The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Berberine, an Epiphany Against Cancer
Open accessAbstract
Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism. Among plant derivatives with biological properties, the isoquinoline quaternary alkaloid berberine possesses a broad range of therapeutic uses against several diseases. In recent years, berberine has been reported to inhibit cell proliferation and to be cytotoxic towards cancer cells. Based on this evidence, many derivatives have been synthesized to improve berberine efficiency and selectivity; the results so far obtained on human cancer cell lines support the idea that they could be promising agents for cancer treatment. The main properties of berberine and derivatives will be illustrated.
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Cites
2 retracted
Mantena, S. K., Sharma, S. D., & Katiyar, S. K. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl043 · Cited by 174
RetractedSingh, T., Vaid, M., Katiyar, N., Sharma, S., & Katiyar, S. K. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq215 · Cited by 136
RetractedBartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Self-consumption: the interplay of autophagy and apoptosis
Mariño, G., Niso-Santano, M., Baehrecke, E. H., & Kroemer, G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3735 · Cited by 2,172
THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE
Carreras, C. W., & Santi, D. V. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003445 · Cited by 768
The anti-inflammatory potential of berberine in vitro and in vivo
Kuo, C.-L., Chi, C.-W., & Liu, T.-Y. (2004) · Cancer Letters · doi:10.1016/j.canlet.2003.09.002 · Cited by 685
Berberine: New perspectives for old remedies
Tillhon, M., Guamán Ortiz, L. M., Lombardi, P., & Scovassi, A. I. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.07.018 · Cited by 477
Self-citationThe Four Faces of Autophagy: Implications for Cancer Therapy
Gewirtz, D. A. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2966 · Cited by 435
Aromatic interactions in model systems
Waters, M. L. (2002) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(02)00359-9 · Cited by 430
Quaternary protoberberine alkaloids
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Cited by
Zou, K., Li, Z., Zhang, Y., Zhang, H.-Y., Li, B., Zhu, W.-L., Shi, J.-Y., Jia, Q., & Li, Y.-M. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.125 · Cited by 317
Berberine as a Potential Anticancer Agent: A Comprehensive Review
Rauf, A., Abu-Izneid, T., Khalil, A. A., Imran, M., Shah, Z. A., Emran, T. B., Mitra, S., Khan, Z., Alhumaydhi, F. A., Aljohani, A. S. M., et al. (2021) · Molecules · doi:10.3390/molecules26237368 · Cited by 292
Metadata
- Authors
- Guamán Ortiz, L., Lombardi, P., Tillhon, M., & Scovassi, A.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2014-08-15
- Volume
- 19
- Issue
- 8
- Pages
- 12349-12367
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2020371869
- Cited by
- 280
- References
- 99
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
