NER and HR pathways act sequentially to promote UV-C-induced germ cell apoptosis in Caenorhabditis elegans
Open accessAbstract
Ultraviolet (UV) radiation-induced DNA damage evokes a complex network of molecular responses, which culminate in DNA repair, cell cycle arrest and apoptosis. Here, we provide an in-depth characterization of the molecular pathway that mediates UV-C-induced apoptosis of meiotic germ cells in the nematode Caenorhabditis elegans. We show that UV-C-induced DNA lesions are not directly pro-apoptotic. Rather, they must first be recognized and processed by the nucleotide excision repair (NER) pathway. Our data suggest that NER pathway activity transforms some of these lesions into other types of DNA damage, which in turn are recognized and acted upon by the homologous recombination (HR) pathway. HR pathway activity is in turn required for the recruitment of the C. elegans homolog of the yeast Rad9-Hus1-Rad1 (9-1-1) complex and activation of downstream checkpoint kinases. Blocking either the NER or HR pathway abrogates checkpoint pathway activation and UV-C-induced apoptosis. Our results show that, following UV-C, multiple DNA repair pathways can cooperate to signal to the apoptotic machinery to eliminate potentially hazardous cells.
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In these conditions, repair may not be completed and ssDNA extension may both activate the checkpoint and channel the problematic lesion to another repair pathway such as recombination.
“In these conditions, repair may not be completed and the extension of the ssDNA region may meet two purposes: activating the checkpoint response and channeling the problematic lesion to a different repair pathway (e.g., recombination) [66–68].”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [68]
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Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317 · see citing works
Molecular mechanism of nucleotide excision repair
de Laat, W. L., Jaspers, N. G. J., & Hoeijmakers, J. H. J. (1999) · Genes & Development · doi:10.1101/gad.13.7.768 · Cited by 1,122 · see citing works
DNA damage checkpoints: from initiation to recovery or adaptation
Bartek, J., & Lukas, J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.009 · Cited by 784 · see citing works
Dernburg, A. F., McDonald, K. L., Moulder, G. L., Barstead, R. J., Dresser, M. E., & Villeneuve, A. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81481-6 · Cited by 770 · see citing works
Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer
Vilenchik, M. M., & Knudson, A. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135498100 · Cited by 717 · see citing works
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
Lee, J.-H., & Paull, T. T. (2007) · Oncogene · doi:10.1038/sj.onc.1210872 · Cited by 545 · see citing works
Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins
Petukhova, G. D., Stratton, S. A., & Sung, P. (1998) · Nature · doi:10.1038/30037 · Cited by 445 · see citing works
Cancer in xeroderma pigmentosum and related disorders of DNA repair
Cleaver, J. E. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1652 · Cited by 427 · see citing works
The eukaryotic nucleotide excision repair pathway
Costa, R. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.017 · Cited by 373 · see citing works
Nucleotide excision repair in yeast
Prakash, S., & Prakash, L. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00037-3 · Cited by 371 · see citing works
Zou, Y., Liu, Y., Wu, X., & Shell, S. M. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20622 · Cited by 364 · see citing works
Xeroderma Pigmentosum p48 Gene Enhances Global Genomic Repair and Suppresses UV-Induced Mutagenesis
Tang, J. Y., Hwang, B. J., Ford, J. M., Hanawalt, P. C., & Chu, G. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80252-x · Cited by 335 · see citing works
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.Preprint
