Deciphering the roles of the constitutive androstane receptor in energy metabolism

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works

The coregulator exchange in transcriptional functions of nuclear receptors

Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233 · see citing works

Role of LXRs in control of lipogenesisPreprint

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Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

Hayhurst, G. P., Lee, Y.-H., Lambert, G., Ward, J. M., & Gonzalez, F. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1393-1403.2001 · Cited by 1,107 · see citing works

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

Bookout, A. L., Jeong, Y., Downes, M., Yu, R. T., Evans, R. M., & Mangelsdorf, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.06.049 · Cited by 1,015 · see citing works

Crucial Step in Cholesterol Homeostasis

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Nuclear Receptor Expression Links the Circadian Clock to Metabolism

Yang, X., Downes, M., Yu, R. T., Bookout, A. L., He, W., Straume, M., Mangelsdorf, D. J., & Evans, R. M. (2006) · Cell · doi:10.1016/j.cell.2006.06.050 · Cited by 934 · see citing works

The Meter of Metabolism

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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

Horton, J. D., Shimomura, I., Brown, M. S., Hammer, R. E., Goldstein, J. L., & Shimano, H. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2961 · Cited by 703 · see citing works

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

Honkakoski, P., Zelko, I. N., Sueyoshi, T., & Negishi, M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5652 · Cited by 701 · see citing works

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

Wei, P., Zhang, J., Egan-Hafley, M., Liang, S., & Moore, D. D. (2000) · Nature · doi:10.1038/35038112 · Cited by 654 · see citing works

Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification

Maglich, J. M., Stoltz, C. M., Goodwin, B. J., Hawkins‐Brown, D., Moore, J. T., & Kliewer, S. A. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.3.638 · Cited by 652 · see citing works

Enzymology of human cytosolic sulfotransferases

Falany, C. N. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.4.9068609 · Cited by 604 · see citing works

Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of theCYP2BGene

Kawamoto, T., Sueyoshi, T., Zelko, I. N., Moore, R., Washburn, K. A., & Negishi, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6318 · Cited by 549 · see citing works

Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis

Uyeda, K., & Repa, J. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.008 · Cited by 531 · see citing works

Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CARPreprint

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Diverse Roles of the Nuclear Orphan Receptor CAR in Regulating Hepatic Genes in Response to Phenobarbital

Ueda, A., Hamadeh, H. K., Webb, H. K., Yamamoto, Y., Sueyoshi, T., Afshari, C. A., Lehmann, J. M., & Negishi, M. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.1.1 · Cited by 465 · see citing works

The Xenobiotic Compound 1,4-Bis[2-(3,5-Dichloropyridyloxy)]Benzene Is an Agonist Ligand for the Nuclear Receptor CAR

Tzameli, I., Pissios, P., Schuetz, E. G., & Moore, D. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.9.2951-2958.2000 · Cited by 409 · see citing works

Nuclear Receptors CAR and PXR Cross Talk with FOXO1 To Regulate Genes That Encode Drug-Metabolizing and Gluconeogenic Enzymes

Kodama, S., Koike, C., Negishi, M., & Yamamoto, Y. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.7931-7940.2004 · Cited by 334 · see citing works

Enzymatic Reduction of Oxysterols Impairs LXR Signaling in Cultured Cells and the Livers of Mice

Chen, W., Chen, G., Head, D. L., Mangelsdorf, D. J., & Russell, D. W. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2006.11.012 · Cited by 316 · see citing works

X-Ray Structure of the hRORα LBD at 1.63 Å

Kallen, J. A., Schlaeppi, J.-M., Bitsch, F., Geisse, S., Geiser, M., Delhon, I., & Fournier, B. (2002) · Structure · doi:10.1016/s0969-2126(02)00912-7 · Cited by 299 · see citing works

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

Huang, W., Zhang, J., Washington, M., Liu, J., Parant, J. M., Lozano, G., & Moore, D. D. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0520 · Cited by 284 · see citing works

Fasting and Postprandial Overproduction of Intestinally Derived Lipoproteins in an Animal Model of Insulin Resistance

Haidari, M., Leung, N. M., Mahbub, F., Uffelman, K. D., Avramoglu, R. K., Lewis, G. F., & Adeli, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200544200 · Cited by 269 · see citing works

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

Dong, B., Saha, P., Huang, W., Chen, W., Abu-Elheiga, L. A., Wakil, S. J., Stevens, R. D., Ilkayeva, O., Newgard, C. B., Chan, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909731106 · Cited by 262 · see citing works

Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice

Aleksunes, L. M., & Klaassen, C. D. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.045112 · Cited by 259 · see citing works

Dexamethasone Enhances Constitutive Androstane Receptor Expression in Human Hepatocytes: Consequences on Cytochrome P450 Gene Regulation

Pascussi, J., Gerbal‐Chaloin, S., Fabre, J., Maurel, P., & Vilarem, M. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.6.1441 · Cited by 252 · see citing works

A Novel Constitutive Androstane Receptor-Mediated and CYP3A-Independent Pathway of Bile Acid Detoxification

Saini, S. P. S., Sonoda, J., Xu, L., Toma, D., Uppal, H., Mu, Y., Ren, S., Moore, D. D., Evans, R. M., & Xie, W. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.2.292 · Cited by 250 · see citing works

The LxxLL motif: a multifunctional binding sequence in transcriptional regulation

Plevin, M. J., Mills, M. M., & Ikura, M. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.12.001 · Cited by 248 · see citing works

The Constitutive Androstane Receptor and Pregnane X Receptor Function Coordinately to Prevent Bile Acid-induced Hepatotoxicity

Zhang, J., Huang, W., Qatanani, M., Evans, R. M., & Moore, D. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409041200 · Cited by 246 · see citing works

The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

Gao, J., He, J., Zhai, Y., Wada, T., & Xie, W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016808 · Cited by 234 · see citing works

Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury

Stedman, C. A. M., Liddle, C., Coulter, S., Sonoda, J., Alvarez, J. G. A., Moore, D. D., Evans, R. M., & Downes, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409794102 · Cited by 228 · see citing works

Phenobarbital Indirectly Activates the Constitutive Active Androstane Receptor (CAR) by Inhibition of Epidermal Growth Factor Receptor Signaling

Mutoh, S., Sobhany, M., Moore, R., Perera, L., Pedersen, L. G., Sueyoshi, T., & Negishi, M. (2013) · Science Signaling · doi:10.1126/scisignal.2003705 · Cited by 197 · see citing works

Functional Inhibitory Cross-talk between Constitutive Androstane Receptor and Hepatic Nuclear Factor-4 in Hepatic Lipid/Glucose Metabolism Is Mediated by Competition for Binding to the DR1 Motif and to the Common Coactivators, GRIP-1 and PGC-1α

Miao, J., Fang, S., Bae, Y., & Kemper, J. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510713200 · Cited by 197 · see citing works

Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 Cells

Kobayashi, K., Sueyoshi, T., Inoue, K., Moore, R., & Negishi, M. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.5.1069 · Cited by 190 · see citing works

The Nuclear Xenobiotic Receptor CAR

Suino, K., Peng, L., Reynolds, R. A., Li, Y., Cha, J.-Y., Repa, J. J., Kliewer, S. A., & Xu, H. E. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.036 · Cited by 186 · see citing works

Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver

Zhang, Y.-K. J., Yeager, R. L., & Klaassen, C. D. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.108.024174 · Cited by 178 · see citing works

Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital

Yoshinari, K., Kobayashi, K., Moore, R., Kawamoto, T., & Negishi, M. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00720-8 · Cited by 170 · see citing works

Role of the Constitutive Androstane Receptor in Xenobiotic-Induced Thyroid Hormone Metabolism

Qatanani, M., Zhang, J., & Moore, D. D. (2004) · Endocrinology · doi:10.1210/en.2004-1350 · Cited by 166 · see citing works

Regulation of Constitutive Androstane Receptor and Its Target Genes by Fasting, cAMP, Hepatocyte Nuclear Factor α, and the Coactivator Peroxisome Proliferator-activated Receptor γ Coactivator-1α

Ding, X., Lichti-Kaiser, K., Kim, I., Gonzalez, F. J., & Staudinger, J. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600931200 · Cited by 151 · see citing works

Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression

Roth, A. B., Looser, R., Kaufmann, M., Blättler, S. M., Rencurel, F., Huang, W., Moore, D. D., & Meyer, U. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.041012 · Cited by 148 · see citing works

Synthetic Drugs and Natural Products as Modulators of Constitutive Androstane Receptor (Car) and Pregnane X Receptor (PXR)

Chang, T. K. H., & Waxman, D. J. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600569828 · Cited by 143 · see citing works

Characterization of a Phenobarbital-responsive Enhancer Module in Mouse P450 Cyp2b10 Gene

