The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

DNA methylation patterns and epigenetic memory

Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124 · see citing works

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836 · see citing works

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · see citing works

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9498 · Cited by 4,727 · see citing works

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works

Oxidative stress, aging, and diseases

Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s158513 · Cited by 3,979 · see citing works

Therapeutic potential of resveratrol: the in vivo evidence

Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works

Molecular chaperones in protein folding and proteostasis

Hartl, F. U., Bracher, A., & Hayer-Hartl, M. K. (2011) · Nature · doi:10.1038/nature10317 · Cited by 3,525 · see citing works

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works

CpG islands and the regulation of transcription

Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187 · see citing works

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works

The role of MicroRNAs in human cancer

Peng, Y., & Croce, C. M. (2016) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2015.4 · Cited by 2,507 · see citing works

Role for DNA methylation in genomic imprinting

Li, E., Beard, C., & Jaenisch, R. (1993) · Nature · doi:10.1038/366362a0 · Cited by 2,070 · see citing works

The DNA methyltransferases of mammals

Bestor, T. H. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.16.2395 · Cited by 2,045 · see citing works

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935 · see citing works

An operational definition of epigenetics: Figure 1.Preprint

Berger, S. L., Kouzarides, T., Shiekhattar, R., & Shilatifard, A. (2009) · Genes & Development · doi:10.1101/gad.1787609 · Cited by 1,889 · see citing works

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868 · see citing works

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

Tönnies, E., & Trushina, E. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161088 · Cited by 1,750 · see citing works

Role for DNA methylation in genomic imprinting

Li, E., Beard, C., & Jaenisch, R. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90228-3 · Cited by 1,691 · see citing works

MicroRNAs in Cancer

Leva, G. D., Garofalo, M., & Croce, C. M. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104715 · Cited by 1,674 · see citing works

HDAC2 negatively regulates memory formation and synaptic plasticity

Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644 · see citing works

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Cantó, C., & Auwerx, J. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328328d0a4 · Cited by 1,624 · see citing works

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602 · see citing works

Inflammation in neurodegenerative diseases

Amor, S., Puentes, F., Baker, D., & Van Der Valk, P. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03225.x · Cited by 1,355 · see citing works

The role of oxidative stress in neurodegenerative diseases

Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355 · see citing works

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,352 · see citing works

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327 · see citing works

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

Steffan, J. S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B. L., Kazantsev, A., Schmidt, E., Zhu, Y.-Z., Greenwald, M., et al. (2001) · Nature · doi:10.1038/35099568 · Cited by 1,228 · see citing works

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

Issa, J.-P. J., Ottaviano, Y. L., Celano, P., Hamilton, S. R., Davidson, N. E., & Baylin, S. B. (1994) · Nature Genetics · doi:10.1038/ng0894-536 · Cited by 1,191 · see citing works

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.011 · Cited by 1,162 · see citing works

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

Gu, T., Guo, F., Yang, H., Wu, H.-P., Xu, G., Liu, W., Xie, Z.-G., Shi, L., He, X., Jin, S., et al. (2011) · Nature · doi:10.1038/nature10443 · Cited by 1,144 · see citing works

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

Ficz, G., Branco, M. R., Seisenberger, S., Santos, F., Krueger, F., Hore, T. A., Marques, C. J., Andrews, S., & Reik, W. (2011) · Nature · doi:10.1038/nature10008 · Cited by 1,123 · see citing works

Finding function in novel targets: C. elegans as a model organism

Kaletta, T., & Hengartner, M. O. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2031 · Cited by 1,091 · see citing works

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., Delalle, I., Baur, J. A., Sui, G., Armour, S. M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601758 · Cited by 1,074 · see citing works

Bioavailability of resveratrol

Walle, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05842.x · Cited by 1,051 · see citing works

Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

Hata, K., Okano, M., Lei, H., & Li, E. (2002) · Development · doi:10.1242/dev.129.8.1983 · Cited by 1,041 · see citing works

Extended Functional Groups (EFG): An Efficient Set for Chemical Characterization and Structure-Activity Relationship Studies of Chemical Compounds

Salmina, E. S., Haider, N., & Tetko, I. V. (2015) · Molecules · doi:10.3390/molecules21010001 · Cited by 1,037 · see citing works

Role of oxidative stress in Alzheimer’s disease

HUANG, W.-J., ZHANG, X., & CHEN, W.-W. (2016) · Biomedical Reports · doi:10.3892/br.2016.630 · Cited by 1,023 · see citing works

Histone core modifications regulating nucleosome structure and dynamics

Tessarz, P., & Kouzarides, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3890 · Cited by 1,018 · see citing works

Epigenetic mechanisms of longevity and aging

Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016) · Cell · doi:10.1016/j.cell.2016.07.050 · Cited by 956 · see citing works

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., et al. (2010) · Science · doi:10.1126/science.1186088 · Cited by 951 · see citing works

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

Min, S.-W., Cho, S.-H., Zhou, Y., Schroeder, S., Haroutunian, V., Seeley, W. W., Huang, E. J., Shen, Y., Masliah, E., Mukherjee, C., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.044 · Cited by 949 · see citing works

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Franceschi, C., Garagnani, P., Morsiani, C., Conte, M., Santoro, A., Grignolio, A., Monti, D., Capri, M., & Salvioli, S. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00061 · Cited by 945 · see citing works

Role of neuroinflammation in neurodegenerative diseases (Review)

Chen, W., Zhang, X., & Huang, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4948 · Cited by 933 · see citing works

Degradation of misfolded proteins in neurodegenerative diseases: Therapeutic targets and strategies

Ciechanover, A., & Kwon, Y. T. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.117 · Cited by 898 · see citing works

Epigenetics and aging

Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860 · see citing works

Regulation of heat shock transcription factors and their roles in physiology and disease

Gómez‐Pastor, R., Burchfiel, E. T., & Thiele, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.73 · Cited by 859 · see citing works

Impaired Proteasome Function in Alzheimer's Disease

Keller, J. N., Hanni, K. B., & Markesbery, W. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750436.x · Cited by 848 · see citing works

Brain-Gut-Microbiota Axis in Alzheimer’s Disease

Kowalski, K., & Mulak, A. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18087 · Cited by 826 · see citing works

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

Szulwach, K. E., Li, X., Li, Y., Song, C., Wu, H., Dai, Q., Irier, H. A., Upadhyay, A. K., Gearing, M., Levey, A. I., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2959 · Cited by 819 · see citing works

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

Özdal, T., Sela, D. A., Xiao, J., Boyacıoğlu, D., Chen, F., & Çapanoğlu, E. (2016) · Nutrients · doi:10.3390/nu8020078 · Cited by 812 · see citing works

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

Liu, Z., Zhou, T., Ziegler, A. C., Dimitrion, P., & Zuo, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2525967 · Cited by 810 · see citing works

Pathways of cellular proteostasis in aging and disease

Klaips, C. L., Jayaraj, G. G., & Hartl, F. U. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201709072 · Cited by 803 · see citing works

Oxidative Stress in Neurodegenerative Diseases

Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9337-5 · Cited by 800 · see citing works

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791 · see citing works

Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate

Valenzano, D. R., Tozzini, E. T., Genade, T., Cattaneo, A., Domenici, L., & Cellerino, A. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.038 · Cited by 786 · see citing works

Maternal Methyl Supplements in Mice Affect Epigenetic Variation and DNA Methylation of Offspring

Cooney, C. A., Dave, A. A., & Wolff, G. L. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2393s · Cited by 784 · see citing works

Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast

Medina, D. A., Jordán‐Pla, A., Millán-Zambrano, G., Chávez, S., Choder, M., & Pérez-Ortín, J. E. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00001 · Cited by 757 · see citing works

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

Turner, R. S., Thomas, R. G., Craft, S., van Dyck, C. H., Mintzer, J. E., Reynolds, B., Brewer, J. B., Rissman, R. A., Raman, R., Aisen, P. S. S., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000002035 · Cited by 752 · see citing works

Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides

Marambaud, P., Zhao, H., & Davies, P. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508246200 · Cited by 750 · see citing works

