The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer
Open accessAbstract
Between January 1991 and December 1992 a phase I trial of superficial photodynamic therapy (PDT) using topical application of 5-aminolaevulinic acid (ALA) was undertaken to treat Bowen's disease, superficial basal cell carcinomas (BCCs) and metastatic skin secondaries from breast (adenocarcinoma) or pinna (squamous cell carcinoma). Promising results were obtained with 36 areas of Bowen's disease, with a complete response rate of 89% at a median follow-up of 18 months. The treatment of BCCs was less successful, with 50% complete responses in 16 lesions at a median follow-up of 17 months. Metastatic nodules responded poorly. The treatment was well tolerated and discomfort during light irradiation could be reduced by prior application of 'Emla' cream. Lesions wept for 1-2 weeks following treatment and healed over a period of approximately 2 months. For large areas of Bowen's disease, particularly in anatomically difficult areas and in elderly patients, PDT using ALA may constitute a single simple alternative outpatient treatment to existing therapies. Further work is required to improve the results with BCCs.
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Cites
Photodynamic therapy with endogenous protoporphyrin
Kennedy, J. C., Pottier, R. H., & Pross, D. C. (1990) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(90)85083-9 · Cited by 1,509
Bedwell, J., MacRobert, A., Phillips, D., & Bown, S. (1992) · British Journal of Cancer · doi:10.1038/bjc.1992.175 · Cited by 253
Cited by
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145
Photodynamic therapy in dermatology
Kalka, K., Merk, H., & Mukhtar, H. (2000) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(00)90209-3 · Cited by 522
Dendrimers in Oncology: An Expanding Horizon
Tekade, R. K., Kumar, P. V., & Jain, N. K. (2009) · Chemical Reviews · doi:10.1021/cr068212n · Cited by 466
Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease
MORTON, C. A., WHITEHURST, C., MOSELEY, H., MCCOLL, J. H., MOORE, J. V., & MACKIE, R. M. (1996) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1996.d01-1076.x · Cited by 306
Photodynamic therapy: a promising new modality for the treatment of cancer
Schuitmaker, J. J., Baas, P., van Leengoed, H. L. L. M., van der Meulen, F. W., Star, W. M., & van Zandwijk, N. (1996) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(96)07342-3 · Cited by 284
Metadata
- Authors
- Cairnduff, F., Stringer, M., Hudson, E., Ash, D., & Brown, S.
- Venue
- British Journal of Cancer
- Published
- 1994-03
- Volume
- 69
- Issue
- 3
- Pages
- 605-608
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W1987479252
- Cited by
- 349
- References
- 2
- FWCI
- 22.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer. https://app.cochat.ai/papers/10.1038/bjc.1994.112
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- Cairnduff, F., Stringer, M., Hudson, E., Ash, D., & Brown, S. (1994). Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer. British Journal of Cancer. https://doi.org/10.1038/bjc.1994.112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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