Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers
Open accessAbstract
Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) that form covalently closed continuous loop structures, lacking the terminal 5 ′ and 3 ′ ends. CircRNAs are generated in the process of back-splicing and can originate from different genomic regions. Their unique circular structure makes circRNAs more stable than linear RNAs. In addition, they also display insensitivity to ribonuclease activity. Generally, circRNAs function as microRNA (miRNA) sponges and have a regulatory role in transcription and translation. They may be also translated in a cap-independent manner in vivo, to generate specific proteins. In the last decade, next-generation sequencing techniques, especially RNA-seq, have revealed great abundance and also dysregulation of many circRNAs in various diseases, suggesting their involvement in disease development and progression. Regarding their high stability and relatively specific differential expression patterns in tissues and extracellular environment (e.g., body fluids), they are regarded as promising novel biomarkers in cancer. Therefore, we focus this review on describing circRNA biogenesis, function, and involvement in human cancer development and address the potential of circRNAs to be effectively used as novel cancer diagnostic and prognostic biomarkers.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CircRNAs are synthesized by the back-splicing of protein-coding precursor mRNAs, primarily in eukaryotes.
“Originating from various genomic regions, circRNAs are synthesized by the back-splicing of protein-coding precursor mRNAs (primarily in eukaryotes) [25,26].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
6 retracted
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family
Chen, L., Zhang, S., Wu, J., Cui, J., Zhong, L., Zeng, L., & Ge, S. (2017) · Oncogene · doi:10.1038/onc.2017.89 · Cited by 391 · see citing works
RetractedYu, L., Gong, X., Sun, L., Zhou, Q., Lu, B., & Zhū, L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158347 · Cited by 356 · see citing works
RetractedRETRACTED ARTICLE: Circular RNA 0000096 affects cell growth and migration in gastric cancer
Li, P., Chen, H., Chen, S., Mo, X., Li, T., Xiao, B., Yu, R., & Guo, J. (2017) · British Journal of Cancer · doi:10.1038/bjc.2016.451 · Cited by 227 · see citing works
RetractedTumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R
Li, J., Li, D., & Zhang, W. (2015) · Oncology Reports · doi:10.3892/or.2015.4498 · Cited by 43 · see citing works
RetractedThe MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5
Wang, H., Dong, X., Gu, X., Qin, R., Jia, H., & Gao, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125474 · Cited by 40 · see citing works
RetractedCircular RNA hsa_circ_0001564 facilitates tumorigenesis of osteosarcoma via sponging miR-29c-3p
Li, J., & Song, Y.-Z. (2017) · Tumor Biology · doi:10.1177/1010428317709989 · Cited by 10 · see citing works
RetractedBartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990 · see citing works
Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985 · see citing works
The Pfam protein families database: towards a more sustainable future
Finn, R. D., Coggill, P., Eberhardt, R. Y., Eddy, S. R., Mistry, J., Mitchell, A. L., Potter, S. C., Punta, M., Qureshi, M., Sangrador-Vegas, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1344 · Cited by 5,975 · see citing works
Long non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654 · see citing works
Li, J.-H., Liu, S., Zhou, H., Qu, L., & Yang, J.-H. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1248 · Cited by 5,587 · see citing works
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388 · see citing works
Genome Regulation by Long Noncoding RNAs
Rinn, J. L., & Chang, H. Y. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051410-092902 · Cited by 4,011 · see citing works
circRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083 · see citing works
Exon-intron circular RNAs regulate transcription in the nucleus
Li, Z., Huang, C., Bao, C., Chen, L., Lin, M., Wang, X., Zhong, G., Yu, B., Hu, W., Dai, L., et al. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2959 · Cited by 2,905 · see citing works
Detecting and characterizing circular RNAs
Jeck, W. R., & Sharpless, N. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2890 · Cited by 2,685 · see citing works
Salzman, J., Gawad, C., Wang, P. L., Lacayo, N. J., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,457 · see citing works
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed
Rybak-Wolf, A., Stottmeister, C., Glažar, P., Jens, M., Pino, N., Giusti, S., Hanan, M., Behm, M., Bartok, O., Ashwal-Fluss, R., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.027 · Cited by 2,423 · cited 2× · see citing works
“High ADAR expression destabilizes intron base pairing interactions, impairing pre-mRNA looping and decreasing the likelihood of pre-mRNA circularization and circRNA formation, for a subset of circRNAs [25, 29].”
BackgroundCircular intronic long noncoding RNAs
Zhang, Y., Zhang, X.-O., Chen, T., Xiang, J.-F., Yin, Q.-F., Xing, Y.-H., Zhu, S., Yang, L., & Chen, L.-L. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.017 · Cited by 2,221 · see citing works
Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis
Li, Y., Zheng, Q., Bao, C., Li, S., Guo, W., Zhao, J., Chen, D., Gu, J., He, X., & Huang, S. (2015) · Cell Research · doi:10.1038/cr.2015.82 · Cited by 2,210 · see citing works
The RNA Binding Protein Quaking Regulates Formation of circRNAs
Conn, S. J., Pillman, K. A., Toubia, J., Conn, V. M., Salmanidis, M., Phillips, C. A., Roslan, S., SCHREIBER, A. W., Gregory, P. A., & Goodall, G. J. (2015) · Cell · doi:10.1016/j.cell.2015.02.014 · Cited by 2,187 · see citing works
Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis
Legnini, I., Di Timoteo, G., Rossi, F., Morlando, M., Briganti, F., Sthandier, O., Fatica, A., Santini, T., Andronache, A., Wade, M., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.02.017 · Cited by 2,173 · see citing works
Zheng, Q., Bao, C., Guo, W., Li, S., Chen, J., Chen, B., Luo, Y., Lyu, D., Li, Y., Shi, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms11215 · Cited by 2,045 · see citing works
CPAT: Coding-Potential Assessment Tool using an alignment-free logistic regression model
Wang, L., Park, H. J., Dasari, S., Wang, S., Kocher, J., & Li, W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt006 · Cited by 2,003 · see citing works
Complementary Sequence-Mediated Exon Circularization
Zhang, X.-O., Wang, H.-B., Zhang, Y., Lu, X., Chen, L.-L., & Yang, L. (2014) · Cell · doi:10.1016/j.cell.2014.09.001 · Cited by 1,999 · cited 4× · see citing works
“, Alu elements) that may promote intron pairing, and exon circularization [12, 24, 25].”
