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Oxidative stress-induced overexpression of miR-25: the mechanism underlying the degeneration of melanocytes in vitiligo
Open accessAbstract
Oxidative stress has a critical role in the pathogenesis of vitiligo. However, the specific molecular mechanism involved in oxidative stress-induced melanocyte death is not well characterized. Given the powerful role of microRNAs (miRNAs) in the regulation of cell survival as well as the fact that the generation of miRNAs can be affected by oxidative stress, we hypothesized that miRNAs may participate in vitiligo pathogenesis by modulating the expression of vital genes in melanocytes. In the present study, we initially found that miR-25 was increased in both serum and lesion samples from vitiligo patients, and its serum level was correlated with the activity of vitiligo. Moreover, restoration of miR-25 promoted the H2O2-induced melanocyte destruction and led to the dysfunction of melanocytes. Further experiments proved that MITF, a master regulator in melanocyte survival and function, accounted for the miR-25-caused damaging impact on melanocytes. Notably, other than the direct role on melanocytes, we observed that miR-25 inhibited the production and secretion of SCF and bFGF from keratinocytes, thus impairing their paracrine protective effect on the survival of melanocytes under oxidative stress. At last, we verified that oxidative stress could induce the overexpression of miR-25 in both melanocytes and keratinocytes possibly by demethylating the promoter region of miR-25. Taken together, our study demonstrates that oxidative stress-induced overexpression of miR-25 in vitiligo has a crucial role in promoting the degeneration of melanocytes by not only suppressing MITF in melanocytes but also impairing the paracrine protective effect of keratinocytes. Therefore, it is worthy to investigate the possibility of miR-25 as a potential drug target for anti-oxidative therapy in vitiligo.
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Oxidative stress compromises the paracrine protective effect of keratinocytes through upregulation of microRNA-25.
“oxidative stress was suggested to compromise paracrine protective effect of KC through upregulation of microRNA-25 [41].”
From Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling (2017) · cites this paper as [41]
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Metadata
- Authors
- Shi, Q., Zhang, W., Guo, S., Jian, Z., Li, S., Li, K., Ge, R., Dai, W., Wang, G., Gao, T., & Li, C.
- Affiliations
- Xijing Hospital (CN)
- Venue
- Cell Death & Differentiation
- Published
- 2015-08-28
- Volume
- 23
- Issue
- 3
- Pages
- 496-508
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC5072443
- OpenAlex
- W1912778406
- Cited by
- 117
- References
- 60
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 12 · 2023: 9 · 2022: 11 · 2021: 11 · 2020: 21 · 2019: 13 · 2018: 6 · 2017: 10 · 2016: 3 · 2015: 1
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81130032, 30972528, 81172749, 81472863)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
- Keywords
- vitiligo, miR-25, oxidative stress, MITF, hydrogen peroxide, keratinocytes, stem cell factor, basic fibroblast growth factor, DNA methylation, microRNA overexpression, paracrine signaling, therapeutic target
- MeSH terms
- Base Sequence, Binding Sites, Cells, Cultured, Humans, Melanocytes, Vitiligo, Keratinocytes, Gene Expression, Case-Control Studies, Fibroblast Growth Factor 2, Apoptosis, Oxidative Stress, Stem Cell Factor, 3' Untranslated Regions, RNA Interference, MicroRNAs, Microphthalmia-Associated Transcription Factor
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