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Aromatase cytochrome P450 gene expression in endometrial carcinoma
Open accessAbstract
We analysed aromatase gene expression and its regulation in seven cases of endometrioid endometrial carcinoma. Immunohistochemistry revealed the presence of strong aromatase immunoreactivity in the stromal cells of carcinoma in five out of seven cases. A polymerase chain reaction after reverse transcription (RT PCR) revealed varying levels of aromatase transcripts (0.1-27.0 amol ng(-1) total mRNA) in five cases. The alternative use of multiple exons 1 was also examined by identifying various human aromatase transcripts specific for exons 1 in RT-PCR products. Gonadal type or exon 1d was primarily used in three cases in which aromatase overexpression was not detected. The two cases in which fibroblasts type or exon 1b was used with other exons 1 as minor transcripts demonstrated aromatase overexpression in immunohistochemistry and RT PCR analysis. Further studies are required, but alternative splicing as well as use of multiple exons 1 transcripts may result in increased aromatase expression in stromal cells observed in endometrial carcinoma.
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Increased immunoexpression of aromatase, STS and 17βHSD enzymes has been reported in endometrial hyperplasia and endometrial cancer.
“Sasano and collaborators have developed novel antibodies and reported evidence of increased immunoexpression of aromatase [81], STS [82] and 17βHSD enzymes [83] in endometrial hyperplasia and EC.”
From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [81]
The Results (Immunohistochemistry, p. 1543) report relatively strong aromatase immunoreactivity in five endometrial carcinoma cases. The paper does not report an immunohistochemical result for endometrial hyperplasia; its Methods say the antibody and staining procedures were described previously. STS and 17βHSD have separate citations in the citing sentence and are not attributed to this paper. (LLM, conf=0.87)
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Metadata
- Authors
- Sasano, H., Kaga, K., Sato, S., Yajima, A., Nagura, H., & Harada, N.
- Affiliations
- Tohoku University (JP)
- Fujita Health University (JP)
- Corresponding author
- Sato, S
- Nagura, H
- Venue
- British Journal of Cancer
- Published
- 1996-11
- Volume
- 74
- Issue
- 10
- Pages
- 1541-1544
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2074845
- OpenAlex
- W2058479118
- Cited by
- 32
- References
- 15
- Citations by year
- 2021: 1 · 2018: 2 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- British Journal of Cancer (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- aromatase, endometrial cancer, endometrioid carcinoma, gene expression, alternative splicing, stromal cells, immunohistochemistry, RT-PCR
- MeSH terms
- Adult, Aged, Aromatase, Estrogens, Exons, Female, Humans, Immunohistochemistry, Middle Aged, RNA, Messenger, Sensitivity and Specificity, Transcription, Genetic, Gene Expression, Polymerase Chain Reaction, Endometrial Neoplasms, Alternative Splicing, Carcinoma, Endometrioid
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