The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Functional regulation of FoxO1 in neural stem cell differentiation
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“Five of the miR-132 targets (BMI1, FOXO1, SPRY1, DPYSL3, CITED2) displaying the highest betweenness centrality, a proxy of network connectivity, have all shown to be involved in cell cycle, and more specifically, in neurogenesis [68–72] (Fig. 5D) (Supplementary Table 7).”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [69]
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In the citing paper
“Five of the miR-132 targets (BMI1, FOXO1, SPRY1, DPYSL3, CITED2) displaying the highest betweenness centrality, a proxy of network connectivity, have all shown to be involved in cell cycle, and more specifically, in neurogenesis [68–72] (Fig. 5D) (Supplementary Table 7).”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [69]
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In the citing paper
“Our data indicate that while there are common ‘core’ miR-132 targets across conditions, possibly involved in ‘housekeeping’ cellular functions, like cell cycle [68–72], there are also context-dependent targets, specific to healthy control or sAD iMGs.”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [69]
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Citations
Cites
Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.
Valencia-Sanchez, M. A., Liu, J., Hannon, G. J., & Parker, R. (2006) · Genes & Development · doi:10.1101/gad.1399806 · Cited by 2,060
Regulation of miRNA expression during neural cell specification
Smirnova, L., Gräfe, A., Seiler, A., Schumacher, S., Nitsch, R., & Wulczyn, F. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03978.x · Cited by 707
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
Kitamura, T., Kitamura, Y. I., Funahashi, Y., Shawber, C. J., Castrillon, D. H., Kollipara, R., DePinho, R. A., Kitajewski, J., & Accili, D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32054 · Cited by 285
Brett, J. O., Renault, V. M., Rafalski, V. A., Webb, A. E., & Brunet, A. (2011) · Aging · doi:10.18632/aging.100285 · Cited by 207
FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis
Webb, A. E., Pollina, E. A., Vierbuchen, T., Urbán, N., Ucar, D., Leeman, D. S., Martynoga, B., Sewak, M., Rando, T. A., Guillemot, F., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.035 · Cited by 164
Research works printed but not linked: 43
- Ro SH, Liu D, Yeo H, Paik JH . FoxOs in neural stem cell fate decision. Arch Biochem Biophys 2013; 534: 55–63. · DOI
- Rafalski VA, Brunet A . Energy metabolism in adult neural stem cell fate. Prog Neurobiol 2011; 93: 182–203. · DOI
- Ambros V . microRNAs: tiny regulators with great potential. Cell 2001; 107: 823–826. · DOI
- Stefani G, Slack FJ . Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol 2008; 9: 219–230. · DOI
- Gao FB . Context-dependent functions of specific microRNAs in neuronal development. Neural Dev 2010; 5: 25. · DOI
- Liu C, Zhao X . MicroRNAs in adult and embryonic neurogenesis. Neuromolecular Med 2009; 11: 141–152. · DOI
- Kawahara H, Imai T, Okano H . MicroRNAs in neural stem cells and neurogenesis. Front Neurosci 2012; 6: 30. · DOI
- Nishino J, Kim I, Chada K, Morrison SJ . Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell 2008; 135: 227–239. · DOI
- Cheng LC, Pastrana E, Tavazoie M, Doetsch F . miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat Neurosci 2009; 12: 399–408. · DOI · Paper page
- De Pietri, Tonelli D, Pulvers JN, Haffner C, Murchison EP, Hannon GJ, Huttner WB . miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development 2008; 135: 3911–3921. · DOI · Paper page
- Krichevsky AM, Sonntag KC, Isacson O, Kosik KS . Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells 2006; 24: 857–864. · DOI · Paper page
- Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S et al. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany, NY) 2010; 2: 415–431. · DOI
- Zhao C, Sun G, Li S, Shi Y . A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nat Struct Mol Biol 2009; 16: 365–371. · DOI · Paper page
- Delaloy C, Liu L, Lee JA, Su H, Shen F, Yang GY et al. MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell 2010; 6: 323–335. · DOI · Paper page
- Nass D, Rosenwald S, Meiri E, Gilad S, Tabibian-Keissar H, Schlosberg A et al. MiR-92b and miR-9/9* are specifically expressed in brain primary tumors and can be used to differentiate primary from metastatic brain tumors. Brain Pathol 2009; 19: 375–383. · DOI
