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Old, new and emerging functions of caspases
Open accessAbstract
Caspases are proteases with a well-defined role in apoptosis. However, increasing evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and caspase-11 have roles in inflammation and mediating inflammatory cell death by pyroptosis. Similarly, caspase-8 has dual role in cell death, mediating both receptor-mediated apoptosis and in its absence, necroptosis. Caspase-8 also functions in maintenance and homeostasis of the adult T-cell population. Caspase-3 has important roles in tissue differentiation, regeneration and neural development in ways that are distinct and do not involve any apoptotic activity. Several other caspases have demonstrated anti-tumor roles. Notable among them are caspase-2, -8 and -14. However, increased caspase-2 and -8 expression in certain types of tumor has also been linked to promoting tumorigenesis. Increased levels of caspase-3 in tumor cells causes apoptosis and secretion of paracrine factors that promotes compensatory proliferation in surrounding normal tissues, tumor cell repopulation and presents a barrier for effective therapeutic strategies. Besides this caspase-2 has emerged as a unique caspase with potential roles in maintaining genomic stability, metabolism, autophagy and aging. The present review focuses on some of these less studied and emerging functions of mammalian caspases.
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“Activated CASP9 can catalyze the proteolytic activation of CASP3 and CASP7, which are widely perceived as the enzymes responsible for cell demolition during intrinsic (and extrinsic, see below) apoptosis in mammalian cells (and hence are commonly known as executioner caspases) [179, 180].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [180]
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Metadata
- Authors
- Shalini, S., Dorstyn, L., Dawar, S., & Kumar, S.
- Affiliations
- University of South Australia (AU)
- Corresponding author
- Kumar, S
- Venue
- Cell Death & Differentiation
- Published
- 2014-12-19
- Volume
- 22
- Issue
- 4
- Pages
- 526-539
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC4356345
- OpenAlex
- W2016540525
- Cited by
- 1,267
- References
- 205
- Citations by year
- 2026: 45 · 2025: 80 · 2024: 140 · 2023: 116 · 2022: 142 · 2021: 152 · 2020: 154 · 2019: 130 · 2018: 79 · 2017: 87 · 2016: 89 · 2015: 50 · 2014: 1
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (1041807, 1002863, 1043057, 1021456)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
- Keywords
- caspases, non-apoptotic caspase function, caspase-1, caspase-11, pyroptosis, caspase-8, necroptosis, caspase-3, caspase-2, CASP14, inflammation, tumor suppression, tumor progression, genome stability, autophagy, aging, tissue regeneration, neural development
- MeSH terms
- Animals, Cell Differentiation, Humans, Regeneration, Apoptosis, Inflammation Mediators, Caspases, Genomic Instability, Carcinogenesis
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