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., & Gan, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509329200 · Cited by 740 · see citing works

Sirt1 and the Mitochondria

Luen Tang, B. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2318 · Cited by 740 · see citing works

Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦

Yamamoto, M., Clark, J. D., Pastor, J. V., Gurnani, P., Nandi, A., Kurosu, H., Miyoshi, M., Ogawa, Y., Castrillón, D. H., Rosenblatt, K. P., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509039200 · Cited by 724 · see citing works

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

Westerheide, S. D., Anckar, J., Stevens, S. M., Sistonen, L., & Morimoto, R. I. (2009) · Science · doi:10.1126/science.1165946 · Cited by 722 · see citing works

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

Moussa, C., Hebron, M. L., Huang, X., Ahn, J., Rissman, R. A., Aisen, P. S. S., & Turner, R. S. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0779-0 · Cited by 712 · see citing works

Neuroinflammation as a common feature of neurodegenerative disorders

Guzman-Martinez, L., Maccioni, R. B., Andrade, V., Navarrete, L. P., Pastor, M. G., & Ramos-Escobar, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01008 · Cited by 702 · see citing works

Epigenetics and aging: the targets and the marks

Fraga, M. F., & Esteller, M. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.05.008 · Cited by 690 · see citing works

The role of protein clearance mechanisms in organismal ageing and age-related diseases

Vı́lchez, D., Sáez, I., & Dillin, A. G. (2014) · Nature Communications · doi:10.1038/ncomms6659 · Cited by 684 · see citing works

Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses

Leonard, S. S., Xia, C., Jiang, B.-H., Stinefelt, B. M., KLANDORF, H., Harris, G. K., & Shi, X. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.105 · Cited by 683 · see citing works

miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

Zhou, S., Jin, J.-P., Wang, J., Zhang, Z., Freedman, J. H., Zheng, Y., & Cai, L. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.30 · Cited by 681 · see citing works

Histone H4 lysine 16 acetylation regulates cellular lifespan

Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667 · see citing works

DNA Methylation Decreases in Aging But Not in Immortal Cells

Wilson, V. L., & Jones, P. A. (1983) · Science · doi:10.1126/science.6844925 · Cited by 649 · see citing works

Collapse of proteostasis represents an early molecular event in <i>Caenorhabditis elegans</i> aging

Ben-Zvi, A., Miller, E. A., & Morimoto, R. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902882106 · Cited by 649 · see citing works

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

Vingtdeux, V., Giliberto, L., Zhao, H., Chandakkar, P., Wu, Q., Simon, J. E., Janle, E. M., Lobo, J., Ferruzzi, M. G., Davies, P. J., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.060061 · Cited by 648 · see citing works

AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

Um, J.-H., Park, S.-J., Kang, H., Yang, S., Foretz, M., McBurney, M. W., Kim, M. K., Viollet, B., & Chung, J. H. (2010) · Diabetes · doi:10.2337/db09-0482 · Cited by 647 · see citing works

Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation

Orang, A., Safaralizadeh, R., & Kazemzadeh, M. (2014) · International Journal of Genomics · doi:10.1155/2014/970607 · Cited by 644 · see citing works

Calorie restriction extends yeast life span by lowering the level of NADH

Lin, S.-J., Ford, E., Haigis, M., Liszt, G., & Guarente, L. (2004) · Genes &amp; Development · doi:10.1101/gad.1164804 · Cited by 632 · see citing works

Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction

Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J. T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602909200 · Cited by 626 · see citing works

Administration of resveratrol: What formulation solutions to bioavailability limitations?

Amri, A., Chaumeil, J. C., Sfar, S., & Charrueau, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.083 · Cited by 622 · see citing works

FOXO transcription factors: key regulators of cellular quality control

Webb, A. E., & Brunet, A. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.003 · Cited by 620 · see citing works

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

Morselli, E., Maiuri, M. C., Markaki, M., Megalou, E., Pasparaki, A., Palikaras, K., Criollo, A., Galluzzi, L., Malik, S. A., Vitale, I., et al. (2010) · Cell Death &amp; Disease · doi:10.1038/cddis.2009.8 · Cited by 613 · see citing works

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

Barger, J. L., Kayo, T., Vann, J. M., Arias, E. B., Wang, J., Hacker, T. A., Wang, Y., Raederstorff, D., Morrow, J. D., Leeuwenburgh, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002264 · Cited by 580 · see citing works

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

Greer, E. L., & Brunet, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00459.x · Cited by 574 · see citing works

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

Hubbard, B. P., & Sinclair, D. A. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.12.004 · Cited by 572 · see citing works

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

Gems, D., & Partridge, L. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183712 · Cited by 545 · see citing works

Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging

Liu, L., Cheung, T. H., Charville, G. W., Hurgo, B. M. C., Leavitt, T., Shih, J., Brunet, A., & Rando, T. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.043 · Cited by 544 · see citing works

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature · doi:10.1038/nature09195 · Cited by 543 · see citing works

α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

Kontopoulos, E., Parvin, J. D., & Feany, M. Β. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl243 · Cited by 539 · see citing works

Biochemistry and biology of mammalian DNA methyltransferases

Hermann, A., Gowher, H., & Jeltsch, A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4201-1 · Cited by 536 · see citing works

The central role of glutathione in the pathophysiology of human diseases

Franco, R., Schoneveld, O., Pappa, A., & Panayiotidis, M. I. (2007) · Archives of Physiology and Biochemistry · doi:10.1080/13813450701661198 · Cited by 536 · see citing works

Resveratrol protects against global cerebral ischemic injury in gerbils

Wang, Q., Xu, J., Rottinghaus, G. E., Simonyi, Á., Lubahn, D. E., Sun, G. Y., & Sun, A. Y. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03543-6 · Cited by 528 · see citing works

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons

Parker, J. A., Arango-Lievano, M., Abderrahmane, S., Lambert, E., Tourette, C., Catoire, H., & Néri, C. (2005) · Nature Genetics · doi:10.1038/ng1534 · Cited by 509 · see citing works

The Impact of Nutrition and Environmental Epigenetics on Human Health and Disease

Tiffon, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113425 · Cited by 504 · see citing works

Transgenerational response to nutrition, early life circumstances and longevity

Kaati, G., Bygren, L. O., Pembrey, M., & Sjöström, M. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201832 · Cited by 500 · see citing works

Apoptotic cell: linkage of inflammation and wound healing

Wu, Y.-S., & Chen, S.-N. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00001 · Cited by 500 · see citing works

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

Wu, Y., Li, X., Zhu, J. X., Xie, W., Le, W., Fan, Z., Jankovic, J. J., & Pan, T. (2011) · Neurosignals · doi:10.1159/000328516 · Cited by 495 · see citing works

SIRT1 in Neurodevelopment and Brain Senescence

Herskovits, A. Z., & Guarente, L. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.028 · Cited by 493 · see citing works

Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

Tsujikawa, H., Kurotaki, Y., Fujimori, T., Fukuda, K., & Nabeshima, Y. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0048 · Cited by 490 · see citing works

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

Karuppagounder, S. S., Pinto, J. T., Xu, H., Chen, H., Beal, M. F., & Gibson, G. E. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.008 · Cited by 488 · see citing works

Nutraceutical Antioxidants as Novel Neuroprotective Agents

Kelsey, N. A., Wilkins, H., & Linseman, D. A. (2010) · Molecules · doi:10.3390/molecules15117792 · Cited by 481 · see citing works

MicroRNAs in cardiovascular disease: an introduction for clinicians

Romaine, S. P. R., Tomaszewski, M., Condorelli, G., & Samani, N. J. (2015) · Heart · doi:10.1136/heartjnl-2013-305402 · Cited by 479 · see citing works

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

Witte, A. V., Kerti, L., Margulies, D. S., & Floel, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0385-14.2014 · Cited by 455 · see citing works

A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans

Boehm, M., & Slack, F. J. (2005) · Science · doi:10.1126/science.1115596 · Cited by 449 · see citing works

MicroRNAs in Cardiovascular Disease

Barwari, T., Joshi, A., & Mayr, M. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.09.945 · Cited by 447 · see citing works

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

Tan, J. M. M., Wong, E. S. P., Kirkpatrick, D. S., Pletniková, O., Ko, H. S., Tay, S.-P., Ho, M. W. L., Troncoso, J. C., Gygi, S. P., Lee, M. K., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm320 · Cited by 444 · see citing works

Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?

