Neurogenesis in the striatum of the adult human brain
Open accessAbstract
In most mammals, neurons are added throughout life in the hippocampus and olfactory bulb. One area where neuroblasts that give rise to adult-born neurons are generated is the lateral ventricle wall of the brain. We show, using histological and carbon-14 dating approaches, that in adult humans new neurons integrate in the striatum, which is adjacent to this neurogenic niche. The neuronal turnover in the striatum appears restricted to interneurons, and postnatally generated striatal neurons are preferentially depleted in patients with Huntington's disease. Our findings demonstrate a unique pattern of neurogenesis in the adult human brain.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In adulthood, neurogenesis is restricted to the hippocampus, rudimentarily present in the olfactory bulb, and possibly occurring in the striatum.
“According to current knowledge in adulthood neurogenesis is restricted to the hippocampus, rudimentarily present in the olfactory bulb and possibly occurring in the striatum (Bergmann et al., 2015;Ernst et al., 2014).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Ernst et al., 2014
The Introduction (p. 2) says adult humans have substantial hippocampal neurogenesis, and the Summary (p. 2) reports new neurons integrating in the adult striatum. But the Introduction explicitly says there is “no detectable adult olfactory bulb neurogenesis” in humans, contrary to the claim that it is rudimentarily present. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe vast majority of neurons in the human telencephalon are generated before birth, and neocortical excitatory neuron generation ends around 27 postconceptional weeks.
“The vast majority of neurons in the human telencephalon are generated before birth and neocortical excitatory neuron generation ends around 27 pcw (Ernst et al., 2014; Larsen et al., 2006; Spalding et al., 2005).”
From The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016) · cites this paper as Ernst et al., 2014
FANS has been used to bypass the incompatibility of neurons with whole-cell sorting.
“A novel variant of FACS, fluorescence activated nuclei sorting (FANS), has recently been used to bypass the incompatibility of neurons with whole-cell sorting.”
From Decoding neuroproteomics: integrating the genome, translatome and functional anatomy (2014) · cites this paper as [114]
Purification of striatal nuclei by NEUN labelling led to observations of adult human neurogenesis in the striatum.
“and striatum114”
From Decoding neuroproteomics: integrating the genome, translatome and functional anatomy (2014) · cites this paper as [114]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Model selection and multimodel inference: a practical information-theoretic approach.
Guthery, F. S., Burnham, K. P., & Anderson, D. R. (2003) · The Journal of Wildlife Management · doi:10.2307/3802723 · Cited by 41,495 · see citing works
A simple salting out procedure for extracting DNA from human nucleated cells
Miller, S. A., Dykes, D. D., & Polesky, H. F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.3.1215 · Cited by 20,341 · see citing works
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130 · see citing works
Self-citationNeuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799 · see citing works
Walker, F. O. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60111-1 · Cited by 2,623 · see citing works
Spatio-temporal transcriptome of the human brain
Kang, H. J., Kawasawa, Y. I., Cheng, F., Zhu, Y., Xu, X., Li, M., Sousa, A. M. M., Pletikos, M., Meyer, K. A., Sedmak, G., et al. (2011) · Nature · doi:10.1038/nature10523 · Cited by 2,084 · see citing works
Dynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841 · see citing works
Self-citationA Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642 · see citing works
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292 · see citing works
Transport Equations in Biology
Benoît Perthame, B. (2006) · Frontiers in mathematics · doi:10.1007/978-3-7643-7842-4 · Cited by 969 · see citing works
A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.002 · Cited by 927 · see citing works
