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Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress

Vallelian, F, Deuel, J W, Opitz, L, Schaer, C A, Puglia, M, Lönn, M, Engelsberger, W, Schauer, S, Karnaukhova, E, Spahn, D R, Stocker, R, Buehler, P W, Schaer, D J·2015·Cell Death & Differentiation
DOI 10.1038/cdd.2014.154PMC PMC4356336
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Research works printed but not linked: 32

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  3. Boretti FS, Buehler PW, D'Agnillo F, Kluge K, Glaus T, Butt OI et al. Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. J Clin Invest 2009; 119: 2271–2280.
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  7. Jeney V, Balla J, Yachie A, Varga Z, Vercellotti GM, Eaton JW et al. Pro-oxidant and cytotoxic effects of circulating heme. Blood 2002; 100: 879–887. · DOI · Paper page
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  10. Higdon AN, Benavides GA, Chacko BK, Ouyang X, Johnson MS, Landar A et al. Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy. Am J Physiol Heart Circ Physiol 2012; 302: H1394–H1409. · DOI
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  13. Schaer CA, Deuel JW, Bittermann AG, Rubio IG, Schoedon G, Spahn DR et al. Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage. Cell Death Differ 2013; 20: 1569–1579. · DOI
  14. Pimenova T, Pereira CP, Gehrig P, Buehler PW, Schaer DJ, Zenobi R . Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin. J Proteome Res 2010; 9: 4061–4070. · DOI
  15. Vallelian F, Schaer CA, Kaempfer T, Gehrig P, Duerst E, Schoedon G et al. Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity. Blood 2010; 116: 5347–5356. · DOI
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  27. Kanayama HO, Tamura T, Ugai S, Kagawa S, Tanahashi N, Yoshimura T et al. Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms. Eur J Biochem 1992; 206: 567–578. · DOI
  28. Santoro AM, Lo Giudice MC, D’Urso A, Lauceri R, Purrello R, Milardi D . Cationic porphyrins are reversible proteasome inhibitors. J Am Chem Soc 2012; 134: 10451–10457. · DOI
  29. Lipiski M, Deuel JW, Baek JH, Engelsberger WR, Buehler PW, Schaer DJ . Human hp1-1 and hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in Guinea pigs to attenuate hemoglobin toxicity. Antioxid Redox Signal 2013; 19: 1619–1633. · DOI
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  32. Schaer CA, Vallelian F, Imhof A, Schoedon G, Schaer DJ . Heme carrier protein (HCP-1) spatially interacts with the CD163 hemoglobin uptake pathway and is a target of inflammatory macrophage activation. J Leukoc Biol 2008; 83: 325–333. · DOI

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Metadata

Authors
Vallelian, F., Deuel, J. W., Opitz, L., Schaer, C. A., Puglia, M., Lönn, M., Engelsberger, W., Schauer, S., Karnaukhova, E., Spahn, D. R., Stocker, R., Buehler, P. W., & Schaer, D. J.
Venue
Cell Death & Differentiation
Publisher
Springer Science and Business Media LLC
Published
2014-10-10
Volume
22
Issue
4
Pages
597-611
ISSN
  • 1350-9047
  • 1476-5403
DOI
10.1038/cdd.2014.154
PMC
PMC4356336
Cited by
66
References
2
Language
en
Licence
creativecommons.org/licenses/by-nc-sa/3.0/ (tdm)

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