BackgroundMethodInfluentialCell-Type Specific Features of Circular RNA Expression
Salzman, J., Chen, R. E., Olsen, M. N., Wang, P. L., & Brown, P. O. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003777 · Cited by 1,955 · see citing works
circBase: a database for circular RNAs
Glažar, P., Papavasileiou, P., & Rajewsky, N. (2014) · RNA · doi:10.1261/rna.043687.113 · Cited by 1,934 · see citing works
Extensive translation of circular RNAs driven by N6-methyladenosine
Yang, Y., Fan, X., Mao, M., Song, X., Wu, P., Zhang, Y., Jin, Y., Yang, Y., Chen, L.-L., Wang, Y., et al. (2017) · Cell Research · doi:10.1038/cr.2017.31 · Cited by 1,855 · see citing works
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
Ebert, M. S., Neilson, J. R., & Sharp, P. A. (2007) · Nature Methods · doi:10.1038/nmeth1079 · Cited by 1,845 · see citing works
Pamudurti, N. R., Bartok, O., Jens, M., Ashwal-Fluss, R., Stottmeister, C., Ruhe, L., Hanan, M., Wyler, E., Perez-Hernandez, D., Ramberger, E., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.02.021 · Cited by 1,810 · see citing works
Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2
Du, W. W., Yang, W., Liu, E., Yang, Z., Dhaliwal, P., & Yang, B. B. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw027 · Cited by 1,699 · see citing works
Expanded identification and characterization of mammalian circular RNAs
Guo, J. U., Agarwal, V., Guo, H., & Bartel, D. P. (2014) · Genome biology · doi:10.1186/s13059-014-0409-z · Cited by 1,578 · see citing works
CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs
Dudekula, D. B., Panda, A. C., Grammatikakis, I., De, S., Abdelmohsen, K., & Gorospe, M. (2015) · RNA Biology · doi:10.1080/15476286.2015.1128065 · Cited by 1,241 · see citing works
MapSplice: Accurate mapping of RNA-seq reads for splice junction discovery
Wang, K., Singh, D., Zeng, Z., Coleman, S. J., Huang, Y., Savich, G. L., He, X., Mieczkowski, P., Grimm, S. A., Perou, C. M., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq622 · Cited by 1,193 · see citing works
Circular RNAs: diversity of form and function
Lasda, E. L., & Parker, R. (2014) · RNA · doi:10.1261/rna.047126.114 · Cited by 1,193 · see citing works
The Landscape of long noncoding RNA classification
Laurent, G. S., Wahlestedt, C., & Kapranov, P. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.03.007 · Cited by 1,192 · see citing works
Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity
You, X., Vlatkovic, I., Babic, A., Will, T., Epstein, I., Tushev, G., Akbalik, G., Wang, M., Glock, C., Quedenau, C., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3975 · Cited by 1,149 · see citing works
CIRI: an efficient and unbiased algorithm for de novo circular RNA identification
Gao, Y., Wang, J., & Zhao, F. (2015) · Genome biology · doi:10.1186/s13059-014-0571-3 · Cited by 1,118 · see citing works
Circular transcripts of the testis-determining gene Sry in adult mouse testis
Capel, B., Swain, A., Nicolis, S. K., Hacker, A., Walter, M. A., Koopman, P. A., Goodfellow, P. N., & Lovell-Badge, R. H. (1993) · Cell · doi:10.1016/0092-8674(93)90279-y · Cited by 1,100 · see citing works
Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals
Ivanov, A., Memczak, S., Wyler, E., Torti, F., Porath, H. T., Orejuela, M. R., Piechotta, M., Levanon, E. Y., Landthaler, M., Dieterich, C., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.12.019 · Cited by 1,092 · see citing works
Non‐coding RNAs: regulators of disease
Taft, R. J., Pang, K. C., Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · The Journal of Pathology · doi:10.1002/path.2638 · Cited by 1,056 · see citing works
Hsu, S., Tseng, Y., Shrestha, S., Lin, Y., Khaleel, A., Chou, C., Chu, C.-F., Huang, H., Lin, C.-M., Ho, S.-Y., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1266 · Cited by 1,036 · see citing works
Diverse alternative back-splicing and alternative splicing landscape of circular RNAsPreprint
Zhang, X.-O., Dong, R., Zhang, Y., Zhang, J., Luo, Z. D., Zhang, J., Chen, L., & Yang, L. C. (2016) · Genome Research · doi:10.1101/gr.202895.115 · Cited by 1,022 · see citing works
PhyloCSF: a comparative genomics method to distinguish protein coding and non-coding regionsPreprint
Lin, M. F., Jungreis, I., & Kellis, M. (2010) · Nature Precedings · doi:10.1093/bioinformatics/btr209 · Cited by 1,008 · see citing works
Westholm, J. O., Miura, P., Olson, S., Shenker, S., Joseph, B. J., Sanfilippo, P., Celniker, S., Graveley, B. R., & Lai, E. C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.062 · Cited by 1,001 · see citing works
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
Hansen, T. B., Wiklund, E. D., Bramsen, J. B., Villadsen, S. B., Statham, A. L., Clark, S. J., & Kjems, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.359 · Cited by 996 · see citing works
Short intronic repeat sequences facilitate circular RNA productionPreprint
Liang, D., & Wilusz, J. E. (2014) · Genes & Development · doi:10.1101/gad.251926.114 · Cited by 959 · see citing works
Circular RNA and miR-7 in Cancer
Hansen, T. B., Kjems, J. K., & Damgaard, C. K. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1568 · Cited by 921 · see citing works
Burd, C. E., Jeck, W. R., Liu, Y., Sanoff, H. K., Wang, Z., & Sharpless, N. E. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001233 · Cited by 895 · see citing works
Wang, K., Long, B., Liu, F., Wang, J., Liu, C.-Y., Zhao, B., Zhou, L., Sun, T., Wang, M., Yu, T., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv713 · Cited by 868 · see citing works
Circular RNAs: analysis, expression and potential functions
Barrett, S. P., & Salzman, J. (2016) · Development · doi:10.1242/dev.128074 · Cited by 859 · see citing works
TopHat-Fusion: an algorithm for discovery of novel fusion transcripts
Kim, D., & Salzberg, S. L. (2011) · Genome biology · doi:10.1186/gb-2011-12-8-r72 · Cited by 806 · see citing works
Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity
Du, W. W., Fang, L., Yang, W., Wu, N., Awan, F. M., Yang, Z., & Yang, B. B. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.133 · Cited by 777 · see citing works
Using circular RNA as a novel type of biomarker in the screening of gastric cancer
Li, P., Chen, S., Chen, H., Mo, X., Li, T., Shao, Y., Xiao, B., & Guo, J. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.02.018 · Cited by 773 · see citing works
Exon Circularization Requires Canonical Splice Signals
Starke, S., Jost, I., Roßbach, O., Schneider, T. P., Schreiner, S., Hung, L.-H., & Bindereif, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.12.002 · Cited by 768 · see citing works
Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAs
Chen, C.-Y., & Sarnow, P. (1995) · Science · doi:10.1126/science.7536344 · Cited by 766 · see citing works
Circular RNA Is Expressed across the Eukaryotic Tree of Life
Wang, P. L., Bao, Y., Yee, M., Barrett, S. P., Hogan, G. J., Olsen, M. N., Dinneny, J. R., Brown, P. O., & Salzman, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090859 · Cited by 754 · see citing works
Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations
Guarnerio, J., Bezzi, M., Jeong, J. C., Paffenholz, S. V., Berry, K., Naldini, M. M., Lo‐Coco, F., Tay, Y., Beck, A. H., & Pandolfi, P. P. (2016) · Cell · doi:10.1016/j.cell.2016.03.020 · Cited by 739 · see citing works
Bachmayr-Heyda, A., Reiner, A. T., Auer, K., Sukhbaatar, N., Aust, S., Bachleitner‐Hofmann, T., Mesteri, I., Grunt, T. W., Zeillinger, R., & Pils, D. (2015) · Scientific Reports · doi:10.1038/srep08057 · Cited by 732 · see citing works
Suzuki, H. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl151 · Cited by 687 · see citing works
