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MicroRNA-125b regulates microglia activation and motor neuron death in ALS

Parisi, C, Napoli, G, Amadio, S, Spalloni, A, Apolloni, S, Longone, P, Volonté, C·2016·Cell Death & Differentiation
DOI 10.1038/cdd.2015.153PMC PMC5072447
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  1. Swinnen B, Robberecht W. The phenotypic variability of amyotrophic lateral sclerosis. Nat Rev Neurol 2014; 10: 661–670. 25311585
  2. Renton AE, Chio A, Traynor BJ. State of play in amyotrophic lateral sclerosis genetics. Nat Neurosci 2014; 17: 17–23. 24369373 PMC4544832
  3. Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 1994; 264: 1772–1775. 8209258
  4. Poppe L, Rue L, Robberecht W, Van Den Bosch L. Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS). Exp Neurol 2014; 262: 138–151. 25017368
  5. Robberecht W, Philips T. The changing scene of amyotrophic lateral sclerosis. Nat Rev Neurosci 2013; 14: 248–264. 23463272
  6. Paez-Colasante X, Figueroa-Romero C, Sakowski SA, Goutman SA, Feldman EL. Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era. Nat Rev Neurol 2015; 11: 266–279. 25896087
  7. Philips T, Rothstein JD. Glial cells in amyotrophic lateral sclerosis. Exp Neurol 2014; 262: 111–120. 24859452 PMC4241182
  8. Brites D, Vaz AR. Microglia centered pathogenesis in ALS: insights in cell interconnectivity. Front Cell Neurosci 2014; 8: 117. 24904276 PMC4033073
  9. D'Ambrosi N, Rossi S, Gerbino V, Cozzolino M. Rac1 at the crossroad of actin dynamics and neuroinflammation in amyotrophic lateral sclerosis. Front Cell Neurosci 2014; 8: 279. 25249940 PMC4157560
  10. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. Mechanisms underlying inflammation in neurodegeneration. Cell 2010; 140: 918–934. 20303880 PMC2873093
  11. Swarup V, Phaneuf D, Dupre N, Petri S, Strong M, Kriz J et al. Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor kappaB-mediated pathogenic pathways. J Exp Med 2011; 208: 2429–2447. 22084410 PMC3256969
  12. Zhu G, Wu CJ, Zhao Y, Ashwell JD. Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. Curr Biol 2007; 17: 1438–1443. 17702576
  13. Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y et al. Mutations of optineurin in amyotrophic lateral sclerosis. Nature 2010; 465: 223–226. 20428114
  14. Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L, Miranda CJ et al. Microglia induce motor neuron death via the classical NF-kappaB pathway in amyotrophic lateral sclerosis. Neuron 2014; 81: 1009–1023. 24607225 PMC3978641
  15. Renner F, Schmitz ML. Autoregulatory feedback loops terminating the NF-kappaB response. Trends Biochem Sci 2009; 34: 128–135. 19233657
  16. Opipari AW Jr, Boguski MS, Dixit VM. The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem 1990; 265: 14705–14708. 2118515
  17. Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004; 430: 694–699. 15258597
  18. Vereecke L, Beyaert R, van Loo G. The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology. Trends Immunol 2009; 30: 383–391. 19643665
  19. Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 2004; 5: 1052–1060. 15334086
  20. Guedes RP, Csizmadia E, Moll HP, Ma A, Ferran C, da Silva CG. A20 deficiency causes spontaneous neuroinflammation in mice. J Neuroinflammation 2014; 11: 122. 25026958 PMC4128606
  21. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215–233. 19167326 PMC3794896
  22. Volonté C, Apolloni S, Parisi C. MicroRNAs: newcomers into the ALS picture. CNS Neurol Disord Drug Targets 2015; 14: 194–207. 25613506
  23. Morlando M, Dini Modigliani S, Torrelli G, Rosa A, Di Carlo V, Caffarelli E et al. FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment. EMBO J 2012; 31: 4502–4510. 23232809 PMC3545295
  24. Di Carlo V, Grossi E, Laneve P, Morlando M, Dini Modigliani S, Ballarino M et al. TDP-43 regulates the microprocessor complex activity during in vitro neuronal differentiation. Mol Neurobiol 2013; 48: 952–963. 24113842
  25. Ma X, Becker Buscaglia LE, Barker JR, Li Y. MicroRNAs in NF-kappaB signaling. J Mol Cell Biol 2011; 3: 159–166. 21502305 PMC3104013
  26. Kim SW, Ramasamy K, Bouamar H, Lin AP, Jiang D, Aguiar RC. MicroRNAs miR-125a and miR-125b constitutively activate the NF-kappaB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20). Proc Natl Acad Sci USA 2012; 109: 7865–7870. 22550173 PMC3356650
  27. Apolloni S, Parisi C, Pesaresi MG, Rossi S, Carri MT, Cozzolino M et al. The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis. J Immunol 2013; 190: 5187–5195. 23589615
  28. D'Ambrosi N, Finocchi P, Apolloni S, Cozzolino M, Ferri A, Padovano V et al. The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis. J Immunol 2009; 183: 4648–4656. 19734218
  29. Apolloni S, Amadio S, Parisi C, Matteucci A, Potenza RL, Armida M et al. Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis. Dis Model Mech 2014; 7: 1101–1109. 25038061 PMC4142730
  30. Parisi C, Arisi I, D'Ambrosi N, Storti AE, Brandi R, D'Onofrio M et al. Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation. Cell Death Dis 2013; 4: e959. 24336079 PMC3877562
