TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221 · see citing works

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068 · see citing works

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

Cho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435 · see citing works

Molecular mechanisms of necroptosis: an ordered cellular explosion

Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382 · see citing works

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

He, S., Wang, L., Miao, L., Wang, T., Du, F., Zhao, L., & Wang, X. (2009) · Cell · doi:10.1016/j.cell.2009.05.021 · Cited by 2,214 · see citing works

Safety and antitumor activity of recombinant soluble Apo2 ligand

Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtrey, A. E., Hebert, A., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6926 · Cited by 2,213 · see citing works

Identification of RIP1 kinase as a specific cellular target of necrostatins

Degterev, A., Hitomi, J., Germscheid, M., Ch'en, I. L., Korkina, O., Teng, X., Abbott, D., Cuny, G. D., Yuan, C., Wagner, G., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.83 · Cited by 2,059 · see citing works

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.-L., Schneider, P., Seed, B., & Tschopp, J. (2000) · Nature Immunology · doi:10.1038/82732 · Cited by 1,932 · see citing works

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

Zhang, D.-W., Shao, J., Lin, J., Zhang, N., Lu, B.-J., Lin, S.-C., Dong, M.-Q., & Han, J. (2009) · Science · doi:10.1126/science.1172308 · Cited by 1,931 · see citing works

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

Hitomi, J., Christofferson, D. E., Ng, A., Yao, J., Degterev, A., Xavier, R. J., & Yuan, J. (2008) · Cell · doi:10.1016/j.cell.2008.10.044 · Cited by 989 · see citing works

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

Schulze‐Osthoff, K., Bakker, A. C., Vanhaesebroeck, B., Beyaert, R., Jacob, W. A., & Fiers, W. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42768-8 · Cited by 935 · see citing works

The effects of extracellular pH on immune function

Lardner, A. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.4.522 · Cited by 864 · see citing works

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

Takeda, K., Hayakawa, Y., Smyth, M. J., Kayagaki, N., Yamaguchi, N., Kakuta, S., Iwakura, Y., Yagita∥, H., & Okumura, K. (2001) · Nature Medicine · doi:10.1038/83416 · Cited by 771 · see citing works

Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response

Festjens, N., Vanden Berghe, T., & Vandenabeele, P. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.06.014 · Cited by 710 · see citing works

Expansion and evolution of cell death programmes

Degterev, A., & Yuan, J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2393 · Cited by 548 · see citing works

Critical contribution of liver natural killer T cells to a murine model of hepatitis

Takeda, K., Hayakawa, Y., Kaer, L. V., Matsuda, H., Yagita∥, H., & Okumura, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040566697 · Cited by 539 · see citing works

Activation and Caspase-mediated Inhibition of PARP: A Molecular Switch between Fibroblast Necrosis and Apoptosis in Death Receptor Signaling

Łoś, M., Mozoluk, M., Ferrari, D., Stępczyńska, A., Stroh, C., Renz, A., Herceg, Z., Wang, Z., & Schulze‐Osthoff, K. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-05-0272 · Cited by 505 · see citing works

Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos

Wang, Y., Dawson, V. L., & Dawson, T. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.020 · Cited by 405 · see citing works

Augmentation of Vα14 Nkt Cell–Mediated Cytotoxicity by Interleukin 4 in an Autocrine Mechanism Resulting in the Development of Concanavalin a–Induced Hepatitis

Kaneko, Y., Harada, M., Kawano, T., Yamashita, M., Shibata, Y., Gejyo, F., Nakayama, T., & Taniguchi, M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.1.105 · Cited by 396 · see citing works

Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria

Jan, G., Belzacq, A.-S., Haouzi, D., Rouault, A., Métivier, D., Kroemer, G., & Brenner, C. (2002) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400935 · Cited by 385 · see citing works

Mitochondrial and Nuclear Cross Talk in Cell Death

Andrabi, S. A., Dawson, T. M., & Dawson, V. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.014 · Cited by 378 · see citing works

New insights into apoptosis signaling by Apo2L/TRAIL

Gonzalvez, F., & Ashkenazi, A. (2010) · Oncogene · doi:10.1038/onc.2010.221 · Cited by 354 · see citing works

Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.

