Old, new and emerging functions of caspases

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Self-eating and self-killing: crosstalk between autophagy and apoptosis

Maiuri, M. C., Zalckvar, E., Kimchi, A., & Kroemer, G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2239 · Cited by 3,638

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399

Pyroptosis: host cell death and inflammation

Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,288

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Czabotar, P. E., Lessene, G., Strasser, A., & Adams, J. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3722 · Cited by 3,219

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080

Caspase Functions in Cell Death and DiseasePreprint

McIlwain, D. R., Berger, T., & Mak, T. W. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008656 · Cited by 2,702

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J. G., et al. (1992) · Nature · doi:10.1038/356768a0 · Cited by 2,613

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680

Activation of apoptosis signalling pathways by reactive oxygen species

Redza-Dutordoir, M., & Averill-Bates, D. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.09.012 · Cited by 3,731

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

Pistritto, G., Trisciuoglio, D., Ceci, C., Garufi, A., & D’Orazi, G. (2016) · Aging · doi:10.18632/aging.100934 · Cited by 1,721

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 1,007

Autophagy-dependent cell death

Denton, D., & Kumar, S. (2019) · Cell Death & Differentiation · doi:10.1038/s41418-018-0252-y · Cited by 777

Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications

Mustafa, M., Ahmad, R., Tantry, I. Q., Ahmad, W., Siddiqui, S., Alam, M., Abbas, K., Moinuddin, Hassan, M. I., Habib, S., et al. (2024) · Cells · doi:10.3390/cells13221838 · Cited by 595

Interleukin-18 in Health and Disease

Yasuda, K., Nakanishi, K., & Tsutsui, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030649 · Cited by 583

Guidelines for the use of flow cytometry and cell sorting in immunological studies *

Cossarizza, A., Chang, H., Radbruch, A., Akdiş, M., Andrä, I., Annunziato, F., Bächer, P., Barnaba, V., Battistini, L., Bauer, W. M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646632 · Cited by 595

Caspase‐3: Structure, function, and biotechnological aspects

Asadi, M., Taghizadeh, S., Kaviani, E., Vakili, O., Taheri‐Anganeh, M., Tahamtan, M., & Savardashtaki, A. (2021) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2233 · Cited by 546

Caspase-1 initiates apoptosis in the absence of gasdermin D

Tsuchiya, K., Nakajima, S., Hosojima, S., Nguyen, D. T., Hattori, T., Le, T. M., Hori, O., Mahib, M. R., Yamaguchi, Y., Miura, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09753-2 · Cited by 512

Programmed cell death in aging

Tower, J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.002 · Cited by 426

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

Aglietti, R. A., & Dueber, E. C. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.01.003 · Cited by 419

A Review on Caspases: Key Regulators of Biological Activities and Apoptosis

Sahoo, G., Samal, D., Khandayataray, P., & Murthy, M. K. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03433-5 · Cited by 414

Microglia: Agents of the CNS Pro-Inflammatory Response

Rodríguez-Gómez, J. A., Kavanagh, E., Engskog-Vlachos, P., Engskog, M. K. R., Herrera, A. J., Espinosa-Oliva, A. M., Joseph, B., Hajji, N., Venero, J. L., & Burguillos, M. A. (2020) · Cells · doi:10.3390/cells9071717 · Cited by 365

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01153-w · Cited by 352

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

Galluzzi, L., López-Soto, A., Kumar, S., & Kroemer, G. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.020 · Cited by 350

An eco-friendly synthesis of Enterococcus sp.–mediated gold nanoparticle induces cytotoxicity in human colorectal cancer cells

Vairavel, M., Ezhilarasan, D., & Rajeshkumar, S. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-07511-x · Cited by 340

Proteomic and interactomic insights into the molecular basis of cell functional diversity

Bludau, I., & Aebersold, R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0231-2 · Cited by 297

The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration

Azam, S., Haque, M. E., Balakrishnan, R., Kim, I., & Choi, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683459 · Cited by 273

Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity

Tsuchiya, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010426 · Cited by 258

H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase

Zhou, J., Yang, L., Zhong, T., Mueller, M., Men, Y., Zhang, N., Xie, J., Giang, K., Chung, H., Sun, X., et al. (2015) · Nature Communications · doi:10.1038/ncomms10221 · Cited by 254

The Roles of Neutrophil-Derived Myeloperoxidase (MPO) in Diseases: The New Progress

Lin, W. C., Chen, H., Chen, X., & Guo, C. (2024) · Antioxidants · doi:10.3390/antiox13010132 · Cited by 290

