The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Multicentricity of breast cancer: whole-organ analysis and clinical implications
Open accessAbstract
We studied the spatial relationship within the breast between multicentric foci (MCF) and the primary tumour in 30 modified radical mastectomy specimens using Egan's correlated pathological-radiological method using 5 mm slices of the whole breast. The relative positions within the breast of the primary tumour and MCF were used to calculate the relative distribution of primary tumour and MCF in the four quadrants of the breast and the per cent breast volume that would be required to be excised to include all MCF. Nineteen (63%) breast harboured MCF. The relative distribution of primary tumour and MCF in the four breast quadrants was significantly different (P = 0.034). MCF were present beyond the index quadrant (25% of breast volume including the tumour) in as many as 79% (15/19) of breasts that harboured MCF; and in half the cases (15/30) when all breast were considered. This is in variance with the suggestion put forward previously that MCF are contained within the index quadrant in 90% of cases. Although the number of patients in the present series is small, the probability of our finding being due to play of chance is 1 in 1500. In a large series of breast conservation studies > 90% of early breast recurrences have been found to occur in the index quadrant. Our finding, that in half the patients (15/30) MCF are present in quadrants other than the index quadrant, suggests that MCF do not give rise to early breast recurrence.
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Cited by
Vaidya, J. S., Wenz, F., Bulsara, M., Tobias, J. S., Joseph, D. J., Keshtgar, M., Flyger, H. L., Massarut, S., Alvarado, M., Saunders, C., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61950-9 · Cited by 831
Self-citationHoussami, N., Ciatto, S., Macaskill, P., Lord, S. J., Warren, R. M., Dixon, J. M., & Irwig, L. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.2108 · Cited by 831
Vaidya, J. S., Joseph, D. J., Tobias, J. S., Bulsara, M., Wenz, F., Saunders, C., Alvarado, M., Flyger, H. L., Massarut, S., Eiermann, W., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60837-9 · Cited by 772
Self-citationVaidya, J. S., Bulsara, M., Baum, M., Wenz, F., Massarut, S., Pigorsch, S., Alvarado, M., Douek, M., Saunders, C., Flyger, H. L., et al. (2020) · BMJ · doi:10.1136/bmj.m2836 · Cited by 293
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Metadata
- Authors
- Vaidya, J., Vyas, J., Chinoy, R., Merchant, N., Sharma, O., & Mittra, I.
- Venue
- British Journal of Cancer
- Published
- 1996-09
- Volume
- 74
- Issue
- 5
- Pages
- 820-824
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2128772705
- Cited by
- 294
- References
- 11
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vaidya, J., Vyas, J., Chinoy, R., Merchant, N., Sharma, O., & Mittra, I. (1996). Multicentricity of breast cancer: whole-organ analysis and clinical implications. British Journal of Cancer. https://doi.org/10.1038/bjc.1996.442
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