Wu, G. S., Burns, T. F., Zhan, Y.-A., Alnemri, E. S., & El‐Deiry, W. S. (1999) · PubMed · Cited by 238 · see citing works

Poly(ADP-ribose) Polymerase-1 Signaling to Mitochondria in Necrotic Cell Death Requires RIP1/TRAF2-mediated JNK1 Activation

Xu, Y., Huang, S., Liu, Z. G., & Han, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508135200 · Cited by 235 · see citing works

Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice

Toyabe, S., Seki, S., Iiai, T., Takeda, K., Shirai, K., Watanabe, H., Hiraide, H., Uchiyama, M., & Abo, T. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.3.1537 · Cited by 228 · see citing works

Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis

Temkin, V., Huang, Q., Liu, H., Osada, H., & Pope, R. M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2215-2225.2006 · Cited by 201 · see citing works

CYTOKINE EXPRESSION IN THREE MOUSE MODELS OF EXPERIMENTAL HEPATITIS

Sass, G., Heinlein, S., Agli, A., Bang, R., Schümann, J., & Tiegs, G. (2002) · Cytokine · doi:10.1006/cyto.2002.1948 · Cited by 197 · see citing works

Critical roles of TRAIL in hepatic cell death and hepatic inflammation

Zheng, S. J., Wang, P., Tsabary, G., & Chen, Y. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19255 · Cited by 173 · see citing works

Disruption of HSP90 Function Reverts Tumor Necrosis Factor-induced Necrosis to Apoptosis

Berghe, T. V., Kalai, M., Loo, G., Declercq, W., & Vandenabeele, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208925200 · Cited by 166 · see citing works

AIF-Mediated Programmed Necrosis: A Highly Orchestrated Way to Die

Boujrad, H., Gubkina, O., Robert, N., Krantic, S. M., & Susín, S. A. (2007) · Cell Cycle · doi:10.4161/cc.6.21.4842 · Cited by 165 · see citing works

Critical roles of TRAIL in hepatic cell death and hepatic inflammation

Zheng, S. J., Wang, P., Tsabary, G., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419255 · Cited by 150 · see citing works

Redox regulation of TNF signaling

Goossens, V., Vos, K. J. D., Vercammen, D., Steemans, M., Vancompernolle, K., Fiers, W., Vandenabeele, P., & Grooten, J. (1999) · BioFactors · doi:10.1002/biof.5520100210 · Cited by 136 · see citing works

Human tumour pH and its variation

Wike-Hooley, J. L., Berg, A. P. V. D., van der Zee, J., & Reinhold, H. S. (1985) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(85)90216-0 · Cited by 97 · see citing works

Cyclophilin A release as a biomarker of necrotic cell death

Christofferson, D. E., & Yuan, J. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.123 · Cited by 80 · see citing works

TRAIL Induces Receptor-Interacting Protein 1–Dependent and Caspase-Dependent Necrosis-Like Cell Death under Acidic Extracellular Conditions

Meurette, O., Rébillard, A., Laurence Therese, H. U. C., Moigne, G. L., Mérino, D., Micheau, O., Lagadic‐Gossmann, D., & Dimanche‐Boitrel, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1610 · Cited by 76 · see citing works

Targeting the Weak Point of Cancer by Induction of Necroptosis

Hu, X., Han, W., & Li, L. (2007) · Autophagy · doi:10.4161/auto.4592 · Cited by 65 · see citing works

Proteomic Investigation of Phosphorylation Sites in Poly(ADP-ribose) Polymerase-1 and Poly(ADP-ribose) Glycohydrolase

Gagné, J., Moreel, X., Gagné, P., Labelle, Y., Droit, A., Chevalier-Paré, M., Bourassa, S., McDonald, D., Hendzel, M. J., Prigent, C., et al. (2008) · Journal of Proteome Research · doi:10.1021/pr800810n · Cited by 54 · see citing works

