The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy
Open accessAbstract
Electrochemotherapy (ECT) enhances the effectiveness of chemotherapeutic agents by administering the drug in combination with short intense electric pulses. ECT is effective because electric pulses permeabilize tumour cell membranes and allow non-permeant drugs, such as bleomycin, to enter the cells. The aim of this study was to demonstrate the anti-tumour effectiveness of ECT with bleomycin on cutaneous and subcutaneous tumours. This article summarizes results obtained in independent clinical trials performed by five cancer centres. A total of 291 cutaneous or subcutaneous tumours of basal cell carcinoma (32), malignant melanoma (142), adenocarcinoma (30) and head and neck squamous cell carcinoma (87) were treated in 50 patients. Short and intense electric pulses were applied to tumours percutaneously after intravenous or intratumour administration of bleomycin. The tumours were measured and the response to the treatment evaluated 30 days after the treatment. Objective responses were obtained in 233 (85.3%) of the 273 evaluable tumours that were treated with ECT. Clinical complete responses were achieved in 154 (56.4%) tumours, and partial responses were observed in 79 (28.9%) tumours. The application of electric pulses to the patients was safe and well tolerated. An instantaneous contraction of the underlying muscles was noticed. Minimal adverse side-effects were observed. ECT was shown to be an effective local treatment. ECT was effective regardless of the histological type of the tumour. Therefore, ECT offers an approach to the treatment of cutaneous and subcutaneous tumours in patients with minimal adverse side-effects and with a high response rate.
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Cites
Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses
Mir, L. M., Orlowski, S., Belehradek, J., & Paoletti, C. (1991) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(91)90064-k · Cited by 643
Self-citationElectrochemotherapy, a new antitumor treatment. First clinical phase I-II trial
Belehradek, M., Domenge, C., Luboinski, B., Orlowski, S., Belehradek, J., & Mir, L. M. (1993) · Cancer · doi:10.1002/1097-0142(19931215)72:12<3694::aid-cncr2820721222>3.0.co;2-2 · Cited by 461
Self-citationTransient electropermeabilization of cells in culture
Orlowski, S., Belehradek, J., Paoletti, C., & Mir, L. M. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90344-9 · Cited by 444
Self-citationElectropermeabilization of mammalian cells. Quantitative analysis of the phenomenon
Rols, M. P., & Teissié, J. (1990) · Biophysical Journal · doi:10.1016/s0006-3495(90)82451-6 · Cited by 394
Self-citationPhase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy
Heller, R., Jaroszeski, M. J., Glass, L. F., Messina, J. L., Rapaport, D. P., DeConti, R. C., Fenske, N. A., Gilbert, R. A., Mir, L. M., & Reintgen, D. S. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960301)77:5<964::aid-cncr24>3.0.co;2-0 · Cited by 288
Self-citationMir, L. M., Banoun, H., & Paoletti, C. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90251-0 · Cited by 282
Self-citationTounekti, O., Pron, G., Belehradek, J., & Mir, L. M. (1993) · PubMed · Cited by 280
Self-citationAntitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice.
Serša, G., Čemažar, M., & Miklavčič, D. (1995) · PubMed · Cited by 270
Self-citationCell electropermeabilization: a new tool for biochemical and pharmacological studies
Orlowski, S., & Mir, L. M. (1993) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(93)90016-h · Cited by 257
Self-citationVery high cytotoxicity of bleomycin introduced into the cytosol of cells in culture
Poddevin, B., Orlowski, S., Belehradek, J., & Mir, L. M. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90394-k · Cited by 228
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Cited by
High-efficiency gene transfer into skeletal muscle mediated by electric pulses
Mir, L. M., Bureau, M. F., Gehl, J., Rangara, R., Rouy, D., Caillaud, J.-M., Delaere, P., Branellec, D., Schwartz, B., & Scherman, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4262 · Cited by 914
Self-citationElectroporation-Based Technologies for Medicine: Principles, Applications, and Challenges
Yarmush, M. L., Golberg, A., Serša, G., Kotnik, T., & Miklavčič, D. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-104622 · Cited by 889
Self-citationDavis, B. S., Chang, G.-J. J., Cropp, B., Roehrig, J. T., Martin, D. A., Mitchell, C. J., Bowen, R., & Bunning, M. L. (2001) · Journal of Virology · doi:10.1128/jvi.75.9.4040-4047.2001 · Cited by 447
Antitumor effectiveness of electrochemotherapy: A systematic review and meta-analysis
Mali, B., Jarm, T., Snoj, M., Sersa, G., & Miklavcic, D. (2013) · European Journal of Surgical Oncology (EJSO) · doi:10.1016/j.ejso.2012.08.016 · Cited by 353
Therapeutic perspectives of in vivo cell electropermeabilization
Mir, L. M. (2001) · Bioelectrochemistry · doi:10.1016/s0302-4598(00)00112-4 · Cited by 344
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Metadata
- Authors
- Mir, L., Glass, L., Serša, G., Teissié, J., Domenge, C., Miklavčič, D., Jaroszeski, M., Orlowski, S., Reintgen, D., Rudolf, Z., Belehradek, M., Gilbert, R., Rols, M., Belehradek, J., Bachaud, J., DeConti, R., Štabuc, B., Čemažar, M., Coninx, P., & Heller, R.
- Venue
- British Journal of Cancer
- Published
- 1998-06
- Volume
- 77
- Issue
- 12
- Pages
- 2336-2342
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2111409695
- Cited by
- 444
- References
- 22
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mir, L., Glass, L., Serša, G., Teissié, J., Domenge, C., Miklavčič, D., Jaroszeski, M., Orlowski, S., Reintgen, D., Rudolf, Z., Belehradek, M., Gilbert, R., Rols, M., Belehradek, J., Bachaud, J., DeConti, R., Štabuc, B., Čemažar, M., Coninx, P., & Heller, R. (1998). Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. British Journal of Cancer. https://doi.org/10.1038/bjc.1998.388
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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