Honkakoski, P., & Negishi, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.23.14943 · Cited by 142 · see citing works

Adiponectin-Activated AMPK Stimulates Dephosphorylation of AKT through Protein Phosphatase 2A Activation

Kim, K.-Y., Baek, A., Hwang, J.-E., Choi, Y. A., Jeong, J., Lee, M.-S., Cho, D. H., Lim, J., Kim, K. I., & Yang, Y. D. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2641 · Cited by 135 · see citing works

Intestinal Insulin Resistance and Aberrant Production of Apolipoprotein B48 Lipoproteins in an Animal Model of Insulin Resistance and Metabolic Dyslipidemia

Federico, L. M., Naples, M., Taylor, D., & Adeli, K. (2006) · Diabetes · doi:10.2337/db04-1084 · Cited by 132 · see citing works

Constitutive Androstane Receptor-Mediated Up-Regulation of ATP-Driven Xenobiotic Efflux Transporters at the Blood-Brain Barrier

Wang, X., Sykes, D. B., & Miller, D. S. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.063685 · Cited by 124 · see citing works

A Structural Model of the Constitutive Androstane Receptor Defines Novel Interactions That Mediate Ligand-Independent Activity

Dussault, I., Lin, M., Hollister, K., Fan, M. Q., Termini, J. S., Sherman, M. A., & FORMAN, B. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5270-5280.2002 · Cited by 111 · see citing works

Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

Uppal, H., Toma, D., Saini, S. P. S., Ren, S., Jones, T. J., & Xie, W. (2005) · Hepatology · doi:10.1002/hep.20512 · Cited by 106 · see citing works

Activation of Orphan Nuclear Constitutive Androstane Receptor Requires Subnuclear Targeting by Peroxisome Proliferator-activated Receptor γ Coactivator-1α

Shiraki, T., Sakai, N., Kanaya, E. N., & Jingami, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212859200 · Cited by 100 · see citing works

AMP-activated Protein Kinase Mediates Phenobarbital Induction of CYP2B Gene Expression in Hepatocytes and a Newly Derived Human Hepatoma Cell Line

Rencurel, F., Stenhouse, A., Hawley, S. A., Friedberg, T., Hardie, D. G., Sutherland, C. D., & Wolf, C. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412711200 · Cited by 100 · see citing works

Quercetin suppresses HeLa cell viability via AMPK‐induced HSP70 and EGFR down‐regulation

Jung, J. H., Lee, J. O., Kim, J. H., Lee, S. K., You, G. Y., Park, S. H., Park, J. M., Kim, E., Suh, P., An, J. K., et al. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22049 · Cited by 96 · see citing works

Gadd45β Is Induced Through a CAR-Dependent, TNF-Independent Pathway in Murine Liver Hyperplasia * #

Columbano, A., Ledda‐Columbano, G. M., Pibiri, M., Cossu, C., Menegazzi, M., Moore, D. D., Huang, W., Tian, J., & Locker, J. D. (2005) · Hepatology · doi:10.1002/hep.20883 · Cited by 91 · see citing works

A Common Set of Immediate–Early Response Genes in Liver Regeneration and Hyperplasia

Locker, J. D., Tian, J., Carver, R. S., Concas, D., Cossu, C., Ledda‐Columbano, G. M., & Columbano, A. (2003) · Hepatology · doi:10.1053/jhep.2003.50299 · Cited by 89 · see citing works

Inhibitory Cross-talk between Estrogen Receptor (ER) and Constitutively Activated Androstane Receptor (CAR)

Min, G., Kim, H., Bae, Y., Petz, L. N., & Kemper, J. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205239200 · Cited by 89 · see citing works

The Nuclear Xenobiotic Receptor CARStructural Determinants of Constitutive Activation and Heterodimerization

Suino, K., PENG, L., Reynolds, R. A., Li, Y., Cha, J., Repa, J. J., Kliewer, S. A., & Xu, H. E. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00727-0 · Cited by 89 · see citing works

Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver

Patel, R. D., Hollingshead, B. D., Omiecinski, C. J., & Perdew, G. H. (2007) · Hepatology · doi:10.1002/hep.21671 · Cited by 88 · see citing works

Stimulation of AMP-Activated Protein Kinase Is Essential for the Induction of Drug Metabolizing Enzymes by Phenobarbital in Human and Mouse Liver

Rencurel, F., Foretz, M., Kaufmann, M., Stroka, D., Looser, R., Leclerc, I., Xavier, G. D. S., Rutter, G. A., Viollet, B., & Meyer, U. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.029421 · Cited by 84 · see citing works