Saiko, P., Szakmary, A., Jaeger, W., & Szekeres, T. (2007) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2007.08.004 · Cited by 442 · see citing works

Environmental enrichment strengthens corticocortical interactions and reduces amyloid-β oligomers in aged mice

Mainardi, M., Garbo, A. D., Caleo, M., Berardi, N., Sale, A., & Maffei, L. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00001 · Cited by 438 · see citing works

Elevated histone expression promotes life span extension

Feser, J., Truong, D., Das, C., Carson, J. J., Kieft, J., Harkness, T., & Tyler, J. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.015 · Cited by 435 · see citing works

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., & Partridge, L. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.07.007 · Cited by 435 · see citing works

Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells

Chen, C.-Y., Jang, J.-H., Li, M.-H., & Surh, Y.-J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.237 · Cited by 428 · see citing works

Pharmacokinetic and safety profile oftrans‐resveratrol in a rising multiple‐dose study in healthy volunteers

Almeida, L., Vaz‐da‐Silva, M., Falcão, A. C., Soares, E., Costa, R., Loureiro, A. I., Fernandes‐Lopes, C., Rocha, J., Nunes, T., Wright, L. C., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800177 · Cited by 427 · see citing works

CpG and non-CpG methylation in epigenetic gene regulation and brain function

Jang, H., Shin, W., Lee, J., & Do, J. (2017) · Genes · doi:10.3390/genes8060148 · Cited by 427 · see citing works

Resveratrol Mitigates Lipopolysaccharide- and Aβ-Mediated Microglial Inflammation by Inhibiting the TLR4/NF-Κb/STAT Signaling cascade

Capiralla, H., Vingtdeux, V., Zhao, H., Sankowski, R., Al‐Abed, Y., Davies, P., & Marambaud, P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07594.x · Cited by 426 · see citing works

Resveratrol regulates microglia M1/M2 polarization via PGC-1α in conditions of neuroinflammatory injury

Yang, X., Xu, S., Qian, Y., & Xiao, Q. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.03.003 · Cited by 417 · see citing works

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

O'Sullivan, R. J., Kubicek, S., Schreiber, S. L., & Karlseder, J. (2010) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.1897 · Cited by 416 · see citing works

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation

Kennedy, D. O., Wightman, E. L., Reay, J. L., Lietz, G., Okello, E. J., Wilde, A., & Haskell, C. F. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28641 · Cited by 415 · see citing works

Neuroprotective action of resveratrol

Bastianetto, S., Ménard, C., & Quirion, R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.09.011 · Cited by 411 · see citing works

A Role for SIR-2.1 Regulation of ER Stress Response Genes in Determining C. elegans Life Span

Viswanathan, M., Kim, S. K., Berdichevsky, A., & Guarente, L. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.017 · Cited by 409 · see citing works

Role of resveratrol in regulation of cellular defense systems against oxidative stress

Truong, V., Jun, M., & Jeong, W. (2017) · BioFactors · doi:10.1002/biof.1399 · Cited by 397 · see citing works

Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation

Cropley, J. E., Suter, C. M., Beckman, K. B., & Martin, D. I. K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607090103 · Cited by 396 · see citing works

Caloric restriction, SIRT1 and longevity

Cantó, C., & Auwerx, J. (2009) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2009.03.008 · Cited by 395 · see citing works

Protective effect of resveratrol on β-amyloid-induced oxidative PC12 cell death

Jang, J.-H. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00062-5 · Cited by 391 · see citing works

Cohort Profile: The Dutch Hunger Winter Families Study

Lumey, L., Stein, A. D., Kahn, H. S., van der Pal-de Bruin, K. M., Blauw, G., Zybert, P. A., & Susser, E. S. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym126 · Cited by 385 · see citing works

Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats

Jin, F. J., Wu, Q., Lu, Y., Gong, Q., & Shi, J. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.10.005 · Cited by 384 · see citing works

Aβ inhibits the proteasome and enhances amyloid and tau accumulation

Tseng, B. P., Green, K. N., Chan, J. L., Blurton-Jones, M., & LaFerla, F. M. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.014 · Cited by 384 · see citing works

Correction: Corrigendum: Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

Hashizume, O., Ohnishi, S., Mito, T., Shimizu, A., Ishikawa, K., Nakada, K., Soda, M., Mano, H., Togayachi, S., Miyoshi, H., et al. (2015) · Scientific Reports · doi:10.1038/srep14591 · Cited by 381 · see citing works

An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells

Lukiw, W. J., Zhao, Y., & Cui, J. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805371200 · Cited by 380 · see citing works

One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease

Tomé‐Carneiro, J., Larrosa, M., Yáñez-Gascón, M. J., Dávalos, A., Gil‐Zamorano, J., Gonzálvez, M., García‐Almagro, F. J., Ros, J. A. R., Tomás-Barberán, F. A., Espı́n, J. C., et al. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.03.011 · Cited by 378 · see citing works

MicroRNAs and their roles in aging

Smith-Vikos, T., & Slack, F. J. (2012) · Journal of Cell Science · doi:10.1242/jcs.099200 · Cited by 371 · see citing works

Genomic DNA methylation decreases in response to moderate folate depletion in elderly women

Rampersaud, G. C., KAUWELL, G. P. A., Hutson, A. D., Cerda, J. J., & Bailey, L. B. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.4.998 · Cited by 365 · see citing works

Grape-Derived Polyphenolics Prevent A Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

Wang, J., Ho, L., Zhao, W., Ono, K., Rosensweig, C., Chen, L., Humala, N., Teplow, D. B., & Pasinetti, G. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0364-08.2008 · Cited by 358 · see citing works

Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats

Sinha, K., Chaudhary, G., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01691-0 · Cited by 356 · see citing works

Naturally occurring phytochemicals for the prevention of Alzheimer’s disease

Kim, J., Lee, H. J., & Lee, K. W. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06562.x · Cited by 354 · see citing works

Resveratrol Attenuates Obesity-Associated Peripheral and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet

Jeon, B. T., Jeong, E. A., Shin, H. J., Lee, Y., Lee, D. H., Kim, H. J., Kang, S. S., Cho, G. J., Choi, W. S., & Roh, G. S. (2012) · Diabetes · doi:10.2337/db11-1498 · Cited by 352 · see citing works

Protein Quality Control by Molecular Chaperones in Neurodegeneration

Ciechanover, A. J., & Kwon, Y. T. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00185 · Cited by 350 · see citing works

Decreased birthweights in infants after maternal in utero exposure to the Dutch famine of 1944–1945

Lumey, L. H. (1992) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.1992.tb00764.x · Cited by 343 · see citing works

Enhancing the bioavailability of resveratrol by combining it with piperine

Johnson, J. J., Nihal, M., Siddiqui, I. A., Scarlett, C. O., Bailey, H. H., Mukhtar, H., & Ahmad, N. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100117 · Cited by 340 · see citing works

Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases

Sun, A. Y., Wang, Q., Simonyi, Á., & Sun, G. Y. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8111-y · Cited by 330 · see citing works

MicroRNAs (miRNAs) in Neurodegenerative Diseases

Nelson, P. T., Wang, W., & Rajeev, B. W. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00120.x · Cited by 325 · see citing works

Nutritional influences on brain development

Georgieff, M., Ramel, S. E., & Cusick, S. E. (2018) · Acta Paediatrica · doi:10.1111/apa.14287 · Cited by 323 · see citing works

Edible flowers: A review of the nutritional, antioxidant, antimicrobial properties and effects on human health

Fernandes, L., Casal, S. I. P., Pereira, J. A., Saraiva, J. A., & Ramalhosa, E. (2017) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2017.03.017 · Cited by 321 · see citing works

