Cited by 422Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeuroscience and Neuropharmacology Research

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The neurocircuitry of addiction: an overview

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Feltenstein, M W, See, R E·2008·British Journal of Pharmacology

DOI 10.1038/bjp.2008.51PMC PMC2442446

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Abstract

Drug addiction presents as a chronic relapsing disorder characterized by persistent drug-seeking and drug-taking behaviours. Given the significant detrimental effects of this disease both socially and economically, a considerable amount of research has been dedicated to understanding a number of issues in addiction, including behavioural and neuropharmacological factors that contribute to the development, loss of control and persistence of compulsive addictive behaviours. In this review, we will give a broad overview of various theories of addiction, animal models of addiction and relapse, drugs of abuse, and the neurobiology of drug dependence and relapse. Although drugs of abuse possess diverse neuropharmacological profiles, activation of the mesocorticolimbic system, particularly the ventral tegmental area, nucleus accumbens, amygdala and prefrontal cortex via dopaminergic and glutamatergic pathways, constitutes a common pathway by which various drugs of abuse mediate their acute reinforcing effects. However, long-term neuroadaptations in this circuitry likely underlie the transition to drug dependence and cycles of relapse. As further elucidated in more comprehensive reviews of various subtopics on addiction in later sections of this special issue, it is anticipated that continued basic neuroscience research will aid in the development of effective therapeutic interventions for the long-term treatment of drug-dependent individuals.

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Authors: Feltenstein, M. W., & See, R. E.
Affiliations: Medical University of South Carolina (US)
Corresponding author: Feltenstein, M W
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2008-05
Volume: 154
Issue: 2
Pages: 261-274
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1038/bjp.2008.51
PMC: PMC2442446
OpenAlex: W1867555087
Cited by: 421
References: 265
Citations by year: 2026: 8 · 2025: 14 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 18 · 2020: 16 · 2019: 21 · 2018: 19 · 2017: 18 · 2016: 28 · 2015: 22 · 2014: 28 · 2013: 41 · 2012: 40
FWCI: 3.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 273 d)
Locations: British Journal of Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1c06rr015455-01a1, DA016511, DA015369)
National Institute on Drug Abuse (DA016511, DA07288, R01DA010462, DA 015369, P50DA015369, P50DA016511, DA010462, T32DA007288)
National Center for Research Resources (C06 RR-015455)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: drug addiction, neurocircuitry, relapse, mesocorticolimbic system, ventral tegmental area, nucleus accumbens, amygdala, prefrontal cortex, dopaminergic pathways, glutamatergic pathways, neural adaptation, animal models of addiction, drugs of abuse, addiction theory, compulsive drug seeking
MeSH terms: Animals, Behavior, Animal, Central Nervous System Agents, Dopamine, Humans, Limbic System, Models, Psychological, Neural Pathways, Recurrence, Substance Withdrawal Syndrome, Behavior, Addictive, Neurotransmitter Agents, Glutamic Acid, Substance-Related Disorders, Models, Animal

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