The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts
Open accessAbstract
The clinical use of anti-oestrogens in breast cancer therapy has traditionally been restricted to tumours that contain measurable oestrogen receptor protein. However, it is now widely recognised that the clinical response to adjuvant anti-oestrogen therapy appears to be independent of the oestrogen receptor content of the primary tumour. The study reported here was designed to investigate the possibility that human stromal cells can respond to anti-oestrogens by an increased synthesis of the inhibitory growth factor, transforming growth factor beta (TGF-beta). Two established human fetal fibroblast strains were used as models for the breast cancer stromal fibroblasts. These cells were found to respond to the addition of anti-oestrogens by a large increase in their synthesis of biologically active TGF-beta. Despite the application of ligand binding, immunoassay and Northern analysis, no oestrogen receptor or oestrogen receptor mRNA was detected in either of the human fetal fibroblasts strains. These observations may provide a mechanism of action of anti-oestrogens that is independent of the presence of oestrogen receptor in the tumour epithelial cells, and thus provide an explantation for the counter-intuitive results of adjuvant anti-oestrogen action.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,221
Molecular Cloning. A Laboratory Manual
Wood, E. (1983) · Biochemical Education · doi:10.1016/0307-4412(83)90068-7 · Cited by 29,533
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,887
Knabbe, C., Lippman, M. E., Wakefield, L. M., Flanders, K. C., Kasid, A., Derynck, R., & Dickson, R. B. (1987) · Cell · doi:10.1016/0092-8674(87)90193-0 · Cited by 975
Self-citationIdentification of a new class of steroid hormone receptors
Giguère, V., Yang, N., Segui, P., & Evans, R. M. (1988) · Nature · doi:10.1038/331091a0 · Cited by 867
Distribution and modulation of the cellular receptor for transforming growth factor-beta.
Wakefield, L. M., Smith, D. M., Masui, T., Harris, C. C., & Sporn, M. B. (1987) · The Journal of cell biology · doi:10.1083/jcb.105.2.965 · Cited by 535
Self-citationA MONOHYDROXYLATED METABOLITE OF TAMOXIFEN WITH POTENT ANTIOESTROGENIC ACTIVITY
JORDAN, V. C., COLLINS, M. M., ROWSBY, L., & PRESTWICH, G. (1977) · Journal of Endocrinology · doi:10.1677/joe.0.0750305 · Cited by 506
Danielpour, D., Dart, L. L., Flanders, K. C., Roberts, A. B., & Sporn, M. B. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041380112 · Cited by 444
Self-citationAdjuvant tamoxifen in the management of operable breast cancer : Scottish Trial
Scottish Cancer Trials Office (1987) · The Lancet · Cited by 428
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Munger, J. S., Harpel, J. G., Gleizes, P.-E., Mazzieri, R., Nunes, I., & Rifkin, D. B. (1997) · Kidney International · doi:10.1038/ki.1997.188 · Cited by 511
Krueger, E. A., Wilkins, E. G., Strawderman, M., Cederna, P., Goldfarb, S., Vicini, F. A., & Pierce, L. J. (2001) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(00)01402-4 · Cited by 386
Multicellular spheroids: a three‐dimensional in vitro culture system to study tumour biology
KUNZ‐SCHUGHART, L. A., KREUTZ, M., & KNUECHEL, R. (1998) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1998.00051.x · Cited by 324
Desmoids in familial adenomatous polyposis
Clark, S. K., & Phillips, R. K. S. (1996) · Journal of British Surgery · doi:10.1002/bjs.1800831105 · Cited by 302
Peyronie's Disease: Etiology, Medical, and Surgical Therapy
HELLSTROM, W. J. G., & BIVALACQUA, T. J. (2000) · Journal of Andrology · doi:10.1002/j.1939-4640.2000.tb03387.x · Cited by 170
Metadata
- Authors
- Colletta, A., Wakefield, L., Howell, F., van Roozendaal, K., Danielpour, D., Ebbs, Sr., Sporn, M., & Baum, M.
- Venue
- British Journal of Cancer
- Published
- 1990-09
- Volume
- 62
- Issue
- 3
- Pages
- 405-409
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2041508666
- Cited by
- 318
- References
- 25
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Colletta, A., Wakefield, L., Howell, F., van Roozendaal, K., Danielpour, D., Ebbs, Sr., Sporn, M., & Baum, M. (1990). Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts. British Journal of Cancer. https://doi.org/10.1038/bjc.1990.307
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