Resveratrol nanoformulations: Challenges and opportunities

Summerlin, N., Soo, E., Thakur, S. S., Qu, Z., Jambhrunkar, S., & Popat, A. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.01.003 · Cited by 319 · see citing works

Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets

Kameswaran, V., Bramswig, N. C., McKenna, L. B., Penn, M. M. C., Schug, J., Hand, N. J., Chen, Y., Choi, I., Vourekas, A., Won, K., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.016 · Cited by 316 · see citing works

Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseases

Alexander, A. G., Marfil, V., & Li, C. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00279 · Cited by 310 · see citing works

Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein 1

Shiraki-Iida, T., Aizawa, H., Matsumura, Y., Sekine, S., Iida, A., Anazawa, H., Nagai, R., Kuro‐o, M., & Nabeshima, Y.-I. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00127-6 · Cited by 309 · see citing works

Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer's disease

Choi, D., Lee, Y., Hong, J. T., & Lee, H. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.11.014 · Cited by 305 · see citing works

Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide‐related toxicity in cultured hippocampal neurons

Bastianetto, S., Zheng, W., & Quirion, R. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703626 · Cited by 302 · see citing works

Neuroprotective effects of resveratrol against β‐amyloid‐induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C

Han, Y.-S., Zheng, W., Bastianetto, S., Chabot, J., & Quirion, R. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705688 · Cited by 300 · see citing works

Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers

Ladiwala, A. R. A., Lin, J. C., Bale, S. S., Marcelino, A. M. C., Bhattacharya, M., Dordick, J. S., & Tessier, P. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.133108 · Cited by 299 · see citing works

Moderate consumption of Cabernet Sauvignon attenuates A� neuropathology in a mouse model of Alzheimer's disease

Wang, J., Ho, L., Zhao, Z., Seror, I., Humala, N., Dickstein, D. L., Thiyagarajan, M., Percival, S. S., Talcott, S. T., & Pasinetti, G. M. (2006) · The FASEB Journal · doi:10.1096/fj.06-6281com · Cited by 299 · see citing works

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

Li, Y., Xu, S., Giles, A. J., Nakamura, K., Lee, J. W., Hou, X., Dönmez, G., Li, J., Luo, Z., Walsh, K., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-173492 · Cited by 298 · see citing works

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

Feng, Y. N., Wang, X., Yang, S., Wang, Y., Zhang, X., Du, X., Sun, X., Zhao, M., Huang, L., & Liu, R. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.08.013 · Cited by 297 · see citing works

Sensory receptors—design principles revisited

Wicher, D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00001 · Cited by 295 · see citing works

The Daily Oral Administration of High Doses of trans-Resveratrol to Rats for 28 Days Is Not Harmful

Juan, M. E., Vinardell, M. P., & Planas, J. M. (2002) · Journal of Nutrition · doi:10.1093/jn/132.2.257 · Cited by 293 · see citing works

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

McCubrey, J. A., Lertpiriyapong, K., Steelman, L. S., Abrams, S. L., Yang, L. V., Murata, R. M., Rosalen, P. L., Scalisi, A., Neri, L. M., Cocco, L., et al. (2017) · Aging · doi:10.18632/aging.101250 · Cited by 292 · see citing works

MicroRNAs Both Promote and Antagonize Longevity in C. elegans

de Lencastre, A., Pincus, Z., Zhou, K. I., Kato, M., Lee, S. S., & Slack, F. J. (2010) · Current Biology · doi:10.1016/j.cub.2010.11.015 · Cited by 291 · see citing works

Are mitochondria critical in the pathogenesis of Alzheimer's disease?

Reddy, P. H., & Beal, M. F. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.03.004 · Cited by 289 · see citing works

Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4).

Spanier, G., Xu, H., Xia, N., Tobias, S., Deng, S., Wojnowski, L., Förstermann, U., & Li, H. (2009) · PubMed · Cited by 288 · see citing works

Resveratrol for Alzheimer's disease

Sawda, C. N., Moussa, C., & Turner, R. S. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13431 · Cited by 281 · see citing works

Polyphenols, food and pharma. Current knowledge and directions for future research

Tresserra‐Rimbau, A., Lamuela-Raventós, R. M., & Moreno, J. J. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.050 · Cited by 280 · see citing works

Food for thought: how nutrition impacts cognition and emotion

Spencer, S. J., Kőrösi, A., Layé, S., Shukitt‐Hale, B., & Barrientos, R. M. (2017) · npj Science of Food · doi:10.1038/s41538-017-0008-y · Cited by 279 · see citing works

Understanding microRNAs in neurodegeneration

Eacker, S. M., Dawson, T. M., & Dawson, V. L. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2726 · Cited by 275 · see citing works

Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia

Bi, X. L., Yang, J., Dong, Y. X., Wang, J., Cui, Y. H., Ikeshima, T., Zhao, Y. Q., & Wu, C. F. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.08.008 · Cited by 274 · see citing works

Lifespan and healthspan extension by resveratrol

Bhullar, K. S., & Hubbard, B. P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.01.012 · Cited by 273 · see citing works

Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD

Tili, E., Michaille, J., Adair, B., Alder, H., Limagne, E., Taccioli, C., Ferracin, M., Delmas, D., Latruffe, N., & Croce, C. M. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq143 · Cited by 273 · see citing works

I’m Eating for Two: Parental Dietary Effects on Offspring Metabolism

Rando, O. J., & Simmons, R. A. (2015) · Cell · doi:10.1016/j.cell.2015.02.021 · Cited by 271 · see citing works

The emerging role of microRNAs in Alzheimer's disease

Femminella, G. D., Ferrara, N., & Rengo, G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00040 · Cited by 270 · see citing works

The microbiome, immunity, and schizophrenia and bipolar disorder.

Dickerson, F., Severance, E., & Yolken, R. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.010 · Cited by 268 · cited 1× · see citing works

Anti-inflammatory activities of resveratrol in the brain: Role of resveratrol in microglial activation

Zhang, F., Liu, J., & Shi, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.03.043 · Cited by 265 · see citing works

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease

Seo, E.-J., Fischer, N., & Efferth, T. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.11.030 · Cited by 265 · cited 1× · see citing works

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

Porquet, D., Casadesús, G., Bayod, S., Vicente, A., Canudas, A. M., Vilaplana, J., Pelegrı́, C., Sanfeliu, C., Camins, A., Pallàs, M., et al. (2012) · AGE · doi:10.1007/s11357-012-9489-4 · Cited by 264 · see citing works

The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide

Albani, D., Polito, L., Batelli, S., Mauro, S. D., Fracasso, C., Martelli, G., Colombo, L., Manzoni, C., Salmona, M., Caccia, S., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06228.x · Cited by 260 · see citing works

Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells

Huang, Y., Chávez, L., Chang, X., Wang, X., Pastor, W. A., Kang, J., Zepeda-Martínez, J. A., Pape, U. J., Jacobsen, S. E., Peters, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322921111 · Cited by 258 · see citing works

Oxidative stress in vascular dementia and Alzheimer’s disease: a common pathology

Bennett, S., Grant, M. M., & Aldred, S. (2008) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1041 · Cited by 254 · see citing works

The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system

Kietzmann, T., Petry, A., Shvetsova, A., Gerhold, J. M., & Görlach, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13792 · Cited by 253 · see citing works

Postsynthetic Trimethylation of Histone H4 at Lysine 20 in Mammalian Tissues Is Associated with Aging

Sarg, B., Koutzamani, E., Helliger, W., Rundquist, I., & Lindner, H. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205166200 · Cited by 252 · see citing works

The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy

Wu, M., Yiang, G., Lai, T.-T., & Li, C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3420187 · Cited by 252 · see citing works

Regulation of CCL2 and CCL3 expression in human brain endothelial cells by cytokines and lipopolysaccharide

Chui, R. W., & Dorovini‐Zis, K. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-1 · Cited by 250 · see citing works

