The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
RETRACTED ARTICLE: Circular RNA 0000096 affects cell growth and migration in gastric cancer
Open accessAbstract
BACKGROUND: Circular RNAs (circRNAs) are a class of non-coding RNAs broadly expressed in cells of various species. Their role in cancers, especially in gastric cancer, is poorly understood. METHODS: Circular RNA 0000096 (hsa_circ_0000096) levels in 101 paired gastric cancer tissues and adjacent non-tumorous tissues from patients with gastric cancer were detected by real-time quantitative reverse transcription-polymerase chain reaction. A receiver operating characteristic curve was generated to evaluate the diagnostic value of hsa_circ_0000096. RNA interference was used to manipulate the expression of hsa_circ_0000096. Its biological effects were evaluated by flow cytometry, real-time cell analysis, a wound scratch assay, western blot analysis and xenograft models. RESULTS: Hsa_circ_0000096 was found to be significantly downregulated in gastric cancer tissues and gastric cancer cell lines compared with paired adjacent non-tumorous tissues and normal gastric epithelial cells (P<0.001). Moreover, knockdown of hsa_circ_0000096 significantly inhibited cell proliferation and migration in vitro and in vivo. The results of both immunohistochemical and western blot analyses showed that the protein levels of cyclin D1, cyclin-dependent kinase 6 (CDK6), matrix metalloproteinase-2 and MMP-9 were significantly reduced in vitro and in vivo. A gastric cancer xenograft nude mouse model indicated that Ki67 and VEGF were reduced in a dose-dependent manner following knockdown of hsa_circ_0000096. However, the expression of E-cadherin increased. CONCLUSIONS: Hsa_circ_0000096 may be used as a potential novel biomarker for gastric cancer. It affects gastric cancer cell growth and migration by regulating cyclin D1, CDK6, MMP-2 and MMP-9.
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Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. (2011) · Cell · doi:10.1016/j.cell.2011.07.014 · Cited by 7,262
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388
Cited by
Circular RNA and its mechanisms in disease: From the bench to the clinic
Han, B., Chao, J., & Yao, H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.010 · Cited by 788
Recent advances in gastric cancer early diagnosis
Necula, L., Matei, L., Dragu, D., Neagu, A. I., Mambet, C., Nedeianu, S., Bleotu, C., Diaconu, C. C., & Chivu-Economescu, M. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i17.2029 · Cited by 435
The pro-metastasis effect of circANKS1B in breast cancer
Zeng, K., He, B., Yang, B. B., Xu, T., Chen, X., Xu, M., Liu, X., Sun, H., Pan, Y., & Wang, S. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0914-x · Cited by 319
Circular RNA: An emerging non-coding RNA as a regulator and biomarker in cancer
Chen, B., & Huang, S. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.011 · Cited by 308
Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers
Bolha, L., Ravnik-Glavač, M., & Glavač, D. (2017) · International Journal of Genomics · doi:10.1155/2017/6218353 · Cited by 166
Metadata
- Authors
- Li, P., Chen, H., Chen, S., Mo, X., Li, T., Xiao, B., Yu, R., & Guo, J.
- Venue
- British Journal of Cancer
- Published
- 2017-01-12
- Volume
- 116
- Issue
- 5
- Pages
- 626-633
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2572935411
- Cited by
- 227
- References
- 4
- FWCI
- 14.66
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- hybrid
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- Li, P., Chen, H., Chen, S., Mo, X., Li, T., Xiao, B., Yu, R., & Guo, J. (2017). RETRACTED ARTICLE: Circular RNA 0000096 affects cell growth and migration in gastric cancer. British Journal of Cancer. https://doi.org/10.1038/bjc.2016.451
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