The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Rare adipose disorders (RADs) masquerading as obesity
Open accessAbstract
Rare adipose disorders (RADs) including multiple symmetric lipomatosis (MSL), lipedema and Dercum's disease (DD) may be misdiagnosed as obesity. Lifestyle changes, such as reduced caloric intake and increased physical activity are standard care for obesity. Although lifestyle changes and bariatric surgery work effectively for the obesity component of RADs, these treatments do not routinely reduce the abnormal subcutaneous adipose tissue (SAT) of RADs. RAD SAT likely results from the growth of a brown stem cell population with secondary lymphatic dysfunction in MSL, or by primary vascular and lymphatic dysfunction in lipedema and DD. People with RADs do not lose SAT from caloric limitation and increased energy expenditure alone. In order to improve recognition of RADs apart from obesity, the diagnostic criteria, histology and pathophysiology of RADs are presented and contrasted to familial partial lipodystrophies, acquired partial lipodystrophies and obesity with which they may be confused. Treatment recommendations focus on evidence-based data and include lymphatic decongestive therapy, medications and supplements that support loss of RAD SAT. Associated RAD conditions including depression, anxiety and pain will improve as healthcare providers learn to identify and adopt alternative treatment regimens for the abnormal SAT component of RADs. Effective dietary and exercise regimens are needed in RAD populations to improve quality of life and construct advanced treatment regimens for future generations.
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Tissue distribution of beta 3-adrenergic receptor mRNA in man
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Köbberling Type of Familial Partial Lipodystrophy
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Oedema in obesity; role of structural lymphatic abnormalities
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Cited by
Obesity, insulin resistance and comorbidities? Mechanisms of association
Castro, A. V. B., Kolka, C. M., Kim, S. P., & Bergman, R. N. (2014) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/0004-2730000003223 · Cited by 254
Skin changes in the obese patient
Hirt, P. A., Castillo, D. E., Yosipovitch, G., & Keri, J. E. (2019) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2018.12.070 · Cited by 182
Quality of life in women with lipoedema: a contextual behavioral approach
Dudek, J. E., Białaszek, W., & Ostaszewski, P. (2016) · Quality of Life Research · doi:10.1007/s11136-015-1080-x · Cited by 108
Metadata
- Authors
- Herbst, K. L.
- Venue
- Acta Pharmacologica Sinica
- Published
- 2012-02
- Volume
- 33
- Issue
- 2
- Pages
- 155-172
- ISSN
- 0253-9756 (ISSN-L)
- 1671-4083
- 1745-7254
- OpenAlex
- W2105645480
- Cited by
- 259
- References
- 9
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Herbst, K. L. (2012). Rare adipose disorders (RADs) masquerading as obesity. Acta Pharmacologica Sinica. https://doi.org/10.1038/aps.2011.153
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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