Chen, J., Li, Y., Zheng, Q., Bao, C., He, J. G., Chen, B., Lyu, D., Zheng, B., Xu, Y., Long, Z., et al. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.12.006 · Cited by 686 · see citing works
Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway
Li, F., Zhang, L.-Y., Li, W., Deng, J., Zheng, J., An, M., Lu, J.-C., & Zhou, Y.-F. (2015) · OncoTarget · doi:10.18632/oncotarget.3469 · Cited by 669 · see citing works
Efficient backsplicing produces translatable circular mRNAs
Wang, Y., & Wang, Z. (2014) · RNA · doi:10.1261/rna.048272.114 · Cited by 665 · see citing works
The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva
Bahn, J. H., Zhang, Q., Li, F., Chan, T.-M., Lin, X., Kim, Y. D., Wong, D. T., & Xiao, X. G. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2014.230433 · Cited by 658 · see citing works
Memczak, S., Papavasileiou, P., Peters, O., & Rajewsky, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141214 · Cited by 639 · see citing works
Circular RNA (circRNA) in Alzheimer’s disease (AD)
Lukiw, W. J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00307 · Cited by 636 · see citing works
Szabo, L. A., Morey, R. E., Palpant, N. J., Wang, P. L., Afari, N., Chuan, J., Parast, M. M., Murry, C. E., Laurent, L. C., & Salzman, J. (2015) · Genome biology · doi:10.1186/s13059-015-0690-5 · Cited by 608 · see citing works
CircHIPK3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells
Li, Y., Zheng, F., Xiao, X., Xie, F., Tao, D., Huang, C., Liu, D., Wang, M., Wang, L., Zeng, F., et al. (2017) · EMBO Reports · doi:10.15252/embr.201643581 · Cited by 559 · see citing works
Weng, W., Wei, Q., Toden, S., Yoshida, K., Nagasaka, T., Fujiwara, T., Cai, S., Qin, H., Ma, Y., & Goel, A. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2541 · Cited by 511 · see citing works
circRNADb: A comprehensive database for human circular RNAs with protein-coding annotations
Chen, X., Han, P., Zhou, T., Guo, X., Song, X., & Li, Y. (2016) · Scientific Reports · doi:10.1038/srep34985 · Cited by 501 · see citing works
Circular RNAs: splicing’s enigma variations
Hentze, M. W., & Preiss, T. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.53 · Cited by 455 · see citing works
Ghosal, S., Das, S., Sen, R., Basak, P., & Chakrabarti, J. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00283 · Cited by 444 · see citing works
Wang, Y., Mo, Y., Gong, Z., Yang, X., Yang, M., Zhang, S., Xiong, F., Xiang, B., Zhou, M., Liao, Q., et al. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0598-7 · Cited by 442 · see citing works
Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma
Qin, M., Liu, G., Huo, X., Tao, X., Sun, X., Ge, Z., Yang, J., Fan, J., Liu, L., & Qin, W. (2016) · Cancer Biomarkers · doi:10.3233/cbm-150552 · Cited by 441 · see citing works
Circular RNA biogenesis can proceed through an exon-containing lariat precursor
Barrett, S. P., Wang, P. L., & Salzman, J. (2015) · eLife · doi:10.7554/elife.07540 · Cited by 439 · see citing works
Xie, H., Ren, X., Xin, S., Lan, X.-L., Lu, G.-F., Lin, Y., Yang, S., Zeng, Z., Liao, W., Ding, Y., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8589 · Cited by 426 · see citing works
Fang, Y., Xue, J., Shen, Q., Chen, J., & Tian, L. (2012) · Hepatology · doi:10.1002/hep.25576 · Cited by 425 · see citing works
Zhong, Z., Lv, M., & Chen, J. (2016) · Scientific Reports · doi:10.1038/srep30919 · Cited by 406 · see citing works
Biogenesis, identification, and function of exonic circular RNAs
Chen, I., Chen, C., & Chuang, T. (2015) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1294 · Cited by 397 · see citing works
Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer
Chen, S., Li, T., Zhao, Q., Xiao, B., & Guo, J. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.01.025 · Cited by 378 · see citing works
Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance
Lasda, E. L., & Parker, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148407 · Cited by 375 · see citing works
Specific identification and quantification of circular RNAs from sequencing data
Cheng, J., Metge, F., & Dieterich, C. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv656 · Cited by 372 · see citing works
Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes
Xia, S., Feng, J. Q., Lei, L., Hu, J., Xia, L., Wang, J., Xiang, Y., Liu, L., Zhong, S., Han, L., et al. (2016) · Briefings in Bioinformatics · doi:10.1093/bib/bbw081 · Cited by 362 · see citing works
A comprehensive overview and evaluation of circular RNA detection tools
Zeng, X., Lin, W., Guo, M., & Zou, Q. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005420 · Cited by 345 · see citing works
CircNet: a database of circular RNAs derived from transcriptome sequencing data
Liu, Y., Li, J., Sun, C.-H., Andrews, E. H., Chao, R.-F., Lin, F.-M., Weng, S.-L., Hsu, S., Huang, C., Cheng, C., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv940 · Cited by 343 · see citing works
Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/β-Catenin Pathway
Wan, L., Zhang, L., Fan, K., Cheng, Z., Sun, Q., & Wang, J. (2016) · BioMed Research International · doi:10.1155/2016/1579490 · Cited by 341 · see citing works
Shang, X., Li, G., Liu, H., Li, T., Liu, J., Zhao, Q., & Wang, C. (2016) · Medicine · doi:10.1097/md.0000000000003811 · Cited by 330 · see citing works
Liang, H., Zhang, X.-Z., Liu, B., Jia, G., & Li, W. (2017) · PubMed Central · Cited by 329 · see citing works
Yang, W., Du, W. W., Li, X., Yee, A., & Yang, B. B. (2015) · Oncogene · doi:10.1038/onc.2015.460 · Cited by 314 · see citing works
Circular RNA profile in gliomas revealed by identification tool UROBORUS
Song, X., Zhang, N., Han, P., Moon, B.-S., Lai, R., Wang, K., & Lu, W. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw075 · Cited by 307 · see citing works
Novel classes of non-coding RNAs and cancer
Šáňa, J., Vychytilova‐Faltejskova, P., Svoboda, M., & Slabý, O. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-103 · Cited by 305 · see citing works
Liu, Q., Zhang, X., Hu, X., Dai, L., Fu, X., Zhang, J., & Ao, Y. (2016) · Scientific Reports · doi:10.1038/srep22572 · Cited by 302 · see citing works
Xu, L., Zhang, M., Zheng, X., Yi, P., Lan, C., & Xu, M. (2016) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-016-2256-7 · Cited by 302 · see citing works
Yao, Z., Luo, J., Hu, K., Lin, J., Huang, H., Wang, Q., Zhang, P., Xiong, Z., He, C., Huang, Z., et al. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12045 · Cited by 299 · see citing works
cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/β-Catenin Pathway
Huang, G., Zhu, H., Shi, Y., Wu, W., Cai, H., & Chen, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131225 · Cited by 295 · see citing works
Zhang, Y., Liu, H., Li, W., Yu, J., Li, J., Shen, Z., Ye, G., Qi, X., & Li, G. (2017) · Aging · doi:10.18632/aging.101254 · Cited by 294 · see citing works
Circular RNAs in cancer: an emerging key player
Dong, Y., He, D., Peng, Z., Peng, W., Shi, W., Wang, J., Li, B., Zhang, C., & Duan, C. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0370-2 · Cited by 289 · see citing works
A multi-split mapping algorithm for circular RNA, splicing, trans-splicing and fusion detection
Hoffmann, S., Otto, C., Doose, G., Andrea Tanzer, A., Langenberger, D., Christ, S., Kunz, M., Holdt, L. M., Teupser, D., Jörg Hackermüller, A., et al. (2014) · Genome biology · doi:10.1186/gb-2014-15-2-r34 · Cited by 271 · see citing works
Xia, W., Qiu, M., Chen, R., Wang, S., Leng, X., Wang, J., Xu, Y., Hu, J., Dong, G., Xu, P. L., et al. (2016) · Scientific Reports · doi:10.1038/srep35576 · Cited by 270 · see citing works
Huang, M., Zhong, Z., Lv, M., Shu, J. S., Tian, Q., & Chen, J. (2016) · Oncotarget · doi:10.18632/oncotarget.9706 · Cited by 259 · see citing works
Circular RNAs as potential biomarkers for cancer diagnosis and therapy.
