Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism
Open accessAbstract
Bone morphogenetic proteins (BMPs) regulate many processes in embryonic development as well as in the maintenance of normal tissue function later in adult life. However, the role of this family of proteins in formation of adipose tissue has been underappreciated in the field of developmental biology. With the growing epidemic of obesity, improved knowledge of adipocyte development and function is urgently needed. Recently, there have been significant advances in understanding the role of different members of the BMP superfamily in control of adipocyte differentiation and systemic energy homeostasis. This review summarizes recent progress in understanding how BMPs specify adipose cell fate in stem/progenitor cells and their potential role in energy metabolism. We propose that BMPs provide instructive signals for adipose cell fate determination and regulate adipocyte function. These findings have opened up exciting opportunities for developing new therapeutic approaches for the treatment of obesity and its many associated metabolic disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BMPs are a family of developmental regulators belonging to the TGF-β superfamily, which promote adipogenesis at different stages.
“BMPs are a family of developmental regulators belonging to the TGF-β superfamily, which promote adipogenesis at different stages 100.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [100]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Bone: Formation by Autoinduction
Urist, M. R. (1965) · Science · doi:10.1126/science.150.3698.893 · Cited by 5,529 · see citing works
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795 · see citing works
Identification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399 · see citing works
Self-citationNovel Regulators of Bone Formation: Molecular Clones and Activities
Wozney, J. M., Rosen, V., Celeste, A. J., Mitsock, L. M., Whitters, M. J., Kriz, R., Hewick, R. M., & Wang, E. A. (1988) · Science · doi:10.1126/science.3201241 · Cited by 3,874 · see citing works
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452 · see citing works
Functional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058 · see citing works
Annual Medical Spending Attributable To Obesity: Payer-And Service-Specific Estimates
Finkelstein, E. A., Trogdon, J. G., Cohen, J. W., & Dietz, W. H. (2009) · Health Affairs · doi:10.1377/hlthaff.28.5.w822 · Cited by 2,956 · see citing works
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
Discher, D. E., Mooney, D. J., & Zandstra, P. W. (2009) · Science · doi:10.1126/science.1171643 · Cited by 2,666 · see citing works
Adipocyte differentiation from the inside out
Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607 · see citing works
Dynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357 · see citing works
PRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · cited 2× · see citing works
“Interestingly, these “systemic” brown adipocytes, such as those present in white fat and muscle, are not derived from myf5-expressing precursors (27), suggesting different developmental origins for these different pools of brown fat.”
BackgroundMethodThe relationship between the spleen colony-forming cell and the haemopoietic stem cell.
Schofield, R. (1978) · PubMed · Cited by 2,319 · see citing works
Adipocytes as regulators of energy balance and glucose homeostasis
Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170 · cited 1× · see citing works
“Adipokines produced by fat cells, such as leptin and adiponectin, are key mediators of physiological processes in distant organs, such as brain, liver and muscle, where they control appetite, digestion of nutrients, energy expenditure and storage, glucose and lipid metabolism and insulin sensitivity [7–9].”
BackgroundCornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162 · see citing works
Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076 · see citing works
Chen, D., Zhao, M., & Mundy, G. R. (2004) · Growth Factors · doi:10.1080/08977190412331279890 · Cited by 1,921 · see citing works
Kingsley, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.2.133 · Cited by 1,920 · see citing works
Inhibition of Adipogenesis by Wnt Signaling
Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., & MacDougald, O. A. (2000) · Science · doi:10.1126/science.289.5481.950 · Cited by 1,876 · see citing works
High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans
Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., et al. (2009) · Diabetes · doi:10.2337/db09-0530 · Cited by 1,848 · see citing works
Transcriptional control of adipocyte formation
Farmer, S. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.001 · Cited by 1,836 · see citing works
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
Nakao, A., Afrakhte, M., Morn, A., Nakayama, T., Christian, J. L., Heuchel, R. L., Itoh, S., Kawabata, M., Heldin, N., Heldin, C., et al. (1997) · Nature · doi:10.1038/39369 · Cited by 1,796 · see citing works
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508 · see citing works
Self-citationTranscriptional Control of Brown Fat Determination by PRDM16
Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.001 · Cited by 1,174 · see citing works
Regional adiposity and morbidity.
