p53 and metabolism

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works

Development by Self-Digestion

Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,671 · see citing works

Blinded by the Light: The Growing Complexity of p53

Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163 · see citing works

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820 · see citing works

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · see citing works

A model for p53-induced apoptosis

Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500 · see citing works

Cancer cell metabolism: warburg and beyond

Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452 · see citing works

Tumor cell metabolism: cancer's Achilles' heel

Kroemer, G., & Pouyssegur, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.005 · Cited by 2,337 · see citing works

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311 · see citing works

p53 in health and disease

Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,275 · see citing works

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

Hardie, D. G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2249 · Cited by 2,207 · see citing works

Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

Hennessy, B. T., Smith, D. L., Ram, P. T., Lu, Y., & Mills, G. B. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1902 · Cited by 2,183 · see citing works

Autophagosome formation: core machinery and adaptations

Xie, Z., & Klionsky, D. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1102 · Cited by 2,165 · see citing works

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124 · see citing works

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116 · see citing works

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019 · see citing works

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G., Mukherjee, C., Shi, Y., Gélinas, C., Fan, Y., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.06.001 · Cited by 2,013 · see citing works

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001 · see citing works

Role of autophagy in cancer

Mathew, R., Karantza-Wadsworth, V., & White, E. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2254 · Cited by 1,798 · see citing works

Hypoxia, HIF1 and glucose metabolism in the solid tumour

Denko, N. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2468 · Cited by 1,707 · see citing works

p53 Regulates Mitochondrial Respiration

Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006) · Science · doi:10.1126/science.1126863 · Cited by 1,650 · see citing works

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Fantin, V. R., St-Pierre, J., & Leder, P. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.023 · Cited by 1,635 · see citing works

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., & Thompson, C. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.027 · Cited by 1,619 · see citing works

A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

Bonnet, S., Archer, S. L., Allalunis‐Turner, J., Haromy, A., Beaulieu, C., Thompson, R. B., Lee, C. T., Lopaschuk, G. D., Puttagunta, L., Bonnet, S. B., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.020 · Cited by 1,530 · see citing works

DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis

Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P. R., Gasco, M., Garrone, O., Crook, T., & Ryan, K. M. (2006) · Cell · doi:10.1016/j.cell.2006.05.034 · Cited by 1,380 · see citing works

Cooperation and Competition in the Evolution of ATP-Producing Pathways

Pfeiffer, T., Schuster, S., & Bonhoeffer, S. (2001) · Science · doi:10.1126/science.1058079 · Cited by 1,365 · see citing works

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

Shimizu, S., Kanaseki, T., Mizushima, N., Mizuta, T., Arakawa-Kobayashi, S., Thompson, C. B., & Tsujimoto, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1192 · Cited by 1,358 · see citing works

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · see citing works

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

Rampino, N. J., Yamamoto, H., Ionov, Y., Li, Y., Sawai, H., Reed, J. C., & Perucho, M. (1997) · Science · doi:10.1126/science.275.5302.967 · Cited by 1,326 · see citing works

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

Olive, K. P., Tuveson, D. A., Ruhe, Z. C., Yin, B., Willis, N. A., Bronson, R. T., Crowley, D., & Jacks, T. (2004) · Cell · doi:10.1016/j.cell.2004.11.004 · Cited by 1,308 · see citing works

The coordinate regulation of the p53 and mTOR pathways in cells

Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235 · see citing works

Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8

Yu, L., Alva, A. S., Su, H. C., Dutt, P., Freundt, E. C., Welsh, S. J., Baehrecke, E. H., & Lenardo, M. J. (2004) · Science · doi:10.1126/science.1096645 · Cited by 1,220 · see citing works

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

Stott, F. J., Bates, S., James, M. C., McConnell, B. B., Starborg, M., Brookes, S., Palmero, I., Ryan, K. M., Hara, E., Vousden, K. H., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.5001 · Cited by 1,165 · see citing works

Regulation of autophagy by cytoplasmic p53

Tasdemir, E., Maiuri, M. C., Galluzzi, L., Vitale, I., Djavaheri-Mergny, M., D'Amelio, M., Criollo, A., Morselli, E., Zhu, C., Harper, F., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1730 · Cited by 1,132 · see citing works

The antioxidant function of the p53 tumor suppressor

Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,110 · see citing works

Tumor suppressors and cell metabolism: a recipe for cancer growth

Jones, R. G., & Thompson, C. B. (2009) · Genes & Development · doi:10.1101/gad.1756509 · Cited by 1,085 · see citing works

