Cited by 170Circular RNAs in diseasesCancer-related molecular mechanisms researchRNA Research and Splicing

Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers

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Bolha, Luka, Ravnik-Glavač, Metka, Glavač, Damjan·2017·International Journal of Genomics

Abstract

Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) that form covalently closed continuous loop structures, lacking the terminal 5 ′ and 3 ′ ends. CircRNAs are generated in the process of back-splicing and can originate from different genomic regions. Their unique circular structure makes circRNAs more stable than linear RNAs. In addition, they also display insensitivity to ribonuclease activity. Generally, circRNAs function as microRNA (miRNA) sponges and have a regulatory role in transcription and translation. They may be also translated in a cap-independent manner in vivo, to generate specific proteins. In the last decade, next-generation sequencing techniques, especially RNA-seq, have revealed great abundance and also dysregulation of many circRNAs in various diseases, suggesting their involvement in disease development and progression. Regarding their high stability and relatively specific differential expression patterns in tissues and extracellular environment (e.g., body fluids), they are regarded as promising novel biomarkers in cancer. Therefore, we focus this review on describing circRNA biogenesis, function, and involvement in human cancer development and address the potential of circRNAs to be effectively used as novel cancer diagnostic and prognostic biomarkers.

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  1. [100]Jin H. Fang M. Man Z. Wang Y. Liu H. Circular RNA 001569 acts as an oncogene and correlates with aggressive characteristics in hepatocellular carcinoma International Journal of Clinical and Experimental Pathology 2017 10 3 2997 3005

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Authors
Bolha, L., Ravnik-Glavač, M., & Glavač, D.
Affiliations
  • University of Ljubljana (SI)
  • Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Corresponding author
Glavač, Damjan
Venue
International Journal of Genomics
Publisher
Wiley
Published
2017
Volume
2017
Pages
1-19
ISSN
  • 2314-436X (ISSN-L)
  • 2314-4378
OpenAlex
W2771561127
Cited by
166
References
150
Citations by year
2026: 2 · 2025: 10 · 2024: 22 · 2023: 17 · 2022: 21 · 2021: 21 · 2020: 38 · 2019: 20 · 2018: 15
FWCI
1.89
Type
journal article
Language
en
Open access
Locations
  • International Journal of Genomics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
circular RNA, circRNA biogenesis, back-splicing, non-coding RNA, microRNA sponge, cap-independent translation, circRNA stability, tumor markers, cancer diagnosis, cancer prognosis

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