Effect of walking on circadian rhythms and sleep quality of patients with lung cancer: a randomised controlled trial
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BACKGROUND: Sleep disturbances and poor rest-activity rhythms, which can reduce the quality of life, are highly prevalent among patients with lung cancer. METHODS: This trial investigated the effects of a 12-week exercise intervention including home-based walking exercise training and weekly exercise counseling on 111 lung cancer patients. Participants were randomly allocated to receive the intervention or usual-care. Outcomes included objective sleep (total sleep time, TST; sleep efficiency, SE; sleep onset latency, SOL; and wake after sleep onset, WASO), subjective sleep (Pittsburgh Sleep Quality Index, PSQI), and rest-activity rhythms (r24 and I<O). Outcomes were assessed at baseline and 3 and 6 months after intervention. RESULTS: =7.59, P=0.023) of the patients in the exercise group significantly improved 3 and 6 months after intervention. The moderating effect of I<O on TST was significant (β of group × I
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Two recent systematic reviews provided mixed evidence for overall sleep quality in cancer survivors, indicating either a positive effect of walking or no effect of exercise.
“Two recent systematic reviews in cancer survivors(49, 50) provided mixed evidence for overall sleep quality, indicating either a positive effect of walking(49), or no effect of exercise(50).”
From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [50]
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- Authors
- Chen, H.-M., Tsai, C.-M., Wu, Y.-C., Lin, K.-C., & Lin, C.-C.
- Affiliations
- National Taipei University of Nursing and Health Science (TW)
- Taipei Veterans General Hospital (TW)
- National Yang Ming University (TW)
- Taipei Medical University (TW)
- Corresponding author
- Lin, Kuan-Chia
- Lin, Chia-Chin
- Venue
- British Journal of Cancer
- Published
- 2016-11
- Volume
- 115
- Issue
- 11
- Pages
- 1304-1312
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC5129819
- OpenAlex
- W2548369948
- Cited by
- 89
- References
- 38
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 10 · 2023: 14 · 2022: 12 · 2021: 7 · 2020: 7 · 2019: 9 · 2018: 10 · 2017: 3
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
- Funders
- National Science Council
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- lung cancer, walking exercise, home-based exercise training, sleep quality, circadian rhythm, rest-activity rhythm, sleep disorders, total sleep time, sleep efficiency, sleep latency, wake after sleep onset, physical activity counseling, quality of life
- MeSH terms
- Adult, Aged, Aged, 80 and over, Circadian Rhythm, Female, Humans, Lung Neoplasms, Male, Middle Aged, Quality of Life, Sleep, Walking
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