Corridors of migrating neurons in the human brain and their decline during infancy
Sanai, N., Nguyen, T., Ihrie, R. A., Mirzadeh, Z., Tsai, H.-H., Wong, M., Gupta, N., Berger, M. S., Huang, E., Garcia-Verdugo, J.-M., et al. (2011) · Nature · doi:10.1038/nature10487 · Cited by 849 · see citing works
Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
Zuccato, C., Valenza, M., & Cattaneo, E. (2010) · Physiological Reviews · doi:10.1152/physrev.00041.2009 · Cited by 848 · see citing works
Nakashiba, T., Cushman, J. D., Pelkey, K. A., Renaudineau, S., Buhl, D. L., McHugh, T. J., Barrera, V. R., Chittajallu, R., Iwamoto, K. S., McBain, C. J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.046 · Cited by 805 · see citing works
Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R. P., Horvat, V., Volk, B., & Kempermann, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008809 · Cited by 650 · see citing works
Retrospective Birth Dating of Cells in Humans
Spalding, K. L., Bhardwaj, R. D., Buchholz, B. A., Druid, H., & Frisén, J. (2005) · Cell · doi:10.1016/j.cell.2005.04.028 · Cited by 626 · see citing works
Self-citationNeurogenesis and generalization: a new approach to stratify and treat anxiety disorders
Kheirbek, M., Klemenhagen, K. C., Sahay, A., & Hen, R. (2012) · Nature Neuroscience · doi:10.1038/nn.3262 · Cited by 543 · see citing works
Functional diversity and specificity of neostriatal interneurons
Tepper, J. M., & Bolam, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.003 · Cited by 526 · see citing works
Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain
Curtis, M. A., Penney, E. B., Pearson, A. G., van Roon‐Mom, W., Butterworth, N. J., Dragunow, M., Connor, B. J., & Faull, R. L. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1532244100 · Cited by 522 · see citing works
Depression and Hippocampal Neurogenesis: A Road to Remission?
Eisch, A. J., & Petrik, D. (2012) · Science · doi:10.1126/science.1222941 · Cited by 516 · see citing works
Limits of Neurogenesis in Primates
RAKIC, P. T. (1985) · Science · doi:10.1126/science.3975601 · Cited by 503 · see citing works
Dayer, A. G., Cleaver, K. M., Abouantoun, T. J., & Cameron, H. A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407053 · Cited by 454 · see citing works
Neocortical neurogenesis in humans is restricted to development
Bhardwaj, R. D., Curtis, M. A., Spalding, K. L., Buchholz, B. A., Fink, D., Björk-Eriksson, T., Nordborg, C., Gage, F. H., Druid, H., Eriksson, P. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605177103 · Cited by 448 · see citing works
Self-citationPlümpe, T., Ehninger, D., Steiner, B., Klempin, F., Jessberger, S., Brandt, M., Römer, B., Rodriguez, G. R., Kronenberg, G., & Kempermann, G. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-77 · Cited by 388 · see citing works
The Age of Olfactory Bulb Neurons in Humans
Bergmann, O., Liebl, J., Bernard, S., Alkass, K., Yeung, M. S. Y., Steier, P., Kutschera, W., Johnson, L., Landén, M., Druid, H., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.030 · Cited by 373 · see citing works
Self-citationWang, C., Liu, F., Liu, Y.-Y., Zhao, C.-H., You, Y., Wang, L., Zhang, J., Wei, B. K., Ma, T., Zhang, Q., et al. (2011) · Cell Research · doi:10.1038/cr.2011.83 · Cited by 309 · see citing works
Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis
Godin, J. D., Colombo, K., Molina-Calavita, M., Keryer, G., Zala, D., Charrin, B. C., Dietrich, P., Volvert, M.-L., Guillemot, F., Dragatsis, I., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.027 · Cited by 287 · see citing works
Increased Generation of Neuronal Progenitors after Ischemic Injury in the Aged Adult Human Forebrain
Macas, J., Nern, C., Plate, K. H., & Momma, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4667-06.2006 · Cited by 274 · see citing works
Topographic Guidance Labels in a Sensory Projection to the Forebrain
Feldheim, D. A., Vanderhaeghen, P., Hansen, M. J., Frisén, J., Lü, Q., Barbacid, M., & Flanagan, J. G. (1998) · Neuron · doi:10.1016/s0896-6273(00)80650-9 · Cited by 265 · see citing works
Self-citationNew neurons for 'survival of the fittest'
Kempermann, G. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3319 · Cited by 236 · see citing works