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Santoro, A., Ostan, R., Candela, M., Biagi, E., Brigidi, P., Capri, M., & Franceschi, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2674-y · Cited by 250 · see citing works

Ageing and neurodegenerative diseases

Hung, C.-W., Chen, Y., Hsieh, W.-L., Chiou, S., & Kao, C.-L. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.006 · Cited by 248 · see citing works

The involvement of microRNAs in neurodegenerative diseases

Maciotta, S., Meregalli, M., & Torrente, Y. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00265 · Cited by 247 · see citing works

DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy

Lin, Q., Weidner, C. I., Costa, I. G., Marioni, R. E., Ferreira, M. R. P., Deary, I. J., & Wagner, W. (2016) · Aging · doi:10.18632/aging.100908 · Cited by 247 · see citing works

Neuroprotective effects of resveratrol in Alzheimer disease pathology

Rege, S. D., Geetha, T., Griffin, G. D., Broderick, T. L., & Babu, J. R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00218 · Cited by 243 · see citing works

Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment

Pasinetti, G. M., Wang, J., Ho, L., Zhao, W., & Dubner, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.006 · Cited by 238 · see citing works

Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats

Virgili, M., & Contestabile, A. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00820-x · Cited by 234 · see citing works

An accelerated assay for the identification of lifespan-extending interventions in <i>Drosophila</i> melanogaster

Bauer, J. H., Goupil, S., Garber, G. B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403493101 · Cited by 234 · see citing works

Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice

Strong, R., Miller, R. A., Astle, C. M., Baur, J. A., de Cabo, R., Fernandez, E., Guo, W., Javors, M. A., Kirkland, J. L., Nelson, J. F., et al. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls070 · Cited by 232 · see citing works

Mechanisms of Mitochondrial Dysfunction in Alzheimer’s Disease

Cadonic, C., Sabbir, M. G., & Albensi, B. C. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9515-5 · Cited by 226 · see citing works

The Neuroprotective Effect of Klotho is Mediated via Regulation of Members of the Redox System

Zeldich, E., Chen, C.-D., Colvin, T. A., Bove‐Fenderson, E., Liang, J. J., Zhou, T. B. T., Harris, D. A., & Abraham, C. R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.567321 · Cited by 225 · see citing works

Rapid changes in Atlantic grey seal milk from birth to weaning – immune factors and indicators of metabolic strain

Lowe, A. D., Bawazeer, S., Watson, D. G., McGill, S., Burchmore, R., Pomeroy, P. P., & Kennedy, M. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-16187-7 · Cited by 225 · see citing works

Resveratrol potently reduces prostaglandin E2production and free radical formation in lipopolysaccharide-activated primary rat microglia

Candelario-Jalil, E., de Oliveira, A. C. P., Gräf, S., Bhatia, H. S., Hüll, M., Muñoz, E., & Fiebich, B. L. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-25 · Cited by 223 · see citing works

Resveratrol and Brain Mitochondria: a Review

Jardim, F. R., de Rossi, F. T., Nascimento, M. X., Barros, R. G. D. S., Borges, P. A., Prescilio, I. C., & de Oliveira, M. R. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0448-z · Cited by 223 · see citing works

Making Sense of … the Microbiome in Psychiatry

Bastiaanssen, T. F. S., Cowan, C. S. M., Claesson, M. J., Dinan, T. G., & Cryan, J. F. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy067 · Cited by 223 · see citing works

MicroRNAs in neurodegenerative diseases and their therapeutic potential

Junn, E., & Mouradian, M. M. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.10.002 · Cited by 222 · see citing works

MicroRNAs - Biology and clinical applications

Ranganathan, K., & Sivasankar, V. (2014) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/0973-029x.140762 · Cited by 219 · see citing works

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works

Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases

Jiang, S., Liu, H., & Li, C. (2021) · Foods · doi:10.3390/foods10081854 · Cited by 230 · see citing works

Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

Migliore, L., & Coppedè, F. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00714-w · Cited by 217 · see citing works

Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

Feng, J., Zheng, Y., Guo, M., Arés, I., Martínez, M., López-Torres, B., Martínez‐Larrañaga, M., Wang, X., Anadón, A., & Martínez, M. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.07.010 · Cited by 181 · see citing works

Antioxidants and Reactive Oxygen Species: Shaping Human Health and Disease Outcomes

Manful, C. F., Fordjour, E., Subramaniam, D., Sey, A. A., Abbey, L., & Thomas, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157520 · Cited by 149 · see citing works

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works

Antioxidant Therapeutic Strategies in Neurodegenerative Diseases

Morén, C., deSouza, R. M., Giraldo, D. M., & Uff, C. E. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169328 · Cited by 123 · see citing works

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

Zhang, H., Wang, Y., Wang, Y., Li, X., Wang, S., & Wang, Z. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114606 · Cited by 109 · see citing works

Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer's disease

Yang, L., Wang, Y., Li, Z., Wu, X., Mei, J., & Zheng, G. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120714 · Cited by 106 · see citing works

Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis

López-Armada, M. J., Fernández-Rodríguez, J. A., & Blanco, F. J. (2022) · Antioxidants · doi:10.3390/antiox11061151 · Cited by 108 · see citing works

Oxidative/Nitrosative Stress, Apoptosis, and Redox Signaling: Key Players in Neurodegenerative Diseases

Üremiş, N., & Üremi̇ş, M. M. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70133 · Cited by 98 · see citing works

Phenolic compounds that cross the blood–brain barrier exert positive health effects as central nervous system antioxidants

Velásquez-Jiménez, D., Corella‐Salazar, D. A., Zuñiga-Martínez, B. S., Domínguez-Avila, J. A., Montiel‐Herrera, M., Salazar‐López, N. J., Rodrigo-García, J., Villegas‐Ochoa, M. A., & González-Aguilar, G. A. (2021) · Food & Function · doi:10.1039/d1fo02017j · Cited by 83 · see citing works

Resveratrol-Mediated Regulation of Mitochondria Biogenesis-associated Pathways in Neurodegenerative Diseases: Molecular Insights and Potential Therapeutic Applications

Shaito, A. A., Al‐Mansoob, M., Ahmad, S. M. S., Haider, M. Z., Eid, A. H., Posadino, A. M., Pintus, G., & Giordo, R. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666221012122855 · Cited by 84 · see citing works

Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy

Zhang, S., Meng, Y., Zhou, L., Qiu, L., Wang, H., Su, D., Zhang, B., Chan, K. M., & Han, J. (2022) · MedComm · doi:10.1002/mco2.173 · Cited by 82 · see citing works

Role of PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway in Resveratrol Alleviation of Zearalenone-Induced Oxidative Stress and Apoptosis in TM4 Cells

Xu, W., Zheng, H., Fu, Y., Gu, Y., Zou, H., Yuan, Y., Gu, J., Liu, Z., & Bian, J. (2022) · Toxins · doi:10.3390/toxins14110733 · Cited by 77 · see citing works

Phytochemicals as Regulators of Genes Involved in Synucleinopathies

Surguchov, A. P., Bernal, L., & Surguchev, A. A. (2021) · Biomolecules · doi:10.3390/biom11050624 · Cited by 76 · see citing works

Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding

Grant, W. B., & Blake, S. M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230418 · Cited by 79 · see citing works

Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

Liu, X., Liu, Y., Liu, J., Zhang, H., Shan, C., Guo, Y., Gong, X., Cui, M., Li, X., & Tang, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382223 · Cited by 69 · see citing works

The hormesis principle of neuroplasticity and neuroprotection

Mattson, M. P., & Leak, R. K. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.022 · Cited by 75 · see citing works

Superparamagnetic iron oxide loaded chitosan coated bilosomes for magnetic nose to brain targeting of resveratrol.

