Endothelial-cell proliferation in experimental tumours
Open accessAbstract
The proliferation characteristics of vascular endothelium have been studied in 131 individual experimental tumours, representing 18 transplanted tumour lines. The labelling index (LI) is high in most tumours, with a mean value of 0.9%, regardless of the growth rate of the tumours, or whether different tumour types are considered or individual tumours from within one line are studied in detail. A similar high LI value has been found by others for a human tumour. These high LI values may even underestimate the proliferation in new capillary buds. The high proliferative index of tumour endothelium is in marked contrast with the previously reported low 3HTdR uptake into normal tissue blood vessels. It seems likely that it is the type of new vessels formed that will influence tumour growth rates more than the simple rate of endothelial-cell proliferation. The large difference between the proliferation characteristics of tumour endothelium and normal tissue endothelium, recently identified as a possible approach for tumour therapy, has now been confirmed for a range of animal tumours and a human tumour.
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Hypoxic regions typically located in the tumor core arise due to the disparity between rapid proliferation of tumor cells and slower proliferation and disorganized arrangement of endothelial cells responsible for vascularization.
“One hallmark of this architecture is the development of hypoxic regions, typically located in the tumor core. These arise due to the disparity between the rapid proliferation of tumor cells and the slower proliferation and disorganized arrangement of endothelial cells responsible for vascularization [103,104].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [104]
The Introduction describes disorganized, inadequate tumour vasculature and reduced oxygenation in cells distant from blood vessels. But the Discussion (pp. 716–717) says endothelial proliferation can be faster or slower than tumour growth and is not closely correlated with it; the paper does not establish slower endothelial proliferation as the cause of hypoxic tumour cores. (LLM, conf=0.88)
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- Authors
- Denekamp, J., & Hobson, B.
- Affiliations
- Mount Vernon Hospital (GB)
- Venue
- British Journal of Cancer
- Published
- 1982-11
- Volume
- 46
- Issue
- 5
- Pages
- 711-720
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2011157
- OpenAlex
- W2059927830
- Cited by
- 237
- References
- 26
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 4
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- British Journal of Cancer (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- endothelial cell proliferation, tumor vasculature, labeling index, transplantable tumors, tumor growth rate, capillary formation, 3H-thymidine uptake, tumor angiogenesis, tumour therapy
- MeSH terms
- Animals, Cell Division, Cell Line, Endothelium, Humans, Mice, Inbred Strains, Neoplasms, Experimental, Rats, Inbred Strains, Thymidine, Mice, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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