TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation
Jouan-Lanhouet, S, Arshad, M I, Piquet-Pellorce, C, Martin-Chouly, C, Le Moigne-Muller, G, Van Herreweghe, F, Takahashi, N, Sergent, O +4 more·2012·Cell Death & Differentiation
Cited by (362)
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- Mitochondrial Ca2+ removal amplifies TRAIL cytotoxicity toward apoptosis-resistant tumor cells via promotion of multiple cell death modalitiesNatsuhiko Takata, Yohei Ohshima, Miki Suzuki‐Karasaki, Yukihiro Yoshida, Yasuaki Tokuhashi, Yoshihiro Suzuki‐Karasaki · 2017 · International Journal of Oncology
- Mitochondria as Regulators of Nonapoptotic Cell Death in CancerSaloni Malla, Rabin Neupane, Saloni Sood, Noor A. Hussein, Mariam Sami Abou-Dahech, David Terrero, Charles R. Ashby, Ramapuram Jayachandra Babu, Amit Kumar Tiwari · 2025 · MedComm
- The Prognostic, Diagnostic, and Therapeutic Potential of TRAIL Signalling in Cardiovascular DiseasesElaina Kelland, Manisha S. Patil, Sanjay Patel, Siân Peta Cartland, Mary Meltem Kavurma · 2023 · International Journal of Molecular Sciences
- Nrf2/HO-1 blocks TXNIP/NLRP3 interaction via elimination of ROS in oxygen-glucose deprivation-induced neuronal necroptosisZhihan Liu, Ping Cheng, Tao Feng, Zhiyuan Xie, Meifang Yang, Zhiren Chen, Shuqun Hu, Dong Kyun Han, Weiwei Chen · 2023 · Brain Research
- Necroptosis in human cancers with special emphasis on oral squamous cell carcinomaReshma Poothakulath Krishnan, Deepak Pandiar, Pratibha Ramani, Selvaraj Jayaraman · 2023 · Journal of Stomatology Oral and Maxillofacial Surgery
- Poly(ADP-ribosylation) and neurodegenerative disordersDavide Alessandro Basello, Anna Ivana Scovassi · 2015 · Mitochondrion
- Phospho‐ΔNp63α‐responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposureEdward A. Ratovitski · 2015 · FEBS Letters
- Programmed cell death with a necrotic-like phenotypeMichael J. Morgan, Zheng-gang Liu · 2013 · BioMolecular Concepts
- Cell Death PathwaysNahmah Kim‐Campbell, Hernando Gómez, Hülya Bayır · 2019 · Elsevier eBooks
- Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1Mohamed Benchekroun, Ludmila P. Ermolenko, Minh Quan Tran, Agathe Vagneux, Hristo Nedev, Claire Delehouzé, Mohamed Souab, Blandine Baratte, Béatrice Josselin, Bogdan Iuliu Iorga et al. · 2020 · European Journal of Medicinal Chemistry
- Recombinant Reg3α protein protects against experimental acute pancreatitis in miceLuting Yu, Mengqi Yang, Jun‐Li Liu, Martin Omondi Alfred, Xiang Li, Xueqing Zhang, Juan Zhang, Mingyuan Wu, Min Wang, Chen Luo · 2015 · Molecular and Cellular Endocrinology
- Terminalia Chebula provides protection against dual modes of necroptotic and apoptotic cell death upon death receptor ligationYoonjung Lee, Hee Sun Byun, Jeong Ho Seok, Kyeong Ah Park, Minho Won, Wonhyoung Seo, Sora Lee, Kidong Kang, Kyung‐Cheol Sohn, Ill Young Lee et al. · 2016 · Scientific Reports
- Multifunctionalized polyethyleneimine-based nanocarriers for gene and chemotherapeutic drug combination therapy through one-step assembly strategyDandan Jiang, Mingfang Wang, Tianqi Wang, Bo Zhang, Chunxi Liu, Na Zhang · 2017 · International Journal of Nanomedicine
- Inhibitors of RIP1 kinase: a patent review (2016–present)Philip A. Harris · 2020 · Expert Opinion on Therapeutic Patents
