Comparing the performance of six human papillomavirus tests in a screening population
Open accessAbstract
BACKGROUND: Several new assays have been developed for high-risk HPV testing of cervical samples; we compare six HPV tests in a screening population. METHODS: Residual material from liquid-based PreservCyt samples was assayed. Four tests (Hybrid Capture 2, Cobas, Abbott and Becton-Dickinson (BD)) measured HPV DNA while two used RNA (APTIMA and NorChip). RESULTS: Positivity rates ranged from 13.4 to 16.3% for the DNA-based tests with a significantly lower positivity rate for the Abbott assay. The Gen-Probe APTIMA assay was positive in 10.3% of women, which was significantly lower than all the DNA tests; the NorChip PreTect HPV-Proofer test was much lower at 5.2%. 40 CIN2+ cases were identified, of which 19 were CIN3+. All CIN3+ cases were HPV positive by all tests except for one, which was negative by the Abbott assay and five which were negative by the NorChip test. CONCLUSION: All HPV tests except NorChip showed high sensitivity for high-grade lesions positive by cytology, suggesting co-testing is unnecessary when using HPV tests. Positivity rates in cytology-negative specimens were similar for the DNA-based tests, but lower for the APTIMA test suggesting this maintains the high sensitivity of DNA tests, but with better specificity.
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The Roche Cobas 4800 assay is known for having relatively high sensitivity compared with other HPV assays.
“as shown by multiple previous studies, the Roche Cobas 4800 assay is known for having a relatively high sensitivity compared with other HPV assays (12, 13, 17).”
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- Authors
- Cuzick, J., Cadman, L., Mesher, D., Austin, J., Ashdown-Barr, L., Ho, L., Terry, G., Liddle, S., Wright, C., Lyons, D., & Szarewski, A.
- Affiliations
- Queen Mary University of London (GB)
- St Mary's Hospital (GB)
- Corresponding author
- Szarewski, A
- Venue
- British Journal of Cancer
- Published
- 2013-01-31
- Volume
- 108
- Issue
- 4
- Pages
- 908-913
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC3590662
- OpenAlex
- W2076776080
- Cited by
- 211
- References
- 23
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 11 · 2023: 15 · 2022: 19 · 2021: 15 · 2020: 17 · 2019: 12 · 2018: 16 · 2017: 12 · 2016: 19 · 2015: 33 · 2014: 18 · 2013: 11
- FWCI
- 19.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by-nc-sa)
- Funders
- Cancer Research UK (C8162/A10406, C569/A10404)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- HPV testing, cervical cancer screening, HPV DNA test, Norchip, Hybrid Capture 2, cobas HPV test, PreservCyt, cervical intraepithelial neoplasia, sensitivity and specificity, co-testing, liquid-based cytology
- MeSH terms
- Uterine Cervical Neoplasms, Cervix Uteri, Cytodiagnosis, DNA, Viral, Female, Humans, Sensitivity and Specificity, Biomarkers, Papillomaviridae, Early Detection of Cancer
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