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Cited by 102Cancer survivorship and careChildhood Cancer Survivors' Quality of LifeCardiac Health and Mental Health

Fear of recurrence and its impact on quality of life in patients with hematological cancers in the course of allogeneic hematopoietic SCT

Sarkar, S, Scherwath, A, Schirmer, L, Schulz-Kindermann, F, Neumann, K, Kruse, M, Dinkel, A, Kunze, S +4 more·2014·Bone Marrow Transplantation
DOI 10.1038/bmt.2014.139
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Abstract

We examined the course and the prevalence of a high fear of cancer recurrence (FCR) in patients undergoing allogeneic PBSC transplantation (hematopoietic SCT (HSCT)) before HSCT (N=239), 100 days after (n=150, and 12 months after allogeneic HSCT (n=102). The Fear of Progression Questionnaire-Short Form (FoP-Q-SF), the EORTC Quality of Life Questionnaire, and the Hospital Anxiety and Depression Scale were used. Pre-HSCT 36% of patients, 100 days after HSCT 24% of patients, and 1 year after HSCT 23% of patients fulfilled the criteria for high FCR (FoP-Q-SF cutoff=34). Being married (b=2.76, P=0.026), female gender (b=4.45, P<0.001) and depression (b=4.44, P<0.001) were significantly associated with FCR at baseline. One hundred days after HSCT, depression significantly predicted FCR (b=6.46, P<0.001). One year following HSCT, female gender (b=6.61, P=0.008) and higher depression were (b=4.88, P=0.004) significant predictors for FCR. Over the three assessment points, patients with high FCR had a significantly lower quality of life compared to patients with low FCR in physical functioning (P=0.019), role functioning (P=0.003), emotional functioning (P<0.001), cognitive functioning (P=0.003), social functioning (P<0.001) and global quality of life (P<0.001). Our data provide evidence that FCR is a prevalent problem in patients with hematological malignancies and has a significant adverse impact on health-related quality of life.

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Authors
Sarkar, S., Scherwath, A., Schirmer, L., Schulz-Kindermann, F., Neumann, K., Kruse, M., Dinkel, A., Kunze, S., Balck, F., Kröger, N., Koch, U., & Mehnert, A.
Affiliations
  • University Medical Center Hamburg-Eppendorf (DE)
  • Charité – Universitätsmedizin Berlin (DE)
  • Medizinische Hochschule Hannover (DE)
  • TUM Klinikum (DE)
  • University Hospital Carl Gustav Carus (DE)
  • University Hospital Leipzig (DE)
Corresponding author
Sarkar, S
ORCID
Venue
Bone Marrow Transplantation
Publisher
Springer Science and Business Media LLC
Published
2014-07-07
Volume
49
Issue
9
Pages
1217-1222
ISSN
  • 0268-3369 (ISSN-L)
  • 1476-5365
DOI
10.1038/bmt.2014.139
OpenAlex
W2048000402
Cited by
102
References
36
Citations by year
2026: 4 · 2025: 11 · 2024: 10 · 2023: 10 · 2022: 13 · 2021: 11 · 2020: 13 · 2019: 10 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 1
FWCI
2.58
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Bone Marrow Transplantation (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Funders
José Carreras Leukämie-Stiftung
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
fear of cancer recurrence, allogeneic hematopoietic stem cell transplantation, hematologic malignancies, health-related quality of life, depression, anxiety, gender differences, marital status, physical function, role functioning, emotional functioning, cognitive function, social functioning
MeSH terms
Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Prospective Studies, Quality of Life, Transplantation, Homologous, Hematopoietic Stem Cell Transplantation, Transplantation Conditioning, Hematologic Neoplasms, Young Adult

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