Kissebah, A. H., & Krakower, G. R. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.4.761 · Cited by 1,132 · see citing works
Reznikoff, C. A., Brankow, D. W., & Heidelberger, C. (1973) · PubMed · Cited by 1,125 · see citing works
Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine
Taylor, S. M., & Jones, P. A. (1979) · Cell · doi:10.1016/0092-8674(79)90317-9 · Cited by 1,114 · see citing works
White Fat Progenitor Cells Reside in the Adipose Vasculature
Tang, W., Zeve, D., Suh, J. M., Bosnakovski, D., Kyba, M., Hammer, R. E., Tallquist, M. D., & Graff, J. M. (2008) · Science · doi:10.1126/science.1156232 · Cited by 1,113 · see citing works
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099 · see citing works
Self-citationDevelopment of obesity in transgenic mice after genetic ablation of brown adipose tissue
Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075 · see citing works
Smad6 inhibits signalling by the TGF-β superfamily
Imamura, T., Takase, M., Nishihara, A., Oeda, E., Hanai, J., Kawabata, M., & Miyazono, K. (1997) · Nature · doi:10.1038/39355 · Cited by 1,023 · see citing works
Identification of White Adipocyte Progenitor Cells In Vivo
Rodeheffer, M. S., Birsoy, K., & Friedman, J. M. (2008) · Cell · doi:10.1016/j.cell.2008.09.036 · Cited by 945 · see citing works
Role of morphogenetic proteins in skeletal tissue engineering and regeneration
Reddi, A. H. (1998) · Nature Biotechnology · doi:10.1038/nbt0398-247 · Cited by 831 · see citing works
Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway
Ulloa, L., Doody, J. F., & Massagué, J. (1999) · Nature · doi:10.1038/17826 · Cited by 812 · see citing works
No place like home: anatomy and function of the stem cell niche
Jones, D. L., & Wagers, A. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2319 · Cited by 794 · see citing works
Mishina, Y. M., Suzuki, A., Ueno, N., & Behringer, R. R. (1995) · Genes & Development · doi:10.1101/gad.9.24.3027 · Cited by 776 · see citing works
Timmons, J. A., Wennmalm, K., Larsson, O., Walden, T. B., Lassmann, T., Petrovic, N., Hamilton, D. L., Gimeno, R. E., Wahlestedt, C., Baar, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610615104 · Cited by 732 · see citing works
Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., & Cinti, S. (2009) · The FASEB Journal · doi:10.1096/fj.09-133546 · Cited by 725 · see citing works
Friedman, J. M. (2000) · Nature · doi:10.1038/35007504 · Cited by 701 · see citing works
Cinti, S. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.010 · Cited by 690 · see citing works
Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation
Smas, C. M., & Sul, H. S. (1993) · Cell · doi:10.1016/0092-8674(93)90252-l · Cited by 677 · see citing works
Cousin, B., Cinti, S., Morroni, M., Raimbault, S., Ricquier, D., Pénicaud, L., & Casteilla, L. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.4.931 · Cited by 665 · see citing works
Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3155 · Cited by 635 · see citing works
Adipose Tissue-Derived Factors: Impact on Health and Disease
Trujillo, M. E., & Scherer, P. E. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0033 · Cited by 611 · see citing works
Nohe, A., Haßel, S., Ehrlich, M., Neubauer, F. B., Sebald, W., Henis, Y. I., & Knaus, P. I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m102750200 · Cited by 566 · see citing works
Rebbapragada, A., Benchabane, H., Wrana, J. L., Celeste, A. J., & Attisano, L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7230-7242.2003 · Cited by 566 · see citing works
Signal transduction of bone morphogenetic protein receptors
Nohe, A. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2003.08.011 · Cited by 514 · see citing works
Suppression of body fat accumulation in myostatin-deficient mice
McPherron, A. C., & Lee, S.-J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213562 · Cited by 505 · see citing works
Bone Morphogenetic Protein-2 Causes Commitment and Differentiation in C3Hl0T1/2 and 3T3 Cells
Wang, E. A., Israel, D. I., Kelly, S. J., & Luxenberg, D. P. (1993) · Growth Factors · doi:10.3109/08977199308991582 · Cited by 490 · see citing works
Craft, S. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362137 · Cited by 487 · see citing works
The transforming growth factor-β superfamily of receptors
de Caestecker, M. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2003.10.004 · Cited by 464 · see citing works
SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues
Picard, F., Géhin, M., Annicotte, J., Rocchi, S., Champy, M., O’Malley, B. W., Chambon, P., & Auwerx, J. H. (2002) · Cell · doi:10.1016/s0092-8674(02)01169-8 · Cited by 444 · see citing works
Adipose tissue cellularity in human obesity
Hirsch, J., & Batchelor, B. R. (1976) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(76)80023-0 · Cited by 441 · see citing works
Differentiation of embryonic stem cells into adipocytes in vitro
Dani, C., Smith, A. G., Dessolin, S., Leroy, P., Staccini-Lavenant, L., Villageois, P., Darimont, C., & Ailhaud, G. P. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.11.1279 · Cited by 435 · see citing works
Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
Tang, Q.-Q., Otto, T. C., & Lane, M. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403100101 · Cited by 415 · see citing works
Yamaguchi, K., Nagai, S., Ninomiya‐Tsuji, J., Nishita, M., Tamai, K., Irie, K., Ueno, N., Nishida, E., Shibuya, H., & Matsumoto, K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.179 · Cited by 395 · see citing works
