The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
PUMA- and Bax-induced autophagy contributes to apoptosis
Open accessAbstract
The p53-inducible BH3-only protein PUMA is a key mediator of p53-dependent apoptosis, and PUMA has been shown to function by activating Bax and mitochondrial outer membrane permeabilization. In this study, we describe an ability of PUMA to induce autophagy that leads to the selective removal of mitochondria. This function of PUMA depends on Bax/Bak and can be reproduced by overexpression of Bax. The induction of autophagy coincides with cytochrome c release, and taken together the results suggest that PUMA functions through Bax to induce mitochondrial autophagy in response to mitochondrial perturbations. Surprisingly, inhibition of PUMA or Bax-induced autophagy dampens the apoptotic response, suggesting that under some circumstances the selective targeting of mitochondria for autophagy can enhance apoptosis.
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1 retracted
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Cited by
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Autophagy and apoptosis: where do they meet?
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Metadata
- Authors
- Yee, K. S., Wilkinson, S., James, J., Ryan, K. M., & Vousden, K. H.
- Venue
- Cell Death & Differentiation
- Published
- 2009-03-20
- Volume
- 16
- Issue
- 8
- Pages
- 1135-1145
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W1969370465
- Cited by
- 236
- References
- 12
- FWCI
- 15.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yee, K. S., Wilkinson, S., James, J., Ryan, K. M., & Vousden, K. H. (2009). PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death & Differentiation. https://doi.org/10.1038/cdd.2009.28
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