Wang, X. W., Vermeulen, W., Coursen, J. D., Gibson, M. K., Lupold, S. E., Forrester, K., Xu, G., Elmore, L. W., Yeh, H., Hoeijmakers, J. H. J., et al. (1996) · Genes & Development · doi:10.1101/gad.10.10.1219 · Cited by 311 · see citing works
Base Excision Repair of Oxidative DNA Damage Activated by XPG Protein
Klungland, A., Höss, M., Gunz, D., Constantinou, A., Clarkson, S. G., Doetsch, P. W., Bolton, P. H., Wood, R. D., & Lindahl, T. L. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80172-0 · Cited by 291 · see citing works
Hofmann, E. R., Milstein, S., Boulton, S. J., Ye, M., Hofmann, J., Stergiou, L., Gartner, A., Vidal, M., & Hengartner, M. O. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01262-9 · Cited by 280 · see citing works
Self-citationAlpi, A. F., Pasierbek, P., Gartner, A., & Loidl, J. (2003) · Chromosoma · doi:10.1007/s00412-003-0237-5 · Cited by 238 · see citing works
Missura, M., Buterin, T., Hindges, R., Hübscher, U., Kašpárková, J., Brabec, V., & Naegeli, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.13.3554 · Cited by 195 · see citing works
Gartner, A., Boag, P. R., & Blackwell, T. K. (2008) · WormBook · doi:10.1895/wormbook.1.145.1 · Cited by 192 · see citing works
Chin, G. M., & Villeneuve, A. M. (2001) · Genes & Development · doi:10.1101/gad.864101 · Cited by 161 · see citing works
García‐Muse, T., & Boulton, S. J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600896 · Cited by 161 · see citing works
Homologous DNA Pairing by Human Recombination Factors Rad51 and Rad54
Sigurðsson, S., Komen, S. V., Petukhova, G. D., & Sung, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208004200 · Cited by 149 · see citing works
Death and more: DNA damage response pathways in the nematode C. elegans
Stergiou, L., & Hengartner, M. O. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401340 · Cited by 140 · see citing works
Self-citationHayashi, M., Chin, G. M., & Villeneuve, A. M. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030191 · Cited by 123 · see citing works
DNA nucleotide excision repair-dependent signaling to checkpoint activation
Marini, F., Nardo, T., Giannattasio, M., Minuzzo, M., Stefanini, M., Plevani, P., & Falconi, M. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605446103 · Cited by 114 · see citing works
Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint
Giannattasio, M., Lazzaro, F., Longhese, M. P., Plevani, P., & Muzi‐Falconi, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600051 · Cited by 113 · see citing works
Stergiou, L., Doukoumetzidis, K., Sendoel, A., & Hengartner, M. O. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402115 · Cited by 110 · see citing works
Self-citationStauffer, M. E., & Chazin, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400029200 · Cited by 105 · see citing works
Regulation of the cellular DNA double-strand break response
Cann, K. L., & Hicks, G. G. (2007) · Biochemistry and Cell Biology · doi:10.1139/o07-135 · Cited by 101 · see citing works
Rad54 protein stimulates the postsynaptic phase of Rad51 protein-mediated DNA strand exchange
Solinger, J. A., & Heyer, W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121009898 · Cited by 98 · see citing works
Involvement of Nucleotide Excision and Mismatch Repair Mechanisms in Double Strand Break Repair
Zhang, Y., Rohde, L. H., & Wu, H. (2009) · Current Genomics · doi:10.2174/138920209788488544 · Cited by 93 · see citing works
de Boer, J., & Hoeijmakers, J. H. J. (1999) · Biochimie · doi:10.1016/s0300-9084(99)80045-5 · Cited by 80 · see citing works
Radiation dose-rate effects, endogenous DNA damage, and signaling resonance
Vilenchik, M. M., & Knudson, A. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607995103 · Cited by 70 · see citing works
Komen, S. V., Petukhova, G. D., Sigurðsson, S., & Sung, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205864200 · Cited by 65 · see citing works
Tissue specific mutagenic and carcinogenic responses in NER defective mouse models
Wijnhoven, S., Hoogervorst, E. M., de Waard, H., van der Horst, G. T. J., & STEEG, H. V. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.12.018 · Cited by 63 · see citing works