Chen, D., Ji, X., Harris, M. A., Feng, J. Q., Karsenty, G., Celeste, A. J., Rosen, V., Mundy, G. R., & Harris, S. E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.295 · Cited by 382 · see citing works
Consequences of knocking out BMP signaling in the mouse
Zhao, G.-Q. (2002) · genesis · doi:10.1002/gene.10167 · Cited by 361 · see citing works
Determinants of specificity in TGF-β signal transductionPreprint
Chen, Y., Hata, A., Lo, R. S., Wotton, D., Shi, Y., Pavletich, N. P., & Massagué, J. (1998) · Genes & Development · doi:10.1101/gad.12.14.2144 · Cited by 361 · see citing works
Changes in Gene Expression Foreshadow Diet-Induced Obesity in Genetically Identical Mice
Koza, R. A., Nikonova, L. V., Hogan, J. C., Rim, J., Mendoza, T. M., Faulk, C. D., Skaf, J. S., & Kozak, L. P. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020081 · Cited by 344 · see citing works
Ahrens, M., Ankenbauer, T., SCHRÖDER, D., Hollnagel, A., MAYER, H., & Groß, G. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.871 · Cited by 338 · see citing works
Myostatin Knockout in Mice Increases Myogenesis and Decreases Adipogenesis
Lin, J., Arnold, H. B., Della-Fera, M. A., Azain, M. J., Hartzell, D. L., & Baile, C. A. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6500 · Cited by 313 · see citing works
Shaping BMP morphogen gradients in theDrosophilaembryo and pupal wing
O’Connor, M. B., Umulis, D. M., Othmer, H. G., & Blair, S. S. (2005) · Development · doi:10.1242/dev.02214 · Cited by 294 · see citing works
Hansen, J. B., Jørgensen, C., Petersen, R. K., Hallenborg, P., De Matteis, R., Bøye, H. A., Petrovic, N., Enerbäck, S., Nedergaard, J., Cinti, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0301964101 · Cited by 287 · see citing works
Almind, K., Manieri, M., Sivitz, W. I., Cinti, S., & Kahn, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610416104 · Cited by 286 · see citing works
BMP signaling and early embryonic patterning
Kishigami, S., & Mishina, Y. M. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.04.002 · Cited by 265 · see citing works
Kimura, N., Matsuo, R., Shibuyà, H., Nakashima, K., & Taga, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m908622199 · Cited by 238 · see citing works
Asahina, I., Sampath, T. K., & Hauschka, P. V. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0005 · Cited by 236 · see citing works
Xiao, Y., Xiang, L., & Shao, J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.045 · Cited by 236 · see citing works
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
Shibuyà, H., Iwata, H., Masuyama, N., Gotoh, Y., Yamaguchi, K., Irie, K., Matsumoto, K., Nishida, E., & Ueno, N. (1998) · The EMBO Journal · doi:10.1093/emboj/17.4.1019 · Cited by 230 · see citing works
Tseng, Y.-H., Butte, A. J., Kokkotou, E., Yechoor, V. K., Taniguchi, C. M., Kriauciunas, K. M., Cypess, A. M., Niinobe, M., Yoshikawa, K., Patti, M. E., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1259 · Cited by 222 · see citing works
Self-citationEmbryonic Patterning: To BMP or Not to BMP, That Is the Question
Graff, J. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80196-8 · Cited by 215 · see citing works
Brown adipose tissue uncoupling protein content in human infants, children and adults
Lean, M. E. J., James, W. P. T., Jennings, G., & Trayhurn, P. (1986) · Clinical Science · doi:10.1042/cs0710291 · Cited by 213 · see citing works
Scimè, A., Grenier, G., Huh, M. S., Gillespie, M. A., Bevilacqua, L., Harper, M.-E., & Rudnicki, M. A. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.002 · Cited by 199 · see citing works
Ghorbani, M., Claus, T. H., & Himms-Hagen, J. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00162-7 · Cited by 195 · see citing works
Notch 1 Impairs Osteoblastic Cell Differentiation
Sciaudone, M. P., Gazzerro, E., Priest, L., Delany, A. M., & CANALIS, E. M. (2003) · Endocrinology · doi:10.1210/en.2003-0463 · Cited by 192 · see citing works
Bone morphogenetic proteins inhibit adipocyte differentiation by bone marrow stromal cells
Gimble, J. M., Morgan, C., Kelly, K. A., Wu, X., Dandapani, V., Wang, C., & Rosen, V. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240580312 · Cited by 189 · see citing works
Song, C., Guo, Z., Ma, Q., Chen, Z., Liu, Z., Jia, H., & Dang, G. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01408-6 · Cited by 189 · see citing works
Hata, K., Nishimura, R., Ikeda, F., Yamashita, K., Matsubara, T., Nokubi, T., & Yoneda, T. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-06-0356 · Cited by 187 · see citing works
Regulatory circuits controlling white versus brown adipocyte differentiation
Hansen, J. B., & Kristiansen, K. (2006) · Biochemical Journal · doi:10.1042/bj20060402 · Cited by 178 · see citing works
Schnurri-2 Controls BMP-Dependent Adipogenesis via Interaction with Smad Proteins
Jin, W., Takagi, T., Kanesashi, S.-N., Kurahashi, T., Nomura, T., Harada, J., & Ishii, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.016 · Cited by 170 · see citing works
Pereira, R. C., Delany, A. M., & CANALIS, E. M. (2002) · Bone · doi:10.1016/s8756-3282(02)00687-7 · Cited by 163 · see citing works
Sottile, V., & Seuwen, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01655-0 · Cited by 160 · see citing works
Metabolic syndrome, hyperinsulinemia, and cancer
Hsu, I. R., Kim, S. P., Kabir, M., & Bergman, R. N. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.867s · Cited by 159 · see citing works
Khalsa, O., Yoon, J., Torres‐Schumann, S., & Wharton, K. A. (1998) · Development · doi:10.1242/dev.125.14.2723 · Cited by 153 · see citing works
Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction
Sebald, W., Nickel, J., Zhang, J., & Mueller, T. D. (2004) · Biological Chemistry · doi:10.1515/bc.2004.086 · Cited by 146 · see citing works
Ji, X., Chen, D., Xu, C., Harris, S. E., Mundy, G. R., & Yoneda, T. (2000) · Journal of Bone and Mineral Metabolism · doi:10.1007/s007740050103 · Cited by 133 · see citing works
Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance
Wang, Z., Qi, C., Krones, A., Woodring, P. J., Zhu, X., Reddy, J. K., Evans, R. M., Rosenfeld, M. G., & Hunter, T. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.002 · Cited by 103 · see citing works
Recent Investigations on the Growth of Bone
Lacroix, P. (1945) · Nature · doi:10.1038/156576a0 · Cited by 93 · see citing works
Böttcher, Y., Unbehauen, H., Klöting, N., Ruschke, K., Körner, A., Schleinitz, D., Tönjes, A., Enigk, B., Wolf, S., Dietrich, K., et al. (2009) · Diabetes · doi:10.2337/db08-1458 · Cited by 77 · see citing works
Self-citationRegulation of bone morphogenetic proteins in early embryonic development
Yamamoto, Y., & Oelgeschl�ger, M. (2004) · Die Naturwissenschaften · doi:10.1007/s00114-004-0575-z · Cited by 68 · see citing works
Chen, T. L., Shen, W., & Kraemer, F. B. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1145 · Cited by 63 · see citing works
Moulin, K., Truel, N., André, M., ARNAULD, E., Nibbelink, M. M., Cousin, B., Dani, C., Pénicaud, L., & Casteilla, L. (2001) · Biochemical Journal · doi:10.1042/bj3560659 · Cited by 59 · see citing works
Shen, J. J., Huang, L., Li, L., Jorgez, C. J., Matzuk, M. M., & Brown, C. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0322 · Cited by 59 · see citing works
Li, X., Schwarz, E. M., Zuscik, M. J., Rosier, R. N., Ionescu, A. M., Puzas, J. E., Drissi, H., Sheu, T.-J., & O’Keefe, R. J. (2003) · Endocrinology · doi:10.1210/en.2002-220969 · Cited by 59 · see citing works
Role of RGM coreceptors in bone morphogenetic protein signaling
Halbrooks, P. J., Ru, D., Wozney, J. M., & Bain, G. (2007) · Journal of Molecular Signaling · doi:10.1186/1750-2187-2-4 · Cited by 55 · see citing works
Role of the RIP140 corepressor in ovulation and adipose biology
Steel, J. H., White, R., & Parker, M. G. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05896 · Cited by 46 · see citing works
GDF-3 is an adipogenic cytokine under high fat dietary condition
Wang, W., Yang, Y., Meng, Y., & Shi, Y. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.058 · Cited by 41 · see citing works
Leconte, I., Fox, J. C., Baldwin, H. S., Buck, C. A., & Swain, J. L. (1998) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199812)213:4 · Cited by 38 · see citing works
Taha, M. F., Valojerdi, M. R., & Mowla, S. J. (2006) · Anatomia Histologia Embryologia · doi:10.1111/j.1439-0264.2006.00680.x · Cited by 35 · see citing works
A Long Search for Glut4 Activation
Kandror, K. V. (2003) · Science s STKE · doi:10.1126/stke.2003.169.pe5 · Cited by 26 · see citing works
Phosphorylation regulation of the interaction between Smad7 and activin type I receptor
Liu, X., Nagarajan, R. P., Vale, W., & Chen, Y. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02718-7 · Cited by 24 · see citing works
Exploring the connection between chronic renal fibrosis and bone morphogenic protein-7.
Kalluri, R. K., & Zeisberg, M. (2003) · PubMed · doi:10.14670/hh-18.217 · Cited by 20 · see citing works
Butterwith, S. C., Wilkie, R., & Clinton, M. (1996) · Biochemical Society Transactions · doi:10.1042/bst024163s · Cited by 19 · see citing works
Loncar, D. (1992) · The International Journal of Developmental Biology · doi:10.1387/ijdb.1525014 · Cited by 15 · see citing works
Flagged first, then by citations
4 of the 110 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [55]Tseng YH He TC Bone Morphogenetic Proteins and Adipocyte Differentiation Cellscience Review 2007 3 3 342 360
Cited by
Sorted by citations
Adipokines in health and disease
Fasshauer, M., & Blüher, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.014 · Cited by 1,050 · see citing works
Cellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works
Self-citationIdentification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
Schulz, T. J., Huang, T. L., Tran, T. T., Zhang, H., Townsend, K. L., Shadrach, J. L., Cerletti, M., McDougall, L. E., Giorgadze, N., Tchkonia, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010929108 · Cited by 459 · see citing works
Self-citationBlüher, M., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.016 · Cited by 399 · see citing works
Brown fat as a therapy for obesity and diabetes
Cypess, A. M., & Kahn, C. R. (2010) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e328337a81f · Cited by 376 · see citing works
Transplantation of adipose tissue and stem cells: role in metabolism and disease
Tran, T. T., & Kahn, C. R. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.20 · Cited by 327 · see citing works
Evidence against a Beneficial Effect of Irisin in Humans
Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 322 · see citing works
Intrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots
Macotela, Y., Emanuelli, B., Mori, M. A., Gesta, S., Schulz, T. J., Tseng, Y., & Kahn, C. R. (2012) · Diabetes · doi:10.2337/db11-1753 · Cited by 300 · see citing works
Self-citationAdipose tissue and its role in organ crosstalk
Romacho, T., Elsen, M., Röhrborn, D., & Eckel, J. (2014) · Acta Physiologica · doi:10.1111/apha.12246 · Cited by 278 · see citing works
Jakab, J., Miškić, B., Mikšić, Š., Juranić, B., Ćosić, V., Schwarz, D., & Včev, A. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s281186 · Cited by 256 · see citing works
Heterogeneity of adipose tissue in development and metabolic function