Induction of necrotic tumor cell death by TRAIL/Apo-2L

Kemp, T. J., Kim, J.-S., Crist, S. A., & Griffith, T. S. (2003) · APOPTOSIS · doi:10.1023/a:1026286108366 · Cited by 33 · see citing works

TRAIL (TNF‐Related Apoptosis‐Inducing Ligand) Induces Necrosis‐Like Cell Death in Tumor Cells at Acidic Extracellular pH

Meurette, O., Laurence Therese, H. U. C., Rébillard, A., Moigne, G. L., Lagadic‐Gossmann, D., & Dimanche‐Boitrel, M. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1352.018 · Cited by 26 · see citing works

Immunotoxicology of T cell-dependent experimental liver injury

Tiegs, G., & Gantner, F. (1996) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(96)80058-3 · Cited by 21 · see citing works

Regulation of poly(ADP-ribose) polymerase-1 functions by leukocyte elastase inhibitor/LEI-derived DNase II during caspase-independent apoptosis

Leprêtre, C., Scovassi, A. I., Shah, G. M., & Torriglia, A. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.09.026 · Cited by 10 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Berghe, T. V., Linkermann, A., Jouan-Lanhouet, S., Walczak, H., & Vandenabeele, P. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3737 · Cited by 1,735 · see citing works

Crosstalk between apoptosis.; necrosis and autophagy

Nikoletopoulou, V., Markaki, M., Palikaras, K., & Tavernarakis, N. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.001 · Cited by 1,366 · see citing works

The role of necroptosis in cancer biology and therapy

Gong, Y., Fan, Z., Luo, G., Yang, C., Huang, Q., Fan, K., He, C., Jin, K., Ni, Q., Yu, X., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1029-8 · Cited by 1,048 · see citing works

Apoptosis, autophagy, necroptosis, and cancer metastasis

Su, Z., Yang, Z., Xu, Y., Chen, Y., & Yu, Q. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0321-5 · Cited by 1,039 · see citing works

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.137 · Cited by 1,002 · see citing works

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

Yuan, J., Amin, P., & Ofengeim, D. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0093-1 · Cited by 967 · see citing works

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 772 · see citing works

Necroptosis: Mechanisms and Relevance to Disease

Galluzzi, L., Kepp, O., Chan, F. K.-M., & Kroemer, G. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100247 · Cited by 721 · see citing works

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

Wree, A., Broderick, L., Canbay, A. E., Hoffman, H. M., & Feldstein, A. E. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.149 · Cited by 608 · see citing works

Initiation and execution mechanisms of necroptosis: an overview

Grootjans, S., Vanden Berghe, T., & Vandenabeele, P. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.65 · Cited by 566 · see citing works

Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury

Linkermann, A., Bräsen, J. H., Darding, M., Jin, M. K., Sanz, A. B., Heller, J.-O., Zen, F. D., Weinlich, R., Ortíz, A., Walczak, H., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305538110 · Cited by 568 · see citing works

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

Harris, P. A., Berger, S. B., Jeong, J. U., Nagilla, R., Bandyopadhyay, D., Campobasso, N., Capriotti, C. A., Cox, J. A., Dare, L. C., Dong, X., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01751 · Cited by 501 · see citing works

Getting TRAIL back on track for cancer therapy

Lemke, J., von Karstedt, S., Zinngrebe, J., & Walczak, H. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.81 · Cited by 455 · see citing works

Necroptosis in health and diseases

Zhou, W., & Yuan, J. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.07.013 · Cited by 414 · see citing works

Antioxidants of Edible Mushrooms

Kozarski, M., Klaus, A., Jakovljevic, D., Todorovic, N., Vunduk, J., Petrović, P., Niksic, M., Vrvic, M., & Van Griensven, L. (2015) · Molecules · doi:10.3390/molecules201019489 · Cited by 413 · see citing works

Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity

Meier, P., Legrand, A. J., Adam, D., & Silke, J. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00674-x · Cited by 405 · see citing works