- Roles of DNA damage repair and precise targeted therapy in renal cancer (Review)Yongchang Lai, Zhibiao Li, Zechao Lu, Hanxiong Zheng, Chiheng Chen, Can Liu, Yafei Yang, Fucai Tang, Zhaohui He · 2022 · Oncology Reports
- IKKε and TBK1 prevent RIPK1 dependent and independent inflammationRemzi Onur Eren, Göksu Gökberk Kaya, Robin Schwarzer, Manolis Pasparakis · 2024 · Nature Communications
- Chrysophanic Acid Induces Necrosis but not Necroptosis in Human Renal Cell Carcinoma Caki-2 CellsJoon‐Seok Choi · 2016 · Journal of Cancer Prevention
- Inhibition of never in mitosis A (NIMA)-related kinase-4 reduces survivin expression and sensitizes cancer cells to TRAIL-induced cell deathSo Jung Park, Doo Sin Jo, Se‐Young Jo, Dong Woon Shin, Sangmi Shim, Yoon Kyung Jo, Ji Hyun Shin, Ye Jin Ha, Seong‐Yun Jeong, Jung Jin Hwang et al. · 2016 · Oncotarget
- TRIM21, a New Component of the TRAIL-Induced Endogenous Necrosome ComplexMélanie Simoes Eugénio, Florence Faurez, Ghania Hounana Kara-Ali, Mélanie Lagarrigue, Perrine Uhart, Marion Bonnet, Isabelle Gallais, Emmanuelle Com, Charles Pineau, Michel Samson et al. · 2021 · Frontiers in Molecular Biosciences
- Effect of combined radiation injury on cell death and inflammation in skinSachin Jadhav, Christopher J. Meeks, Nicholas M. Mordwinkin, Theresa B. Espinoza, Stan G. Louie, Gere S. diZerega, Kathleen E. Rodgers · 2015 · APOPTOSIS
- CD38 plays key roles in both antioxidation and cell survival of H2O2-treated primary rodent astrocytes.Yingxin Ma, Danhong Wu, Xianting Ding, Weihai Ying · 2014 · Europe PMC (PubMed Central)
- N-glycosylation by Mgat5 imposes a targetable constraint on immune-mediated tumor clearanceErin E. Hollander, Rosemary E. Flock, Jayne C. McDevitt, William P. Vostrejs, Sydney L. Campbell, Margo Orlen, Samantha B. Kemp, Benjamin Kahn, Kathryn E. Wellen, Il‐Kyu Kim et al. · 2024 · JCI Insight
- Cytosolic Double-Stranded DNA Induces Nonnecroptotic Programmed Cell Death in Trophoblasts via IFI16Xiao Ting Chu, Wei Chen, Ning Li, Xiao-Zhu Hu, Chongtao Du, Shui-Xing Yu, Min Zhou, Xiao-Jing Zhang, Gui-Mei Jiang, Wenyu Han et al. · 2014 · The Journal of Infectious Diseases
- Caspase‐independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non‐alcoholic steatohepatitisKeisuke Kakisaka, Yuji Suzuki, Yudai Fujiwara, Akiko Suzuki, Jo Kanazawa, Yasuhiro Takikawa · 2018 · Journal of Gastroenterology and Hepatology
- The Bulk Osteosarcoma and Osteosarcoma Stem Cell Activity of a Necroptosis‐Inducing Nickel(II)–Phenanthroline ComplexArvin Eskandari, Marie Flamme, Zhiyin Xiao, Kogularamanan Suntharalingam · 2020 · ChemBioChem
- PUMA/RIP3 Mediates Chemotherapy Response via Necroptosis and Local Immune Activation in Colorectal CancerDongshi Chen, Kaylee Ermine, Yi-Jun Wang, Xiaojun Chen, Xinyan Lu, Peng Wang, Donna Beer Stolz, Jian Yu, Lin Zhang · 2023 · Molecular Cancer Therapeutics
- An anti-ErbB2 fully human antibody circumvents trastuzumab resistanceQiong Lu, Lingfei Wang, Yajun Zhang, Xiaojie Yu, Chao Wang, Huajing Wang, Yang� Yang, Xiaodan Chong, Tian Xia, Yanchun Meng et al. · 2016 · Oncotarget
- The Novel, Orally Bioavailable CDK9 Inhibitor Atuveciclib Sensitises Pancreatic Cancer Cells to TRAIL-induced Cell DeathJan-Philipp Ruff, Anna-Laura Kretz, Marko Kornmann, Doris Henne‐Bruns, Johannes Lemke, Benno Traub · 2021 · Anticancer Research