Schöttl, T., Kapser-Fischer, I., & Ussar, S. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.162958 · Cited by 215 · see citing works
Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism
Scheele, C. C., & Wolfrum, C. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz007 · Cited by 212 · see citing works
Brown and Beige Adipose Tissue and Aging
Zoico, E., Rubele, S., Caro, A. D., Nori, N., Mazzali, G., Fantin, F., Rossi, A. P., & Zamboni, M. M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00368 · Cited by 206 · see citing works
Zamani, N., & Brown, C. (2010) · Endocrine Reviews · doi:10.1210/er.2010-0018 · Cited by 198 · see citing works
Brown Adipose Tissue—A Translational Perspective
Carpentier, A. C., Blondin, D. P., Haman, F., & Richard, D. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac015 · Cited by 202 · see citing works
Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors
Zaragosi, L.-E., Wdziekonski, B., Villageois, P., Keophiphath, M., Maumus, M., Tchkonia, T., Bourlier, V., Mohsen-Kanson, T., Ladoux, A., Elabd, C., et al. (2010) · Diabetes · doi:10.2337/db10-0013 · Cited by 184 · see citing works
Lee, M.-W., Lee, M., & Oh, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060854 · Cited by 180 · see citing works
Brown adipose tissue: Development, metabolism and beyond
Schulz, T. J., & Tseng, Y.-H. (2013) · Biochemical Journal · doi:10.1042/bj20130457 · Cited by 173 · see citing works
Self-citationBMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells
Elsen, M., Raschke, S., Tennagels, N., Schwahn, U., Jeleník, T., Roden, M., Romacho, T., & Eckel, J. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00290.2013 · Cited by 168 · see citing works
Myocardin-Related Transcription Factor A Regulates Conversion of Progenitors to Beige Adipocytes
McDonald, M. E., Li, C., Bian, H.-J., Smith, B. D., Layne, M. D., & Farmer, S. R. (2015) · Cell · doi:10.1016/j.cell.2014.12.005 · Cited by 164 · see citing works
A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance
Martins, L., Seoane-Collazo, P., Contreras, C., González-García, I., Martínez-Sánchez, N., González, F., Zalvide, J., Gallego, R., Diéguez, C., Nogueiras, R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.045 · Cited by 154 · see citing works
Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes
Ferland-McCollough, D., Fernandez-Twinn, D. S., Cannell, I. G., David, H., Warner, M., Vaag, A. A., Bork-Jensen, J., Brøns, C., Gant, T. W., Willis, A. E., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.183 · Cited by 149 · see citing works
Brown Adipose Tissue Growth and Development
Symonds, M. E. (2013) · Scientifica · doi:10.1155/2013/305763 · Cited by 133 · see citing works
Fournier, B., Murray, B., Gutzwiller, S., Marcaletti, S., Marcellin, D., Bergling, S., Brachat, S., Persohn, E., Pierrel, E., Bombard, F., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06575-11 · Cited by 108 · see citing works
The role and importance of brown adipose tissue in energy homeostasis
Cypess, A. M., & Kahn, C. R. (2010) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32833a8d6e · Cited by 118 · see citing works
Mostafa, S., Pakvasa, M., Coalson, E., Zhu, A. C., Alverdy, A., Castillo, H., Fan, J., Li, A., Feng, Y., Wu, D., et al. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.07.003 · Cited by 118 · see citing works
Townsend, K. L., Suzuki, R., Huang, T. L., Jing, E., Schulz, T. J., Lee, K., Taniguchi, C. M., Espinoza, D. O., McDougall, L. E., Zhang, H., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-199067 · Cited by 105 · see citing works
Self-citationSong, S. J., Choi, S., & Park, T. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/718379 · Cited by 105 · see citing works
BMP7 Activates Brown Adipose Tissue and Reduces Diet-Induced Obesity Only at Subthermoneutrality
Boon, M. R., van den Berg, S. A. A., Wang, Y., den Bossche, J. V., Karkampouna, S., Bauwens, M., Saint‐Hubert, M. D., van der Horst, G., Vukičević, S., de Winther, M. P. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074083 · Cited by 102 · see citing works
Schwab, E. H., Pohl, T. L. M., Haraszti, T., Schwaerzer, G. K., Hiepen, C., Spatz, J. P., Knaus, P. I., & Cavalcanti‐Adam, E. A. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b00315 · Cited by 99 · see citing works
Townsend, K. L., An, D., Lynes, M. D., Huang, T. L., Zhang, H., Goodyear, L. J., & Tseng, Y. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4536 · Cited by 96 · see citing works
Self-citationWojciechowicz, K., Gledhill, K., Ambler, C. A., Manning, C. B., & Jahoda, C. A. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059811 · Cited by 98 · see citing works
BMPs and their clinical potentials
Kim, M.-J., & Choe, S. (2011) · BMB Reports · doi:10.5483/bmbrep.2011.44.10.619 · Cited by 92 · see citing works
Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue
Wankhade, U. D., Shen, M., Yadav, H., & Thakali, K. M. (2016) · BioMed Research International · doi:10.1155/2016/2365609 · Cited by 89 · see citing works
Hu, T., Yuan, X., Wei, G., Luo, H., Lee, H. J., & Jin, W. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1433-z · Cited by 85 · see citing works
Jouy, S. H., Mohan, S., Scichilone, G., Mostafa, A., & Mahmoud, A. M. (2024) · Biomedicines · doi:10.3390/biomedicines12092129 · Cited by 92 · see citing works
Grgurević, L., Christensen, G. L., Schulz, T. J., & Vukičević, S. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.12.009 · Cited by 80 · see citing works
Self-citationThe developmental transition of ovine adipose tissue through early life