Cancer therapy in the necroptosis era

Su, Z., Yang, Z., Xie, L., DeWitt, J. P., & Chen, Y. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.8 · Cited by 337 · see citing works

Molecular mechanisms of hepatic apoptosis

Wang, K. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.499 · Cited by 331 · see citing works

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

Dondelinger, Y., Aguileta, M. A., Goossens, V, Dubuisson, C., Grootjans, S., Dejardin, E., Vandenabeele, P., & Bertrand, M. J. M. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.94 · Cited by 312 · see citing works

Cell Death in Liver Diseases: A Review

Shojaie, L., Iorga, A., & Dara, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249682 · Cited by 299 · see citing works

Ferroptosis and Necroptosis in the Kidney

Belavgeni, A., Meyer, C., Stumpf, J., Hugo, C., & Linkermann, A. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.03.016 · Cited by 279 · see citing works

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

Lewerenz, J., Ates, G., Methner, A., Conrad, M., & Maher, P. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00214 · Cited by 273 · see citing works

The concanavalin A model of acute hepatitis in mice

Heymann, F., Hamesch, K., Weiskirchen, R., & Tacke, F. (2015) · Laboratory Animals · doi:10.1177/0023677215572841 · Cited by 263 · see citing works

Oxidative stress-mediated HMGB1 biology

Yan, Y. Q., Tang, D., & Kang, R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00093 · Cited by 262 · see citing works

Regulation of Tumor Progression by Programmed Necrosis

Lee, S. Y., Ju, M. K., Jeon, H. M., Jeong, E. K., Lee, Y. J., Kim, C. H., Park, H. G., Han, S. I., & Kang, H. S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3537471 · Cited by 225 · see citing works

The Dendritic Cell Response to Classic, Emerging, and Homeostatic Danger Signals. Implications for Autoimmunity

Gallo, P. M., & Gallucci, S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00138 · Cited by 193 · see citing works

Roles of RIPK3 in necroptosis, cell signaling, and disease

Morgan, M. J., & Kim, Y. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00868-z · Cited by 189 · see citing works

Necroptosis: an alternative cell death program defending against cancer

Chen, D., Yu, J., & Zhang, L. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.03.003 · Cited by 182 · see citing works

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

Azijli, K., Weyhenmeyer, B., Peters, G. J., de Jong, S., & Kruyt, F. A. E. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.28 · Cited by 178 · see citing works

Oncolytic Viruses—Natural and Genetically Engineered Cancer Immunotherapies

Jhawar, S. R., Thandoni, A., Bommareddy, P. K., Hassan, S., Kohlhapp, F. J., Goyal, S., Schenkel, J. M., Silk, A. W., & Zloza, A. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00202 · Cited by 178 · see citing works

Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy

Rosenbaum, S. R., Wilski, N. A., & Aplin, A. E. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0805 · Cited by 172 · see citing works

Absence of RIPK3 predicts necroptosis resistance in malignant melanoma

Geserick, P., Wang, J., Schilling, R., Horn, S., Harris, P. A., Bertin, J., Gough, P. J., Feoktistova, M., & Leverkus, M. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.240 · Cited by 168 · see citing works

Cell Death in the Developing Brain after Hypoxia-Ischemia

Thornton, C., Leaw, B., Mallard, C. E., Nair, S., Jinnai, M., & Hagberg, H. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00248 · Cited by 163 · see citing works

Necroptosis, in vivo detection in experimental disease models

Jouan-Lanhouet, S., Riquet, F. B., Duprez, L., Berghe, T. V., Takahashi, N., & Vandenabeele, P. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.08.010 · Cited by 160 · see citing works

TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death

Sosna, J., Voigt, S., Mathieu, S., Lange, A., Thon, L., Davarnia, P., Herdegen, T., Linkermann, A., Rittger, A., Chan, F. K.-M., et al. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1381-6 · Cited by 162 · see citing works

Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target

Radogna, F., Dicato, M. A., & Diederich, M. F. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.12.018 · Cited by 162 · see citing works