Autophagy mediates the mitotic senescence transition

Young, A. R. J., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, J. F. J., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F. M., et al. (2009) · Genes & Development · doi:10.1101/gad.519709 · Cited by 1,078 · see citing works

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome

Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.006 · Cited by 1,069 · see citing works

Brick by brick: metabolism and tumor cell growth

DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.02.003 · Cited by 1,018 · see citing works

Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

Buzzai, M., Jones, R. G., Amaravadi, R. K., Lum, J. J., DeBerardinis, R. J., Zhao, F., Viollet, B., & Thompson, C. B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4447 · Cited by 923 · see citing works

Regulation of PTEN Transcription by p53

Stambolic, V., MacPherson, D. P., Sas, D., Lin, Y., Snow, B., Jang, Y., Benchimol, S., & Mak, T. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00323-9 · Cited by 913 · see citing works

A crucial role for adipose tissue p53 in the regulation of insulin resistance

Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2014 · Cited by 891 · see citing works

Autophagy in metazoans: cell survival in the land of plenty

Lum, J., DeBerardinis, R., & Thompson, C. (2005) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1660 · Cited by 842 · see citing works

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

An, W. G., Kanekal, M., Simon, M. C., Maltepe, E., Blagosklonny, M. V., & Neckers, L. Μ. (1998) · Nature · doi:10.1038/32925 · Cited by 820 · see citing works

Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

Mathupala, S. P., Ko, Y. H., & Pedersen, P. L. (2006) · Oncogene · doi:10.1038/sj.onc.1209603 · Cited by 766 · see citing works

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V., & Chumakov, P. M. (2004) · Science · doi:10.1126/science.1095569 · Cited by 731 · see citing works

The Tumor Suppressor p53 Down-Regulates Glucose Transporters GLUT1 and GLUT4 Gene Expression

Bar‐Yoseph, F., Armoni, M., & Karnieli, E. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-0846 · Cited by 728 · see citing works

Central role of p53 in the suntan response and pathologic hyperpigmentation

Cui, R., Widlund, H. R., Feige, E., Lin, J. Y., Wilensky, D. L., Igras, V. E., D'Orazio, J., Fung, C. Y., Schanbacher, C. F., Granter, S. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.045 · Cited by 657 · see citing works

The ARF/p53 pathway.

Sherr, C. J., & Weber, J. D. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00038-6 · Cited by 654 · see citing works

Glycolytic Enzymes Can Modulate Cellular Life Span

Kondoh, H., Lleonart, M. E., Gil, J., Wang, J., Degan, P., Peters, G., Martinez, D., Carnero, A., & Beach, D. (2005) · Cancer Research · doi:10.1158/0008-5472.177.65.1 · Cited by 647 · see citing works

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

Kawauchi, K., Araki, K., Tobiume, K., & Tanaka, N. (2008) · Nature Cell Biology · doi:10.1038/ncb1724 · Cited by 635 · see citing works

The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

Feng, Z., Hu, W., de Stanchina, E., Teresky, A. K., Jin, S., Lowe, S., & Levine, A. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4149 · Cited by 633 · see citing works

The interplay between MYC and HIF in cancer

Dang, C. V., Kim, J., Gao, P., & Yustein, J. T. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2274 · Cited by 614 · see citing works

Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in Drosophila

Berry, D. L., & Baehrecke, E. H. (2007) · Cell · doi:10.1016/j.cell.2007.10.048 · Cited by 602 · see citing works

A subset of p53-deficient embryos exhibit exencephaly

Sah, V. P., Attardi, L. D., Mulligan, G., Williams, B. O., Bronson, R. T., & Jacks, T. (1995) · Nature Genetics · doi:10.1038/ng0695-175 · Cited by 579 · see citing works

Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells

Feron, O. (2009) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2009.06.025 · Cited by 559 · see citing works

p53 Regulates Hematopoietic Stem Cell Quiescence

Liu, Y., Elf, S. E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J. M., Deblasio, A., Menendez, S., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.11.006 · Cited by 547 · see citing works

Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis

Robey, R. B., & Hay, N. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.11.010 · Cited by 535 · see citing works

Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

Bourdon, A., Minai, L., Serre, V., Jaïs, J., Sarzi, E., Aubert, S., Chrétien, D., de Lonlay, P., Paquis‐Flucklinger, V., Arakawa, H., et al. (2007) · Nature Genetics · doi:10.1038/ng2040 · Cited by 530 · see citing works

Coping with stress: multiple ways to activate p53

Horn, H. F., & Vousden, K. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210263 · Cited by 522 · see citing works