Boyd, W. A., Crocker, T. L., Rodriguez, A. M., Leung, M. C. K., Lehmann, D. W., Freedman, J. H., Houten, B. V., & Meyer, J. N. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.10.008 · Cited by 54 · see citing works
Nucleotide excision repair in differentiated cells
van der Wees, C. G. C., Jansen, J. G., Vrieling, H., van der Laarse, A., van Zeeland, A., & Mullenders, L. H. F. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.06.005 · Cited by 35 · see citing works
Carvalho, H., Ortolan, T. G., dePaula, T., Leite, R. A., Weinlich, R., Amarante-Mendes, G. P., & Menck, C. F. M. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.003 · Cited by 16 · see citing works
Komatsu, Y., Tsujino, T., Suzuki, T., Nikaido, O., & Ohtsuka, E. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.19.3889 · Cited by 15 · see citing works
Toussaint, M., Wellinger, R. J., & Conconi, A. (2010) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2010.03.013 · Cited by 7 · see citing works
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Biomarkers of platinum resistance in ovarian cancer: what can we use to improve treatment
van Zyl, B., Tang, D., & Bowden, N. A. (2018) · Endocrine Related Cancer · doi:10.1530/erc-17-0336 · Cited by 228 · see citing works
Woglar, A., & Villeneuve, A. M. (2018) · Cell · doi:10.1016/j.cell.2018.03.066 · Cited by 132 · see citing works
Vermezovic, J., Stergiou, L., Hengartner, M. O., & di Fagagna, F. D. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.69 · Cited by 76 · see citing works
Self-citationSPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair
Nottke, A. C., Beese‐Sims, S. E., Pantalena, L. F., Reinke, V., Shi, Y., & Colaiácovo, M. P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102298108 · Cited by 76 · see citing works
DNA repair, recombination, and damage signaling
Gartner, A., & Engebrecht, J. (2021) · Genetics · doi:10.1093/genetics/iyab178 · Cited by 73 · see citing works
“Consistent with DSB processing being an integral part of checkpoint signaling, strains mutant for the MRE-11 and RAD-54 recombination enzymes are also defective for checkpoint-induced apoptosis (Stergiou et al. 2011).”
BackgroundYin, Y., & Smolikove, S. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00055-13 · Cited by 64 · see citing works
Treitz, C., Cassidy, L., Höckendorf, A., Leippe, M., & Tholey, A. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.09.027 · Cited by 56 · see citing works
Lawrence, K. S., Tapley, E. C., Cruz, V. E., Li, Q., Aung, K., Hart, K. C., Schwartz, T., Starr, D. A., & Engebrecht, J. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201604112 · Cited by 54 · see citing works
“We also examined the loading and removal of replication protein A (RPA; RPA-1::YFP; Stergiou et al., 2011), which is loaded onto single-stranded DNA during replication and repair and is exchanged for RAD-51 during HR (Sleeth et al., 2007).”
BackgroundMethodJanisiw, E., Stritto, M. R. D., Jantsch, V., & Silva, N. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007653 · Cited by 58 · see citing works
Saito, T. T., Mohideen, F., Meyer, K., Harper, J. W., & Colaiácovo, M. P. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002888 · Cited by 53 · see citing works
“Transgenes: opIs263 [Prpa-1::RPA-1-YFP::39UTR] [68].”
Nucleotide Excision Repair inCaenorhabditis elegans
Lans, H., & Vermeulen, W. (2011) · Molecular Biology International · doi:10.4061/2011/542795 · Cited by 50 · see citing works
“Apoptosis induction furthermore involves the same checkpoint signaling proteins that are also involved after ionizing radiation, such as orthologs of the 9-1-1 signaling complex, the PI3 kinases ATM and ATR and p53 [72].”
BackgroundLEM-3 – A LEM Domain Containing Nuclease Involved in the DNA Damage Response in C. elegans
Dittrich, C. M., Kratz, K., Sendoel, A., Gruenbaum, Y., Jiricny, J., & Hengartner, M. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0024555 · Cited by 50 · see citing works
“We have already shown that RAD-54 forms foci following IR, likely marking sites of active repair [30].”