An evolutionary perspective on the necroptotic pathway

Dondelinger, Y., Hulpiau, P., Saeys, Y., Bertrand, M. J. M., & Vandenabeele, P. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.06.004 · Cited by 159 · see citing works

Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis

Weinlich, R., Oberst, A., Dillon, C. P., Janke, L. J., Milasta, S., Lukens, J. R., Rodriguez, D. A., Gurung, P., Savage, C., Kanneganti, T. D., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.045 · Cited by 157 · see citing works

Programmed necrosis and necroptosis signalling

Feoktistova, M., & Leverkus, M. (2014) · FEBS Journal · doi:10.1111/febs.13120 · Cited by 153 · see citing works

Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling

Kang, Y. J., Bang, B., Han, K. H., Hong, L., Shim, E.-J., Ma, J., Lerner, R. A., & Otsuka, M. (2015) · Nature Communications · doi:10.1038/ncomms9371 · Cited by 144 · see citing works

Parthanatos and its associated components: Promising therapeutic targets for cancer

Zhou, Y., Liu, L., Tao, S., Yao, Y., Wang, Y., Wei, Q., Shao, A., & Deng, Y. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105299 · Cited by 144 · see citing works

Shikonin Kills Glioma Cells through Necroptosis Mediated by RIP-1

Huang, C., Luo, Y., Zhao, J., Yang, F., Zhao, H., Fan, W., & Ge, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066326 · Cited by 139 · see citing works

Nonapoptotic cell death in acute kidney injury and transplantation

Linkermann, A. (2016) · Kidney International · doi:10.1016/j.kint.2015.10.008 · Cited by 140 · see citing works

The mechanism of necroptosis in normal and cancer cells

Fulda, S. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.26428 · Cited by 134 · see citing works

Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury

Deutsch, M., Graffeo, C. S., Rokosh, R. S., Pansari, M., Ochi, A., Levie, E., Heerden, E. V., Tippens, D. M., Greco, S., Barilla, R., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.126 · Cited by 131 · see citing works

Apoptosis Initiation Through the Cell-Extrinsic Pathway

Nair, P. M., Lu, M., Petersen, S., & Ashkenazi, A. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-417158-9.00005-4 · Cited by 125 · see citing works

The linear ubiquitin chain assembly complex regulates TRAIL‐induced gene activation and cell death

Lafont, E., Kantari‐Mimoun, C., Draber, P., De Miguel, D., Hartwig, T., Reichert, M., Kupka, S., Shimizu, Y., Taraborrelli, L., Spit, M., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695699 · Cited by 114 · see citing works

Predictive biomarkers for cancer therapy with PARP inhibitors

Michels, J., Vitale, I., Saparbaev, M. K., Castedo, M., & Kroemer, G. (2013) · Oncogene · doi:10.1038/onc.2013.352 · Cited by 113 · see citing works

A decade of cell death studies: Breathing new life into necroptosis

Khan, I., Yousif, A., Chesnokov, M. S., Hong, L., & Chefetz, I. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107717 · Cited by 112 · see citing works

Poly(ADP-ribose): A signaling molecule in different paradigms of cell death

Aredia, F., & Scovassi, A. I. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.06.021 · Cited by 108 · see citing works

Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53

Shin, H., Kwon, H., Lee, J.-H., Gui, X., Achek, A., Kim, J. H., & Choi, S. (2015) · Scientific Reports · doi:10.1038/srep15798 · Cited by 108 · see citing works

Current translational potential and underlying molecular mechanisms of necroptosis

Molnár, T., Mázló, A., Tslaf, V., Szöllősi, A. G., Emri, G., & Koncz, G. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2094-z · Cited by 107 · see citing works

β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells

Park, E. J., Min, K.-J., Lee, T.-J., Yoo, Y. H., Kim, Y.-S., & Kwon, T. K. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.202 · Cited by 105 · see citing works

Questions and controversies: the role of necroptosis in liver disease

Dara, L., Liu, Z., & Kaplowitz, N. (2016) · Cell Death Discovery · doi:10.1038/cddiscovery.2016.89 · Cited by 100 · see citing works