Wang, F., Nazarali, A. J., & Ji, S. (2016) · PubMed Central · Cited by 254 · see citing works
Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value
Yao, J., Zhao, S., Liu, Q., Lv, M., Zhou, D., Zi-jun, L., & Nan, K. (2017) · Pathology - Research and Practice · doi:10.1016/j.prp.2017.02.011 · Cited by 249 · see citing works
Zhang, X., Xu, L., & Wang, F. (2017) · Cell Biology International · doi:10.1002/cbin.10826 · Cited by 241 · see citing works
Zheng, L., Li, J., Wu, J., Sun, W., Liu, S., Wang, Z., Zhou, H., Yang, J., & Qu, L. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1273 · Cited by 225 · see citing works
Zhao, X., Dou, W., He, L., Liang, S., Tie, J., Liu, C., Li, T., Lu, Y., Mo, P., Shi, Y., et al. (2012) · Oncogene · doi:10.1038/onc.2012.156 · Cited by 218 · see citing works
The complexity of the translation ability of circRNAs
Granados-Riveron, J. T., & Aquino‐Jarquín, G. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.07.009 · Cited by 217 · see citing works
TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway
Zheng, J., Liu, X., Xue, Y., Gong, W., Ma, J., Xi, Z., Que, Z., & Liu, Y. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0422-2 · Cited by 217 · see citing works
microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis
Zhang, N., Li, X., Wu, C. W., Dong, Y., Cai, M., Mok, M. T. S., Wang, H., Chen, J., Ng, S. S. M., Chen, M., et al. (2012) · Oncogene · doi:10.1038/onc.2012.526 · Cited by 212 · see citing works
Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances.
Wang, X., Zhang, Y., Huang, L., Zhang, J., Pan, F., Li, B., Yan, Y., Jia, B., Liu, H., Li, S., et al. (2015) · PubMed Central · Cited by 210 · see citing works
IRESite—a tool for the examination of viral and cellular internal ribosome entry sites
Mokrejš, M., Mašek, T., Vopálenský, V., Hlubuček, P., Delbos, P., & Pospíšek, M. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp981 · Cited by 207 · see citing works
Yang, P., Qiu, Z., Jiang, Y., Dong, L., Yang, W., Gu, C., Li, G., & Zhu, Y. T. (2016) · Oncotarget · doi:10.18632/oncotarget.11523 · Cited by 199 · see citing works
Kong, X., Li, G., Yuan, Y., He, Y., Wu, X., Zhang, W., Wu, Z., Chen, T., Wu, W., Lobie, P. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041523 · Cited by 195 · see citing works
Xiong, S., Zheng, Y., Jiang, P., Liu, R., Liu, X., & Chu, Y. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.805 · Cited by 192 · see citing works
Circular RNA: a novel biomarker for progressive laryngeal cancer.
Xuan, L., Qu, L., Zhou, H., Wang, P., Yu, H., Wu, T., Wang, X., Li, Q., Tian, L., Liu, M., et al. (2016) · PubMed Central · Cited by 192 · see citing works
Fu, L., Yao, T. S., Chen, Q., Mo, X., Hu, Y., & Guo, J. (2017) · Oncotarget · doi:10.18632/oncotarget.16881 · Cited by 178 · see citing works
Peng, L., Chen, G., Zhu, Z., Shen, Z., Du, C., Zang, R., Su, Y., Xie, H., Li, H., Xu, X., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13656 · Cited by 174 · see citing works
Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7
Tang, W., Ji, M., He, G., Yang, L., Niu, Z., Jian, M., Wei, Y., Ren, L., & Xu, J. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s131597 · Cited by 167 · see citing works
Inverted repeats are necessary for circularization of the mouse testis Sry transcript
Dubin, R. A., Kazmi, M. A., & D, H. O. M. (1995) · Gene · doi:10.1016/0378-1119(95)00639-7 · Cited by 154 · see citing works
Guo, J., Li, J., Zhu, C., Feng, W.-T., Shao, J.-X., Wan, L., Huang, M., & He, J. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s123220 · Cited by 153 · see citing works
Circular mRNA can direct translation of extremely long repeating-sequence proteins in vivo
Perriman, R., & Ares, M. (1998) · RNA · doi:10.1017/s135583829898061x · Cited by 151 · see citing works
Reduced expression of circ RNA hsa_circ_0003159 in gastric cancer and its clinical significance
Tian, M., Chen, R., Li, T., & Xiao, B. (2017) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22281 · Cited by 148 · see citing works
Lariat intronic RNAs in the cytoplasm of Xenopus tropicalis oocytes
Talross, G. J. S., & Gall, J. G. (2014) · RNA · doi:10.1261/rna.045781.114 · Cited by 147 · see citing works
dos Santos, G. A., Kats, L. M., & Pandolfi, P. P. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131121 · Cited by 141 · see citing works
Using artificial microRNA sponges to achieve microRNA loss-of-function in cancer cells
Tay, F. C., Lim, J. K., Zhu, H., Hin, L. C., & Wang, S. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.05.010 · Cited by 135 · see citing works
Liang, Y., Wang, W., Fang, C., Raj, S. S., Hu, W.-M., Li, Q.-W., & Zhou, Z.-W. (2016) · Oncotarget · doi:10.18632/oncotarget.10391 · Cited by 125 · see citing works
Chuang, T., Wu, C.-S., Chen, C.-Y., Hung, L.-Y., Chiang, T.-W., & Yang, M.-Y. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1013 · Cited by 122 · see citing works
MicroRNA-7: a promising new target in cancer therapy
Zhao, J., Tao, Y., Zhou, Y., Qin, N., Chen, C., Tian, D., & Xu, L. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0259-0 · Cited by 118 · see citing works
Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme
Barbagallo, D., Condorelli, A. G., Ragusa, M., Salito, L., Sammito, M., Banelli, B., Caltabiano, R., Barbagallo, G. M. V., Zappalà, A., Battaglia, R., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6621 · Cited by 118 · see citing works
Fu, L., Chen, Q., Yao, T. S., Li, T., Ying, S., Hu, Y., & Guo, J. (2017) · Oncotarget · doi:10.18632/oncotarget.16709 · Cited by 117 · see citing works
Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance
Li, W., Song, Y., Zhang, H., Zhou, Z., Xie, X., Zeng, Q., Guo, K., Wang, T., Xia, P., & Chang, D. (2017) · Disease Markers · doi:10.1155/2017/4587698 · Cited by 108 · see citing works
CircPro: an integrated tool for the identification of circRNAs with protein-coding potential
Meng, X., Chen, Q., Zhang, P., & Chen, M. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx446 · Cited by 106 · see citing works
miRNA-7-5p inhibits melanoma cell migration and invasion
