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Cited by 428

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Cytotoxic studies of paclitaxel (Taxol®) in human tumour cell lines

Open access
Liebmann, JE, Cook, JA, Lipschultz, C, Teague, D, Fisher, J, Mitchell, JB·1993·British Journal of Cancer
DOI 10.1038/bjc.1993.488
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Abstract

The cytotoxicity of paclitaxel against eight human tumour cell lines has been studied with in vitro clonogenic assays. The fraction of surviving cells fell sharply after exposure for 24 h to paclitaxel concentrations ranging from 2 to 20 nM; the paclitaxel IC50 was found to range between 2.5 and 7.5 nM. Increasing the paclitaxel concentration above 50 nM, however, resulted in no additional cytotoxicity after a 24 h drug exposure. Cells incubated in very high concentrations of paclitaxel (10,000 nM) had an increase in survival compared with cells treated with lower concentrations of the drug. Prolonging the time of exposure of cells to paclitaxel from 24 to 72 h increased cytotoxicity from 5 to 200 fold in different cell lines. Exponentially growing cells were more sensitive to paclitaxel than were cells in the plateau phase of growth. Cremophor EL, the diluent in which the clinical preparation of paclitaxel is formulated, antagonised paclitaxel at concentrations of 0.135% (v/v). These data suggest that paclitaxel will be most effective clinically when there is prolonged exposure of tumour to the drug. Further, it appears that modest concentrations (i.e., 50 nM) should be as effective as higher concentrations of paclitaxel. Finally, we have noted that Cremophor EL is a biologically active diluent and, at high concentrations (0.135% v/v), can antagonise paclitaxel cytotoxicity.

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Metadata

Authors
Liebmann, J., Cook, J., Lipschultz, C., Teague, D., Fisher, J., & Mitchell, J.
Venue
British Journal of Cancer
Publisher
Springer Science and Business Media LLC
Published
1993-12
Volume
68
Issue
6
Pages
1104-1109
ISSN
  • 0007-0920 (ISSN-L)
  • 1532-1827
DOI
10.1038/bjc.1993.488
OpenAlex
W2075960393
Cited by
428
References
17
FWCI
5.05
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Cytotoxic studies of paclitaxel (Taxol®) in human tumour cell lines. https://app.cochat.ai/papers/10.1038/bjc.1993.488
The paper
Liebmann, J., Cook, J., Lipschultz, C., Teague, D., Fisher, J., & Mitchell, J. (1993). Cytotoxic studies of paclitaxel (Taxol®) in human tumour cell lines. British Journal of Cancer. https://doi.org/10.1038/bjc.1993.488

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.