Dose-Dependent ATP Depletion and Cancer Cell Death following Calcium Electroporation, Relative Effect of Calcium Concentration and Electric Field Strength

Hansen, E. L., Sozer, E. B., Romeo, S., Frandsen, S. K., Vernier, P. T., & Gehl, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122973 · Cited by 98 · see citing works

Therapeutic exploitation of necroptosis for cancer therapy

Fulda, S. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.07.002 · Cited by 96 · see citing works

Necrostatin-1 Attenuates Renal Ischemia and Reperfusion Injury via Meditation of HIF-1α/mir-26a/TRPC6/PARP1 Signaling

Shen, B., Mei, M., Pu, Y., Zhang, H., Liu, H., Tang, M., Pan, Q., He, Y., Wu, X., & Zhao, H. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.06.025 · Cited by 93 · see citing works

The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer

Cousin, F., Jouan-Lanhouet, S., Théret, N., Brenner, C., Jouan, E., Moigne-Muller, G. L., Dimanche‐Boitrel, M., & Jan, G. (2016) · Oncotarget · doi:10.18632/oncotarget.6881 · Cited by 93 · see citing works

HMGB1‐associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia/reperfusion in rats

Wen, S., Li, X., Ling, Y., Chen, S., Deng, Q., Yang, L., Li, Y., Shen, J., Qiu, Y., Zhan, Y., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201900817r · Cited by 88 · see citing works

Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy

Meng, M.-B., Wang, H.-H., Cui, Y.-L., Wu, Z.-Q., Shi, Y., Zaorsky, N. G., Deng, L., Yuan, Z., Lü, Y., & Wang, P. (2016) · Oncotarget · doi:10.18632/oncotarget.10548 · Cited by 87 · see citing works

Novel Apoptosis-Inducing Agents for the Treatment of Cancer, a New Arsenal in the Toolbox

Lim, B., Greer, Y. E., Lipkowitz, S., & Takebe, N. (2019) · Cancers · doi:10.3390/cancers11081087 · Cited by 83 · see citing works

Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance

Khan, H. A., Ahmad, M. Z., Khan, J. A., & Arshad, M. I. (2017) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(17)60014-6 · Cited by 84 · see citing works

The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells

Zhang, M., Harashima, N., Moritani, T., Huang, W., & Harada, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127386 · Cited by 84 · see citing works

TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis

Karl, I., Jossberger-Werner, M., Schmidt, N., Horn, S., Goebeler, M., Leverkus, M., Wajant, H., & Giner, T. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.404 · Cited by 84 · see citing works

Necroptosis in cardiovascular disease - a new therapeutic target

Gupta, K., Phan, N., Wang, Q., & Liu, B. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.03.003 · Cited by 84 · see citing works

RIPK1 protects from TNF-α-mediated liver damage during hepatitis

Filliol, A. A., Piquet‐Pellorce, C., Seyec, J. L., Farooq, M., Genêt, V., Lucas‐Clerc, C., Bertin, J., Gough, P. J., Dimanche‐Boitrel, M., Vandenabeele, P., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.362 · Cited by 79 · see citing works

Melatonin attenuates carbon tetrachloride–induced liver fibrosis via inhibition of necroptosis

Choi, H., Kang, J., & Lee, S. (2015) · Translational research · doi:10.1016/j.trsl.2015.04.002 · Cited by 79 · see citing works

Cell Death and Liver Disease

Aizawa, S., Brar, G., & Tsukamoto, H. (2019) · Gut and Liver · doi:10.5009/gnl18486 · Cited by 77 · see citing works

Cancer and necroptosis: friend or foe?