Glucocorticoid Receptor-interacting Protein 1 Mediates Ligand-independent Nuclear Translocation and Activation of Constitutive Androstane Receptor in Vivo

Min, G., Kemper, J. K., & KEMPER, B. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200051200 · Cited by 83 · see citing works

In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase

Blättler, S. M., Rencurel, F., Kaufmann, M., & Meyer, U. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610216104 · Cited by 82 · see citing works

25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway

Ma, Y., Xu, L., Rodríguez‐Agudo, D., Li, X., Heuman, D. M., Hylemon, P. B., Pandak, W. M., & Ren, S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90555.2008 · Cited by 80 · see citing works

Extracellular Signal-Regulated Kinase Is an Endogenous Signal Retaining the Nuclear Constitutive Active/Androstane Receptor (CAR) in the Cytoplasm of Mouse Primary Hepatocytes

Koike, C., Moore, R., & Negishi, M. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.034538 · Cited by 79 · see citing works

Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter

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Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25‐Hydroxycholesterol and 25‐Hydroxycholesterol‐3‐sulfate

Xu, L., Bai, Q., Rodríguez‐Agudo, D., Hylemon, P. B., Heuman, D. M., Pandak, W. M., & Ren, S. (2010) · Lipids · doi:10.1007/s11745-010-3451-y · Cited by 74 · see citing works

Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes

Roth, A. B., Looser, R., Kaufmann, M., & Meyer, U. (2008) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3282f706e0 · Cited by 73 · see citing works

An Okadaic Acid-Sensitive Pathway Involved in the Phenobarbital-Mediated Induction of CYP2B Gene Expression in Primary Rat Hepatocyte Cultures

Sidhu, J. S., & Omiecinski, C. J. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36871-5 · Cited by 73 · see citing works

Serine 202 Regulates the Nuclear Translocation of Constitutive Active/Androstane Receptor

Hosseinpour, F., Moore, R., Negishi, M., & Sueyoshi, T. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.019505 · Cited by 73 · see citing works

miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cells

Takwi, A. A., Ym, W., Wu, J., Michaelis, M., Cinatl, J. J., & Chen, T. (2013) · Oncogene · doi:10.1038/onc.2013.330 · Cited by 72 · see citing works

Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells

Bai, Q., Xu, L., Kakiyama, G., Runge‐Morris, M., Hylemon, P. B., Yin, L., Pandak, W. M., & Ren, S. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.11.021 · Cited by 70 · see citing works

Demethoxycurcumin Modulates Prostate Cancer Cell Proliferation via AMPK-Induced Down-regulation of HSP70 and EGFR

Hung, C., Su, Y.-H., Lin, H.-Y., Lin, J.-N., Liu, L., Ho, C., & Way, T. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302754w · Cited by 64 · see citing works

ATF5 Is a Highly Abundant Liver-Enriched Transcription Factor that Cooperates with Constitutive Androstane Receptor in the Transactivation of CYP2B6: Implications in Hepatic Stress Responses

Pascual, M., Gómez-Lechón, M. J., Castell, J. V., & Jover, R. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.019380 · Cited by 64 · see citing works

Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

Chen, W., Fu, X., Dong, B., Wang, Y., Shiah, S., Moore, D. D., & Huang, W. (2012) · Hepatology · doi:10.1002/hep.25766 · Cited by 60 · see citing works

Active ERK1/2 Protein Interacts with the Phosphorylated Nuclear Constitutive Active/Androstane Receptor (CAR; NR1I3), Repressing Dephosphorylation and Sequestering CAR in the Cytoplasm

Osabe, M., & Negishi, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.284596 · Cited by 60 · see citing works

A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction

Shindo, S., Numazawa, S., & Yoshida, T. (2007) · Biochemical Journal · doi:10.1042/bj20061238 · Cited by 59 · see citing works

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers

Režen, T., Tamási, V., Lövgren‐Sandblom, A., Björkhem, I., Meyer, U., & Rozman, D. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-384 · Cited by 59 · see citing works

Amino Acids Important for Ligand Specificity of the Human Constitutive Androstane Receptor

Jyrkkärinne, J., Windshügel, B., Mäkinen, J., Ylisirniö, M., Peräkylä, M., Poso, A., Sippl, W., & Honkakoski, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411241200 · Cited by 56 · see citing works