Pope, M., Budge, H., & Symonds, M. E. (2013) · Acta Physiologica · doi:10.1111/apha.12053 · Cited by 78 · see citing works
Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes
Xue, R., Wan, Y., Zhang, S., Zhang, Q., Ye, H., & Li, Y. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00119.2013 · Cited by 75 · see citing works
Mulberry and mulberry wine extract increase the number of mitochondria during brown adipogenesis
You, Y., Yuan, X., Lee, H. J., Huang, W., Jin, W., & Zhan, J. (2014) · Food & Function · doi:10.1039/c4fo00719k · Cited by 66 · see citing works
You, Y., Han, X., Guo, J., Guo, Y., Yin, M., Liu, G., Huang, W., & Zhan, J. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.025 · Cited by 65 · see citing works
Role of brown adipose tissue in metabolic syndrome, aging, and cancer cachexia
Dong, M., Lin, J., Lim, W., Jin, W., & Lee, H. J. (2017) · Frontiers of Medicine · doi:10.1007/s11684-017-0555-2 · Cited by 61 · see citing works
Guiu‐Jurado, E., Unthan, M., Böhler, N., Kern, M., Landgraf, K., Dietrich, A., Schleinitz, D., Ruschke, K., Klöting, N., Faßhauer, M., et al. (2016) · Obesity · doi:10.1002/oby.21571 · Cited by 60 · see citing works
Cross Talk between Insulin and Bone Morphogenetic Protein Signaling Systems in Brown Adipogenesis
Zhang, H., Schulz, T. J., Espinoza, D., Huang, T. L., Emanuelli, B., Kristiansen, K., & Tseng, Y. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00363-10 · Cited by 59 · see citing works
Self-citationChattopadhyay, T., Singh, R. R., Gupta, S., & Surolia, A. (2017) · BioFactors · doi:10.1002/biof.1334 · Cited by 56 · see citing works
Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation
Wei, Q., Pohl, T. L. M., Seckinger, A., Spatz, J. P., & Cavalcanti‐Adam, E. A. (2015) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.11.87 · Cited by 54 · see citing works
López, Á. V., García, M. N. V., Melen, G. J., Martínez, A. E., Cubillo, I., Garcı́a-Castro, J., Ramírez, M. R., & Zapata, A. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084496 · Cited by 53 · see citing works
Rui, Y., Lui, P. P. Y., Wong, Y. M., Tan, Q., & Chan, K. M. (2012) · Journal of Orthopaedic Research® · doi:10.1002/jor.22290 · Cited by 53 · see citing works
Determinants of stem cell lineage differentiation toward chondrogenesis versus adipogenesis
Zhou, S., Chen, S., Jiang, Q., & Pei, M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03017-4 · Cited by 52 · see citing works
Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue
Homan, E. P., Brandão, B. B., Softic, S., Ouaamari, A. E., O'Neill, B. T., Kulkarni, R. N., Kim, J. K., & Kahn, C. R. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143328 · Cited by 51 · see citing works
Arzi, B., Verstraete, F. J. Μ., Huey, D. J., Cissell, D. D., & Athanasiou, K. A. (2014) · Veterinary Surgery · doi:10.1111/j.1532-950x.2014.12123.x · Cited by 50 · see citing works
The dual role of BMP4 in adipogenesis and metabolism
Modica, S., & Wolfrum, C. (2017) · Adipocyte · doi:10.1080/21623945.2017.1287637 · Cited by 50 · see citing works
Mu, W., Qian, S., Song, Y.-J., Yang, L., Song, S., Yang, Q., Liu, H., Liu, Y., Pan, D., Tang, Y., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101979 · Cited by 50 · see citing works
Emerging Role of Bone Morphogenetic Protein 4 in Metabolic Disorders
Baboota, R. K., Blüher, M., & Smith, U. (2021) · Diabetes · doi:10.2337/db20-0884 · Cited by 47 · see citing works
BMP8 and activated brown adipose tissue in human newborns
Urisarri, A., González‐García, I., Estévez‐Salguero, Á., Pata, M. P., Milbank, E., López, N., Mandiá, N., Grijota-Martínez, C., Salgado, C. A., Nogueiras, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25456-z · Cited by 45 · see citing works
The transforming growth factor-beta/bone morphogenetic protein signalling pathway in adipogenesis
Margoni, A., Fotis, L., & Papavassiliou, A. G. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.12.014 · Cited by 44 · see citing works
Role of bone morphogenetic protein‐9 in the regulation of glucose and lipid metabolism
Yang, M. H., Liang, Z., Yang, M., Jia, Y., Yang, G., He, Y., Li, X., Gu, H. F., Zheng, H., Zhu, Z., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802544rr · Cited by 44 · see citing works
Schleinitz, D., Klöting, N., Böttcher, Y., Wolf, S., Dietrich, K., Tönjes, A., Breitfeld, J., Enigk, B., Halbritter, J., Körner, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016155 · Cited by 43 · see citing works
Self-citationLuo, Y., Li, L., Xu, X., Wu, T., Yang, M., Zhang, C., Mou, H., Zhou, T., Jia, Y., Cai, C., et al. (2016) · Clinical Science · doi:10.1042/cs20160543 · Cited by 41 · see citing works
Fifty shades of white: Understanding heterogeneity in white adipose stem cells
Cleal, L., Aldea, T., & Chau, Y.-Y. (2017) · Adipocyte · doi:10.1080/21623945.2017.1372871 · Cited by 39 · see citing works
Abnormal lipid metabolism in cancer-associated cachexia and potential therapy strategy
Fang, R., Yan, L., & Liao, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1123567 · Cited by 37 · see citing works
Inhibition of CK2 binding to BMPRIa induces C2C12 differentiation into osteoblasts and adipocytes
Moseychuk, O., Akkiraju, H., Dutta, J., D’Angelo, A., Bragdon, B. C., Duncan, R. L., & Nohe, A. (2013) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-013-0199-1 · Cited by 35 · see citing works
The impact of adipokines on vascular networks in adipose tissue
Vliora, M., Ravelli, C., Grillo, E., Corsini, M., Flouris, A. D., & Mitola, S. M. F. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.07.008 · Cited by 35 · see citing works
Histopathological changes in tendinopathy--potential roles of BMPs?