- Crosstalk Between Cell Death and the cGAS-STING Pathway in Sepsis-Associated Acute Lung InjuryXuelin Li, Min Wang, Yifan Li, Ying Huang, Zhang Xiangcheng · 2025 · Journal of Inflammation Research
- Proteolytic control of regulated necrosisJohaiber Fuchslocher Chico, Carina Saggau, Dieter Adam · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- SERUM TNF- RELATED WEAK INDUCER OF APOPTOSIS (TWEAK), TNF- RELATED APOPTOSIS-INDUCING LIGAND (TRAIL) LEVELS IN PATIENTS WITH BIPOLAR DEPRESSION, MAJOR DEPRESSION AND A HEALTHY CONTROL GROUPHasan Karadağ, Gorkem Saygih, Rabia Nazik Yüksel, Mirak Baris Usta, Canan Topçuoğlu, Gamze Erzın · 2021 · Psychiatria Danubina
- Enhanced DR5 binding capacity of nanovectorized TRAIL compared to its cytotoxic version by affinity chromatography and molecular docking studiesAlbatoul Zakaria, Fabien Picaud, Yves Claude Guillaume, Tijani Gharbi, Olivier Micheau, Guillaume Herlem · 2016 · Journal of Molecular Recognition
- Current position of TNF-α in melanomagenesisIuliana Nenu, Diana Valentina Tudor, Gabriela Adriana Filip, Ioana Bâldea · 2015 · Tumor Biology
- Targeting Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL): A Promising Therapeutic Strategy in GliomasGeorge Α. Alexiou, Konstantinos Ioannis Tsamis, Athanassios P. Kyritsis · 2014 · Seminars in Pediatric Neurology
- Death Receptor 5 (TNFRSF10B) Is Upregulated and TRAIL Resistance Is Reversed in Hypoxia and Normoxia in Colorectal Cancer Cell Lines after Treatment with Skyrin, the Active Metabolite of Hypericum spp.Marián Babinčák, Rastislav Jendželovský, Ján Košuth, Martin Majerník, Jana Vargová, Kamil Mikulášek, Zbyněk Zdráhal, Peter Fedoročko · 2021 · Cancers
- Identification and Characterization of NTB451 as a Potential Inhibitor of NecroptosisEun-Jung In, Yuno Lee, Sushruta Koppula, Kim Taeyeon, Jun‐Hyuk Han, Kwang‐Ho Lee, Tae‐Bong Kang · 2018 · Molecules
- NF-κB RelA Is Required for Hepatoprotection during Pneumonia and SepsisYoung Kyu Kim, Eri Allen, Lillia A. Baird, Elise M. Symer, Filiz T. Korkmaz, Elim Na, Christine V. Odom, Matthew R. Jones, Joseph P. Mizgerd, Katrina E. Traber et al. · 2019 · Infection and Immunity
- Flavopiridol Strongly Sensitizes Canine Lymphoma Cells to TRAIL-induced ApoptosisAleksandra Pawlak, Diego de Miguel, Justyna Kutkowska, Bożena Obmińska‐Mrukowicz, Andrzej Rapak, Luis Martínez‐Lostao · 2017 · Anticancer Research
- Carbon ion triggered immunogenic necroptosis of nasopharyngeal carcinoma cells involving necroptotic inhibitor BCL-xCihang Bao, Yun Sun, Bilikere Srinivasa Rao Dwarakanath, Yuanli Dong, Yangle Huang, Xiaodong Wu, Chandan Guha, Lin Kong, Jiade Jay Lu · 2021 · Journal of Cancer
- Die hard: necroptosis and its impact on age-dependent neuroinflammatory diseasesKaitlan Smith, Meagan Colie, Trinity Moore, Jonathan Cummings Schisler · 2024 · Frontiers in Cell Death
- PARP2 deficiency affects invariant-NKT-cell maturation and protects mice from concanavalin A-induced liver injuryAveline A. Filliol, Claire Piquet‐Pellorce, Sarah Dion, Valentine Genêt, Catherine Lucas‐Clerc, Françoise Dantzer, Michel Samson · 2017 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- In vitro and in vivo discrepancy in inducing apoptosis by mesenchymal stromal cells delivering membrane-bound tumor necrosis factor–related apoptosis inducing ligand in osteosarcoma pre-clinical modelsGuiho, ROMAIN, BITEAU, KEVIN, GRISENDI, GIULIA, CHATELAIS, MATHIAS, BRION, REGIS, TAURELLE, JULIEN, RENAULT, SARAH, HEYMANN, DOMINIQUE, DOMINICI, MASSIMO, REDINI, FRANÇOISE · 2018 · Cytotherapy