A Functional Cross-Talk between Liver X Receptor-α and Constitutive Androstane Receptor Links Lipogenesis and Xenobiotic Responses

Zhai, Y., Wada, T., Zhang, B., Khadem, S., Ren, S., Kuruba, R., Li, S., & Xie, W. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.064618 · Cited by 56 · see citing works

Acetaminophen Modulates P-Glycoprotein Functional Expression at the Blood-Brain Barrier by a Constitutive Androstane Receptor–Dependent Mechanism

Slosky, L. M., Thompson, B. J., Sanchez‐Covarrubias, L., Zhang, Y., Laracuente, M., Vanderah, T. W., Ronaldson, P. T., & Davis, T. P. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.086298 · Cited by 54 · see citing works

PPP1R16A, The Membrane Subunit of Protein Phosphatase 1β, Signals Nuclear Translocation of the Nuclear Receptor Constitutive Active/Androstane Receptor

Sueyoshi, T., Moore, R., Sugatani, J., Matsumura, Y., & Negishi, M. (2008) · Molecular Pharmacology · doi:10.1124/mol.107.042960 · Cited by 52 · see citing works

Cholesterol Sulfate and Cholesterol Sulfotransferase Inhibit Gluconeogenesis by Targeting Hepatocyte Nuclear Factor 4α

Shi, X., Cheng, Q., Xu, L., Yan, J., Jiang, M., He, J., Xu, M., Stefanović-Račić, M., SIPULA, I. J., O'Doherty, R. M., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01094-13 · Cited by 51 · see citing works

Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR

Tojima, H., Kakizaki, S., Yamazaki, Y., Takizawa, D., Horiguchi, N., Sato, K., & Mori, M. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.06.001 · Cited by 50 · see citing works

Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice

Sberna, A.-L., Assem, M., Gautier, T., Grober, J., Guiu, B., Jeannin, A., de Barros, J.-P. P., Athias, A., Lagrost, L., & Masson, D. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.10.029 · Cited by 50 · see citing works

Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood–brain barrier after CITCO activation

Lemmen, J., Tozakidis, I. E. P., Bele, P., & Galla, H. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.025 · Cited by 47 · see citing works

PPARα‐dependent induction of the energy homeostasis‐regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: Potential role in starvation adaptation

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MicroRNA-122 Down-Regulation Is Involved in Phenobarbital-Mediated Activation of the Constitutive Androstane Receptor

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Nuclear Receptors Reverse McGarry's Vicious Cycle to Insulin Resistance

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Molecular Determinants of Steroid Inhibition for the Mouse Constitutive Androstane Receptor

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The Antiapoptotic Factor Growth Arrest and DNA-Damage-Inducible 45 β Regulates the Nuclear Receptor Constitutive Active/Androstane Receptor-Mediated Transcription

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Treatment with constitutive androstane receptor ligand during pregnancy prevents insulin resistance in offspring from high-fat diet-induced obese pregnant mice

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Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4α

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SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism

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p38 Mitogen–Activated Protein Kinase Regulates Nuclear Receptor CAR that Activates the CYP2B6 Gene

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Histone Deacetylase Inhibitors Induce Cytochrome P450 2B by Activating Nuclear Receptor Constitutive Androstane Receptor

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Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR

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Association of a single nucleotide polymorphism in the constitutive androstane receptor gene with bone mineral density

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The Orphan Nuclear Receptor DAX-1 Functions as a Potent Corepressor of the Constitutive Androstane Receptor (NR1I3)

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Constitutive androstane/active receptor is a target of retinoic acid receptor in humans

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Thyroid Hormone Is Necessary for Expression of Constitutive Androstane Receptor in Rat Hepatocytes

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In Vivo Deletion of CAR Resulted in High Bone Mass Phenotypes in Male Mice

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Dependence on the Microtubule Network and 90-kDa Heat Shock Protein of Phenobarbital-Induced Nuclear Translocation of the Rat Constitutive Androstane Receptor

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Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members

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Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4α/CAR/RXR/PSF complex

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Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression

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Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?