BackgroundSelf-citationHonnen, S. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-1944-7 · Cited by 50 · see citing works
Mind the gap: keeping UV lesions in check
Novarina, D., Amara, F., Lazzaro, F., Plevani, P., & Muzi-Falconi, M. (2011) · DNA Repair · doi:10.1016/j.dnarep.2011.04.030 · Cited by 43 · see citing works
Herbette, M., Mercier, M., Michal, F., Cluet, D., Burny, C., Yvert, G., Robert, V. J. P., & Palladino, F. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.07.007 · Cited by 41 · see citing works
Girard, C., Roelens, B., Zawadzki, K. A., & Villeneuve, A. M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719029115 · Cited by 41 · see citing works
Checchi, P. M., Lawrence, K. S., Van, M. V., Larson, B. J., & Engebrecht, J. (2014) · Genetics · doi:10.1534/genetics.114.164152 · Cited by 37 · see citing works
“COSA-1:: GFP worms were obtained from Anne Villeneuve (Yokoo et al. 2012); the LGV lacO integrant was obtained from Paul Sternberg (Gonzalez-Serricchio and Sternberg 2006); the LacO on X strains was derived from lines from Christian Frokjaer-Jensen and Erik Jorgensen; strains harboring the transgene RPA-1::YFP (opls26…”
MethodReplication stress promotes cell elimination by extrusion
Dwivedi, V. K., Pardo-Pastor, C., Droste, R., Kong, J. N., Tucker, N., Denning, D. P., Rosenblatt, J., & Horvitz, H. R. (2021) · Nature · doi:10.1038/s41586-021-03526-y · Cited by 37 · see citing works
Eberhard, R., Stergiou, L., Hofmann, E. R., Hofmann, J., Haenni, S., Teo, Y., Furger, A., & Hengartner, M. O. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003943 · Cited by 36 · see citing works
“In addition to its role in meiotic recombination, RAD-54 is also recruited to repair foci when DNA has been damaged exogenously [44,45].”
BackgroundSelf-citationGao, J., Kim, H., Elia, A. E. H., Elledge, S. J., & Colaiácovo, M. P. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005029 · Cited by 38 · see citing works
Caenorhabditis elegans as a Model to Study Aging and Photoaging
Jeayeng, S., Thongsroy, J., & Chuaijit, S. (2024) · Biomolecules · doi:10.3390/biom14101235 · Cited by 29 · see citing works
“Specifically, UVC-induced DNA lesions are processed by the NER pathway, which subsequently activates the homologous recombination (HR) pathway and down-stream checkpoint kinases, leading to apoptosis in meiotic germ cells [81].”
BackgroundIntermittent Stem Cell Cycling Balances Self-Renewal and Senescence of the C. elegans Germ Line
Cinquin, A., Chiang, M., Paz, A., Hallman, S., Yuan, O., Vysniauskaite, I., Fowlkes, C. C., & Cinquin, O. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005985 · Cited by 25 · see citing works
Chung, G., Rose, A. M., Petalcorin, M. I. R., Martin, J. S., Kessler, Z., Sanchez-Pulido, L., Ponting, C. P., Yanowitz, J. L., & Boulton, S. J. (2015) · Genes & Development · doi:10.1101/gad.266056.115 · Cited by 28 · see citing works
“5G) due to massive apoptosis of germline nuclei (Stergiou et al. 2011), and all of the eggs that are laid fail to hatch (Fig.”
BackgroundC. elegans CEP-1/p53 and BEC-1 Are Involved in DNA Repair
Hoffman, S., Martin, D., Meléndez, A., & Bargonetti, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088828 · Cited by 21 · see citing works
“Clearance of the DNA lesions for the treated glp-1(ar202gf) and cep-1(gk138); glp-1(ar202gf) animals showed an intriguing result that supports a previous report of a UVC-mediated coordination between the nucleotide excision repair pathway (NER) and the homologous repair pathway (HR) [34].”