Roles of p53, MYC and HIF-1 in regulating glycolysis–the seventh hallmark of cancer

Yeung, S. J., Pan, J., & Lee, M.-H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8224-x · Cited by 514 · see citing works

p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington’s Disease

Bae, B.-I., Xu, H., Igarashi, S., Fujimuro, M., Agrawal, N., Taya, Y., Hayward, S. D., Moran, T. H., Montell, C., Ross, C. A., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.005 · Cited by 480 · see citing works

Nucleolus, Ribosomes, and Cancer

Montanaro, L., Treré, D., & Derenzini, M. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070752 · Cited by 456 · see citing works

p53 regulates maternal reproduction through LIF

Hu, W., Feng, Z., Teresky, A. K., & Levine, A. J. (2007) · Nature · doi:10.1038/nature05993 · Cited by 446 · see citing works

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

Trinei, M., Giorgio, M., Cicalese, A., Barozzi, S., Ventura, A., Migliaccio, E., Milia, E., Padura, I. M., Raker, V. A., Maccarana, M., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205513 · Cited by 436 · see citing works

Control of autophagy by oncogenes and tumor suppressor genes

Maiuri, M. C., Tasdemir, E., Criollo, A., Morselli, E., Vicencio, J. M., Carnuccio, R., & Kroemer, G. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.131 · Cited by 433 · see citing works

GermlineTP53 mutations and Li-Fraumeni syndrome

Varley, J. M. (2003) · Human Mutation · doi:10.1002/humu.10185 · Cited by 429 · see citing works

Akt-dependent transformation: there is more to growth than just surviving

Plas, D. R., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1209097 · Cited by 427 · see citing works

Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function

Jones, N. C., Lynn, M. L., Gaudenz, K., Sakai, D., Aoto, K., Rey, J., Glynn, E. F., Ellington, L. R., Du, C., Dixon, J., et al. (2008) · Nature Medicine · doi:10.1038/nm1725 · Cited by 426 · see citing works

p53 suppresses the self-renewal of adult neural stem cells

Meletis, K., Wirta, V., Hede, S., Nistér, M., Lundeberg, J., & Frisén, J. (2005) · Development · doi:10.1242/dev.02208 · Cited by 414 · see citing works

The PTEN, Mdm2, p53 tumor suppressor–oncoprotein network

Mayo, L. D., & Donner, D. B. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02166-7 · Cited by 408 · see citing works

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

Hussain, S. P., Amstad, P., He, P., Robles, A. I., Lupold, S. E., Kaneko, I., Ichimiya, M., Sengupta, S., Mechanic, L. E., Okamura, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-2287-2 · Cited by 385 · see citing works

Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects

McGowan, K. A., Li, J. Z., Park, C. Y., Beaudry, V. G., Tabor, H. K., Sabnis, A. J., Zhang, W., Fuchs, H., de Angelis, M. H., Myers, R., et al. (2008) · Nature Genetics · doi:10.1038/ng.188 · Cited by 363 · see citing works

p53 Suppresses the Nrf2-dependent Transcription of Antioxidant Response Genes

Faraonio, R., Vergara, P., Marzo, D. D., Pierantoni, G. M., Napolitano, M., Russo, T., & Cimino, F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605707200 · Cited by 350 · see citing works

Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions

Macip, S., Igarashi, M., Berggren, P., Yu, J., Lee, S. W., & Aaronson, S. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8576-8585.2003 · Cited by 331 · see citing works

Hypoxia Links ATR and p53 through Replication Arrest

Hammond, E. M., Denko, N. C., Dorie, M. J., Abraham, R. T., & Giaccia, A. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1834-1843.2002 · Cited by 321 · see citing works

Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways

Levine, A. J., Feng, Z., Mak, T. W., You, H., & Jin, S. (2006) · Genes & Development · doi:10.1101/gad.1363206 · Cited by 321 · see citing works

Mutant p53 protein localized in the cytoplasm inhibits autophagy

Morselli, E., Tasdemir, E., Maiuri, M. C., Galluzzi, L., Kepp, O., Criollo, A., Vicencio, J. M., Soussi, T., & Kroemer, G. (2008) · Cell Cycle · doi:10.4161/cc.7.19.6751 · Cited by 279 · see citing works

Stimulation of autophagy by the p53 target gene Sestrin2

Maiuri, M. C., Malik, S. A., Morselli, E., Kepp, O., Criollo, A., Mouchel, P., Carnuccio, R., & Kroemer, G. (2009) · Cell Cycle · doi:10.4161/cc.8.10.8498 · Cited by 278 · see citing works