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The exposome and liver disease - how environmental factors affect liver health

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The Roles of Xenobiotic Receptors: Beyond Chemical Disposition

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The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis

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Regulation of CAR and PXR Expression in Health and Disease

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RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome

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AhR, PXR and CAR: From Xenobiotic Receptors to Metabolic Sensors

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Prevention of Oxidative Stress by α-Ketoglutarate via Activation of CAR Signaling and Modulation of the Expression of Key Antioxidant-Associated Targets in Vivo and in Vitro

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Family reunion of nuclear hormone receptors: structures, diseases, and drug discovery

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Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells

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Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

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Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses

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Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver

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Glutathione Protects against Paraquat-Induced Oxidative Stress by Regulating Intestinal Barrier, Antioxidant Capacity, and CAR Signaling Pathway in Weaned Piglets

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Metabolome-wide association study of four groups of persistent organic pollutants and abnormal blood lipids

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Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis

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Clinical Relevance of the Constitutive Androstane Receptor

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Gut microbiota regulates hepatic ketogenesis and lipid accumulation in ketogenic diet-induced hyperketonemia by disrupting bile acid metabolism

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Regulation of protein-coding gene and long noncoding RNA pairs in liver of conventional and germ-free mice following oral PBDE exposure

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NTP Technical Report on the Toxicology and Carcinogenesis Studies of Perfluorooctanoic Acid (CASRN 335-67-1) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats

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Role of the constitutive androstane receptor (CAR) in human liver cancer

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Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling

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Bioactive Components in Traditional Foods Aimed at Health Promotion: A Route to Novel Mechanistic Insights and Lead Molecules?

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A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per‐ and polyfluoroalkyl substances and relevance to human health

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HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver

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Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells

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Steatosis and Metabolic Disorders Associated with Synergistic Activation of the CAR/RXR Heterodimer by Pesticides

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Metabolomic approaches reveal the role of CAR in energy metabolism

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Zinc lactate alleviates oxidative stress by modulating crosstalk between constitutive androstane receptor signaling pathway and gut microbiota profile in weaned piglets

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Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor

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Analysis of the Potential Association of Drug-Metabolizing Enzymes CYP2C9*3 and CYP2C19*3 Gene Variations With Type 2 Diabetes: A Case-Control Study

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Constitutive androstane receptor, liver pathophysiology and chemical contaminants: current evidence and perspectives

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Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice

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The Function of Xenobiotic Receptors in Metabolic Diseases

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The CAR agonist TCPOBOP inhibits lipogenesis and promotes fibrosis in the mammary gland of adolescent female mice

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Association between serum per- and polyfluoroalkyl substances levels and metabolic dysfunction-associated steatotic liver disease

Zhang, J., Cheng, X., Wang, Y., Guo, H. Y., Liu, L., Liu, L., Gao, J., & He, M. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.125233 · Cited by 9 · see citing works

Advances in antituberculosis drug-induced liver injury: Molecular mechanisms, genetic insights, and emerging animal-free prediction models

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Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3

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Overexpression of the constitutive androstane receptor and shaken 3D-culturing increase biotransformation and oxidative phosphorylation and sensitivity to mitochondrial amiodarone toxicity of HepaRG cells

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Genome-wide expression profiling reveals increased stability and mitochondrial energy metabolism of the human liver cell line HepaRG-CAR

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2-Substituted quinazolines: Partial agonistic and antagonistic ligands of the constitutive androstane receptor (CAR)

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Role of mixtures of organic pollutants in the development of metabolic disorders via the activation of xenosensors

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Environmental chemical TCPOBOP disrupts milk lipid homeostasis during pregnancy and lactation

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Effect of PFAS serum exposure pattern on the lipid metabolism: Time to step-forward in causal inference in epidemiology

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CAR: Discovery and development by the pharmacogenetics laboratory at NIEHS, NIH

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Synergistic Steatosis Induction in Mice: Exploring the Interactions and Underlying Mechanisms between PFOA and Tributyltin

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Activation of Nuclear Receptor CAR: A Pathway to Delay Aging through Enhanced Capacity for Xenobiotic Resistance

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Assessment of binding potencies of polychlorinated biphenyls and polybrominated diphenyl ethers with Baikal seal and mouse constitutive androstane receptors: Comparisons across species and congeners

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Humanized monoacylglycerol acyltransferase 2 mice on a high-fat diet exhibit impaired liver detoxification during metabolic dysfunction-associated steatotic liver disease

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Activation of constitutive androstane receptor inhibits intestinal CFTR-mediated chloride transport

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Induction of cytochrome P450 via upregulation of CAR and PXR: a potential mechanism for altered florfenicol metabolism by macranthoidin B in vivo

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Biphasic hCAR Inhibition-Activation by Two Aminoazo Liver Carcinogens

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Metabolomic approaches reveal the role of CAR in energy metabolism

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Clinical Relevance of the Constitutive Androstane Receptor

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