Abbas, H., Refai, H., Sayed, N. S. E., Rashed, L., Mousa, M. H., & Zewail, M. (2021) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2021.121244 · Cited by 58 · see citing works

Resveratrol—A Promising Therapeutic Agent with Problematic Properties

Radeva, L., & Yoncheva, K. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17010134 · Cited by 67 · see citing works

The Tragedy of Alzheimer’s Disease: Towards Better Management via Resveratrol-Loaded Oral Bilosomes

Abbas, H., Gad, H. A., Khattab, M. A., & Mansour, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101635 · Cited by 62 · see citing works

Role of Epigenetic Modulation in Neurodegenerative Diseases: Implications of Phytochemical Interventions

Prasanth, M. I., Sivamaruthi, B. S., Cheong, C. S. Y., Verma, K., Tencomnao, T., Brimson, J. M., & Prasansuklab, A. (2024) · Antioxidants · doi:10.3390/antiox13050606 · Cited by 57 · see citing works

The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature

Warren, A., Nyavor, Y., Zarabian, N., Mahoney, A., & Frame, L. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1365673 · Cited by 62 · see citing works

Resveratrol Activates Antioxidant Protective Mechanisms in Cellular Models of Alzheimer’s Disease Inflammation

Bartra, C., Yuan, Y., Vuraić, K., Valdés-Quiroz, H., Garcia-Baucells, P., SLEVIN, M. A., Pastorello, Y., Sunol, C. E., & Sanfeliu, C. (2024) · Antioxidants · doi:10.3390/antiox13020177 · Cited by 56 · see citing works

Tail-vein injection of MSC-derived small extracellular vesicles facilitates the restoration of hippocampal neuronal morphology and function in APP / PS1 mice

Wang, H., Liu, Y., Li, J., Wang, T., Hei, Y., Li, H., Wang, X., Wang, L., Zhao, R., Liu, W., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00620-y · Cited by 56 · see citing works

New Mechanisms of Action of Natural Antioxidants in Health and Disease

Hrelia, S., & Angeloni, C. (2020) · Antioxidants · doi:10.3390/antiox9040344 · Cited by 55 · see citing works

Copper, Iron, Selenium and Lipo-Glycemic Dysmetabolism in Alzheimer’s Disease

Aaseth, J., Skalny, A. V., Roos, P. M., Alexander, J., Aschner, M., & Tinkov, A. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179461 · Cited by 57 · see citing works

Oxidative Stress in Tauopathies: From Cause to Therapy

Bartolomé, F. B., Carro, E., & Alquézar, C. (2022) · Antioxidants · doi:10.3390/antiox11081421 · Cited by 57 · see citing works

Phenolic Characterization and Neuroprotective Properties of Grape Pomace Extracts

Chiavaroli, A., Balaha, M. F., Acquaviva, A., Ferrante, C., Cataldi, A., Menghini, L., Rapino, M., Orlando, G., Brunetti, L., Leone, S., et al. (2021) · Molecules · doi:10.3390/molecules26206216 · Cited by 52 · see citing works

Dietary Polyphenols as Anti-Aging Agents: Targeting the Hallmarks of Aging

Liu, Y., Fang, M., Tu, X., Mo, X., Zhang, L., Yang, B., Wang, F., Kim, Y., Huang, C., Chen, L., et al. (2024) · Nutrients · doi:10.3390/nu16193305 · Cited by 58 · see citing works

Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer's disease and beyond

Webber, E. K., Fivaz, M., Stutzmann, G. E., & Griffioen, G. (2023) · Alzheimer's &amp; Dementia · doi:10.1002/alz.13065 · Cited by 50 · see citing works

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Chen, Z., Wang, X., Du, S., Liu, Q., Xu, Z., Guo, Y., & Lin, X. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00900-6 · Cited by 51 · see citing works

Antioxidant Intervention to Improve Cognition in the Aging Brain: The Example of Hydroxytyrosol and Resveratrol

Terracina, S. A., Petrella, C., Francati, S., Lucarelli, M., Barbato, C., Minni, A., Ralli, M., Greco, A., Tarani, L., Fiore, M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415674 · Cited by 51 · see citing works

Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine

Li, J., Long, Q., Ding, H., Wang, Y., Luo, D., Li, Z., & Zhang, W. (2024) · Advanced Science · doi:10.1002/advs.202308677 · Cited by 47 · see citing works

Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging

Uddin, M. J., Farjana, M., Moni, A., Hossain, K. S., Hannan, M. A., & Ha, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158258 · Cited by 47 · see citing works

Roles of physical exercise in neurodegeneration: reversal of epigenetic clock

Xu, M., Zhu, J., Liu, X.-D., Luo, M.-Y., & Xu, N.-J. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00254-1 · Cited by 46 · see citing works

Enhancing the Therapeutic Effect in Alzheimer's Disease Drugs: The role of Polypharmacology and Cholinesterase inhibitors

Martins, M. M., Branco, P. S., & Ferreira, L. M. (2023) · ChemistrySelect · doi:10.1002/slct.202300461 · Cited by 45 · see citing works

Artificial intelligence for dementia prevention

Newby, D., Orgeta, V., Marshall, C. R., Lourida, I., Albertyn, C. P., Tamburin, S., Raymont, V., Veldsman, M., Koychev, I., Bauermeister, S., et al. (2023) · Alzheimer's &amp; Dementia · doi:10.1002/alz.13463 · Cited by 42 · see citing works

Insulin resistance in Alzheimer’s disease: The genetics and metabolomics links

Amin, A. M., Mostafa, H. M. A., & Khojah, H. M. J. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.12.016 · Cited by 43 · see citing works

Resveratrol alleviates Mono-2-ethylhexyl phthalate-induced mitophagy, ferroptosis, and immunological dysfunction in grass carp hepatocytes by regulating the Nrf2 pathway

Wang, X., Gao, M., Lu, X., Lei, Y., Sun, J., Ren, M., Xu, T., & Lin, H. (2024) · Journal of Environmental Management · doi:10.1016/j.jenvman.2024.123235 · Cited by 42 · see citing works

Resveratrol as a Therapeutic Agent in Alzheimer’s Disease: Evidence from Clinical Studies

Puranik, N., Kumari, M., Tiwari, S., Dhakal, T., & Song, M. (2025) · Nutrients · doi:10.3390/nu17152557 · Cited by 47 · see citing works

Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review

Jalili, C., Kiani, A., Gholami, M., Bahrehmand, F., Fakhri, S., Kakehbaraei, S., & Kakebaraei, S. (2023) · IET Nanobiotechnology · doi:10.1049/nbt2.12127 · Cited by 42 · see citing works

Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future

Ziętara, P., Dziewięcka, M., & Augustyniak, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010728 · Cited by 40 · see citing works

Therapeutic Potential of Targeting Mitochondria for Alzheimer’s Disease Treatment

Atlante, A., Amadoro, G., Latina, V., & Valenti, D. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226742 · Cited by 39 · see citing works

The protective role of microbiota in the prevention of MPTP/P-induced Parkinson's disease by resveratrol

Tao, J., An, Y., Xu, L., Wang, Y., Wang, C., Li, P., Li, M., Yan, D., Wang, M., Zhong, G., et al. (2023) · Food & Function · doi:10.1039/d2fo03379h · Cited by 39 · see citing works

Oxidative Stress and Natural Antioxidants: Back and Forth in the Neurological Mechanisms of Alzheimer’s Disease

Mani, S., Dubey, R., Lai, I., Babu, M. A., Tyagi, S., Swargiary, G., Mody, D., Singh, M., Agarwal, S., Iqbal, D., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220700 · Cited by 40 · see citing works

Influence of human gut microbiome on the healthy and the neurodegenerative aging

Borrego-Ruiz, A., & Borrego, J. J. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112497 · Cited by 42 · see citing works

Interplay between Phytochemicals and the Colonic Microbiota

Kwon, C., Ediriweera, M. K., & Cho, S. K. (2023) · Nutrients · doi:10.3390/nu15081989 · Cited by 43 · see citing works

Resveratrol has an Overall Neuroprotective Role in Ischemic Stroke: A Meta-Analysis in Rodents

Liu, J., He, J., Huang, Y., & Hu, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.795409 · Cited by 36 · see citing works

Plant-derived bioactive components regulate gut microbiota to prevent depression and depressive-related neurodegenerative diseases: Focus on neurotransmitters