Philipp, S., Sosna, J., & Adam, D. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2193-2 · Cited by 74 · see citing works

Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up‐regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo

Qiao, X., Wang, X., Shang, Y., Li, Y., & Chen, S. (2018) · 癌症：英文版 · doi:10.1186/s40880-018-0309-9 · Cited by 75 · see citing works

New components of the necroptotic pathway

Zhou, Z., Han, V. K. M., & Han, J. (2012) · Protein & Cell · doi:10.1007/s13238-012-2083-9 · Cited by 75 · see citing works

Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury

Yin, B., Xu, Y., Wei, R., He, F., Luo, B., & Wang, J. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.024 · Cited by 74 · see citing works

Generation of small molecules to interfere with regulated necrosis

Degterev, A., & Linkermann, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2198-x · Cited by 71 · see citing works

TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling

Guerrache, A., & Micheau, O. (2024) · Cells · doi:10.3390/cells13060521 · Cited by 74 · see citing works

Activation-induced necroptosis contributes to B-cell lymphopenia in active systemic lupus erythematosus

Fan, H., Liu, F., Dong, G., Ren, D., Xu, Y., Dou, J., Wang, T., Sun, L., & Hou, Y. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.375 · Cited by 73 · see citing works

Autophagy, Oxidative Stress and Cancer Development

Taucher, E., Mykoliuk, I., Fediuk, M., & Smolle‐Jüttner, F. (2022) · Cancers · doi:10.3390/cancers14071637 · Cited by 74 · see citing works

Bufalin inhibits human breast cancer tumorigenesis by inducing cell death through the ROS-mediated RIP1/RIP3/PARP-1 pathways

Li, Y., Tian, X., Liu, X., & Gong, P. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy039 · Cited by 71 · see citing works

Apoptosis-Inducing TNF Superfamily Ligands for Cancer Therapy

Arguello, O. A. D., & Haisma, H. J. (2021) · Cancers · doi:10.3390/cancers13071543 · Cited by 73 · see citing works

Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death

Bhattacharya, S., Chalk, A. M., Ng, A. J. M., Martin, T. J., Zannettino, A. C. W., Purton, L. E., Lü, J., Baker, E. K., & Walkley, C. R. (2016) · Oncogene · doi:10.1038/onc.2016.68 · Cited by 72 · see citing works

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase

Harris, P. A., Faucher, N., George, N. S., Eidam, P. M., King, B. W., White, G. V., Anderson, N. A., Bandyopadhyay, D., Beal, A. M., Bénéton, V., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00318 · Cited by 70 · see citing works

RIPK3 signaling and its role in the pathogenesis of cancers

Liu, S., Joshi, K., Denning, M. F., & Zhang, J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03947-y · Cited by 70 · see citing works

Necroptotic signaling in adaptive and innate immunity

Lu, J. V., Chen, H. C., & Walsh, C. M. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.07.003 · Cited by 69 · see citing works

Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL-mediated Necroptosis From Contributing to Liver Pathologies

Preston, S., Stutz, M. D., Allison, C. C., Nachbur, U., Gouil, Q. A., Tran, B. M., Duvivier, V., Arandjelovic, P., Cooney, J. P., Mackiewicz, L., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.08.040 · Cited by 68 · see citing works

Pseudomonas aeruginosa Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses

Wood, S. J., Goldufsky, J. W., Seu, M. Y., Dorafshar, A. H., & Shafikhani, S. H. (2023) · Cells · doi:10.3390/cells12010195 · Cited by 70 · see citing works

Transient receptor potential melastatin 4 and cell death

Simard, J. M., Woo, S. K., & Gerzanich, V. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1166-z · Cited by 67 · see citing works

Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy

Yang, M., Liu, L., Xie, M., Sun, X., Yu, Y. H., Kang, R., Yang, L., Zhu, S., Cao, L., & Tang, D. (2015) · Autophagy · doi:10.4161/15548627.2014.994400 · Cited by 64 · see citing works

The Impact of the Interferon/TNF-Related Apoptosis-Inducing Ligand Signaling Axis on Disease Progression in Respiratory Viral Infection and Beyond

Peteranderl, C., & Herold, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00313 · Cited by 63 · see citing works

Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB

Suda, J., Dara, L., Yang, L., Aghajan, M., Song, Y., Kaplowitz, N., & Liu, Z. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600690 · Cited by 63 · see citing works

Harnessing the Power of Invariant Natural Killer T Cells in Cancer Immunotherapy

Bedard, M., Salio, M., & Cerundolo, V. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01829 · Cited by 61 · see citing works