Lui, P. P. Y. (2013) · Lara D. Veeken · doi:10.1093/rheumatology/ket165 · Cited by 35 · see citing works
Inhibition of beta cell growth and function by bone morphogenetic proteins
Bruun, C., Christensen, G. L., Jacobsen, M. L. B., Kanstrup, M. B., Jensen, P. R., Fjordvang, H., Mandrup-Poulsen, T. R., & Billestrup, N. (2014) · Diabetologia · doi:10.1007/s00125-014-3384-8 · Cited by 33 · see citing works
Hino, J., Nakatani, M., Arai, Y., Tsuchida, K., Shirai, M., Miyazato, M., & Kangawa, K. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.15 · Cited by 33 · see citing works
Of mice and men: novel insights regarding constitutive and recruitable brown adipocytes
Townsend, K. L., & Tseng, Y.-H. (2015) · International Journal of Obesity Supplements · doi:10.1038/ijosup.2015.5 · Cited by 31 · see citing works
Self-citationRegulation of embryonic stem cell self-renewal and differentiation by TGF-β family signaling
Fei, T., & Chen, Y. (2010) · Science China Life Sciences · doi:10.1007/s11427-010-0096-2 · Cited by 31 · see citing works
Emerging role for RNA binding motif protein 4 in the development of brown adipocytes
Lin, J.-C., Tarn, W., & Hsieh, W.-K. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.12.018 · Cited by 31 · see citing works
Lee, J. S., Park, J., Kwon, I. K., & Lim, J. Y. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.042 · Cited by 31 · see citing works
Liu, J., Chen, L., Zhou, Y. L., Liu, X., & Tang, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085469 · Cited by 30 · see citing works
GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury
Platko, K., Lebeau, P. F., Byun, J. H., Poon, S. V., Day, E. A., MacDonald, M. E., Holzapfel, N. T., Mejía‐Benítez, A., Maclean, K. N., Krepinsky, J. C., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.06.021 · Cited by 29 · see citing works
The role of focal adhesion kinase in BMP4 induction of mesenchymal stem cell adipogenesis
Lee, J. S., Ha, L., Kwon, I. K., & Lim, J. Y. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.045 · Cited by 29 · see citing works
Kim, M.-J., Park, S. Y., Chang, H. R., Jung, E. Y., Munkhjargal, A., Lim, J., Lee, M., & Kim, Y. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.6.059 · Cited by 28 · see citing works
Opportunities and challenges in three-dimensional brown adipogenesis of stem cells
Unser, A. M., Tian, Y. I., & Xie, Y. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.07.005 · Cited by 27 · see citing works
Pyrżak, B., Demkow, U., & Kucharska, A. M. (2015) · Advances in experimental medicine and biology · doi:10.1007/5584_2015_149 · Cited by 26 · see citing works
A simple method to sort ESC‐derived adipocytes
Schaedlich, K., Knelangen, J. M., Santos, A. N., Fischer, B., & Santos, A. N. (2010) · Cytometry Part A · doi:10.1002/cyto.a.20953 · Cited by 26 · see citing works
Effect of Diabetes Mellitus on Adipocyte‐Derived Stem Cells in Rat
Jumabay, M., Moon, J. H., Yeerna, H., & Boström, K. I. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25012 · Cited by 25 · see citing works
The Role of Bone Morphogenetic Proteins in Diabetic Complications
Perera, N., Ritchie, R. H., & Tate, M. (2019) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00064 · Cited by 25 · see citing works
3D brown adipogenesis to create “Brown-Fat-in-Microstrands”
Unser, A. M., Mooney, B., Corr, D. T., Tseng, Y., & Xie, Y. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.10.017 · Cited by 25 · see citing works
Self-citationOn the role of macrophages in the control of adipocyte energy metabolism
Keuper, M. (2019) · Endocrine Connections · doi:10.1530/ec-19-0016 · Cited by 25 · see citing works
Chang, J. C., Durinck, S., Chen, M. Z., Martinez-Martín, N., Zhang, J. A., Lehoux, I. E., Li, H., Lin, M. H., Wu, J., Bainbridge, T. W., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45354-1 · Cited by 24 · see citing works
Casana, E., Jiménez, V., Sacristan, V., MUÑOZ, S. A., Jambrina, C., Rodó, J., García, M., Mallol, C., León, X., Franckhauser, S., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-00700-6 · Cited by 24 · see citing works
The Role of Bone Morphogenetic Protein 9 in Nonalcoholic Fatty Liver Disease in Mice
Sun, Q., Cai, L.-Y., Jian, J., Cui, Y., Huang, C., Liu, S., Lu, J., Wang, W., Zeng, X., & Zhong, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.605967 · Cited by 21 · see citing works
Emerging Roles for Browning of White Adipose Tissue in Prostate Cancer Malignant Behaviour
Álvarez-Artime, A., García-Soler, B., Sainz, R. M., & Mayo, J. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115560 · Cited by 21 · see citing works