- Schraivogel D, Weinmann L, Beier D, Tabatabai G, Eichner A, Zhu JY et al. CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells. EMBO J 2011; 30: 4309–4322. · DOI
- Shibata M, Nakao H, Kiyonari H, Abe T, Aizawa S . MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. J Neurosci 2011; 31: 3407–3422. · DOI · Paper page
- Coolen M, Thieffry D, Drivenes O, Becker TS, Bally-Cuif L . miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors. Dev Cell 2012; 22: 1052–1064. · DOI
- Boulias K, Horvitz HR . The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO. Cell Metab 2012; 15: 439–450. · DOI · Paper page
- Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D et al. miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010; 12: 247–256. · DOI
- Ernst A, Alkass K, Bernard S, Salehpour M, Perl S, Tisdale J et al. Neurogenesis in the striatum of the adult human brain. Cell 2014; 156: 1072–1083. · DOI · Paper page
- Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y et al. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 2011; 476: 228–231. · DOI · Paper page
- Deo M, Yu JY, Chung KH, Tippens M, Turner DL . Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides. Dev Dyn 2006; 235: 2538–2548. · DOI
- Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 2009; 5: 540–553. · DOI · Paper page
- Ren H, Orozco IJ, Su Y, Suyama S, Gutiérrez-Juárez R, Horvath TL et al. FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell 2012; 149: 1314–1326. · DOI
- Kim MS, Pak YK, Jang PG, Namkoong C, Choi YS, Won JC et al. Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat Neurosci 2006; 9: 901–906. · DOI
- Qiang L, Banks AS, Accili D . Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization. J Biol Chem 2010; 285: 27396–27401. · DOI
- Kobayashi T, Mizuno H, Imayoshi I, Furusawa C, Shirahige K, Kageyama R . The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev 2009; 23: 1870–1875. · DOI
- Mercher T, Cornejo MG, Sears C, Kindler T, Moore SA, Maillard I et al. Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell 2008; 3: 314–326. · DOI
- Pui JC, Allman D, Xu L, DeRocco S, Karnell FG, Bakkour S et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 1999; 11: 299–308. · DOI
- Blanpain C, Lowry WE, Pasolli HA, Fuchs E . Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev 2006; 20: 3022–3035. · DOI
- Bouras T, Pal B, Vaillant F, Harburg G, Asselin-Labat ML, Oakes SR et al. Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell 2008; 3: 429–441. · DOI
- Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS et al. Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev 2002; 16: 846–858. · DOI
- Tun T, Hamaguchi Y, Matsunami N, Furukawa T, Honjo T, Kawaichi M . Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. Nucleic Acids Res 1994; 22: 965–971. · DOI
- Nakae J, Kitamura T, Kitamura Y, Biggs WH 3rd, Arden KC, Accili D et al. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev Cell 2003; 4: 119–129. · DOI
- Dengler HS, Baracho GV, Omori SA, Bruckner S, Arden KC, Castrillon DH et al. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol 2008; 9: 1388–1398. · DOI
- Sengupta A, Chakraborty S, Paik J, Yutzey KE, Evans-Anderson HJ . FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development. Dev Dyn 2012; 241: 803–813. · DOI
- Wu J, Xie X . Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol 2006; 7: R85. · DOI · Paper page
- Bredenkamp N, Seoighe C, Illing N . Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation. Dev Genes Evol 2007; 217: 227–233. · DOI
- Bonev B, Stanley P, Papalopulu N . MicroRNA-9 Modulates Hes1 ultradian oscillations by forming a double-negative feedback loop. Cell Rep 2012; 2: 10–18. · DOI
- Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J et al. Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nat Med 2011; 17: 961–967. · DOI · Paper page
- Jeon JH, Suh HN, Kim MO, Ryu JM, Han HJ . Glucosamine-induced OGT activation mediates glucose production through cleaved Notch1 and FoxO1, which coordinately contributed to the regulation of maintenance of self-renewal in mouse embryonic stem cells. Stem Cells Dev 2014; 23: 2067–2079. · DOI
- Yeo H, Lyssiotis CA, Zhang Y, Ying H, Asara JM, Cantley LC et al. FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells. EMBO J 2013; 32: 2589–2602. · DOI
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Metadata
- Authors
- Kim, D.-Y., Hwang, I., Muller, F. L., & Paik, J.-H.
- Venue
- Cell Death & Differentiation
- Published
- 2015-10-16
- Volume
- 22
- Issue
- 12
- Pages
- 2034-2045
- ISSN
- 1350-9047
- 1476-5403
- Cited by
- 90
- References
- 5
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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