Seki, T. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10387 · Cited by 202 · see citing works
Cicchetti, F., Prensa, L., Wu, Y., & Parent, A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00039-4 · Cited by 192 · see citing works
Hou, S., Wang, Y., Xu, M., Shen, D., Wang, J., Huang, F., Zhang, Y., & Sun, F. (2008) · Stroke · doi:10.1161/strokeaha.107.510982 · Cited by 192 · see citing works
Sulzer, D., Mosharov, E. V., Tallóczy, Z., Zucca, F. A., Simon, J. D., & Zecca, L. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05385.x · Cited by 190 · see citing works
Kohler, S. J., Williams, N. I., Stanton, G. B., Cameron, J. L., & Greenough, W. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017099108 · Cited by 178 · see citing works
Tonchev, A. B., Yamashima, T., Zhao, L., Okano, H. J., & Okano, H. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00058-7 · Cited by 172 · see citing works
Neurogenesis in the Caudate Nucleus of the Adult Rabbit
Luzzati, F., Marchis, S. D., Fasolo, A., & Peretto, P. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4371-05.2006 · Cited by 150 · see citing works
Klempin, F., Kronenberg, G., Cheung, G. T. Y., Kettenmann, H., & Kempermann, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025760 · Cited by 137 · see citing works
Bédard, A., Lévesque, M., Bernier, P. J., & Parent, A. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02263.x · Cited by 124 · see citing works
Proliferating cells can differentiate into neurons in the striatum of normal adult monkey
Bédard, A., Cossette, M., Lévesque, M., & Parent, A. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00530-x · Cited by 118 · see citing works
Neural Stem Cells and Neurogenesis in the Adult
Göritz, C., & Frisén, J. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.04.005 · Cited by 110 · see citing works
Self-citationTonchev, A. B., Yamashima, T., Sawamoto, K., & Okano, H. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20604 · Cited by 109 · see citing works
Nácher, J., Alonso-Llosà, G., Rosell, D., & McEwen, B. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03241-3 · Cited by 95 · see citing works
Targeting neural precursors in the adult brain rescues injured dopamine neurons
Androutsellis‐Theotokis, A., Rueger, M. A., Park, D. M., Mkhikian, H., Korb, E., Poser, S., Walbridge, S., Munasinghe, J., Koretsky, A. P., Lonser, R. R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905125106 · Cited by 94 · see citing works
Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease
Kohl, Z., Regensburger, M., Aigner, R., Kandasamy, M., Winner, B., Aigner, L., & Winkler, J. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-114 · Cited by 72 · see citing works
Restorative Effects of Platelet Derived Growth Factor-BB in Rodent Models of Parkinson's Disease
Zachrisson, O., Zhao, M., Andersson, A., Dannaeus, K., Häggblad, J., Isacson, R., Nielsen, E. I., Patrone, C., Rönnholm, H., Wikström, L., et al. (2011) · Journal of Parkinson s Disease · doi:10.3233/jpd-2011-0003 · Cited by 71 · see citing works
Hippocampal Neurogenesis, Cognitive Deficits and Affective Disorder in Huntington's Disease
Ransome, M. I., Renoir, T., & Hannan, A. J. (2012) · Neural Plasticity · doi:10.1155/2012/874387 · Cited by 64 · see citing works
Huntingtin Mediates Anxiety/Depression-Related Behaviors and Hippocampal Neurogenesis
M'Barek, K. B., Pla, P., Orvoen, S., Benstaali, C., Godin, J., Gardier, A., Saudou, F., David, D., & Humbert, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5110-12.2013 · Cited by 47 · see citing works
Immunofluorescent Detection of Two Thymidine Analogues (CldU and IdU) in Primary Tissue
Tuttle, A. H., Rankin, M. M., Teta, M., Sartori, D. J., Stein, G. M., Kim, G. J., Virgilio, C., Granger, A., Zhou, D., Long, S. H., et al. (2010) · Journal of Visualized Experiments · doi:10.3791/2166 · Cited by 46 · see citing works
Wei, B. K., Nie, Y., Li, X., Wang, C., Ma, T., Huang, Z., Tian, M., Sun, C., Cai, Y., You, Y., et al. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07570.x · Cited by 37 · see citing works
Accelerator mass spectrometry of ultra-small samples with applications in the biosciences
Salehpour, M., Håkansson, K., & Possnert, G. (2012) · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms · doi:10.1016/j.nimb.2012.08.054 · Cited by 30 · see citing works
