The DOI matches its Crossref record; 187 of the 187 references it cites were found in a registry or an index.
Circular RNA and its mechanisms in disease: From the bench to the clinic
Abstract
The emerging recognition of the functional roles of circular RNAs (circRNAs) has given rise to a new perspective regarding our understanding of cellular physiology and disease pathogenesis. Unlike linear RNAs, circRNAs are covalently closed continuous loops that act as gene regulators in mammals, and their sequence composition determines the mode of circRNA biogenesis. The availability and integrated use of advanced genome analysis platforms have allowed the identification of a large number of these molecules. Their high abundance, stability and evolutionary conservation among species endow circRNAs with numerous potential functions, such as acting as microRNA (miRNA) sponges or binding to RNA-associated proteins to form RNA-protein complexes that regulate gene transcription. Moreover, circRNAs have been shown to be expressed in a tissue-specific manner and in pathological conditions, which has stimulated significant interest in their role in human disease and cancer. In this concise review, we outline the characteristics, functions and mechanisms of action of circRNAs as well as their involvement in different diseases. Although their exact roles and mechanisms of gene regulation remain to be clarified, circRNAs have potential applications as disease biomarkers and novel therapeutic targets.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
3 retracted
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family
Chen, L., Zhang, S., Wu, J., Cui, J., Zhong, L., Zeng, L., & Ge, S. (2017) · Oncogene · doi:10.1038/onc.2017.89 · Cited by 392
RetractedYu, L., Gong, X., Sun, L., Zhou, Q., Lu, B., & Zhu, L. (2016) · PLOS ONE · doi:10.1371/journal.pone.0158347 · Cited by 356
RetractedRETRACTED ARTICLE: Circular RNA 0000096 affects cell growth and migration in gastric cancer
Li, P., Chen, H., Chen, S., Mo, X., Li, T., Xiao, B., Yu, R., & Guo, J. (2017) · British Journal of Cancer · doi:10.1038/bjc.2016.451 · Cited by 227
RetractedSiegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
Long non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654
Non-coding RNAs in human disease
Esteller, M. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3074 · Cited by 4,825
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388
circRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083
Cited by
Yang, L., Han, B., Zhang, Z., Wang, S., Bai, Y., Zhang, Y., Tang, Y., Du, L., Xu, L., Wu, F., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.045765 · Cited by 376
Self-citationThe pro-metastasis effect of circANKS1B in breast cancer
Zeng, K., He, B., Yang, B. B., Xu, T., Chen, X., Xu, M., Liu, X., Sun, H., Pan, Y., & Wang, S. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0914-x · Cited by 319
Non-coding RNAs in depression: Promising diagnostic and therapeutic biomarkers
Shi, Y., Wang, Q., Song, R., Kong, Y., & Zhang, Z. (2021) · eBioMedicine · doi:10.1016/j.ebiom.2021.103569 · Cited by 79
Shi, Y., Song, R., Wang, Z., Zhang, H., Zhu, J., Yue, Y., Zhao, Y., & Zhang, Z. (2021) · eBioMedicine · doi:10.1016/j.ebiom.2021.103337 · Cited by 65
Functions of Circular RNA in Human Diseases and Illnesses
Gu, A., Jaijyan, D. K., Yang, S., Zeng, M., Pei, S., & Zhu, H. (2023) · Non-Coding RNA · doi:10.3390/ncrna9040038 · Cited by 65
Metadata
- Authors
- Han, B., Chao, J., & Yao, H.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 187
- Pages
- 31-44
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2791173369
- Cited by
- 788
- References
- 187
- FWCI
- 29.74
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Circular RNA and its mechanisms in disease: From the bench to the clinic. https://app.cochat.ai/papers/10.1016/j.pharmthera.2018.01.010
- The paper
- Han, B., Chao, J., & Yao, H. (2018). Circular RNA and its mechanisms in disease: From the bench to the clinic. Pharmacology & Therapeutics. https://doi.org/10.1016/j.pharmthera.2018.01.010
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