  31. Liu B, Jiang D, Ou Y, Hu Z, Jiang J, Lei X. An anti-inflammatory role of A20 zinc finger protein during trauma combined with endotoxin challenge. J Surg Res 2013; 185: 717–725. 24055365
  32. Lai TY, Wu SD, Tsai MH, Chuang EY, Chuang LL, Hsu LC et al. Transcription of Tnfaip3 is regulated by NF-kappaB and p38 via C/EBPbeta in activated macrophages. PLoS One 2013; 8: e73153. 24023826 PMC3759409
  33. Austin JW, Gilchrist C, Fehlings MG. High molecular weight hyaluronan reduces lipopolysaccharide mediated microglial activation. J Neurochem 2012; 122: 344–355. 22587438
  34. Ferrari D, Wesselborg S, Bauer MK, Schulze-Osthoff K. Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65. J Cell Biol 1997; 139: 1635–1643. 9412459 PMC2132650
  35. Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature 2014; 512: 69–73. 25043000 PMC4126806
  36. Collart MA, Baeuerle P, Vassalli P. Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B. Mol Cell Biol 1990; 10: 1498–1506. 2181276 PMC362253
  37. Hide I, Tanaka M, Inoue A, Nakajima K, Kohsaka S, Inoue K et al. Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. J Neurochem 2000; 75: 965–972. 10936177
  38. Lim H, Kim D, Lee SJ. Toll-like receptor 2 mediates peripheral nerve injury-induced NADPH oxidase 2 expression in spinal cord microglia. J Biol Chem 2013; 288: 7572–7579. 23386616 PMC3597798
  39. Leto TL, Morand S, Hurt D, Ueyama T. Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases. Antioxid Redox Signal 2009; 11: 2607–2619. 19438290 PMC2782575
  40. Mancuso R, Navarro X. Amyotrophic lateral sclerosis: current perspectives from basic research to the clinic. Prog Neurobiol 2015; 133: 1–26. 26253783
  41. Valori CF, Brambilla L, Martorana F, Rossi D. The multifaceted role of glial cells in amyotrophic lateral sclerosis. Cell Mol Life Sci 2014; 71: 287–297. 23912896 PMC11113174
  42. Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S et al. Astrocyte-derived TGF-beta1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells. Cell Rep 2015; 11: 592–604. 25892237
  43. Zhao W, Beers DR, Appel SH. Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis. J Neuroimmune Pharmacol 2013; 8: 888–899. 23881705 PMC4126425
  44. Volonté C, Apolloni S, Skaper SD, Burnstock G. P2X7 receptors: channels, pores and more. CNS Neurol Disord Drug Targets 2012; 11: 705–721. 22963440
  45. Volonté C, Apolloni S, Carri MT, D'Ambrosi N. ALS: focus on purinergic signalling. Pharmacol Ther 2011; 132: 111–122. 21704075
  46. Butovsky O, Jedrychowski MP, Cialic R, Krasemann S, Murugaiyan G, Fanek Z et al. Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Ann Neurol 2015; 77: 75–99. 25381879 PMC4432483
  47. Aga M, Watters JJ, Pfeiffer ZA, Wiepz GJ, Sommer JA, Bertics PJ. Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-kappa B signaling pathways in murine RAW 264.7 macrophages. Am J Physiol Cell Physiol 2004; 286: C923–C930. 14684387
  48. Zhao Y, Bhattacharjee S, Jones BM, Hill J, Dua P, Lukiw WJ. Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b in Alzheimer's disease (AD) and in primary human neuronal-glial (HNG) cells. Mol Neurobiol 2014; 50: 97–106. 24293102 PMC4038663
  49. Colton CA. Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 2009; 4: 399–418. 19655259 PMC2773116
  50. Ivashkiv LB. Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states. Eur J Immunol 2008; 41: 2477–2481. PMC3264328 21952800
  51. Beers DR, Zhao W, Liao B, Kano O, Wang J, Huang A et al. Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice. Brain Behav Immun 2011; 25: 1025–1035. 21176785 PMC3096756
  52. Valente T, Mancera P, Tusell JM, Serratosa J, Saura J. C/EBPbeta expression in activated microglia in amyotrophic lateral sclerosis. Neurobiol Aging 2012; 33: 2186–2199. 22015310
  53. Catrysse L, Vereecke L, Beyaert R, van Loo G. A20 in inflammation and autoimmunity. Trends Immunol 2014; 35: 22–31. 24246475
  54. Coornaert B, Carpentier I, Beyaert R. A20: central gatekeeper in inflammation and immunity. J Biol Chem 2009; 284: 8217–8221. 19008218 PMC2659177
  55. Turer EE, Tavares RM, Mortier E, Hitotsumatsu O, Advincula R, Lee B et al. Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. J Exp Med 2008; 205: 451–464. 18268035 PMC2271029
  56. Spalloni A, Albo F, Ferrari F, Mercuri N, Bernardi G, Zona C et al. Cu/Zn-superoxide dismutase (GLY93—>ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture. Neurobiol Dis 2004; 15: 340–350. 15006704

Cited by

Sorted by citations

Authors
Parisi, C., Napoli, G., Amadio, S., Spalloni, A., Apolloni, S., Longone, P., & Volonté, C.
Venue
Cell Death & Differentiation
Publisher
Springer Science and Business Media LLC
Published
2016-01-22
Volume
23
Issue
3
Pages
531-541
ISSN
  • 1350-9047
  • 1476-5403
DOI
10.1038/cdd.2015.153
PMC
PMC5072447
Cited by
127
References
5
Language
en
Licence
creativecommons.org/licenses/by-nc-nd/4.0 (tdm)

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