BackgroundJuillerat‐Jeanneret, L., Staedler, D., Prina‐Mello, A., Chapuis‐Bernasconi, C., Kenzaoui, B. H., Crosbie-Staunton, K., Movia, D., & Schuetz, C. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s65082 · Cited by 18 · see citing works
“PARP is involved in DNA repair and is inactivated by caspase cleavage in apoptosis, and the histone H2AX (γH2AX) is phosphorylated in response to DNA damage.(23,24) The GST-π is regulated by the HIF-1α, by a hypoxic stress and the level of cell iron.”
BackgroundRyu, J. S., Kang, S., & Koo, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064028 · Cited by 18 · see citing works
“elegans [41], as HSR-9 does in response to DSBs.”
BackgroundWagner, J. T., & Podrabsky, J. E. (2014) · Journal of Experimental Zoology Part A Ecological Genetics and Physiology · doi:10.1002/jez.1890 · Cited by 17 · see citing works
Forestier, A., Douki, T., Rosa, V. D., Beal, D. M., & Rachidi, W. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160817422 · Cited by 17 · see citing works
“elegans and showed that its capacity to trigger apoptosis following a genotoxic stress was reduced [47].”
BackgroundOvarian cancer resistance to PARPi and platinum-containing chemotherapy
Summey, R., & Uyar, D. S. (2022) · Cancer Drug Resistance · doi:10.20517/cdr.2021.146 · Cited by 18 · see citing works
Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples
Staedler, D., Magouroux, T., Passemard, S., Schwung, S., Dubled, M., Schneiter, G. S., Rytz, D., Gerber‐Lemaire, S., Bonacina, L., & Wolf, J. (2014) · Nanoscale · doi:10.1039/c3nr05897b · Cited by 15 · see citing works
Bae, W., Hong, S., Park, M. S., Jeong, H.-K., Lee, M., & Koo, H. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.01.007 · Cited by 14 · see citing works
Combined loss of three DNA damage response pathways renders C. elegans intolerant to light
van Bostelen, I., & Tijsterman, M. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.04.002 · Cited by 11 · see citing works
Yamaya, K., Wang, B., Memar, N., Odiba, A. S., Woglar, A., Gartner, A., & Villeneuve, A. M. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad638 · Cited by 12 · see citing works
“L null background ( 84 ).”
DNA topoisomerase 3 is required for efficient germ cell quality control
Stritto, M. R. D., Bauer, B., Barraud, P., & Jantsch, V. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202012057 · Cited by 10 · see citing works
“To determine whether the top-3 phenotype is caused by problems during early DSB repair events, we assessed the kinetics of RPA-1 and RAD-51 foci dynamics during prophase I (Alpi et al., 2003; Colaiácovo et al., 2003; Stergiou et al., 2011).”
BackgroundZhai, X., Li, X., Wang, Y., Qin, K., Hu, J.-R., Li, M., Wang, H.-L., & Guo, R. C. (2022) · Endocrinology and Metabolism · doi:10.3803/enm.2022.1431 · Cited by 8 · see citing works
Fernandes, J., de Amorim, G. C., da Veiga, T. E., Cardoso, J., Arruda, A. C., Arruda, M. S. P., & Castelo-Branco, M. T. L. (2019) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-019-01661-6 · Cited by 7 · see citing works
Xu, J., Sabatino, B., Yan, J., Ermakova, G., Doering, K. R. S., & Taubert, S. (2024) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkae017 · Cited by 6 · see citing works
“C) light induces DSBs if the resulting bipyrimidine photoproducts are not resolved by the nucleotide excision repair (NER) pathway (Stergiou et al .”