Song, Z., Cheng, L., Liu, Y., Zhan, S., Wu, Z., & Zhang, X. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.10.019 · Cited by 37 · see citing works

Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective

Guan, Y., Li, L., Yang, R., Lü, Y., & Tang, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06605-0 · Cited by 35 · see citing works

Some Candidate Drugs for Pharmacotherapy of Alzheimer’s Disease

Miziak, B., Błaszczyk, B., & Czuczwar, S. J. (2021) · Pharmaceuticals · doi:10.3390/ph14050458 · Cited by 35 · see citing works

Histopathological, physiological and biochemical assessment of resveratrol nanocapsules efficacy in bleomycin-induced acute and chronic lung injury in rats

Albanawany, N. M., Samy, D. M., Zahran, N. M., El‐Moslemany, R. M., Elsawy, S. M., & Nazel, M. W. A. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2105445 · Cited by 35 · see citing works

Neuroactive Phytochemicals as Multi-Target Modulators of Mental Health and Cognitive Function: An Integrative Review

Ткаченко, Г. М., Buyun, L., Kołodziejska, R., Kamiński, P., & Kurhaluk, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188907 · Cited by 34 · see citing works

Gut Microbial Metabolome and Dysbiosis in Neurodegenerative Diseases: Psychobiotics and Fecal Microbiota Transplantation as a Therapeutic Approach—A Comprehensive Narrative Review

Uceda, S., Echeverry‐Alzate, V., Reiriz, M., Miguel, E. M., Pérez-Curiel, A., Gómez-Senent, S., & Beltrán-Velasco, A. I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713294 · Cited by 35 · see citing works

Nanocarriers for natural polyphenol senotherapeutics

Joma, N., Bielawski, P., Saini, A., Kakkar, A. K., & Maysinger, D. (2024) · Aging Cell · doi:10.1111/acel.14178 · Cited by 33 · see citing works

The Effect of Dietary Supplementation with Resveratrol on Growth Performance, Carcass and Meat Quality, Blood Lipid Levels and Ruminal Microbiota in Fattening Goats

Shen, Y., Jiang, Y., Zhang, S., Zou, J., Gao, X., Song, Y., Zhang, Y., Hu, Y. P., Huang, Y., & Jiang, Q. (2022) · Foods · doi:10.3390/foods11040598 · Cited by 31 · see citing works

Micelle/Hydrogel Composite as a “Natural Self-Emulsifying Reversible Hybrid Hydrogel (N’SERH)” Enhances the Oral Bioavailability of Free (Unconjugated) Resveratrol

Joseph, A., Balakrishnan, A., Shanmughan, P., Maliakel, B. P., & Krishnakumar, I. M. (2022) · ACS Omega · doi:10.1021/acsomega.2c00116 · Cited by 31 · see citing works

Polyphenols: Natural food grade biomolecules for treating neurodegenerative diseases from a multi-target perspective

Li, Z., Zhao, T., Shi, M., Wei, Y., Huang, X., Shen, J., Zhang, X., Xie, Z., Huang, P., Yuan, K., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1139558 · Cited by 33 · see citing works

Resveratrol Loaded by Folate-Modified Liposomes Inhibits Osteosarcoma Growth and Lung Metastasis via Regulating JAK2/STAT3 Pathway

Zhu, W. T., Zeng, X. F., Yang, H., Jia, M. L., Zhang, W., Liu, W., & Liu, S. Y. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s398046 · Cited by 31 · see citing works

Smart stimuli-responsive biofunctionalized niosomal nanocarriers for programmed release of bioactive compounds into cancer cells in vitro and in vivo

Abtahi, N. A., Naghib, S. M., Haghiralsadat, F., Reza, J. Z., Hakimian, F., Yazdian, F. A., & Tofighi, D. (2021) · Nanotechnology Reviews · doi:10.1515/ntrev-2021-0119 · Cited by 30 · see citing works

Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling

Kang, N., Shi, Y., Song, J., Gao, F., Fan, M., Jin, W., Gao, Y., & Lv, P. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.868484 · Cited by 28 · see citing works

Functionalized Cerium Dioxide Nanoparticles with Antioxidative Neuroprotection for Alzheimer’s Disease

Hu, Y., Guo, H., Cheng, S., Sun, J., Du, J., Liu, X., Xiong, Y., Chen, L., Liu, C., Wu, C., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s434873 · Cited by 28 · see citing works

Neuro-Nutraceutical Polyphenols: How Far Are We?

Gentile, M. T., Camerino, I., Ciarmiello, L. F., Woodrow, P., Muscariello, L., Chiara, I. D., & Pacifico, S. (2023) · Antioxidants · doi:10.3390/antiox12030539 · Cited by 28 · see citing works

The Role of Reactive Oxygen Species in Alzheimer's Disease: From Mechanism to Biomaterials Therapy

Yu, Z., & Luo, F. H. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304373 · Cited by 28 · see citing works

New Uses of Melatonin as a Drug; A Review

Pohanka, M. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220105115755 · Cited by 27 · see citing works

Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?

Hieber, C., Grabbe, S., & Bros, M. (2023) · Biomolecules · doi:10.3390/biom13071085 · Cited by 28 · see citing works

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Socała, K., Żmudzka, E., Lustyk, K., Zagaja, M., Brighenti, V., Costa, A., Andres-Mach, M., Pytka, K., Martinelli, I., Mandrioli, J., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8101 · Cited by 24 · see citing works

The dual role of cellular senescence in human tumor progression and therapy

Ma, L., Yu, J., Fu, Y., He, X., Ge, S., Jia, R., Zhuang, A., Yang, Z. H., & Fan, X. (2024) · MedComm · doi:10.1002/mco2.695 · Cited by 29 · see citing works

Mechanistic insight into the capacity of natural polar phenolic compounds to abolish Alzheimer's disease-associated pathogenic effects of apoE4 forms

Mountaki, C., Dafnis, I., Panagopoulou, E. A., Vasilakopoulou, P. B., Karvelas, M., Chiou, A., Karathanos, V. Τ., & Chroni, A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.022 · Cited by 27 · see citing works

Plant‐derived peptides for the improvement of Alzheimer's disease: Production, functions, and mechanisms

Lin, L., Li, C., Li, T., Zheng, J., Shu, Y., Zhang, J., Shen, Y., & Ren, D. (2023) · Food Frontiers · doi:10.1002/fft2.210 · Cited by 27 · see citing works

How can we modulate aging through nutrition and physical exercise? An epigenetic approach

Rajado, A. T., Silva, N., Esteves, F., Brito, D. V. C., Binnie, A., Araújo, I. M., Nóbrega, C., Bragança, J., & Castelo‐Branco, P. (2023) · Aging · doi:10.18632/aging.204668 · Cited by 30 · see citing works

Sirtuin dysregulation in Parkinson's disease: Implications of acetylation and deacetylation processes

Dhiman, S., Mannan, A., Taneja, A., Mohan, M., & Singh, T. G. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122537 · Cited by 25 · see citing works

TNFSF14+ natural killer cells prevent spontaneous abortion by restricting leucine-mediated decidual stromal cell senescence

Shi, J., Lai, Z., Zhou, W., Yang, H., Zhang, T., Sun, J., Zhao, J., & Li, M. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00220-3 · Cited by 24 · see citing works

Development, Statistical Optimization, and Characterization of Resveratrol‐Containing Solid Lipid Nanoparticles (SLNs) and Determination of the Efficacy in Reducing Neurodegenerative Symptoms Related to Alzheimer’s Disease: In Vitro and In Vivo Study

Khishvand, M. A., Yeganeh, E. M., Zarei, M., Soleimani, M., Mohammadi, M., & Mahjub, R. (2024) · BioMed Research International · doi:10.1155/2024/7877265 · Cited by 22 · see citing works

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Jin, L. J., Nie, L., Deng, Y., Khana, G. J., & He, N. (2025) · Cell Proliferation · doi:10.1111/cpr.13804 · Cited by 24 · see citing works