Patschan, D., Schwarze, K., Lange, A., Meise, N., Henze, E., Becker, J. U., Patschan, S. A., & Muller, G. A. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00677.2012 · Cited by 21 · see citing works
White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming
Boychenko, S. S., Egorova, V. S., Brovin, A. N., & Egorov, A. D. (2024) · Pharmaceuticals · doi:10.3390/ph17060790 · Cited by 20 · see citing works
Huang, H., Wang, W., Yang, G., Zhang, Y., Li, X., Liu, H., Zhang, L., Zheng, H., & Li, L. (2018) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2018.02.007 · Cited by 20 · see citing works
Wojciechowicz, K., Gledhill, K., Ambler, C. A., Manning, C. B., & Jahoda, C. A. B. (2013) · PLoS ONE · doi:10.1371/annotation/cf897d66-612e-42a7-a247-9979e4a61a8d · Cited by 20 · see citing works
Prevalence and Correlated Factors of Obesity, Overweight and Central Obesity in Southwest of Iran
Ghaderian, S. B., Yazdanpanah, L., Shahbazian, H. B., Sattari, A. R., Latifi, S. M., & Sarvandian, S. (2020) · Iranian Journal of Public Health · doi:10.18502/ijph.v48i7.2966 · Cited by 18 · see citing works
Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A
Townsend, K. L., Madden, C. J., Blaszkiewicz, M., McDougall, L. E., Tupone, D., Lynes, M. D., Mishina, Y. M., Yu, P. B., Morrison, S. F., & Tseng, Y. (2017) · Endocrinology · doi:10.1210/en.2017-00212 · Cited by 18 · see citing works
Self-citationMiR-503 inhibits adipogenesis by targeting bone morphogenetic protein receptor 1a.
Man, X., Tan, S., Tang, H., Guo, Y., Tang, C.-Y., Tang, J., Zhou, C., & Zhou, H. (2016) · Europe PMC (PubMed Central) · Cited by 17 · see citing works
Hampel, M., Blasco, J., Babbucci, M., Ferraresso, S., Bargelloni, L., & Milan, M. (2017) · Marine Environmental Research · doi:10.1016/j.marenvres.2017.04.012 · Cited by 17 · see citing works
Inorganic Self-Assembled Bioactive Artificial Proto-Osteocells Inducing Bone Regeneration
Shi, M., Yang, R., Li, Q., Lv, K., Miron, R. J., Sun, J., Li, M., & Zhang, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b00385 · Cited by 17 · see citing works
Lustig, R. H. (2010) · Endocrine updates · doi:10.1007/978-1-4419-7034-3 · Cited by 23 · see citing works
Nasal Septum Deviation as the Consequence of BMP-Controlled Changes to Cartilage Properties
Baddam, P., Young, D. W., Dunsmore, G., Nie, C., Eaton, F., Elahi, S., Jovel, J., Adesida, A. B., Dufour, A., & Graf, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.696545 · Cited by 14 · see citing works
Ojha, S., Symonds, M. E., & Budge, H. (2014) · Reproduction Fertility and Development · doi:10.1071/rd14007 · Cited by 14 · see citing works
Liu, Z., Wang, P., Cen, S., Gao, L., Xie, Z., Wu, X., Su, H., Wu, Y., & Shen, H. (2019) · Stem Cells International · doi:10.1155/2019/4143167 · Cited by 14 · see citing works
Adipokines regulate mesenchymal stem cell osteogenic differentiation
Xu, Z., Xiong, C.-W., Miao, K., Yu, Z.-T., Zhang, J., Yu, C., Huang, Y., & Zhou, X. (2023) · World Journal of Stem Cells · doi:10.4252/wjsc.v15.i6.502 · Cited by 15 · see citing works
Association of circulating BMP9 with coronary heart disease and hypertension in Chinese populations
Liu, R., Hu, W., Li, X., Pu, D., Yang, G., Liu, H., Tan, M., & Zhu, D. (2019) · BMC Cardiovascular Disorders · doi:10.1186/s12872-019-1095-2 · Cited by 14 · see citing works
- Authors
- Schulz, T. J., & Tseng, Y.-H.
- Affiliations
- Joslin Diabetes Center (US)
- Corresponding author
- Tseng, Yu-Hua
- Venue
- Cytokine & Growth Factor Reviews
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 20
- Issue
- 5-6
- Pages
- 523-531
- ISSN
- 1359-6101 (ISSN-L)
- PMC
- PMC2799934
- OpenAlex
- W2054468779
- Cited by
- 154
- References
- 110
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 11 · 2020: 4 · 2019: 14 · 2018: 6 · 2017: 14 · 2016: 6 · 2015: 14 · 2014: 15 · 2013: 17 · 2012: 12
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cytokine & Growth Factor Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077097, P30DK040561)
- National Center for Research Resources (UL1RR025758)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- bone morphogenetic proteins, adipogenesis, energy homeostasis, adipose tissue development, cell fate determination, stem/progenitor cells, obesity, metabolic disorders, BMP signaling
- MeSH terms
- Adipose Tissue, Animals, Cell Differentiation, Energy Metabolism, Humans, Models, Biological, Bone Morphogenetic Proteins, Adipogenesis, Bone Morphogenetic Protein Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