Giles, K. M., Brown, R. A. M., Epis, M. R., Kalinowski, F. C., & Leedman, P. J. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.086 · Cited by 93 · see citing works
Decreased expression of hsa_circ_0001895 in human gastric cancer and its clinical significances
Shao, Y., Chen, L., Lu, R., Zhang, X., Xiao, B., Ye, G., & Guo, J. (2017) · Tumor Biology · doi:10.1177/1010428317699125 · Cited by 89 · see citing works
Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells
Jin, H., Jin, X., Zhang, H., & Wang, W. (2017) · Oncotarget · doi:10.18632/oncotarget.16104 · Cited by 84 · see citing works
Identification of differentially expressed circular RNAs in human colorectal cancer
Zhang, P., Zuo, Z., Shang, W., Wu, A., Bi, R., Wu, J., Li, S., Sun, X., & Jiang, L. (2017) · Tumor Biology · doi:10.1177/1010428317694546 · Cited by 82 · see citing works
Allen‐Rhoades, W. A., Kurenbekova, L., Satterfield, L., Parikh, N., Fuja, D. G., Shuck, R. L., Rainusso, N. C., Trucco, M. M., Barkauskas, D. A., Jo, E., et al. (2015) · Cancer Medicine · doi:10.1002/cam4.438 · Cited by 81 · see citing works
PTESFinder: a computational method to identify post-transcriptional exon shuffling (PTES) events
Izuogu, O. G., Alhasan, A. A., Al-Afghani, H. M., Santibanez‐Koref, M., Elliott, D. J., & Jackson, M. S. (2016) · BMC Bioinformatics · doi:10.1186/s12859-016-0881-4 · Cited by 66 · see citing works
Zhang, Y., Li, J., Yu, J., Liu, H., Shen, Z., Ye, G., Mou, T., Qi, X., & Li, G. (2017) · Oncotarget · doi:10.18632/oncotarget.15288 · Cited by 65 · see citing works
Hsu, C., Shen, G., & Ko, J. (2006) · Lung Cancer · doi:10.1016/j.lungcan.2006.01.011 · Cited by 64 · see citing works
In vitro Generation of a Circular Exon from a Linear Pre-mRNA Transcript
Schindewolf, C., Braun, S., & Domdey, H. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.7.1260 · Cited by 57 · see citing works
Wang, W., DAI, L. X., ZHANG, S., Yu, Y., YAN, N., FAN, P., DAI, L., Tian, H. W., Cheng, L., Zhang, X., et al. (2013) · Neoplasma · doi:10.4149/neo_2013_036 · Cited by 51 · see citing works
Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances
Lu, R., Shao, Y., Ye, G., Xiao, B., & Guo, J. (2017) · Tumor Biology · doi:10.1177/1010428317704175 · Cited by 50 · see citing works
Xu, Z., & Wang, T. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.140 · Cited by 47 · see citing works
Kameyama, T., Suzuki, H., & Mayeda, A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks520 · Cited by 30 · see citing works
Yu, X., Wei, F., Yu, J., Zhao, H., Jia, L., Ye, Y., Du, R., Ren, X., & Li, H. (2015) · Cancer Genetics · doi:10.1016/j.cancergen.2015.01.006 · Cited by 28 · see citing works
Fang, Y., Ma, M., Wang, J., Liu, X., & Wang, Y. (2017) · Tumor Biology · doi:10.1177/1010428317705850 · Cited by 25 · see citing works
MicroRNA124 regulate cell growth of prostate cancer cells by targeting iASPP.
Chen, J., Xiao, H., Huang, Z., Hu, Z., Qi, T., Zhang, B., Tao, X., & Liu, S. (2014) · PubMed Central · Cited by 20 · see citing works
Nakagawa, Y., Akao, Y., Taniguchi, K., Kamatani, A., Tahara, T., Kamano, T., Nakano, N., Komura, N., Ikuno, H., Ohmori, T., et al. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16011526 · Cited by 20 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [100]Jin H. Fang M. Man Z. Wang Y. Liu H. Circular RNA 001569 acts as an oncogene and correlates with aggressive characteristics in hepatocellular carcinoma International Journal of Clinical and Experimental Pathology 2017 10 3 2997 3005
Cited by
Sorted by citations
Zheng, X., Huang, M., Xing, L., Yang, R., Wang, X., Jiang, R., Zhang, L., & Chen, J. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01183-9 · Cited by 456 · see citing works
Dave, V. P., Ngo, T. A., Pernestig, A.-K., Tilevik, D., Kant, K., Nguyen, T. B., Wolff, A., & Bang, D. D. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0143-3 · Cited by 249 · see citing works
Noncoding RNAs in Extracellular Fluids as Cancer Biomarkers: The New Frontier of Liquid Biopsies
Pardini, B., Sabo, A. A., Birolo, G., & Calin, G. A. (2019) · Cancers · doi:10.3390/cancers11081170 · Cited by 198 · see citing works
Li, T., Sun, X.-Z., & Chen, L. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28239 · Cited by 141 · see citing works
Xu, Q., Zhou, L., Yang, G., Meng, F., Wan, Y., Wang, L., & Zhang, L. (2020) · Cell Biology International · doi:10.1002/cbin.11444 · Cited by 134 · see citing works
Circular RNAs in Cancer – Lessons Learned From microRNAs
Dragomir, M. P., & Călin, G. A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00179 · Cited by 134 · see citing works
Chi, Y., Luo, Q., Song, Y., Yang, F., Wang, Y., Jin, M., & Zhang, D. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29225 · Cited by 98 · see citing works
circRNAs Are Involved in the Rice-Magnaporthe oryzae Interaction
Fan, J., Quan, W., Li, G., Hu, X., Wang, Q., Wang, H., Li, X., Luo, X., Feng, Q., Hu, Z.-J., et al. (2019) · PLANT PHYSIOLOGY · doi:10.1104/pp.19.00716 · Cited by 97 · see citing works
Zhu, K., Zhang, C., Jian-Ping, H., & Zhang, L. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.27523 · Cited by 91 · see citing works
Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy
Abaza, T., El‐Aziz, M. K. A., Daniel, K. A., Karousi, P., Papatsirou, M., Fahmy, S. A., Hamdy, N. Μ., Kontos, C. K., & Youness, R. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216484 · Cited by 91 · see citing works
CircRNAs and lung cancer: Biomarkers and master regulators
Di, X., Jin, X., Li, R., Zhao, M., & Wang, K. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.01.055 · Cited by 90 · see citing works
Chi, B. J., Zhao, D.-X., Liu, L., Yin, X., Wang, F. F., Bi, S., Gui, S.-L., Zhou, S., Qin, W. B., Wu, D., et al. (2018) · Neoplasma · doi:10.4149/neo_2018_180318n185 · Cited by 86 · see citing works
Elkhouly, A. M., Youness, R. A., & Gad, M. Z. (2020) · Non-coding RNA Research · doi:10.1016/j.ncrna.2020.01.001 · Cited by 87 · see citing works
Epigenetic regulation of cancer stem cell formation and maintenance
French, R., & Pauklin, S. (2020) · International Journal of Cancer · doi:10.1002/ijc.33398 · Cited by 83 · see citing works
How are circRNAs translated by non-canonical initiation mechanisms?
