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Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system
Open accessAbstract
It has been widely recognized that inflammation, particularly chronic inflammation, can increase the risk of cancer and that the simultaneous treatment of inflammation and cancer may produce excellent therapeutic effects. Berberine, an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic with a long history. Over the past decade, many reports have demonstrated that this natural product and its derivatives have high activity against both cancer and inflammation. In this review, we summarize the advances in studing berberine and its derivatives as anti-inflammatory and anti-tumor agents in the digestive system; we also discuss their structure-activity relationship. These data should be useful for the development of this natural product as novel anticancer drugs with anti-inflammation activity.
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Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Tumour necrosis factor and cancer
Balkwill, F. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2628 · Cited by 1,915
Inflammation and cancer: advances and new agents
Crusz, S. M., & Balkwill, F. R. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.105 · Cited by 1,184
The anti-inflammatory potential of berberine in vitro and in vivo
Kuo, C.-L., Chi, C.-W., & Liu, T.-Y. (2004) · Cancer Letters · doi:10.1016/j.canlet.2003.09.002 · Cited by 685
Understanding resistance to EGFR inhibitors—impact on future treatment strategies
Wheeler, D. L., Dunn, E. F., & Harari, P. M. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.97 · Cited by 683
Focus on nasopharyngeal carcinoma
Lo, K. W., To, K. F., & Huang, D. P. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00119-9 · Cited by 559
Tang, J., Feng, Y., Tsao, S., Wang, N., Curtain, R., & Wang, Y. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.08.009 · Cited by 491
Cancer and the tumor microenvironment: a review of an essential relationship
Mbeunkui, F., & Johann, D. J. (2009) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-008-0881-9 · Cited by 487
Berberine suppresses proinflammatory responses through AMPK activation in macrophages
Jeong, H. W., Hsu, K. C., Lee, J.-W., Ham, M., Huh, J. Y., Shin, H. J., Kim, W. S., & Kim, J. B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90599.2008 · Cited by 454
A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs
Sun, Y., Xun, K., Wang, Y., & Chen, X. (2009) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e328330d95b · Cited by 417
Ning, Y., Manegold, P. C., Hong, Y. K., Zhang, W., Pohl, A., Lurje, G., Winder, T., Yang, D., LaBonte, M. J., Wilson, P. M., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.25562 · Cited by 406
Erratum to “Pro/Anti-Inflammatory Cytokine Imbalance in Postischemic Left Ventricular Remodeling”
Pasqui, A. L., Di Renzo, M., Maffei, S., Pastorelli, M., Pompella, G., Auteri, A., & Puccetti, L. (2010) · Mediators of Inflammation · doi:10.1155/2010/723589 · Cited by 376
Mantena, S. K., Sharma, S. D., & Katiyar, S. K. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0448 · Cited by 353
Wang, N., Feng, Y., Zhu, M., Tsang, C., Man, K., Tong, Y., & Tsao, S. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22869 · Cited by 289
Berberine, an Epiphany Against Cancer
Guamán Ortiz, L., Lombardi, P., Tillhon, M., & Scovassi, A. (2014) · Molecules · doi:10.3390/molecules190812349 · Cited by 280
Kim, W. S., Lee, Y. S., Cha, S. H., Jeong, H. W., Choe, S. S., Lee, M.-R., Oh, G. T., Park, H.-S., Lee, K.-U., Lane, M. D., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90710.2008 · Cited by 239
Amasheh, M., Fromm, A., Krug, S. M., Amasheh, S., Andres, S., Zeitz, M., Fromm, M., & Schulzke, J.-D. (2010) · Journal of Cell Science · doi:10.1242/jcs.070896 · Cited by 224
Yan, F., Wang, L., Shi, Y., Cao, H., Liu, L., Washington, M. K., Chaturvedi, R., Israel, D. A., Cao, H., Wang, B., et al. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00312.2011 · Cited by 181
Gu, L., Li, N., Gong, J., Li, Q., Zhu, W., & Li, J. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir147 · Cited by 166
Self-citationKaboli, P. J., Rahmat, A. B., Ismail, P., & Ling, K. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.025 · Cited by 157