Adalimumab Reduces Photoreceptor Cell Death in A Mouse Model of Retinal Degeneration

de la Cámara, C. M.-F., Hernández‐Pinto, A. M., Olivares‐González, L., Cuevas-Martín, C., Sánchez‐Aragó, M., Hervás, D., Salom, D., Cuezva, J. M., de la Rosa, E. J., Millán, J. M., et al. (2015) · Scientific Reports · doi:10.1038/srep11764 · Cited by 63 · see citing works

Compartmentalization of TNF-related apoptosis-inducing ligand (TRAIL) death receptor functions: emerging role of nuclear TRAIL-R2

Bertsch, U., Röder, C., Kalthoff, H., & Trauzold, A. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.351 · Cited by 62 · see citing works

Necroptosis Signaling Pathways in Stroke: From Mechanisms to Therapies

Huang, J., Li, Y., Zhao, B.-L., Li, J., Zhang, N., Ye, Z., Xue-Jun, S., & Wen-wu, L. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180416152243 · Cited by 60 · see citing works

Targeting death receptors for TRAIL by agents designed by Mother Nature

Prasad, S., Kim, J. H., Gupta, S. C., & Aggarwal, B. B. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.07.004 · Cited by 60 · see citing works

Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members

Tischner, D., Manzl, C., Soratroi, C., Villunger, A., & Krumschnabel, G. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0756-8 · Cited by 59 · see citing works

ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts

Washington, M. N., Suh, G. K., Orozco, A. F., Sutton, M. N., Yang, H., Wang, Y., Mao, W., Millward, S. W., Ornelas, A., Atkinson, N., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.208 · Cited by 59 · see citing works

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell‐death mediator receptor‐interacting protein kinase 1

Koppe, C., Verheugd, P., Gautheron, J., Reisinger, F., Kreggenwinkel, K., Roderburg, C., Quagliata, L., Terracciano, L., Gaßler, N., Tolba, R. H., et al. (2016) · Hepatology · doi:10.1002/hep.28723 · Cited by 60 · see citing works

TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells

Voigt, S., Philipp, S., Davarnia, P., Winoto‐Morbach, S., Röder, C., Arenz, C., Trauzold, A., Kabelitz, D., Schütze, S., Kalthoff, H., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-74 · Cited by 57 · see citing works

Roles and Clinical Applications of OPG and TRAIL as Biomarkers in Cardiovascular Disease

Bernardi, S., Bossi, F., Toffoli, B., & Fabris, B. (2016) · BioMed Research International · doi:10.1155/2016/1752854 · Cited by 58 · see citing works

Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy

Zhang, J. C., Wang, G., Zhou, Y., Chen, Y., Ouyang, L., & Liu, B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2759-2 · Cited by 58 · see citing works

Modèles de nécroptose induite par TRAIL (TNF-Related Apoptosis Inducing Ligand) in vitro et in vivo

Jouan-Lanhouet, S. (2011)

TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor

Wang, L., Chang, X., Feng, J., Yu, J., & Chen, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00393 · Cited by 60 · see citing works

TRAIL-mediated apoptosis requires NF- k B inhibition and the mitochondrial permeability transition in human hepatoma cells

Kim, Y. S., Schwabe, R. F., Qian, T., Lemasters, J. J., & Brenner, D. A. (2002) · Hepatology · doi:10.1002/hep.1840360627 · Cited by 107 · see citing works

Proapoptotic signaling induced by deletion of receptor‐interacting kinase 1 and TNF receptor‐associated factor 2 results in liver carcinogenesis

Hirsova, P., Guicciardi, M. E., & Gores, G. J. (2017) · Hepatology · doi:10.1002/hep.29272 · Cited by 8 · see citing works

TRAIL-mediated apoptosis requires NF-κB inhibition and the mitochondrial permeability transition in human hepatoma cells

Kim, Y.-S. (2002) · Hepatology · doi:10.1053/jhep.2002.36942 · Cited by 32 · see citing works