Diallo, L. H., Tatin, F., David, F., Godet, A.-C., Zamora, A., Prats, A., Garmy-Susini, B. H., & Lacazette, É. (2019) · Biochimie · doi:10.1016/j.biochi.2019.06.015 · Cited by 81 · see citing works
Zhao, R., Ni, J., Si, L., Jiang, S., You, L., Liu, H., Shou, J., Zhai, C., Zhang, W., Shao, S., et al. (2019) · Aging · doi:10.18632/aging.102334 · Cited by 81 · see citing works
Circular RNAs—The Road Less Traveled
Guria, A., Sharma, P., Natesan, S., & Pandi, G. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00146 · Cited by 80 · see citing works
Youness, R. A., Hassan, H. A., Abaza, T., Hady, A. A., Magdoub, H. M. E., Ali, M. K., Vogel, J., Thiersch, M., Gassmann, M., Hamdy, N. Μ., et al. (2024) · Cells · doi:10.3390/cells13151245 · Cited by 76 · see citing works
Which long noncoding RNAs and circular RNAs contribute to inflammatory bowel disease?
Lin, L., Zhou, G., Chen, P., Wang, Y., Han, J., Chen, M., He, Y., & Zhang, S. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2657-z · Cited by 67 · see citing works
Tran, A. M., Chalbatani, G. M., Berland, L., Santos, M. C. D. L., Raj, P. S., Jalali, S. A., Gharagouzloo, E., Ivan, C., Dragomir, M. P., & Călin, G. A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00050 · Cited by 64 · see citing works
Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance
Beltrán-García, J., Osca-Verdegal, R., Nácher-Sendra, E., Pallardó, F. V., & García‐Giménez, J. L. (2020) · Cells · doi:10.3390/cells9061544 · Cited by 65 · see citing works
Wang, W., Wang, J., Zhang, X., & Liu, G. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s220700 · Cited by 63 · see citing works
Xie, B., Zhao, Z., Liu, Q., Wang, X., Ma, Z., & Li, H. (2018) · Gene · doi:10.1016/j.gene.2018.10.043 · Cited by 60 · see citing works
Ma, H., Lu, L., Xia, H., Xiang, Q., Sun, J., Xue, J., Xiao, T., Cheng, C., Liu, Q., & Shi, A. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.141181 · Cited by 58 · see citing works
Protein-Related Circular RNAs in Human Pathologies
Wawrzyniak, O., Zarębska, Ż., Kuczyński, K., Gotz‐Więckowska, A., & Rolle, K. (2020) · Cells · doi:10.3390/cells9081841 · Cited by 57 · see citing works
The regulatory functions of circular RNAs in osteosarcoma
Soghli, N., Qujeq, D., Yousefi, T., & Soghli, N. (2020) · Genomics · doi:10.1016/j.ygeno.2020.03.024 · Cited by 55 · see citing works
Circular RNA in Lung Cancer Research: Biogenesis, Functions, and Roles
Zhang, C., Ma, L., Niu, Y., Wang, Z., Xu, X., Li, Y., & Yu, Y. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.39212 · Cited by 53 · see citing works
Circular RNA CircVAPA Regulates Breast Cancer Cell Migration and Invasion Via Sponging miR-130a-5p
Zhou, S., Chen, W., Yang, S., Li, J., Zhang, J., Zhang, H.-D., Zhong, S., & Tang, J. (2020) · Epigenomics · doi:10.2217/epi-2019-0124 · Cited by 51 · see citing works
Circ_0027599/PHDLA1 suppresses gastric cancer progression by sponging miR-101-3p.1
Wang, L., Shen, J., & Jiang, Y. (2018) · Cell & Bioscience · doi:10.1186/s13578-018-0252-0 · Cited by 48 · see citing works
The emerging role of circular RNAs in breast cancer
Zhou, S., Chen, W., Yang, S., Xu, Z., Hu, J.-H., Zhang, H.-D., Zhong, S., & Tang, J. (2019) · Bioscience Reports · doi:10.1042/bsr20190621 · Cited by 47 · see citing works
Circular RNA expression profile in blood according to ischemic stroke etiology
Ostolaza, A., Blanco‐Luquin, I., Urdánoz‐Casado, A., Rubio, I., Labarga, A., Zandio, B., Roldán, M., Martínez-Cascales, J., Mayor, S., Herrera, M., et al. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00394-3 · Cited by 47 · see citing works
Huang, Y., Dai, Y., Wen, C., He, S., Shi, J., Zhao, D., Wu, L., & Zhou, H. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.07.027 · Cited by 43 · see citing works
Urdánoz‐Casado, A., de Gordoa, J. S., Robles, M., Acha, B., Roldán, M., Zelaya, M. V., Blanco‐Luquin, I., & Mendióroz, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179205 · Cited by 42 · see citing works
Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential
Gan, H., Lei, Y., Yuan, N., Tang, K., Hao, W., Ma, Q., Wu, M., Zhou, X., Li, X., Huang, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111244 · Cited by 41 · see citing works
Wang, Z., Zhu, Z., Wang, H., Qin, B., Liu, J., Yao, X., Li, W., & Kuisheng, C. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28403 · Cited by 40 · see citing works
Research progress of circular RNAs in lung cancer
Ma, Y., Zhang, X., Wang, Y., Tian, H., & Xu, S. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2018.1523848 · Cited by 40 · see citing works
Circular RNA hsa_circ_0075828 Promotes Bladder Cancer Cell Proliferation Through Activation of CREB1
Zhuang, C., Huang, X., Yu, J., & Gui, Y. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.2.059 · Cited by 38 · see citing works
Nepotchatykh, E., Elremaly, W., Caraus, I., Godbout, C., Leveau, C., Chalder, L., Beaudin, C., Kanamaru, E., Kosovskaia, R., Lauzon, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76438-y · Cited by 38 · see citing works
Critical Roles of Circular RNA in Tumor Metastasis via Acting as a Sponge of miRNA/isomiR
Guo, L., Jia, L., Luo, L., Xu, X., Xiang, Y., Ren, Y., Ren, D., Shen, L., & Liang, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137024 · Cited by 38 · see citing works
Su, W., Sun, S., Wang, F., Shen, Y., & Yang, H. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1830-6 · Cited by 37 · see citing works
RetractedXu, X., Wu, Z., Qiu, H., & Wu, J. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s288669 · Cited by 33 · see citing works
Circ_0056618 and CXCR4 act as competing endogenous in gastric cancer by regulating miR‐206
Li, H., Yao, G., Feng, B. C., Lu, X., & Fan, Y. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27271 · Cited by 31 · see citing works
Liu, S., Wang, Y., Wang, T., Shi, K., Fan, S., Li, C., Chen, R., Wang, J., Jiang, W., Zhang, Y., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01950-y · Cited by 31 · see citing works