Ji, C., Yang, B., Yang, Y.-L., He, S.-H., Miao, D.-S., He, L., & Bi, Z.-G. (2010) · Oncogene · doi:10.1038/onc.2010.379 · Cited by 154
The Effect of Berberine Chloride on Experimental Colitis in Rats In Vivo and In Vitro
Zhou, H., & Mineshita, S. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39141-4 · Cited by 145
Peng, P.-L., Kuo, W., Tseng, H., & Chou, F. (2008) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.08.034 · Cited by 139
Expression and regulation of tumor necrosis factor α in normal and malignant ovarian epithelium
Szlosarek, P. W., Grimshaw, M. J., Kulbe, H., Wilson, J. L., Wilbanks, G. D., Burke, F., & Balkwill, F. R. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0303 · Cited by 135
Serafim, T. L., Oliveira, P. J., Sardão, V. A., Perkins, E., Parke, D., & Holy, J. M. (2007) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-007-0558-9 · Cited by 131
Amasheh, M., Grotjohann, I., Amasheh, S., Fromm, A., Söderholm, J. D., Zeitz, M., Fromm, M., & Schulzke, J. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520903131973 · Cited by 131
Wang, L., Liu, L., Shi, Y., Cao, H., Chaturvedi, R., Calcutt, M. W., Hu, T., Ren, X., Wilson, K. T., Polk, D. B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036418 · Cited by 126
Zhang, Q., Piao, X., Piao, X., Lu, T., Wang, D., & Kim, S. W. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.09.032 · Cited by 122
Germoush, M. O., & Mahmoud, A. M. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1665-8 · Cited by 112
Berberine Inhibits Human Hepatoma Cell Invasion without Cytotoxicity in Healthy Hepatocytes
Liu, B., Wang, G., Yang, J., Pan, X., Yang, Z., & Zang, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021416 · Cited by 112
Choi, M. S., Oh, J. H., Kim, S. M., Jung, H. Y., Yoo, H. S., Lee, Y., Moon, D. C., Han, S., & Hong, J. T. (2009) · PubMed · Cited by 110
Murthy, K. N. C., Jayaprakasha, G. K., & Patil, B. S. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.05.004 · Cited by 109
Hur, J., Hyun, M., Lim, S., Lee, W., & Kim, D. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22198 · Cited by 107
Berberine Inhibits Inflammatory Response and Ameliorates Insulin Resistance in Hepatocytes
Lou, T., Zhang, Z., Xi, Z., Liu, K., Li, L., Liu, B., & Huang, F. (2010) · Inflammation · doi:10.1007/s10753-010-9276-2 · Cited by 105
Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147
Hou, Q., Tang, X., Liu, H.-Q., Tang, J., Yang, Y., Jing, X., Xiao, Q., Wang, W., Gou, X., & Wang, Z. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01933.x · Cited by 103
Tsang, C. M., Cheung, Y. C., Lui, V. W. Y., Yip, Y. L., Zhang, G., Lin, V. W., Cheung, K. C.-P., Feng, Y., & Tsao, S. W. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-619 · Cited by 102
Tang, F., Wang, D., Duan, C., Huang, D., Wu, Y. Q., Chen, Y. Z., Wang, W., Xie, C., Meng, J., Wang, L., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033795 · Cited by 100
Wang, X.-N., Han, X., Xu, L., Yin, L.-H., Xu, Y., Qi, Y., & Peng, J. (2008) · Phytomedicine · doi:10.1016/j.phymed.2008.05.002 · Cited by 96
Wang, N., Zhu, M., Wang, X., Tan, H., Tsao, S., & Feng, Y. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.027 · Cited by 93
Thirupurasundari, C. J., PADMINI, R., & Devaraj, S. N. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.09.027 · Cited by 91
Yang, X., & Huang, N. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1506 · Cited by 90
Min, Y. D., Kwon, H. C., Yang, M. C., et al. (2007) · Archives of Pharmacal Research · doi:10.1007/bf02977779 · Cited by 90
Li, N., Gu, L., Qu, L., Gong, J., Li, Q., Zhu, W., & Li, J. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.02.001 · Cited by 89
Self-citationTRAIL combinations: The new ‘trail’ for cancer therapy (Review)
Refaat, A., Abdrabou, A., & Reda, A. M. (2014) · Oncology Letters · doi:10.3892/ol.2014.1922 · Cited by 87
Lin, C. C., Lin, S. Y., Chung, J., Lin, J., Chen, G. W., & Kao, S. T. (2006) · PubMed · Cited by 85
Eom, K., Hong, J.-M., Youn, M., So, H., Park, R., Kim, J., & Kim, T. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.558 · Cited by 83
Wang, L., Cao, H., Lü, N., Liu, L., Wang, B., Hu, T., Israel, D. A., Peek, R. M., Polk, D. B., & Yan, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056666 · Cited by 82
Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis.
