TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation
Jouan-Lanhouet, S, Arshad, M I, Piquet-Pellorce, C, Martin-Chouly, C, Le Moigne-Muller, G, Van Herreweghe, F, Takahashi, N, Sergent, O +4 more·2012·Cell Death & Differentiation
Cited by (362)
Items 301–362 of 362
- AATF Competitively Interacts with Nuclear AIF and Inhibits Parthanatos of Neurons in dMCAO/R and OGD/R ModelsWei Xu, Zhen Hu, Dou Yin, Yue Zeng, Xiaoxiao Zhang, Wei Jin, Chuancheng Ren · 2022 · Journal of Molecular Neuroscience
- NecroptosisBen A. Croker, James A. Rickard, Inbar Shlomovitz, Arshed Al‐Obeidi, Akshay A. D’Cruz, Motti Gerlic · 2018 · Wiley eBooks
- Small-molecule modulators of the necroptotic pathway: A medicinal chemistry perspectiveDe-Chang Li, Nannan Chen, Qi-Dong You, Xiaoli Xu · 2026 · European Journal of Medicinal Chemistry
- Necroptosis, a Potential Therapeutic Target for Neurological DisordersJing Chen, Richard M. Kostrzewa, Xingshun Xu · 2014 · Springer eBooks
- Seminars in Cell & Developmental BiologyWen Zhou, Junying Yuan · 2014
- Programmed cell death and liver diseasesН. А. Онищенко, З. З. Гоникова, Alla O. Nikolskaya, Л. А. Кирсанова, V. I. Sevastianov · 2022 · Russian Journal of Transplantology and Artificial Organs
- RIPK3-dependent sequential recruitment of MLKL and RIPK1 drives PANoptotic cell death and chemokine productionYu Yang, Yue Wang, Yang Wang, Erpeng Wu, Hao Chen, Liming Sun, Chi Zhang, Shuhui Cao, JINGWEN LI, Huiping Qiang et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Regulation of Necroptosis by Aspergillus fumigatus Exopolysaccharide in Human Macrophages Derived from THP-1 Cells: Involvement of the RIP1-RIP3-MLKL Signaling AxisWei Shen, Meng Wang, Ting Han, Yan Yao, Xinyi Ying, Yuyue Cui, Peng Du · 2025 · Current Microbiology
- Discovery of benzothiazole derivatives as novel orally receptor-interacting protein kinase 1 (RIPK1) inhibitors for inflammatory disease therapyChufeng Zhang, Yulian Chen, Minghai Tang, Shunjie Zhang, Wei Yan, Yong Li, Na Li, Haoyu Zhao, Mingrui Li, Ziyan Ma et al. · 2025 · European Journal of Medicinal Chemistry
- Cyclopropyl as a versatile tool in the development of kinase-targeted therapeuticsWenwu Liu, Yaoguang Huang, Wenyan Hao, Zhuona Rong, Xinhua Liu, Ying Zhou, Song Song, Xiaocong Pang · 2026 · European Journal of Medicinal Chemistry
- Le criblage à RoscoffBlandine Baratte, Benoît Serive, Stéphane Bach · 2015 · médecine/sciences
- Small-Molecule Inhibitors of NecroptosisColleen R. McNamara, Alexei Degterev · 2014 · Springer eBooks
- NOX1, Reactive Oxygen Species, JNK, and Necrotic Cell DeathMichael J. Morgan, You‐Sun Kim · 2014 · Springer eBooks
- Mechanisms of Cell Death in the Developing BrainClaire Thornton, Henrik Hagberg · 2016 · Elsevier eBooks
- Cell Death and Autoimmune DiseaseStefania Gallucci, Roberto Caricchio, Philip L. Cohen · 2019 · Elsevier eBooks
- Endogenous Soluble TRAIL Contributes to the Survival and Growth of Human Mesenchymal Stem CellsJoaquín Marco-Brualla, Ana Gallego-Lleyda, Sanz Jara, Desportes Paula, Fernandez Hernandez Pablo, Luis Martínez‐Lostao, Lapuente Pedro, Alberto Anel · 2021 · International Journal of Stem cell Research & Therapy
- Targeting Necroptosis as Therapeutic Potential in Central Nervous System DiseasesHao Li, Meiling Xia, Jing Chen, Richard M. Kostrzewa, Xingshun Xu · 2022 · Springer eBooks
- Roles in innate immune receptors: Host : pathogen interactions and strengthening vaccinesSanna Nyström · 2013 · Figshare
- Cellular Injury and ApoptosisStefania Gallucci, Roberto Caricchio, Philip L. Cohen · 2013 · Elsevier eBooks
- Necrostatin-1: Its Discovery and Application in Cell Death ResearchDana E. Christofferson, Ying Li, Junying Yuan · 2014 · Springer eBooks