Activation of AMP-activated Protein Kinase Induces p53-dependent Apoptotic Cell Death in Response to Energetic Stress

Okoshi, R., Ozaki, T., Yamamoto, H., Ando, K., Koida, N., Ono, S., Koda, T., Kamijo, T., Nakagawara, A., & Kizaki, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705232200 · Cited by 276 · see citing works

Transcriptional Activation of the Human Glutathione Peroxidase Promoter by p53

Tan, M., Li, S., Swaroop, M., Guan, K., Oberley, L. W., & Sun, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.12061 · Cited by 251 · see citing works

Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses

Yoon, K., Nakamura, Y., & Arakawa, H. (2004) · Journal of Human Genetics · doi:10.1007/s10038-003-0122-3 · Cited by 236 · see citing works

PUMA- and Bax-induced autophagy contributes to apoptosis

Yee, K. S. Y., Wilkinson, S., James, J., Ryan, K. M., & Vousden, K. H. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.28 · Cited by 235 · see citing works

Glucose Catabolism in Cancer Cells

Mathupala, S. P., Heese, C., & Pedersen, P. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22776 · Cited by 231 · see citing works

Glucose Catabolism in Cancer Cells.

Mathupala, S. P., Rempel, A., & Pedersen, P. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16918 · Cited by 229 · see citing works

Metabolic transformation in cancer

Tennant, D. A., Durán, R. V., Boulahbel, H., & Gottlieb, E. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp070 · Cited by 226 · see citing works

p53‐dependent neuronal cell death in a DJ‐1‐deficient zebrafish model of Parkinson's disease

Bretaud, S., Allen, C. E., Ingham, P. W., & Bandmann, O. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04291.x · Cited by 219 · see citing works

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans

Kang, H.-J., Feng, Z., Sun, Y., Atwal, G., Murphy, M. E., Rebbeck, T. R., Rosenwaks, Z., Levine, A. J., & Hu, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904280106 · Cited by 193 · see citing works

Loss of p53 enhances catalytic activity of IKKβ through O-linked β-N-acetyl glucosamine modification

Kawauchi, K., Araki, K., Tobiume, K., & Tanaka, N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813210106 · Cited by 193 · see citing works

The dark side of a tumor suppressor: anti-apoptotic p53

Jänicke, R. U., Sohn, D., & Schulze‐Osthoff, K. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.33 · Cited by 187 · see citing works

Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis

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LKB1 Is Recruited to the p21/WAF1 Promoter by p53 to Mediate Transcriptional Activation

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Cyclin-dependent Kinases Phosphorylate p73 at Threonine 86 in a Cell Cycle-dependent Manner and Negatively Regulate p73

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Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis

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Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy

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DNA damage response and metabolic disease

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Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation

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Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics

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Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

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The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.

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The Role of p53 in Metabolic Regulation

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A role for the Warburg effect in preimplantation embryo development: Metabolic modification to support rapid cell proliferation

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The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase

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Chaperone-Mediated Autophagy Is Required for Tumor Growth

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Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging.

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Cystathionine Beta-Synthase (CBS) Contributes to Advanced Ovarian Cancer Progression and Drug Resistance

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Training-Induced Changes in Mitochondrial Content and Respiratory Function in Human Skeletal Muscle

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p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

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Targeting Tumor Suppressor p53 for Cancer Therapy: Strategies, Challenges and Opportunities

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Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

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Cancer metabolism: Key players in metabolic reprogramming

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Revisited Metabolic Control and Reprogramming Cancers by Means of the Warburg Effect in Tumor Cells

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Evolutionary biology of high-risk multiple myeloma

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Basal Cell Carcinomas Arise from Hair Follicle Stem Cells in Ptch1+/− Mice

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Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes

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Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors

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Metabolic Dependencies in RAS -Driven Cancers

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Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance

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Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress

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Metabolic host responses to infection by intracellular bacterial pathogens

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Detection of precancerous gastric lesions and gastric cancer through exhaled breath

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Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

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The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels

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Detection of volatile organic compounds (VOCs) from exhaled breath as noninvasive methods for cancer diagnosis

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Beyond Warburg effect – dual metabolic nature of cancer cells

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Tumor suppressor p53 and its mutants in cancer metabolism

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The latest research progress on P53 and tumor metabolism

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Taking up the reins of power: metabolic functions of p53

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Metabolic regulation by p53: Implications for cancer therapy

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Emerging Roles of the Tumor Suppressor p53 in Metabolism

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