Triad3A-Dependent TLR4 Ubiquitination and Degradation Contributes to the Anti-Inflammatory Effects of Pterostilbene on Vascular Dementia

Xu, J., Liu, J., Mi, Y., Zhao, T., Mu, D., Meng, Q., Wang, F., Li, N., & Hou, Y. W. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01219 · Cited by 22 · see citing works

Resveratrol Protects BEAS-2B Cells against Erastin-Induced Ferroptosis through the Nrf2/Keap1 Pathway

Huang, W., Yu, L., Cai, W., & Ma, C. (2022) · Planta Medica · doi:10.1055/a-1923-4399 · Cited by 22 · see citing works

Protective Effects of Resveratrol on Adolescent Social Isolation-Induced Anxiety-Like Behaviors via Modulating Nucleus Accumbens Spine Plasticity and Mitochondrial Function in Female Rats

Zhao, J., Ye, L., Liu, Z., Cui, Y., Deng, D., Bai, S., Yang, L., Shi, Y., Liu, Z., & Zhang, R. (2022) · Nutrients · doi:10.3390/nu14214542 · Cited by 22 · see citing works

Emerging antioxidant therapies in Friedreich’s ataxia

Edzeamey, F. J., Ramchunder, Z., Pourzand, C., & Virmouni, S. A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1359618 · Cited by 23 · see citing works

Unraveling mitochondrial dysfunction: comprehensive perspectives on its impact on neurodegenerative diseases

Yusoff, A. A. M., & Khair, S. Z. N. M. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0080 · Cited by 22 · see citing works

Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis

Li, S., Zhao, J., Xi, Y., Ren, J., Zhu, Y., Lu, Y., & Dong, D. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.371366 · Cited by 21 · see citing works

Neutrophil extracellular traps boost laser‐induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF‐1α pathway

Zeng, J., Wang, Y., Zhu, M., Wu, M., Zhou, Y., Wang, Q., Xu, Y., Lin, F., Wang, J., Li, Y., et al. (2023) · FEBS Journal · doi:10.1111/febs.16928 · Cited by 20 · see citing works

Unraveling the Serotonergic Mechanism of Stress-Related Anxiety: Focus on Co-Treatment with Resveratrol and Selective Serotonin Reuptake Inhibitors

Цейликман, В. Э., Tseilikman, O. B., Karpenko, M. N., Traktirov, D. S., Obukhova, D. A., Shatilov, V. A., Zhukov, M. S., Валерьевич, М. Г., Yegorov, O. N., Aristov, M. R., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12112455 · Cited by 20 · see citing works

Trained immunity in monocyte/macrophage: Novel mechanism of phytochemicals in the treatment of atherosclerotic cardiovascular disease

Wang, J., Liu, Y., Hu, J., & Chen, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1109576 · Cited by 23 · see citing works

Integrated multi-omics profiling highlights the benefits of resveratrol hydroxypropyl-β-cyclodextrin inclusion complex for A53T transgenic mice through the microbiota–gut–brain axis

Sun, X., Feng, S., Qin, B., Ye, J., Xie, L., Gui, J., & Sang, M. (2024) · Food & Function · doi:10.1039/d3fo03667g · Cited by 20 · see citing works

Potential Roles of Natural Antioxidants in Modulating Neurodegenerative Disease Pathways

Oyovwi, M. O., Agbonifo‐Chijiokwu, E., Ben‐Azu, B., Atere, A. D., Joseph, G. U., Godsday, O. U., & Udi, O. A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04874-w · Cited by 20 · see citing works

The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer’s Disease Treatment

Knight, E., Geetha, T., Broderick, T. L., & Babu, J. R. (2023) · Metabolites · doi:10.3390/metabo13030438 · Cited by 19 · see citing works

The potential benefits of polyphenols for corneal diseases

Feng, J., & Zhang, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115862 · Cited by 19 · see citing works

Resveratrol and Extra Virgin Olive Oil: Protective Agents Against Age-Related Disease

Morkovin, E. I., Litvinov, R., Koushner, A., & Babkov, D. A. (2024) · Nutrients · doi:10.3390/nu16244258 · Cited by 18 · see citing works

On the Chemical and Biological Characteristics of Multifunctional Compounds for the Treatment of Parkinson’s Disease

García‐Beltrán, O., Urrutia, P. J., & Núñez, M. T. (2023) · Antioxidants · doi:10.3390/antiox12020214 · Cited by 19 · see citing works

Research progress on pleiotropic neuroprotective drugs for traumatic brain injury

Zhao, Q., Li, H., Li, H., & Zhang, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1185533 · Cited by 18 · see citing works

Neuroprotective Effects of Microglial Membrane‐Derived Biomimetic Particles for Spinal Cord Injury

Wang, W., Li, S., Li, H., Guo, P., Lyu, C., Ye, P., Yang, W., Wang, J., Yu, D., Lu, G., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301592 · Cited by 18 · see citing works

Development of a brain-targeted nano drug delivery system to enhance the treatment of neurodegenerative effects of resveratrol

Yu, Y., Li, S., Kong, L., Du, Y., Liu, Y., Zang, J., Guo, R., Zhang, L., Zhao, Z., Ju, R.-J., et al. (2023) · Journal of Liposome Research · doi:10.1080/08982104.2023.2290050 · Cited by 18 · see citing works

Long-Term Resveratrol Intake for Cognitive and Cerebral Blood Flow Impairment in Carotid Artery Stenosis/Occlusion

Hattori, Y., Kakino, Y., Hattori, Y., Iwashita, M., UCHIYAMA, H., Noda, K., Yoshimoto, T., Iida, H., & Ihara, M. (2024) · Journal of Stroke · doi:10.5853/jos.2023.02733 · Cited by 18 · see citing works

A comprehensive study on epigenetic biomarkers in early detection and prognosis of Alzheimer's disease

Parikh, D., & Shah, M. (2024) · Biomedical Analysis · doi:10.1016/j.bioana.2024.05.005 · Cited by 18 · see citing works

New Mechanisms of Action of Natural Antioxidants in Health and Disease II

Hrelia, S., & Angeloni, C. (2021) · Antioxidants · doi:10.3390/antiox10081200 · Cited by 17 · see citing works

The Potential Effects of Red Wine and Its Components on Neurocognitive Disorders: A Narrative Review

Boccardi, V., Tagliafico, L., Persia, A., Page, E., Ottaviani, S., Cremonini, A., Borgarelli, C., Pisciotta, L., Mecocci, P., Nencioni, A., et al. (2024) · Nutrients · doi:10.3390/nu16203431 · Cited by 12 · see citing works

Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice

Rosell‐Cardona, C., Griñán‐Ferré, C., Pérez‐Bosque, A., Polo, J., Pallàs, M., Amat, C., Moretó, M., & Miró, L. (2021) · Nutrients · doi:10.3390/nu13072369 · Cited by 17 · see citing works

Therapeutic effects of resveratrol on epigenetic mechanisms in age‐related diseases: A comprehensive review

Zhang, S., & Kiarasi, F. (2024) · Phytotherapy Research · doi:10.1002/ptr.8176 · Cited by 34 · see citing works

Effects of Resveratrol and Other Polyphenols on the Most Common Brain Age-Related Diseases

Sarubbo, F., Moranta, D., Asensio, V. J., Miralles, A., & Esteban, S. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170724102743 · Cited by 71 · see citing works

Dietary antioxidants, epigenetics, and brain aging: A focus on resveratrol

Griñán‐Ferré, C., Izquierdo, V., & Pallàs, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817780-8.00022-0 · Cited by 3 · see citing works

Neuroprotective action of resveratrol

Bastianetto, S., Ménard, C., & Quirion, R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.09.011 · Cited by 411 · see citing works

Chronic resveratrol administration reduces oxidative stress and brain cell loss and improves memory of recognition in old rats

Juárez-Serrano, D., Arteaga, I. C., Cortes, H., Vázquez‐Roque, R. A., López‐López, G., Flores, G., Treviño, S., Guevara, J., & Díaz, A. (2023) · Synapse · doi:10.1002/syn.22271 · Cited by 22 · see citing works