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Cited by 149Birth, Development, and HealthMicroRNA in disease regulationAdipose Tissue and Metabolism

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes

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Ferland-McCollough, D, Fernandez-Twinn, D S, Cannell, I G, David, H, Warner, M, Vaag, A A, Bork-Jensen, J, Brøns, C +5 more·2012·Cell Death & Differentiation
DOI 10.1038/cdd.2011.183PMC PMC3354052
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Abstract

Nutrition during early mammalian development permanently influences health of the adult, including increasing the risk of type 2 diabetes and coronary heart disease. However, the molecular mechanisms underlying such programming are poorly defined. Here we demonstrate that programmed changes in miRNA expression link early-life nutrition to long-term health. Specifically, we show that miR-483-3p is upregulated in adipose tissue from low-birth-weight adult humans and prediabetic adult rats exposed to suboptimal nutrition in early life. We demonstrate that manipulation of miR-483-3p levels in vitro substantially modulates the capacity of adipocytes to differentiate and store lipids. We show that some of these effects are mediated by translational repression of growth/differentiation factor-3, a target of miR-483-3p. We propose that increased miR-483-3p expression in vivo, programmed by early-life nutrition, limits storage of lipids in adipose tissue, causing lipotoxicity and insulin resistance and thus increasing susceptibility to metabolic disease.

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  • Maternal low protein diets during gestation are associated with an increase in miRNA-483-3p levels, which is known to reduce adipose adipogenesis.

    “Furthermore, maternal low protein diets during gestation were associated with an increase in miRNA-483-3p levels, which is known to reduce adipose adipogenesis [145].”

    From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [145]

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Research works printed but not linked: 37

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Authors
Ferland-McCollough, D., Fernandez-Twinn, D. S., Cannell, I. G., David, H., Warner, M., Vaag, A. A., Bork-Jensen, J., Brøns, C., Gant, T. W., Willis, A. E., Siddle, K., Bushell, M., & Ozanne, S. E.
Affiliations
  • Koch Institute for Integrative Cancer Research At MIT (US)
  • University of Cambridge (GB)
  • MRC Toxicology Unit (GB)
Corresponding author
  • Willis, A E
  • Siddle, K
  • Bushell, M
  • Ozanne, S E
ORCID
Venue
Cell Death & Differentiation
Publisher
Springer Science and Business Media LLC
Published
2012-01-06
Volume
19
Issue
6
Pages
1003-1012
ISSN
  • 1350-9047 (ISSN-L)
  • 1476-5403
DOI
10.1038/cdd.2011.183
PMC
PMC3354052
OpenAlex
W2056284153
Cited by
149
References
3
Citations by year
2026: 4 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 13 · 2020: 10 · 2019: 10 · 2018: 11 · 2017: 13 · 2016: 13 · 2015: 10 · 2014: 17 · 2013: 12 · 2012: 10
FWCI
13.78
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Cell Death and Differentiation (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
  • Leicester Research Archive (University of Leicester) (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • Apollo (University of Cambridge) (submittedVersion, cc-by-nc-nd)
  • Apollo
Funders
  • British Heart Foundation (FS/09/029/27902)
  • University of Cambridge
  • European Commission (27902)
  • Cambridge University Hospitals
  • Medical Research Council
  • Biotechnology and Biological Sciences Research Council (BB/F014279/2, BB/F015364/1, BB/B500915/1, BB/F019017/1, BB/F-14279/1, BB/F014279/1, BB/F019017/2, BB/F-15364/1, BB/F011806/1)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
miR-483-3p, maternal diet, early life nutrition, type 2 diabetes, adipose tissue, adipogenesis, fat deposition, protein synthesis inhibition, low birth weight, insulin resistance, lipotoxicity, developmental programming, prediabetes
MeSH terms
Adipose Tissue, Adult, Animals, Animals, Newborn, Base Sequence, Cell Differentiation, Diabetes Mellitus, Type 2, Diet, Disease Models, Animal, Female, Humans, Male, Down-Regulation, Rats, Wistar, 3' Untranslated Regions, RNA Interference, RNA, Small Interfering, MicroRNAs, Lipid Metabolism, Rats, Growth Differentiation Factor 3, HEK293 Cells

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