Intracellular regulation of TNF activity in health and disease

Varfolomeev, E. E., & Vucic, D. (2016) · Cytokine · doi:10.1016/j.cyto.2016.08.035 · Cited by 257

Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Liu, Y., Teng, L., Yin, B., Meng, H., Yin, X., Huan, S., Song, G., & Zhang, X. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00875 · Cited by 250

Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

Tsuchiya, K. (2020) · Microbiology and Immunology · doi:10.1111/1348-0421.12771 · Cited by 245

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Lee, L. C., & Lo, K. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00629 · Cited by 255

Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease

Fogarty, C. E., & Bergmann, A. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.47 · Cited by 237

Proteolytic Cleavage—Mechanisms, Function, and “Omic” Approaches for a Near-Ubiquitous Posttranslational Modification

Klein, T., Eckhard, U., Dufour, A., Solis, N., & Overall, C. M. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00120 · Cited by 237

A Cell’s Fate: An Overview of the Molecular Biology and Genetics of Apoptosis

Cavalcante, G. C., Schaan, A. P., Cabral, G. F., Santana-da-Silva, M. N., Pinto, P., Vidal, A. F., & Ribeiro‐dos‐Santos, Â. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174133 · Cited by 233

Mechanisms of apoptosis

Savitskaya, M. A., & Онищенко, Г. Е. (2015) · Biochemistry (Moscow) · doi:10.1134/s0006297915110012 · Cited by 224

NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy

Luo, B., Huang, F., Liu, Y., Liang, Y., Wei, Z., Ke, H., Zeng, Z., Huang, W., & He, Y. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00519 · Cited by 213

Mechanistic insights from inflammasome structures

Fu, J., Schroder, K., & Wu, H. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00995-w · Cited by 223

Apoptosis Regulators Bcl-2 and Caspase-3

Hussar, P. (2022) · Encyclopedia · doi:10.3390/encyclopedia2040111 · Cited by 228

The interplay between inflammation and metabolism in rheumatoid arthritis

Chimenti, M. S., Triggianese, P., Conigliaro, P., Candi, E., Melino, G., & Perricone, R. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.246 · Cited by 220

Dietary and Physiological Effects of Zinc on the Immune System

Weßels, I., Fischer, H. J., & Rink, L. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122019-120635 · Cited by 213

Mechanisms for the transition from physiological to pathological cardiac hypertrophy

Oldfield, C. J., Duhamel, T. A., & Dhalla, N. S. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0566 · Cited by 219

Cell Death and Inflammation: The Role of Mitochondria in Health and Disease

Picca, A., Calvani, R., Coelho‐Júnior, H. J., & Marzetti, E. (2021) · Cells · doi:10.3390/cells10030537 · Cited by 207

Neutrophil pyroptosis: new perspectives on sepsis

Liu, L., & Sun, B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03060-1 · Cited by 200

Caspase-2 cleavage of tau reversibly impairs memory

Zhao, X., Kotilinek, L. A., Smith, B., Hlynialuk, C., Zahs, K., Ramsden, M., Cleary, J., & Ashe, K. H. (2016) · Nature Medicine · doi:10.1038/nm.4199 · Cited by 187

Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment

Zhu, P., Ke, Z.-R., Chen, J.-X., Li, S., Ma, T., & Fan, X.-L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1120034 · Cited by 200

Caspase involvement in autophagy

Tsapras, P., & Nezis, I. P. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.43 · Cited by 197

Endoplasmic Reticulum Stress and Unfolded Protein Response in Breast Cancer: The Balance between Apoptosis and Autophagy and Its Role in Drug Resistance

Sisinni, L., Pietrafesa, M., Lepore, S., Maddalena, F., Condelli, V., Esposito, F., & Landriscina, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040857 · Cited by 188

Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery

Wang, Y.-S., Shen, C., & Jiang, J. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104520 · Cited by 189

Cell death regulation: A new way for natural products to treat osteoporosis

Li, Z., Li, D., Chen, R., Gao, S., Xu, Z., & Li, N. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106635 · Cited by 183

Crosstalk between cGAS–STING signaling and cell death

Murthy, A. M. V., Robinson, N., & Kumar, S. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00624-8 · Cited by 178

PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment

Gao, J., Xiong, A., Liu, J., Li, X., Wang, J., Zhang, L., Liu, Y., Xiong, Y., Li, G., & He, X. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00765-9 · Cited by 188

Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistance

Shahar, N., & Larisch, S. (2020) · Drug Resistance Updates · doi:10.1016/j.drup.2020.100712 · Cited by 175