- Down-Regulation of Survivin by Nemadipine-A Sensitizes Cancer Cells to TRAIL-Induced ApoptosisSeong Ho Park, So Jung Park, Joo-Oh Kim, Ji Hyun Shin, Eun Sung Kim, Yoon Kyung Jo, Jae‐Sung Kim, So Jung Park, Dong‐Hoon Jin, Jung Jin Hwang et al. · 2013 · Biomolecules & Therapeutics
- A matter of regeneration and repair: caspases as the key moleculesŞehnaz Bolkent, Füsun Öztay, Selda Gezginci-Oktayoğlu, Serap SANCAR BAŞ, Ayşe Karatuğ Kaçar · 2016 · TURKISH JOURNAL OF BIOLOGY
- Induction of interferon-β and interferon signaling by TRAIL and Smac mimetics via caspase-8 in breast cancer cellsVictoria Granqvist, Christian Holmgren, Christer Larsson · 2021 · PLoS ONE
- SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumoniaYuwei Luo, Jiang-Peng Zhou, Hongyu Ji, Doudou Xu, Anqi Zheng, Xin Wang, Zhizheng Dai, Zhicheng Luo, Fang Cao, Xingyue Wang et al. · 2024 · Nature Communications
- Intracellular pH Regulates TRAIL-Induced Apoptosis and Necroptosis in Endothelial CellsZhu‐Xu Zhang, Ingrid Gan, Alexander Pavlosky, Xuyan Huang, Benjamin Fuhrmann, Anthony M. Jevnikar · 2017 · Journal of Immunology Research
- Receptor-interacting serine/threonine kinase 1- and 3-dependent inflammation induced in lungs of chicken infected with Pasteurella multocidaWeitian Li, Qiyu Tang, Na Dai, Weikuan Feng, Changqing Xie, Guofu Cheng, Xiaoli Liu, Wanpo Zhang, Xueying Hu, Changqin Gu · 2020 · Scientific Reports
- New Frontiers in Cancer Chemotherapy — Targeting Cell Death PathwaysYong Zhong Xu, Cynthia Kanagaratham, Mina Youssef, Danuta Radzioch · 2016 · InTech eBooks
- 3-Aminobenzamide Prevents Concanavalin A-Induced Acute Hepatitis by an Anti-inflammatory and Anti-oxidative MechanismJoram Wardi, Orna Ernst, Anna Lilja, Hussein Aeed, Sebastián Katz, Idan Ben-Nachum, Iris Ben‐Dror, Dolev Katz, Olga Bernadsky, Rajendar Kandhikonda et al. · 2018 · Digestive Diseases and Sciences
- Immune-Mediated Nephropathy and Systemic Autoimmunity in Mice Does Not Require Receptor Interacting Protein Kinase 3 (RIPK3)Chelsea Corradetti, Neelakshi R. Jog, Stefania Gallucci, Michael P. Madaio, Siddharth Balachandran, Roberto Caricchio · 2016 · PLoS ONE
- TRAIL-induced apoptosis and proteasomal activity – Mechanisms, signalling and interplayChiara Boccellato, Markus Rehm · 2024 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Unlocking cardioprotection: iPSC exosomes deliver Nec-1 to target PARP1/AIFM1 axis, alleviating HF oxidative stress and mitochondrial dysfunctionXiaobing Lv, Boqin Liu, Xiaoting Su, Xintao Tian, Huating Wang · 2024 · Journal of Translational Medicine
- FDA-approved phensuximide inhibits RIPK1-dependent immunogenic cell deathByeong-Ju Kim, Sun Mi Hong, Hyun-Jin Noh, Jihye Kim, Su‐Yeon Seon, Jeong Eun Lee, Dahye Jeong, Ju‐Mi Park, Sejeong Park, Sanghoon Lee et al. · 2025 · Cell Death and Disease