Choi, M. S., Yuk, D. Y., Oh, J. H., Jung, H. Y., Han, S., Moon, D. C., & Hong, J. T. (2008) · PubMed · Cited by 80
Kuang, Y., Chen, X., Su, J., Wu, L., Liao, L., Li, D., Chen, Z., & Kanekura, T. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.11.010 · Cited by 79
Lui, V. W. Y., Wong, E. Y. L., Ho, Y., Hong, B., Wong, S. C. C., Tao, Q., Choi, G. C. G., Au, T. C. C., Ho, K., Yau, D., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24567 · Cited by 75
Li, H., Wang, Y., Wang, H., Cao, W., Yu, X., Lu, D., Qi, R., Hu, C., & Yan, Y. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.102 · Cited by 73
Plaen, I. G. D., Han, X., Liu, X., Hsueh, W., Ghosh, S., & May, M. J. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02344.x · Cited by 72
Dai, J., Ke-feng, D., Wang, C., Zhao, P., Lau, W. B., Tao, L., Wu, Y., Tang, J., Jiang, J., & Chen, Z. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-337 · Cited by 69
Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo
Cai, Y., Xia, Q., Luo, R., Huang, P., Sun, Y.-L., Shi, Y., & Jiang, W. (2013) · Journal of Natural Medicines · doi:10.1007/s11418-013-0766-z · Cited by 69
Neutral sulfate berberine modulates cytokine secretion and increases survival in endotoxemic mice
Li, F., Wang, H., Lu, D., Wang, Y., Qi, R., Fu, Y., & Chu-jie, L. (2006) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00368.x · Cited by 67
Remppis, A. B., Bea, F., Greten, H. J., Buttler, A., Wang, H., Zhou, Q., Preusch, M. R., Enk, R., Ehehalt, R., Katus, H. A., et al. (2010) · Mediators of Inflammation · doi:10.1155/2010/194896 · Cited by 67
Multiple Effects of Berberine Derivatives on Colon Cancer Cells
Guamán‐Ortiz, L. M., Tillhon, M., Parks, M., Dutto, I., Prosperi, E., Savio, M., Arcamone, A. G., Buzzetti, F., Lombardi, P., & Scovassi, A. I. (2014) · BioMed Research International · doi:10.1155/2014/924585 · Cited by 66
Refaat, A., Abdelhamed, S., Yagita∥, H., Inoue, H., Yokoyama, S., Hayakawa, Y., & Saiki, I. (2013) · Oncology Letters · doi:10.3892/ol.2013.1434 · Cited by 61
Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF-κB
Yu, M., Tong, X., Qi, B.-Q., Qu, H., Dong, S., Yu, B., ZHANG, N., Tang, N., Wang, L., & Zhang, C. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1762 · Cited by 60
Liu, Y., Tan, Y.-N., Wang, Z.-L., Zeng, L., Lu, Z., Li, L., Luo, W., Tang, M., & Cao, Y. (2008) · International Journal of Molecular Medicine · doi:10.3892/ijmm.21.2.153 · Cited by 60
Comprehensive Study in the Inhibitory Effect of Berberine on Gene Transcription, Including TATA Box
Wang, Y., Kheir, M. M., Chai, Y., Hu, J., Xing, D., Fan, L., & Du, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023495 · Cited by 56
Youn, M., So, H., Cho, H.-J., Kim, H.-J., Kim, Y., Lee, J., Sohn, J. S., Kim, Y. K., Chung, S.-Y., & Park, R. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.789 · Cited by 55
Inflammation and prostate cancer: A focus on infections
Sutcliffe, S., & Platz, E. A. (2008) · Current Urology Reports · doi:10.1007/s11934-008-0042-z · Cited by 54
Huang, Z., Zeng, Y., Lan, P., et al. (2011) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955711797655362 · Cited by 48
Chueh, W.-H., & Lin, J. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.09.116 · Cited by 39
Ma, C., Tang, K., Liu, Q., Zhu, R., & Cao, Z. (2013) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12124 · Cited by 38
STAT3 as a therapeutic target for Epstein-Barr virus (EBV) – associated nasopharyngeal carcinoma
Ho, Y., Tsao, S., Zeng, M., & Lui, V. W. Y. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.052 · Cited by 36
Liu, S., Sun, Y., Tian, D., He, Y., Zeng, L., He, Y., Ling, C., & Sun, S. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604167 · Cited by 34
Wang, L., Wei, D., Han, X., Zhang, W., Fan, C., Zhang, J., Mo, C., Yang, M. J., Li, J., Wang, Z., et al. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24715 · Cited by 27
Li, Y.-B., Zhao, W., Wang, Y., Zhang, C., Jiang, J., Bi, C., Tang, S., Chen, R., Shao, R., & Song, D. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.07.026 · Cited by 25
Self-citation[Advances in the study of berberine and its derivatives].
Li, B., Zhu, W., & Chen, K. (2008) · PubMed · Cited by 23
Self-citationJin, X., Yan, L., Li, H., Wang, R.-L., Hu, Z., Jiang, Y., Cao, Y., Yan, T., & Sun, Q. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520614666141203142012 · Cited by 22
Li, C., Wu, D., Ding, H., Zhao, Y., Zhou, K., & Xu, D. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.4.1851 · Cited by 21
Kaur, J., & Sanyal, S. N. (2010) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e32833ad385 · Cited by 15
Effect of Berberine on cell proliferation and apoptosis in gastric carcinoma cells
Wu, K. (2011) · Cited by 5
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Metadata
- Authors
- Zou, K., Li, Z., Zhang, Y., Zhang, H.-Y., Li, B., Zhu, W.-L., Shi, J.-Y., Jia, Q., & Li, Y.-M.
- Venue
- Acta Pharmacologica Sinica
- Published
- 2016-12-05
- Volume
- 38
- Issue
- 2
- Pages
- 157-167
- ISSN
- 0253-9756 (ISSN-L)
- 1671-4083
- 1745-7254
- OpenAlex
- W2560593836
- Cited by
- 317
- References
- 75
- FWCI
- 13.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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