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Macrophages in human breast disease: a quantitative immunohistochemical study
Open accessAbstract
We describe a quantitative histological study of 34 breast biopsies using a marker for human macrophages, the monoclonal antibody EBM/11. Seventeen of the biopsies were of malignant tumours. Both benign and malignant breast tissue contained large numbers of macrophages with significantly higher numbers occurring in the malignant group. An analysis was made of macrophage counts according to stage, grade and prognostic index of the malignant tumours. There was no correlation between macrophage numbers and any of these parameters in malignant breast tumours. We discuss the possible reasons why some earlier studies (using other markers such as lysozyme), have shown an apparently insignificant number of intratumoral macrophages.
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Cited by
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Metadata
- Authors
- Kelly, P., Davison, R., Bliss, E., & McGee, J.
- Venue
- British Journal of Cancer
- Published
- 1988-02
- Volume
- 57
- Issue
- 2
- Pages
- 174-177
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2011129758
- Cited by
- 167
- References
- 0
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kelly, P., Davison, R., Bliss, E., & McGee, J. (1988). Macrophages in human breast disease: a quantitative immunohistochemical study. British Journal of Cancer. https://doi.org/10.1038/bjc.1988.36
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