Self-citationBernard, S., Frisén, J., & Spalding, K. L. (2009) · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms · doi:10.1016/j.nimb.2009.10.156 · Cited by 24 · see citing works
Self-citationHeterogeneous intrastriatal pattern of proteins regulating axon growth in normal adult human brain
Tong, J., Furukawa, Y., Sherwin, A. L., Hornykiewicz, O., & Kish, S. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.10.017 · Cited by 20 · see citing works
Walker, T. L., Turnbull, G. W., Mackay, E., Hannan, A. J., & Bartlett, P. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018153 · Cited by 15 · see citing works
Georgiadou, E. A., Stenström, K. E., Uvo, C. B., Nilsson, P. M., Skog, G., & Mattsson, S. (2013) · Radiation and Environmental Biophysics · doi:10.1007/s00411-013-0458-9 · Cited by 12 · see citing works
Life Science Applications Utilizing Radiocarbon Tracing
Salehpour, M. (2013) · Radiocarbon · doi:10.2458/azu_js_rc.55.16479 · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Annual research review: enduring neurobiological effects of childhood abuse and neglect
Teicher, M. H., & Samson, J. A. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12507 · Cited by 1,473 · see citing works
The Cellular and Molecular Landscapes of the Developing Human Central Nervous System
Silbereis, J. C., Pochareddy, S., Zhu, Y., Li, M., & Sestan, N. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.008 · Cited by 818 · see citing works
Human Adult Neurogenesis: Evidence and Remaining Questions
Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.04.004 · Cited by 790 · see citing works
Self-citationAdult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791 · see citing works
Regulation and function of adult neurogenesis: from genes to cognition.
Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., & Gage, F. H. (2014) · Physiological Reviews · doi:10.1152/physrev.00004.2014 · Cited by 635 · see citing works
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients
Tobin, M. K., Musaraca, K., Disouky, A., Shetti, A., Bheri, A., Honer, W. G., Kim, N., Dawe, R. J., Bennett, D. A., Arfanakis, K., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.003 · Cited by 603 · see citing works
The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571 · see citing works
Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain
Yeung, M. S. Y., Zdunek, S., Bergmann, O., Bernard, S., Salehpour, M., Alkass, K., Perl, S., Tisdale, J., Possnert, G., Brundin, L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.011 · Cited by 541 · see citing works
Self-citationThe Lifespan and Turnover of Microglia in the Human Brain
Réu, P., Khosravi, A., Bernard, S., Mold, J. E., Salehpour, M., Alkass, K., Perl, S., Tisdale, J., Possnert, G., Druid, H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.004 · Cited by 515 · see citing works
Self-citationSingle-cell analysis reveals T cell infiltration in old neurogenic niches
Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521 · see citing works
Neurogenesis in the embryonic and adult brain: same regulators, different roles
Urbán, N., & Guillemot, F. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00396 · Cited by 493 · see citing works
Kraus, C., Castrén, E., Kasper, S., & Lanzenberger, R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.007 · Cited by 457 · see citing works
Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain
Kalamakis, G., Brüne, D., Ravichandran, S., Bolz, J., Fan, W., Ziebell, F., Stiehl, T., Catalá-Martinez, F., Kupke, J., Zhao, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.040 · Cited by 399 · see citing works
The role of inflammatory cytokines as key modulators of neurogenesis
Borsini, A., Zunszain, P. A., Thuret, S., & Pariante, C. M. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.12.006 · Cited by 381 · see citing works
Dynamics of oligodendrocyte generation in multiple sclerosis
Yeung, M. S. Y., Djelloul, M., Steiner, E., Bernard, S., Salehpour, M., Possnert, G., Brundin, L., & Frisén, J. (2019) · Nature · doi:10.1038/s41586-018-0842-3 · Cited by 376 · see citing works
Self-citationAdult neuroplasticity: more than 40 years of research