BackgroundUV-C Exposure Induces an Apoptosis-Like Process in Euglena gracilis
Bumbulis, M. J., & Balog, B. M. (2013) · ISRN Cell Biology · doi:10.1155/2013/869216 · Cited by 6 · see citing works
Rose, A. M. (2014) · WormBook · doi:10.1895/wormbook.1.54.2 · Cited by 5 · see citing works
“UV-C-induced lesions are recognized and processed by the nucleotide excision repair pathway and some may apparently become DSBs, which are then processed by homologous recombination (Stergiou et al., 2011).”
BackgroundXeroderma pigmentosum protein XPD controls caspase-mediated stress responses
Wei, H., Weaver, Y. M., & Weaver, B. P. (2024) · Nature Communications · doi:10.1038/s41467-024-53755-8 · Cited by 4 · see citing works
“Given the function of xpd-1 in germline DNA repair following UV damage 32 , we next sought to understand the relative contributions of germline and somatic tissues.”
Multi-step implementation of meiotic crossover patterningPreprint
Čavka, I., Woglar, A., Wu, Y., Durmus, E. B., Sloat, L. M., Gros, O., López, C. P., Hecht, F., Villeneuve, A. M., Ries, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.12.687980 · Cited by 3 · see citing works
Nucleotide ExcisionRepair in Caenorhabditiselegans
Lansand, H., & Vermeulen, W. (2011) · Cited by 2 · see citing works
Genome Stability in Caenorhabditis elegans
Rieckher, M., Lopes, A. F. C., & Schumacher, B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803309-8.00011-2 · Cited by 2 · see citing works
THSC/TREX-2 deficiency causes replication stress and genome instability in Caenorhabditis elegans
Zheleva, A., Camino, L. P., Fernández-Fernández, N., García-Rubio, M. L., Askjaer, P., García‐Muse, T., & Aguilera, A. (2021) · Journal of Cell Science · doi:10.1242/jcs.258435 · Cited by 2 · see citing works
“…against the single-strand binding protein RPA-1, which is involved in replication and recombination, and against the DNA damage checkpoint protein ATL-1, which is recruited to sites of DNA damage where it activates the DNA damage checkpoint (GarciaMuse and Boulton, 2005, Stergiou et al. 2011).”
BackgroundGenome stability in Caenorhabditis elegans
Kovalchuk, I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85679-9.00011-8 · Cited by 1 · see citing works
Derry, W. B. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718188163.793487867
Lilienfeldt, N., Tai, Y., Sun, H., Waddell, B., Yang, W., Branicky, R. S., & Hekimi, S. (2026) · Genetics · doi:10.1093/genetics/iyag157
“To assess whether germline DNA was damaged by t-shifting, we used the rpa-1 translational reporter for DNA damage (Stergiou et al. 2011), but no increase in expression was observed after t-shifting (Fig.”
- Authors
- Stergiou, L., Eberhard, R., Doukoumetzidis, K., & Hengartner, M. O.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Hengartner, M O
- ORCID
- Eberhard, R
- Venue
- Cell Death & Differentiation
- Published
- 2010-12-10
- Volume
- 18
- Issue
- 5
- Pages
- 897-906
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC3131928
- OpenAlex
- W2057510083
- Cited by
- 48
- References
- 40
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 5 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 3
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health
- National Center for Research Resources
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- germ cells, nucleotide excision repair, homologous recombination, DNA damage response, meiotic cells, checkpoint kinase, Caenorhabditis elegans
- MeSH terms
- Animals, Cell Survival, DNA Repair, DNA-Binding Proteins, Endonucleases, Germ Cells, Pyrimidine Dimers, Recombination, Genetic, Ultraviolet Rays, Signal Transduction, Caenorhabditis elegans, Apoptosis, Cell Cycle Proteins, Caenorhabditis elegans Proteins, Animals, Genetically Modified, RNA Interference, Apoptosis Regulatory Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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