A delicate balance – The BCL-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics

Knight, T. E., Luedtke, D. A., Edwards, H. J., Taub, J. W., & Ge, Y. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.01.015 · Cited by 170

The Life and Death of a Plant Cell

Kabbage, M., Kessens, R., Bartholomay, L. C., & Williams, B. (2017) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-043015-111655 · Cited by 161

An unexpected friend − ROS in apoptosis-induced compensatory proliferation: Implications for regeneration and cancer

Diwanji, N., & Bergmann, A. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.07.004 · Cited by 155

Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond

Dho, S. H., Cho, M., Woo, W., Jeong, S., & Kim, L. K. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01470-9 · Cited by 175

Targeted contrast agents and activatable probes for photoacoustic imaging of cancer

Zhao, Z., Swartchick, C. B., & Chan, J. (2022) · Chemical Society Reviews · doi:10.1039/d0cs00771d · Cited by 155

Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways

Banjerdpongchai, R., Wudtiwai, B., Khaw-on, P., Rachakhom, W., Duangnil, N., & Kongtawelert, P. (2015) · Tumor Biology · doi:10.1007/s13277-015-3774-7 · Cited by 150

Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease

Avrutsky, M. I., & Troy, C. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.701301 · Cited by 151

Antitumor Effects of Carvacrol and Thymol: A Systematic Review

Sampaio, L. A., Pina, L. T. S., Serafini, M. R., Tavares, D. D. S., & Guimarães, A. G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.702487 · Cited by 158

Spontaneous preterm birth: advances toward the discovery of genetic predisposition

Strauss, J. F., Romero, R. J., Gomez‐Lopez, N., Haymond‐Thornburg, H., Modi, B. P., Teves, M. E., Pearson, L. N., York, T. P., & Schenkein, H. A. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.12.009 · Cited by 153

Quercetin modulates signaling pathways and induces apoptosis in cervical cancer cells

Sundaram, M. K., Raina, R., Afroze, N., Bajbouj, K., Hamad, M. A., Haque, S., & Hussain, A. (2019) · Bioscience Reports · doi:10.1042/bsr20190720 · Cited by 150

A Photoacoustic Probe for the Imaging of Tumor Apoptosis by Caspase‐Mediated Macrocyclization and Self‐Assembly

Wang, Y., Hu, X., Weng, J., Li, J., Fan, Q., Zhang, Y., & Ye, D. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201813748 · Cited by 146

Activatable Multimodal Probes for In Vivo Imaging and Theranostics

Wang, Y., Hu, Y., & Ye, D. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202209512 · Cited by 142

Different types of cell death and their shift in shaping disease

Shen, S., Shao, Y., & Li, C. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01581-0 · Cited by 157

Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans

Theofilas, P., Ehrenberg, A. J., Nguy, A. K., Thackrey, J. M., Dunlop, S. R., Mejia, M. B., Alho, A. T. D. L., Leite, R. E. P., Rodriguez, R. D., Suemoto, C. K., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.007 · Cited by 134

Peptide‐Based Multifunctional Nanomaterials for Tumor Imaging and Therapy

Zhang, C., Wu, W. H., Li, R., Qiu, W., Zhuang, Z., Cheng, S., & Zhang, X. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201804492 · Cited by 136

Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes

Tsuchiya, K., Hosojima, S., Hara, H., Kushiyama, H., Mahib, M. R., Kinoshita, T., & Suda, T. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108887 · Cited by 137

A natural products solution to diabetic nephropathy therapy

Hu, Q., Jiang, L., Qi, Y., Zeng, J., Ma, X., & Zhao, Y. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108314 · Cited by 137

Evolution of caspase-mediated cell death and differentiation: twins separated at birth

Bell, R. A. V., & Megeney, L. A. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.37 · Cited by 131

The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer

He, Y., Zhu, Q., Chen, M., Huang, Q., Wang, W., Li, Q., Huang, Y., & Di, W. J. (2016) · Oncotarget · doi:10.18632/oncotarget.12223 · Cited by 136

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy—Mitochondria, Calcium Dynamics and Reactive Oxygen Species

Kovac, S., Dinkova‐Kostova, A. T., Herrmann, A. M., Melzer, N., Meuth, S. G., & Gorji, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091935 · Cited by 129

Mechanisms of Cadmium-Induced Testicular Injury: A Risk to Male Fertility

Ali, W., Ma, Y., Zhu, J., Zou, H., & Liu, Z. (2022) · Cells · doi:10.3390/cells11223601 · Cited by 127