- The Paradoxical Roles of Cell Death Pathways in Immune CellsScott McComb · 2013 · uO Research (University of Ottawa)
- Other Determinants of SensitivityNaoyuki Okita, Atsushi Shibata · 2015 · Cancer drug discovery and develogment/Cancer drug discovery and development
- Necrobiology of Liver Cancer: Necrosis and NecroptosisArthur Zimmermann · 2016 · Springer eBooks
- TRAIL-induced kinases activation and apoptosis: towards improved death receptor targeted therapy for lung cancerKaamar Azijli · 2013 · Pure Amsterdam UMC
- Nouvelles voies de mort cellulaire des hépatocytesAveline A. Filliol, Jacques Le Seyec, Marie‐Françoise Samson · 2017
- The Role of NFκB Factor Relish in Developmentally Programmed Cell DeathAnubhab Nandy · 2018 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
- Pro-necroptotic agents in cancer therapyAhmed M Elsharkawy, Ahmed M Malki · 2018 · Annals of Breast Cancer
- Targeting Necroptosis as Therapeutic Potential in Central Nervous System DiseasesHao Li, Meiling Xia, Jing Chen, Richard M. Kostrzewa, Xingshun Xu · 2021 · Springer eBooks
- Potent and Selective RIPK1 Inhibitors Targeting Dual‐Pockets for the Treatment of Systemic Inflammatory Response Syndrome and SepsisXiangbo Yang, Huimin Lu, Hang Xie, Binbin Zhang, Tianqing Nie, Chen Fan, Tao Yang, Yechun Xu, Haixia Su, Wei Tang et al. · 2021 · Angewandte Chemie
- TNF signalingAmrit Mann, Mark J. Czaja, Jörn Markus Schattenberg · 2015 · Wiley eBooks
- Necrobiology of Liver Cancer: Necrosis and NecroptosisArthur Zimmermann · 2016 · Springer eBooks
- APO2L/TRAILLuis Martínez‐Lostao, Diego de Miguel, Alberto Anel, Javier Naval · 2016 · Springer eBooks
- APO2L/TRAILLuis Martínez‐Lostao, Diego de Miguel, Alberto Anel, Javier Naval · 2017 · Springer eBooks
- ROS/Redox Signaling and Apoptosis/Necroptosis/Autophagy in CancerMohinder Pal Bansal · 2023 · Springer eBooks
- Novel functions of LUBAC-mediated M1 poly-ubiquitination in TNFR1-mediated necroptosisNadine Weinelt · 2024
- Cell Death Mechanisms, Associated Toxicity and Therapeutic ApplicationsJulio C Davila, Natalia Kovalova, Zaher A. Radi · 2025 · Elsevier eBooks
- TRAIL (DR5) receptor and the modulation of TRAIL pathway in PLWHIV: key mechanisms in the progression of HIV diseaseSarah Ratkovich-González, Mariana del Rocío Ruiz-Briseño, Judith Carolina De Arcos-Jiménez, Monserrat Álvarez-Zavala, Jaime Federico Andrade-Villanueva, Pedro Martínez-Ayala, Vida Verónica Ruíz-Herrera, Luz Alicia González-Hernández, Karina Sánchez-Reyes · 2025 · BMC Molecular and Cell Biology
- Inflammatory cell death and leukemia treatmentSaqib Ishaq, Sajida Afzal, Shabir Ahmad Usmani, Ibtasam Wajid, Abdul Aziz, Raheel Tahir, Ajaz Ahmad, Amin Ullah · 2025 · Critical Reviews in Oncology/Hematology
- NEUROCOGNITION, PLASMA LEVEL OF TUMOUR NECROSIS FACTORRELATED APOPTOSIS INDUCING LIGAND (TRAIL), AND PHAGOCYTIC ACTIVITY IN HIV PATIENTS ON LONG-TERM ANTIRETROVIRAL THERAPY.Sheu Kadiri Rahamon, T B Kasali, Abdulfatah Adekunle Onifade, Sunday Peter Ogundeji, OLATUBOSUN GANIYU ARINOLA · 2025 · PubMed Central
- Advances in Pseudomonas aeruginosa-Induced Programmed Cell Death and Potential Targeted Treatment StrategiesChunjiang Tan, Yifeng Luo · 2025 · Microorganisms
- Additional file 1 of Unlocking cardioprotection: iPSC exosomes deliver Nec-1 to target PARP1/AIFM1 axis, alleviating HF oxidative stress and mitochondrial dysfunctionXiaobing Lv, Boqin Liu, Xiaoting Su, Xintao Tian, Wang, Huating · 2024 · Figshare
- Additional file 2 of Unlocking cardioprotection: iPSC exosomes deliver Nec-1 to target PARP1/AIFM1 axis, alleviating HF oxidative stress and mitochondrial dysfunctionXiaobing Lv, Boqin Liu, Xiaoting Su, Tian, Xintao, Wang, Huating · 2024 · Figshare
