The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The impact of comprehensive geriatric assessment interventions on tolerance to chemotherapy in older people
Open accessAbstract
BACKGROUND: Although comorbidities are identified in routine oncology practice, intervention plans for the coexisting needs of older people receiving chemotherapy are rarely made. This study evaluates the impact of geriatrician-delivered comprehensive geriatric assessment (CGA) interventions on chemotherapy toxicity and tolerance for older people with cancer. METHODS: Comparative study of two cohorts of older patients (aged 70+ years) undergoing chemotherapy in a London Hospital. The observational control group (N=70, October 2010-July 2012) received standard oncology care. The intervention group (N=65, September 2011-February 2013) underwent risk stratification using a patient-completed screening questionnaire and high-risk patients received CGA. Impact of CGA interventions on chemotherapy tolerance outcomes and grade 3+ toxicity rate were evaluated. Outcomes were adjusted for age, comorbidity, metastatic disease and initial dose reductions. RESULTS: Intervention participants undergoing CGA received mean of 6.2±2.6 (range 0-15) CGA intervention plans each. They were more likely to complete cancer treatment as planned (odds ratio (OR) 4.14 (95% CI: 1.50-11.42), P=0.006) and fewer required treatment modifications (OR 0.34 (95% CI: 0.16-0.73), P=0.006). Overall grade 3+ toxicity rate was 43.8% in the intervention group and 52.9% in the control (P=0.292). CONCLUSIONS: Geriatrician-led CGA interventions were associated with improved chemotherapy tolerance. Standard oncology care should shift towards modifying coexisting conditions to optimise chemotherapy outcomes for older people.
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The Multidisciplinary Team (MDT) Approach and Quality of Care
Taberna, M., Gil Moncayo, F., Jané-Salas, E., Antonio, M., Arribas, L., Vilajosana, E., Peralvez Torres, E., & Mesía, R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00085 · Cited by 513
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Cancer mortality in the oldest old: a global overview
Hashim, D., Carioli, G., Malvezzi, M., Bertuccio, P., Waxman, S., Negri, E., La Vecchia, C., & Boffetta, P. (2020) · Aging · doi:10.18632/aging.103503 · Cited by 36
Metadata
- Authors
- Kalsi, T., Babic-Illman, G., Ross, P. J., Maisey, N. R., Hughes, S., Fields, P., Martin, F. C., Wang, Y., & Harari, D.
- Venue
- British Journal of Cancer
- Published
- 2015-04
- Volume
- 112
- Issue
- 9
- Pages
- 1435-1444
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2047503765
- Cited by
- 265
- References
- 6
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kalsi, T., Babic-Illman, G., Ross, P. J., Maisey, N. R., Hughes, S., Fields, P., Martin, F. C., Wang, Y., & Harari, D. (2015). The impact of comprehensive geriatric assessment interventions on tolerance to chemotherapy in older people. British Journal of Cancer. https://doi.org/10.1038/bjc.2015.120
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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