Fuchs, E., & Flügge, G. (2014) · Neural Plasticity · doi:10.1155/2014/541870 · Cited by 325 · see citing works
Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells
Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3989 · Cited by 329 · see citing works
Keeley, T. P., & Mann, G. E. (2019) · Physiological Reviews · doi:10.1152/physrev.00041.2017 · Cited by 329 · see citing works
Hill, W. D., Marioni, R. E., Maghzian, O., Ritchie, S. J., Hagenaars, S. P., McIntosh, A. M., Gale, C. R., Davies, G., & Deary, I. J. (2019) · Molecular Psychiatry · doi:10.1038/s41380-017-0001-5 · Cited by 311 · see citing works
Chronic peripheral inflammation, hippocampal neurogenesis, and behavior
Chesnokova, V., Pechnick, R. N., & Wawrowsky, K. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.01.017 · Cited by 299 · see citing works
Bergmann, O., Spalding, K. L., & Frisén, J. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018994 · Cited by 256 · see citing works
Self-citationAging and Rejuvenation of Neural Stem Cells and Their Niches
Navarro Negredo, P., Yeo, R. W., & Brunet, A. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.07.002 · Cited by 246 · see citing works
The HD iPSC Consortium, Lim, R. G., Salazar, L. L., Wilton, D. K., King, A. R., Stocksdale, J. T., Sharifabad, D., Lau, A. L., Stevens, B., Reidling, J. C., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4532 · Cited by 221 · see citing works
New approaches for brain repair-from rescue to reprogramming
Barker, R. A., Götz, M., & Parmar, M. (2018) · Nature · doi:10.1038/s41586-018-0087-1 · Cited by 214 · see citing works
Cathepsin B: A sellsword of cancer progression
Mijanović, O., Branković, A., Panin, A. N., Savchuk, S., Timashev, P., Ulasov, I., & Lesniak, M. S. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.02.035 · Cited by 205 · see citing works
Neural stem cell therapy for subacute and chronic ischemic stroke
Boese, A. C., Le, Q.-S. E., Pham, D., Hamblin, M. H., & Lee, J.-P. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0913-2 · Cited by 205 · see citing works
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715911114 · Cited by 186 · see citing works
Adult neurogenesis and neurodegenerative diseases: A systems biology perspective
Horgusluoglu, E., Nudelman, K., Nho, K., & Saykin, A. J. (2017) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32429 · Cited by 174 · see citing works
Ketamine for the treatment of addiction: evidence and potential mechanisms
Ivan Ezquerra-Romano, I., Lawn, W., Krupitsky, E., & Morgan, C. J. A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.017 · Cited by 163 · see citing works
Alzheimer’s disease and hippocampal adult neurogenesis; exploring shared mechanisms
Hollands, C., Bartolotti, N., & Lazarov, O. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00178 · Cited by 160 · see citing works
Quinti, L., Dayalan Naidu, S., Träger, U., Chen, X., Kegel-Gleason, K., Llères, D., Connolly, C., Chopra, V., Low, C., Moniot, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614943114 · Cited by 140 · see citing works
Djelloul, M., Holmqvist, S., Boza-Serrano, A., Azevedo, C., Yeung, M. S., Goldwurm, S., Frisén, J., Deierborg, T., & Roybon, L. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.07.002 · Cited by 138 · see citing works
Self-citationA unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons
Kozlenkov, A., Li, J., Apontes, P., Hurd, Y. L., Byne, W. M., Koonin, E. V., Wegner, M., Mukamel, E. A., & Dracheva, S. (2018) · Science Advances · doi:10.1126/sciadv.aau6190 · Cited by 103 · see citing works
Notch2 signaling maintains NSC quiescence in the murine ventricular-subventricular zone
Engler, A., Rolando, C., Giachino, C., Saotome, I., Erni, A., Brien, C., Zhang, R., Zimber-Strobl, U., Radtke, F., Artavanis-Tsakonas, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.094 · Cited by 125 · see citing works
Ojala, D. S., Sun, S., Santiago-Ortiz, J. L., Shapiro, M. G., Romero, P. A., & Schaffer, D. V. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2017.09.006 · Cited by 97 · see citing works
Adult neurogenesis: bridging the gap between mice and humans
Jessberger, S., & Gage, F. H. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.07.003 · Cited by 116 · see citing works