- Additional file 3 of Unlocking cardioprotection: iPSC exosomes deliver Nec-1 to target PARP1/AIFM1 axis, alleviating HF oxidative stress and mitochondrial dysfunctionXiaobing Lv, Boqin Liu, Xiaoting Su, Tian, Xintao, Wang, Huating · 2024 · Figshare
- Role of TRAIL-receptors in apoptosis and nonapoptotic signaling in cancer cells populations undergoing fractional killingYelyzaveta Shlyakhtina · 2016
- Caractérisation de nouveaux inhibiteurs de la kinase RIPK1 et de la nécroptoseFabienne Le Cann · 2017 · theses.fr (ABES)
- Mise en place et étude de modèles de progression de la NASH jusqu’au développement du CHC : effet du régime hyperlipidique sur l’environnement hépatiqueMélanie Simoes Eugénio · 2019
- Role of RIPK1 in the survival and death of hepatocytes : its involvement in murine hepatitis modelsMuhammad Farooq · 2019 · theses.fr (ABES)
- Étude de l’origine moléculaire de l’hétérogénéité de réponse cellulaire à TRAIL et son rôle dans la résistance non-génétiqueMickaël Meyer · 2020 · theses.fr (ABES)
- Caractérisation moléculaire et fonctionnelle de deux nouveaux déficits immunitaires primitifs associés à une dérégulation de la mort cellulaireBoris Sorin · 2023
- The resveratrol-induced apoptosis and/or necroptosis of lung cancer cells is dependent on the activation status of PARP-1 and MLKL under oxidative stressGwan-Hwan Wi, Seon‐Hee Oh · 2026 · Toxicological Research
- Redox-modulation of regulated cell death: implications for synergistic anticancer therapiesPooja Singh, Shreya Sridhar, Dwarithaa Balasubramanian, Devi Maigandan, Harish Chinna Konda Chandramoorthy, T T Ganesan, Rajesh Kumar Gandhirajan · 2026 · Naunyn-Schmiedeberg s Archives of Pharmacology
- Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylationSeongmi Kim, Seung Ri Lee, Hyunjin K. Rho, Hye-Jung Kim, Hyuk Wan Ko, Dong Hyuk Shin, Seung‐Mo Hong, Minjoong Kim, Jiyoung Yu, Kyunggon Kim et al. · 2026 · Cell Death and Differentiation
- Integrated Necroptosis Within Programmed Cell Death in Traumatic Brain InjuryAo Li, Tian-Wei Pei, Hao Qi, Juan Fang, Zhi‐Song Ding, Yu Wang, Yu-qiang Zhang, Tao Chen · 2026 · Molecular Neurobiology
- TRAIL splice variant TRAILshort disrupts T cell receptor signaling and promotes immune tolerance in vivoShahrzad Jalali, Sekar Natesampillai, Zilin Nie, Ying Zhang, İsmail Can, Aswath P. Chandrasekar, Brianna M. Hameister, Cristina Correia, Tuantuan V. Zhao, Dong‐Gi Mun et al. · 2026 · Journal of Clinical Investigation
- Host- and genotype-specific transcriptomic responses to Mycoplasma bovis infection in bison and Holstein peripheral blood mononuclear cellsBryan S. Kaplan, Kaitlyn M. Sarlo Davila, Jamison Ray Slate, Steven C. Olsen, Rohana P. Dassanayake, David J. Holthausen, Daniel W. Nielsen, Randy E. Sacco · 2026 · Frontiers in Immunology
- E3 ubiquitin ligase-mediated necroptosis: regulatory mechanisms and therapeutic implication in cancerMingzhen Wei, Aiqin Sun · 2026 · Molecular Biology Reports
- BindingDB Entry 50020763: Discovery of Sibiriline derivatives as novel receptor-interacting protein kinase 1 inhibitors.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50017144: Discovery of novel 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 kinase inhibitors.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50049028: Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.BindingDB · 2019 · UC San Diego
- BindingDB Entry 50013369: Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1.BindingDB · 2022 · UC San Diego
- BindingDB Entry 50015323: Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50007823: Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.BindingDB · 2021 · UC San Diego