · Cited by 161 · see citing works
(1824) · The Lancet · doi:10.1016/s0140-6736(02)92910-7 · Cited by 161 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Circadian Clock and Human Health
Roenneberg, T., & Merrow, M. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.011 · Cited by 1,004 · see citing works
Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease
Musiek, E. S., Xiong, D. D., & Holtzman, D. M. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.121 · Cited by 529 · see citing works
Animal models of major depression and their clinical implications
Czéh, B., Fuchs, E., Wiborg, O., & Simon, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.004 · Cited by 375 · see citing works
Circadian dysfunction induces leptin resistance in mice
Kettner, N. M., Mayo, S. A., Hua, J., Lee, C., Moore, D. D., & Fu, L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.005 · Cited by 260 · see citing works
Endocrine Effects of Circadian Disruption
Bedrosian, T. A., Fonken, L. K., & Nelson, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105102 · Cited by 170 · see citing works
Circadian gene variants in cancer
Kettner, N. M., Katchy, C. A., & Fu, L. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.914808 · Cited by 147 · see citing works
Smarr, B. L., Grant, A. D., Perez, L., Zucker, I., & Kriegsfeld, L. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-03406-4 · Cited by 86 · see citing works
Circadian Disruption in Psychiatric Disorders
Jones, S. G., & Benca, R. M. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.07.004 · Cited by 86 · see citing works
Central and peripheral circadian clocks and their role in Alzheimer's disease
Chauhan, R., Chen, K.-F., Kent, B. A., & Crowther, D. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030627 · Cited by 58 · see citing works
“Given the importance of circadian biology in regulating organismal health, it is of no surprise that the breakdown of daily circadian rhythms (see Glossary, Box 1) is a risk factor for a range of diseases, including metabolic syndrome, vascular disease and cancer (Anea et al., 2009; Bass and Takahashi, 2010; Evans and…”
BackgroundIkeno, T., & Yan, L. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416642065 · Cited by 37 · see citing works
- Authors
- Evans, J. A., & Davidson, A. J.
- Affiliations
- Morehouse School of Medicine (US)
- Venue
- Progress in Molecular Biology and Translational Science
- Publisher
- Elsevier
- Published
- 2013
- Volume
- 119
- Pages
- 283-323
- ISSN
- 1877-1173 (ISSN-L)
- OpenAlex
- W31275902
- Cited by
- 291
- References
- 429
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 12 · 2023: 23 · 2022: 29 · 2021: 24 · 2020: 44 · 2019: 26 · 2018: 28 · 2017: 19 · 2016: 22 · 2015: 31 · 2014: 13
- FWCI
- 13.94
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in molecular biology and translational science (publishedVersion)
- PubMed (publishedVersion)
- e-Publications@Marquette (Marquette University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Keywords
- circadian rhythm disruption, circadian system, biological clock, health effects, cancer risk, metabolic syndrome, cardiovascular dysfunction, immune dysregulation, reproductive disorders, mood disorders, learning deficits, premature mortality, genetic and environmental factors
- MeSH terms
- Animals, Circadian Rhythm, Humans, Models, Animal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review