Cited by 291Circadian rhythm and melatoninSleep and Work-Related FatigueImpact of Light on Environment and Health

Health Consequences of Circadian Disruption in Humans and Animal Models

Evans, Jennifer A., Davidson, Alec J.·2013·Progress in Molecular Biology and Translational Science

Abstract

Daily rhythms in behavior and physiology are programmed by a hierarchical collection of biological clocks located throughout the brain and body, known as the circadian system. Mounting evidence indicates that disruption of circadian regulation is associated with a wide variety of adverse health consequences, including increased risk for premature death, cancer, metabolic syndrome, cardiovascular dysfunction, immune dysregulation, reproductive problems, mood disorders, and learning deficits. Here we review the evidence for the pervasive effects of circadian disruption in humans and animal models, drawing from both environmental and genetic studies, and identify questions for future research.

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Crossref · 10.1016/b978-0-12-396971-2.00010-5

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Authors
Evans, J. A., & Davidson, A. J.
Affiliations
Morehouse School of Medicine (US)
Venue
Progress in Molecular Biology and Translational Science
Publisher
Elsevier
Published
2013
Volume
119
Pages
283-323
ISSN
1877-1173 (ISSN-L)
OpenAlex
W31275902
Cited by
291
References
429
Citations by year
2026: 10 · 2025: 9 · 2024: 12 · 2023: 23 · 2022: 29 · 2021: 24 · 2020: 44 · 2019: 26 · 2018: 28 · 2017: 19 · 2016: 22 · 2015: 31 · 2014: 13
FWCI
13.94
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in molecular biology and translational science (publishedVersion)
  • PubMed (publishedVersion)
  • e-Publications@Marquette (Marquette University) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
Keywords
circadian rhythm disruption, circadian system, biological clock, health effects, cancer risk, metabolic syndrome, cardiovascular dysfunction, immune dysregulation, reproductive disorders, mood disorders, learning deficits, premature mortality, genetic and environmental factors
MeSH terms
Animals, Circadian Rhythm, Humans, Models, Animal

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