Siopi, E., Denizet, M., Gabellec, M.-M., de Chaumont, F., Olivo-Marin, J.-C., Guilloux, J.-P., Lledo, P.-M., & Lazarini, F. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2817-15.2016 · Cited by 111 · see citing works
Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner
Petrik, D., Myoga, M. H., Grade, S., Gerkau, N. J., Pusch, M., Rose, C. R., Grothe, B., & Götz, M. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.04.016 · Cited by 104 · see citing works
Sex differences in depression during pregnancy and the postpartum period
Sundström Poromaa, I., Comasco, E., Georgakis, M. K., & Skalkidou, A. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23859 · Cited by 96 · see citing works
Kawai, H., Kawaguchi, D., Kuebrich, B. D., Kitamoto, T., Yamaguchi, M., Gotoh, Y., & Furutachi, S. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0001-17.2017 · Cited by 85 · see citing works
Neurogenesis and Gliogenesis in Nervous System Plasticity and Repair
Frisén, J. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-124953 · Cited by 83 · see citing works
Self-citationDuque, A., Arellano, J. I., & Rakic, P. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01314-8 · Cited by 63 · see citing works
Decoding neuroproteomics: integrating the genome, translatome and functional anatomy
Kitchen, R. R., Rozowsky, J. S., Gerstein, M. B., & Nairn, A. C. (2014) · Nature Neuroscience · doi:10.1038/nn.3829 · Cited by 63 · see citing works
Plasticity in the Hippocampus, Neurogenesis and Drugs of Abuse
Avchalumov, Y., & Mandyam, C. D. (2021) · Brain Sciences · doi:10.3390/brainsci11030404 · Cited by 49 · see citing works
Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead
Sánchez-Martín, F. J., Lindquist, D. M., Landero-Figueroa, J., Zhang, X., Chen, J., Cecil, K. M., Medvedovic, M., & Puga, A. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2014.12.004 · Cited by 43 · see citing works
Maybury‐Lewis, S. Y., Brown, A. K., Yeary, M., Sloutskin, A., Dhakal, S., Juven‐Gershon, T., & Webb, A. E. (2021) · Aging Cell · doi:10.1111/acel.13499 · Cited by 27 · see citing works
Mechanisms of Neuron Loss in Alzheimer’s Disease
Mukhin, V. N., Pavlov, K. I., & Klimenko, V. M. (2017) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-017-0427-x · Cited by 27 · see citing works
Evidence of adult neurogenesis in non-human primates and human
Yuan, T.-F., Li, J., Ding, F., & Arias-Carrion, O. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1980-z · Cited by 26 · see citing works
Hippocampal proliferation is increased in presymptomatic Parkinson’s disease and due to microglia
Doorn, K. J., Drukarch, B., van Dam, A.-M., & Lucassen, P. J. (2014) · Neural Plasticity · doi:10.1155/2014/959154 · Cited by 24 · see citing works
- Authors
- Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., Possnert, G., Druid, H., & Frisén, J.
- Affiliations
- Uppsala University (SE)
- Karolinska Institutet (SE)
- Centre National de la Recherche Scientifique (FR)
- National Institutes of Health (US)
- Corresponding author
- Frisén, Jonas
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 156
- Issue
- 5
- Pages
- 1072-1083
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2045314069
- Cited by
- 937
- References
- 58
- Citations by year
- 2026: 26 · 2025: 43 · 2024: 47 · 2023: 53 · 2022: 57 · 2021: 81 · 2020: 87 · 2019: 94 · 2018: 73 · 2017: 108 · 2016: 108 · 2015: 87 · 2014: 72
- FWCI
- 43.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Uppsala University Publications (Uppsala University) (submittedVersion, other-oa)
- Funders
- National Institute for Health and Care Research
- Cancerfonden
- Karolinska Institutet (ALF 20080508)
- Knut och Alice Wallenbergs Stiftelse
- Stockholms Läns Landsting
- Vetenskapsrådet
- Rättsmedicinalverket
- NIHR Cambridge Biomedical Research Centre
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, striatum, lateral ventricle, neuronal turnover, interneurons, Huntington's disease, radiocarbon dating, human brain, neurogenic niche
- MeSH terms
- Adult, Animals, Basal Ganglia, Brain, Hippocampus, Humans, Huntington Disease, Interneurons, Models, Biological, Neurons, Olfactory Bulb, Mice, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