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Ferreira, M. A. R., Gamazon, E. R., Al‐Ejeh, F., Aittomäki, K., Andrulis, I. L., Anton‐Culver, H., Arason, A., Arndt, V., Aronson, K. J., Arun, B., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08053-5 · Cited by 127

Pathway network of pyroptosis and its potential inhibitors in acute kidney injury

Li, N., Wang, Y., Wang, X., Sun, N., & Gong, Y.-H. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.106033 · Cited by 129

Omega-3 PUFA Loaded in Resveratrol-Based Solid Lipid Nanoparticles: Physicochemical Properties and Antineoplastic Activities in Human Colorectal Cancer Cells In Vitro

Serini, S., Cassano, R., Corsetto, P. A., Rizzo, A. M., Calviello, G., & Trombino, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020586 · Cited by 123

Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific

Guerrini, V., Prideaux, B., Blanc, L., Bruiners, N., Arrigucci, R., Singh, S., Liang, H.-P. H., Salamon, H., Chen, P., Lakehal, K., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007223 · Cited by 116

A Novel Circular RNA Mediates Pyroptosis of Diabetic Cardiomyopathy by Functioning as a Competing Endogenous RNA

Yang, F., Li, A., Qin, Y., Che, H., Wang, Y., Lv, J., Li, Y., Li, H., Yue, E., Ding, X., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.06.026 · Cited by 120

Ovulation and ovarian wound healing are impaired with advanced reproductive age

Mara, J. N., Zhou, L. T., Larmore, M. J., Johnson, B., Ayiku, R., Amargant, F., Pritchard, M. T., & Duncan, F. E. (2020) · Aging · doi:10.18632/aging.103237 · Cited by 118

Microglial Corpse Clearance: Lessons From Macrophages

Márquez-Ropero, M., Benito, E., Plaza‐Zabala, A., & Sierra, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00506 · Cited by 115

Bortezomib in cancer therapy: Mechanisms, side effects, and future proteasome inhibitors

Sogbein, O., Paul, P., Umar, M., Châari, A., Batuman, V., & Upadhyay, R. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123125 · Cited by 123

Reassessing apoptosis in plants

Dickman, M. B., Williams, B., Li, Y., de Figueiredo, P., & Wolpert, T. (2017) · Nature Plants · doi:10.1038/s41477-017-0020-x · Cited by 112

Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts

Zhang, Q., Peng, W., Wei, S., Wei, D., Li, R., Liu, J., Peng, L., Yang, S., Gao, Y., Wu, C., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109367 · Cited by 111

Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease

Liu, P., Zhang, Z., & Yao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.603416 · Cited by 112

NLRP3 inflammasome: The rising star in cardiovascular diseases

Zheng, Y., Li, X., Dong, N., & Li, F. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.927061 · Cited by 122

A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis

Gomez‐Lopez, N., Romero, R. J., Xu, Y., Plazyo, O., Unkel, R., Leng, Y., Than, N. G., Chaiworapongsa, T., Panaitescu, B., Dong, Z., et al. (2017) · Reproductive Sciences · doi:10.1177/1933719116687656 · Cited by 108

Interplay between Cell Death and Cell Proliferation Reveals New Strategies for Cancer Therapy

Loftus, L. V., Amend, S. R., & Pienta, K. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094723 · Cited by 128

A Role for the Inflammasome in Spontaneous Labor at Term

Romero, R. J., Xu, Y., Plazyo, O., Chaemsaithong, P., Chaiworapongsa, T., Unkel, R., Than, N. G., Chiang, P. J., Dong, Z., Xu, Z., et al. (2016) · American Journal of Reproductive Immunology · doi:10.1111/aji.12440 · Cited by 110

Potentiation of in Vivo Anticancer Efficacy of Selenium Nanoparticles by Mushroom Polysaccharides Surface Decoration

Zeng, D., Zhao, J., Luk, K.-H., Cheung, S.-T., Wong, K., & Chen, T. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00193 · Cited by 105

Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential

Boudreau, M. W., Peh, J., & Hergenrother, P. J. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00338 · Cited by 104

Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila

Pérez, E., Lindblad, J. L., & Bergmann, A. (2017) · eLife · doi:10.7554/elife.26747 · Cited by 101

Vascular ageing: Underlying mechanisms and clinical implications

Laina, A., Stellos, K., & Stamatelopoulos, K. S. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.06.007 · Cited by 106

Caspases and their role in inflammation and ischemic neuronal death. Focus on caspase-12

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