- Virus-infection in cochlear supporting cells induces audiosensory receptor hair cell death by TRAIL-induced necroptosisYushi Hayashi, Hidenori Suzuki, Wataru Nakajima, Ikuno Uehara, Atsuko Tanimura, Toshiki Himeda, Satoshi Koike, Tatsuya Katsuno, Shin‐ichiro Kitajiri, Naoto Koyanagi et al. · 2021 · PLoS ONE
- Identification of an antibody‐based immunoassay for measuring direct target binding of RIPK 1 inhibitors in cells and tissuesJoshua N. Finger, Jean-Marie G. Brusq, Nino Campobasso, Michael N. Cook, Jennifer Deutsch, Heather Haag, Philip A. Harris, Earl L. Jenkins, Devika Joglekar, John D. Lich et al. · 2017 · Pharmacology Research & Perspectives
- IL-33 ameliorates liver injury and inflammation in Poly I:C and Concanavalin-A induced acute hepatitisHilal Ahmad Khan, Tariq Munir, Junaid Ali Khan, Al-Hafizah Shafia Tehseen Gul, Muhammad Zishan Ahmad, Muhammad Aamir Aslam, Muhammad Numman Umar, Muhammad Imran Arshad · 2020 · Microbial Pathogenesis
- Comprehensive analysis of regulated cell death pathways: intrinsic disorder, protein–protein interactions, and cross-pathway communicationOleksandr Sorokin, Frank Hause, Alice Wedler, Tala Alakhras, Theresa Bauchspiess, Anne Dietrich, Wiebke F. Günther, Coninika Guha, Kingsley Benjamin Obika, Joshua Kraft et al. · 2025 · APOPTOSIS
- TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling ComplexKelly Airiau, Pierre Vacher, Olivier Micheau, Valérie Prouzet‐Mauleon, Guido Kroemer, Mohammad Amin Moosavi, Mojgan Djavaheri‐Mergny · 2021 · Cells
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- Selective inhibition of tumor necrosis factor-α converting enzyme attenuates liver toxicity in a murine model of concanavalin A induced auto-immune hepatitisManoranjan Sharma, Jogeswar Mohapatra, Umar Malik, Akshaya Wagh, Anuj Kumar Singh, Hiren M. Patel, Dheerendra Pandey, Shekhar B. Kadam, Gourang B. Shah, Abhijit Chatterjee et al. · 2013 · International Immunopharmacology
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- Parthanatos‐associated proteins are stimulated intraocularly during development of experimental murine cytomegalovirus retinitis in mice with retrovirus‐induced immunosuppressionJay J. Oh, Jessica J. Carter, J.G. Nemeno, Richard D. Dix · 2019 · Journal of Medical Virology
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- "Yin-Yang" of PARP1 in genotoxic and inflammatory responseSijia Wang, Yukang Wu, Wen Zong, Zhao‐Qi Wang · 2025 · DNA repair
- Discovery, Optimization and Evaluation of Isothiazolo[5,4-B]Pyridine Derivatives as RIPK1 Inhibitors with Potent in Vivo Anti-SIRS ActivityYongjin Hao, Chengkui Yang, Chang Shu, Zhanhui Li, Kaijiang Xia, Shuwei Wu, Haikuo Ma, Sheng Tian, Yuting Ji, Jingjing Li et al. · 2022 · Bioorganic Chemistry
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- Drug Combination Antagonism and Single Agent Dominance Result from Differences in Death Activation KineticsRyan Richards, Hannah R. Schwartz, Mariah S. Stewart, Peter Cruz‐Gordillo, Megan E. Honeywell, Anna J. Joyce, Benjamin D. Landry, Michael J. Lee · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
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- Omics approaches to better understand the molecular mechanism of necroptosis and their translational implicationsApoorva J. Pradhan, Gunes Ekin Atilla‐Gokcumen · 2023 · Molecular Omics
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