The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation
Open accessAbstract
A characteristic of apoptosis is the rapid accumulation of cytoplasmic lipid droplets, which are composed largely of neutral lipids. The proton signals from these lipids have been used for the non-invasive detection of cell death using magnetic resonance spectroscopy. We show here that despite an apoptosis-induced decrease in the levels and activities of enzymes involved in lipogenesis, which occurs downstream of p53 activation and inhibition of the mTOR signaling pathway, the increase in lipid accumulation is due to increased de novo lipid synthesis. This results from inhibition of mitochondrial fatty acid β-oxidation, which coupled with an increase in acyl-CoA synthetase activity, diverts fatty acids away from oxidation and into lipid synthesis. The inhibition of fatty acid oxidation can be explained by a rapid rise in mitochondrial membrane potential and an attendant increase in the levels of reactive oxygen species.
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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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Blinded by the Light: The Growing Complexity of p53
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p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
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Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells
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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
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Cited by
Lipid droplets in the nervous system
Ralhan, I., Chang, C.-L., Lippincott-Schwartz, J., & Ioannou, M. S. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202102136 · Cited by 281
Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight
Palmieri, E. M., McGinity, C., Wink, D. A., & McVicar, D. W. (2020) · Metabolites · doi:10.3390/metabo10110429 · Cited by 237
Pan, B., Yang, L., Wang, J., Wang, Y., Wang, J., Zhou, X., Yin, X., Zhang, Z., & Zhao, D. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8646-4 · Cited by 54
STI571 protects neuronal cells from neurotoxic prion protein fragment-induced apoptosis
Pan, Y., Sun, L., Wang, J., Fu, W., Fu, Y., Wang, J., Tong, Y., & Pan, B. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.029 · Cited by 33
Metadata
- Authors
- Boren, J., & Brindle, K. M.
- Venue
- Cell Death & Differentiation
- Published
- 2012-03-30
- Volume
- 19
- Issue
- 9
- Pages
- 1561-1570
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W2057499586
- Cited by
- 254
- References
- 10
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