Duan, X., Li, L., Gan, J., Peng, C., Wang, X., Chen, W., & Peng, D. (2019) · Gene · doi:10.1016/j.gene.2019.03.053 · Cited by 29 · see citing works
Circular RNAs in stem cells: from basic research to clinical implications
Lu, H., Li, J., Yang, G.-D., Yi, C., Zhang, D., Yu, F.-G., & Ma, Z. (2021) · Bioscience Reports · doi:10.1042/bsr20212510 · Cited by 17 · see citing works
Protein arginine methyltransferase 1, a major regulator of biological processes
Sudhakar, S. R. N., Khan, S. N., Clark, A. M., Hendrickson-Rebizant, T., Patel, S., Lakowski, T. M., & Davie, J. (2023) · Biochemistry and Cell Biology · doi:10.1139/bcb-2023-0212 · Cited by 29 · see citing works
Circular RNAs in nasopharyngeal carcinoma
Yang, M., & Huang, W. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.05.029 · Cited by 27 · see citing works
Sun, D., & Zhu, D. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1814026 · Cited by 28 · see citing works
Biogenesis, cellular effects, and biomarker value of circHIPK3
Fu, Y., & Sun, H. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01956-2 · Cited by 28 · see citing works
Wang, S., Li, W., Yang, L., Yuan, J., Wang, L., Li, N., & Zhao, H. (2022) · Functional & Integrative Genomics · doi:10.1007/s10142-022-00865-5 · Cited by 28 · see citing works
Zhang, Z., Zhou, Q., Luo, F., Zhou, R., Xu, J., Xiao, J., Dai, F., & Song, L. (2021) · Human Cell · doi:10.1007/s13577-021-00564-6 · Cited by 27 · see citing works
Shafaghat, Z., Radmehr, S., Saharkhiz, S., Khosrozadeh, A., Feiz, K., Alkhathami, A. G., Taheripak, G., Farani, M. R., Rahmati, R., Zarimeidani, F., et al. (2025) · Topics in Current Chemistry · doi:10.1007/s41061-025-00505-z · Cited by 26 · see citing works
Altered expression of circular RNA in primary Sjögren’s syndrome
Su, L., Xu, W., Liu, X.-Y., Fu, L., & Huang, A. (2019) · Clinical Rheumatology · doi:10.1007/s10067-019-04728-6 · Cited by 26 · see citing works
Liu, W., Yin, C., & Liu, Y. (2020) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2019.3472 · Cited by 26 · see citing works
Non-Coding RNAs and Brain Tumors: Insights Into Their Roles in Apoptosis
Tamtaji, O. R., Derakhshan, M., Noshabad, F. Z. R., Razaviyan, J., Hadavi, R., Jafarpour, H., Jafari, A., Rajabi, A., Hamblin, M. R., Mahabady, M. K., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.792185 · Cited by 26 · see citing works
Approaches for identification and analysis of plant circular RNAs and their role in stress responses
Kalwan, G., Gill, S. S., Priyadarshini, P., Gill, R., Yadava, Y. K., Yadav, S., Baruah, P. M., Agarwala, N., Gaikwad, K., & Jain, P. K. (2022) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2022.105099 · Cited by 24 · see citing works
Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer
Gopikrishnan, M., Hephzibah Cathryn, R., Ramanathan, G., Ashour, H. M., Pintus, G., Hammad, M., Kashyap, M. K., Doss, C. G. P., & Zayed, H. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01083-3 · Cited by 25 · see citing works
Regulation of the Key Epithelial Cancer Suppressor miR-124 Function by Competing Endogenous RNAs
Александровна, Б. Э., Fridman, M. V., Burdennyy, A. M., Филиппова, Е. А., Loginov, V. I., Валерьевна, П. И., Dmitriev, A. A., & Кушлинский, Н. Е. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113620 · Cited by 24 · see citing works
Ma, Q., Huai, B., Liu, Y., Jia, Z., & Zhao, Q. (2021) · Cancer Management and Research · doi:10.2147/cmar.s278913 · Cited by 24 · see citing works
Castro, J., Daniels, M. H., Brennan, D., Johnston, B., Gotur, D., Lee, Y., Knockenhauer, K. E., Lu, C., Wu, J., Nayak, S. P., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-0397 · Cited by 23 · see citing works
Liang, C., Yang, Q., Hu, C., Yu, Q., Hao, S., & Li, D. (2019) · Medical Science Monitor · doi:10.12659/msm.916697 · Cited by 23 · see citing works
Cerina: systematic circRNA functional annotation based on integrative analysis of ceRNA interactions
Cardenas, J., Balaji, U., & Gu, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-78469-x · Cited by 21 · see citing works
Dai, Y., Zhu, Y., & Xu, H. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24486 · Cited by 22 · see citing works
Zhang, D., Ma, Y., Naz, M., Ahmed, N., Zhang, L., Zhou, J., Ding, Y., & Chen, Z. (2024) · Genes · doi:10.3390/genes15070958 · Cited by 23 · see citing works
Yan, X., Wang, T., & Wang, J. (2020) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2020.3621 · Cited by 21 · see citing works
The Prognostic and Predictive Significance of circRNA CDR1as in Tumor Progression
Jian, F., Yangyang, R., Xu, W., Jiadan, X., Na, L., Peng, Y., Maohong, B., Guoping, N., & Pan, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.549982 · Cited by 21 · see citing works
Circular RNAs in Hepatocellular Carcinoma: Emerging Functions to Clinical Significances
Zhang, Y., & Wang, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.667428 · Cited by 21 · see citing works
Dysregulation of the miR‐30c/DLL4 axis by circHIPK3 is essential for KSHV lytic replication
Harper, K. L., Mottram, T. J., Anene, C. A., Foster, B., Patterson, M. R., McDonnell, E., Macdonald, A., Westhead, D. R., & Whitehouse, A. (2022) · EMBO Reports · doi:10.15252/embr.202154117 · Cited by 20 · see citing works
Circular RNAs in inflammatory bowel disease
Lun, J., Guo, J., Yu, M., Zhang, H., & Fang, J. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1307985 · Cited by 22 · see citing works
Circ-HIPK3 plays an active role in regulating myoblast differentiation
Yao, R., Yao, Y., Li, C., Li, X., Ni, W., Quan, R., Liu, L., Li, H., Xu, Y., Zhang, M., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.119 · Cited by 19 · see citing works
Qu, Y., Li, Q., Hao, L., & Zhu, J. (2021) · Oncology Letters · doi:10.3892/ol.2021.12649 · Cited by 19 · see citing works
Non-coding RNAs in gynecologic cancer
Solati, A., Taghvimi, S., Khatami, S. H., Shabaninejad, Z., Malekzadegan, Y., Alizadeh, M., Mousavi, P., Taheri‐Anganeh, M., Razmjoue, D., Bahmyari, S., et al. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117618 · Cited by 18 · see citing works
