The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Dietary Intake and Risk of Developing Inflammatory Bowel Disease: A Systematic Review of the Literature
Abstract
OBJECTIVES: The incidence of inflammatory bowel disease (IBD) is increasing. Dietary factors such as the spread of the "Western" diet, high in fat and protein but low in fruits and vegetables, may be associated with the increase. Although many studies have evaluated the association between diet and IBD risk, there has been no systematic review. METHODS: We performed a systematic review using guideline-recommended methodology to evaluate the association between pre-illness intake of nutrients (fats, carbohydrates, protein) and food groups (fruits, vegetables, meats) and the risk of subsequent IBD diagnosis. Eligible studies were identified via structured keyword searches in PubMed and Google Scholar and manual searches. RESULTS: Nineteen studies were included, encompassing 2,609 IBD patients (1,269 Crohn's disease (CD) and 1,340 ulcerative colitis (UC) patients) and over 4,000 controls. Studies reported a positive association between high intake of saturated fats, monounsaturated fatty acids, total polyunsaturated fatty acids (PUFAs), total omega-3 fatty acids, omega-6 fatty acids, mono- and disaccharides, and meat and increased subsequent CD risk. Studies reported a negative association between dietary fiber and fruits and subsequent CD risk. High intakes of total fats, total PUFAs, omega-6 fatty acids, and meat were associated with an increased risk of UC. High vegetable intake was associated with a decreased risk of UC. CONCLUSIONS: High dietary intakes of total fats, PUFAs, omega-6 fatty acids, and meat were associated with an increased risk of CD and UC. High fiber and fruit intakes were associated with decreased CD risk, and high vegetable intake was associated with decreased UC risk.
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“A systematic review concluded that diets with high levels of total fats, polyunsaturated fatty acids, omega-6 fatty acids, and meat were associated with an increased risk of CD and UC; high fiber and high fruit intake were associated with a decreased risk of CD, whereas high vegetable intake was associated with a decreased for UC65.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [65]
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Cites
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Dietary Risk Factors for Inflammatory Bowel Disease
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Pre-illness dietary factors in inflammatory bowel disease.
Reif, S. S., Klein, I., Lubin, F., Farbstein, M., Hallak, A., & Gilat, T. (1997) · Gut · doi:10.1136/gut.40.6.754 · Cited by 336
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The impact of dietary fiber on gut microbiota in host health and disease
Makki, K., Deehan, E. C., Walter, J., & Bäckhed, F. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.012 · Cited by 2,517
Baumgart, D. C., & Sandborn, W. J. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60026-9 · Cited by 2,290
Dextran Sulfate Sodium (DSS)‐Induced Colitis in Mice
Chassaing, B., Aitken, J. D., Malleshappa, M., & Vijay–Kumar, M. (2014) · Current Protocols in Immunology · doi:10.1002/0471142735.im1525s104 · Cited by 2,094
Critical review: vegetables and fruit in the prevention of chronic diseases
Boeing, H., Bechthold, A., Bub, A., Ellinger, S., Haller, D., Kroke, A., Leschik‐Bonnet, E., Müller, M. J., Oberritter, H., Schulze, M. B., et al. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0380-y · Cited by 1,875
“No association was found between ulcerative colitis and fruit, while a trend was observed towards a risk reduction regarding vegetables [118].”
BackgroundEpidemiology and risk factors for IBD
Ananthakrishnan, A. N. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.34 · Cited by 1,741
Metadata
- Authors
- Hou, J. K., Abraham, B., & El-Serag, H.
- Affiliations
- Michael E. DeBakey VA Medical Center (US)
- Baylor College of Medicine (US)
- Corresponding author
- Hou, Jason K
- Venue
- American Journal of Gastroenterology
- Published
- 2011-04
- Volume
- 106
- Issue
- 4
- Pages
- 563-573
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2030631780
- Semantic Scholar
- 846fa3e7e7f98a379c5e4b67d65a7f58ab57640c
- Cited by
- 1,009
- References
- 33
- Citations by year
- 2026: 35 · 2025: 72 · 2024: 84 · 2023: 105 · 2022: 96 · 2021: 83 · 2020: 65 · 2019: 88 · 2018: 43 · 2017: 65 · 2016: 67 · 2015: 52 · 2014: 53 · 2013: 54 · 2012: 39
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK-56338, P30DK056338)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- inflammatory bowel disease, Crohn's disease, ulcerative colitis, dietary intake, Western diet, saturated fat, polyunsaturated fatty acids, omega-6 fatty acids, omega-3 fatty acids, dietary fiber, fruit consumption, vegetable consumption, meat consumption, dietary risk factors
- MeSH terms
- Colitis, Ulcerative, Crohn Disease, Diet, Dietary Carbohydrates, Dietary Fats, Dietary Fiber, Dietary Proteins, Fatty Acids, Unsaturated, Fruit, Humans, Meat, Vegetables, Inflammatory Bowel Diseases, Risk Assessment, Fatty Acids, Omega-6
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