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The C. elegans MicroRNA mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO

Boulias, Konstantinos, Horvitz, H. Robert·2012·Cell Metabolism
DOI 10.1016/j.cmet.2012.02.014
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Abstract

The life span of Caenorhabditis elegans is controlled by signaling between the germline and the soma. Germ cell removal extends life span by triggering the activation of the DAF-16/FOXO transcription factor in the intestine. Here we analyze microRNA function in C. elegans aging and show that the microRNA mir-71 functions to mediate the effects of germ cell loss on life span. mir-71 is required for the life span extension caused by germline removal, and overexpression of mir-71 further extends the life span of animals lacking germ cells. mir-71 functions in the nervous system to facilitate the localization and transcriptional activity of DAF-16 in the intestine. Our findings reveal a microRNA-dependent mechanism of life span regulation by the germline and indicate that signaling among the gonad, the nervous system, and the intestine coordinates the life span of the entire organism.

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Metadata

Authors
Boulias, K., & Horvitz, H. R.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2012-04
Volume
15
Issue
4
Pages
439-450
ISSN
1550-4131
DOI
10.1016/j.cmet.2012.02.014
Cited by
184
References
6
Language
en
Licence
Funders
  • European Molecular Biology Organization
  • Howard Hughes Medical Institute
  • Ellison Medical Foundation

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