MetaDE-Based Analysis of circRNA Expression Profiles Involved in Gastric Cancer
Ding, H.-X., Xu, Q., Wang, B., Lv, Z., & Yuan, Y. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-06014-6 · Cited by 18 · see citing works
Shu, X., Cheng, L., Dong, Z., & Shu, S. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28888 · Cited by 17 · see citing works
Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 via miR-411-5p
Pan, J., Liu, Z., Yang, Z., Liang, E., Cheng, F., Zhang, D., Zhou, X., Niu, Y., Xin, Z., Chen, Y., et al. (2021) · The World Journal of Men s Health · doi:10.5534/wjmh.200204 · Cited by 17 · see citing works
Ma, S., Xu, Y., Qin, X., Tao, M., Gu, X., Shen, L., Chen, Y., Zheng, M., Qin, S., Wu, G., et al. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00610-9 · Cited by 16 · see citing works
Liu, J., Zhang, M., Li, D., Li, M., Kong, L., Cao, M., Wang, Y., Song, C., Fang, X., Chen, H., et al. (2020) · Genes · doi:10.3390/genes11030336 · Cited by 16 · see citing works
Gao, F., Jia, L., Han, J., Wang, Y., Luo, W., & Zeng, Y. (2020) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000001014 · Cited by 16 · see citing works
Circ_0005576 Promotes Malignant Progression Through miR-874/CDK8 Axis in Colorectal Cancer
Chen, Y., Li, S., & Hu, X. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s249494 · Cited by 15 · see citing works
RetractedDanac, J. M. C., & Garcia, R. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-88539-3 · Cited by 15 · see citing works
Li, H., Liu, X., Sun, N., Wang, T., Zhu, J., Yang, S., Song, X., Wang, R., Wang, X., Zhao, Y., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.657544 · Cited by 15 · see citing works
Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma
Ma, S., Adzavon, Y. M., Wen, X., Zhao, P., Xie, F., Liu, M., & Ma, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.873029 · Cited by 15 · see citing works
Liu, X., Zhang, L., Wang, J.-H., Zeng, H., Zou, J., Tan, W., Zhao, H., He, Y., Shi, J., Yoshida, S., et al. (2020) · Current Eye Research · doi:10.1080/02713683.2020.1722179 · Cited by 14 · see citing works
Li, W., Liu, R., Wei, D., Zhang, W., Zhang, H., Huang, W., & Hao, L. (2020) · BioMed Research International · doi:10.1155/2020/3501451 · Cited by 14 · see citing works
Long Non-Coding RNAs as Epigenetic Regulators of Immune Checkpoints in Cancer Immunity
Saadi, W., Fatmi, A., Pallardó, F. V., García‐Giménez, J. L., & Mena, S. (2022) · Cancers · doi:10.3390/cancers15010184 · Cited by 14 · see citing works
Sheng, J., Liu, L., Dong, T., & Wu, X. (2021) · Journal of Chemotherapy · doi:10.1080/1120009x.2021.2009991 · Cited by 13 · see citing works
Urdánoz‐Casado, A., de Gordoa, J. S., Robles, M., Roldán, M., Zelaya, M. V., Blanco‐Luquin, I., & Mendióroz, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147682 · Cited by 13 · see citing works
Lei, X., Yang, M., Xiao, Z., Zhang, H., & Tan, S. (2021) · Open Life Sciences · doi:10.1515/biol-2021-0041 · Cited by 12 · see citing works
Li, Y., Shi, R., Zhu, G., Chen, C., Huang, H., Gao, M., Xu, S., Cao, P., Zhang, Z., Wu, D., et al. (2021) · Thoracic Cancer · doi:10.1111/1759-7714.14226 · Cited by 12 · see citing works
Yan, D., Liu, W., Liu, Y., & Zhu, X. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15862 · Cited by 11 · see citing works
Liu, Y., Yang, Y., Li, M., Fu, X., He, X., Li, X., Cho, J. Y., Li, P., & Yu, T. (2024) · iScience · doi:10.1016/j.isci.2024.109502 · Cited by 11 · see citing works
RetractedProgress of research into circular RNAs in urinary neoplasms
Wan, B., Лю, Б., & Lv, C. (2020) · PeerJ · doi:10.7717/peerj.8666 · Cited by 10 · see citing works
Zheng, L., Yan, B., Jin, G., Han, W., Wang, H., Wang, Z., Ma, Y., Nian, Y., Meng, X., & Jiang, Z. (2022) · Journal of Molecular Histology · doi:10.1007/s10735-021-10044-8 · Cited by 12 · see citing works
Circ_TNFRSF21 promotes cSCC metastasis and M2 macrophage polarization via miR-214-3p/CHI3L1
Ma, J., Huang, L., Gao, Y., Li, M., Chen, L., & Yang, L. (2023) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2023.06.001 · Cited by 10 · see citing works
Zhang, J., Chu, G., Zheng, L., Liu, J., & He, J. (2023) · Journal of Applied Genetics · doi:10.1007/s13353-023-00772-w · Cited by 10 · see citing works
Yu, B., Li, M., Han, S., Yu, Z., & Zhu, J. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12501 · Cited by 10 · see citing works
Wu, B., Xia, L., Zhang, S., Jin, K., Li, L., Sun, C., Xia, T., & Chen, G. (2023) · PubMed · doi:10.14670/hh-18-587 · Cited by 9 · see citing works
MicroRNAs in Tumor Endothelial Cells: Regulation, Function and Therapeutic Applications
Gu, Y. J., Becker, M. A., Müller, L., Reuss, K., Umlauf, F., Tang, T., Menger, M. D., & Laschke, M. W. (2023) · Cells · doi:10.3390/cells12131692 · Cited by 8 · see citing works
Circulating non-coding RNAs as a tool for liquid biopsy in solid tumors
Dogan, B. K., Yılmaz, S. S., Izgi, G. N., & Özen, M. (2025) · Epigenomics · doi:10.1080/17501911.2025.2467021 · Cited by 8 · see citing works
Roles of Circular RNAs And Their Interactions With MicroRNAs in Human Disorders
Sun, J. (2018) · Clinical surgery research communications · doi:10.31491/csrc.2018.6.012 · Cited by 8 · see citing works
- Authors
- Bolha, L., Ravnik-Glavač, M., & Glavač, D.
- Affiliations
- University of Ljubljana (SI)
- Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- Corresponding author
- Glavač, Damjan
- Venue
- International Journal of Genomics
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-19
- ISSN
- 2314-436X (ISSN-L)
- 2314-4378
- PMC
- PMC5733622
- OpenAlex
- W2771561127
- Cited by
- 166
- References
- 150
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 22 · 2023: 17 · 2022: 21 · 2021: 21 · 2020: 38 · 2019: 20 · 2018: 15
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Genomics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- circular RNA, circRNA biogenesis, back-splicing, non-coding RNA, microRNA sponge, cap-independent translation, circRNA stability, tumor markers, cancer diagnosis, cancer prognosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review