Cited by 50Adenosine and Purinergic SignalingPain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy

Open access
Oliveira-Giacomelli, Ágatha, Naaldijk, Yahaira, Sardá-Arroyo, Laura, Gonçalves, Maria C. B., Corrêa-Velloso, Juliana, Pillat, Micheli M., de Souza, Héllio D. N., Ulrich, Henning·2018·Frontiers in Pharmacology

Abstract

Since proving adenosine triphosphate (ATP) functions as a neurotransmitter in neuron/glia interactions, the purinergic system has been more intensely studied within the scope of the central nervous system. In neurological disorders with associated motor symptoms, including Parkinson's disease (PD), motor neuron diseases (MND), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Huntington's Disease (HD), restless leg syndrome (RLS), and ataxias, alterations in purinergic receptor expression and activity have been noted, indicating a potential role for this system in disease etiology and progression. In neurodegenerative conditions, neural cell death provokes extensive ATP release and alters calcium signaling through purinergic receptor modulation. Consequently, neuroinflammatory responses, excitotoxicity and apoptosis are directly or indirectly induced. This review analyzes currently available data, which suggests involvement of the purinergic system in neuro-associated motor dysfunctions and underlying mechanisms. Possible targets for pharmacological interventions are also discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fphar.2018.00325

Cites

317 of 317 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In animal models for neurodegeneration, P2X7 receptor antagonism exerted beneficial anti-inflammatory effects, indicating that P2X7 receptor activation and subsequent neuroinflammation is tightly related to neurodegeneration worsening.

    “In animal models for neurodegeneration P2X7 receptor antagonism exerted beneficial anti-inflammatory effects [138, 139], indicating that P2X7 receptor activation and subsequent neuroinflammation is tightly related to neurodegeneration worsening.”
  • In neurodegenerative diseases, cell death is accompanied by neuroinflammatory processes and massive ATP release.

    “In neurodegenerative diseases, cell death is accompanied by neuroinflammatory processes and massive ATP release [138].”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Oliveira-Giacomelli, Á., Naaldijk, Y., Sardá-Arroyo, L., Gonçalves, M. C. B., Corrêa-Velloso, J., Pillat, M. M., de Souza, H. D. N., & Ulrich, H.
Affiliations
  • Universidade de São Paulo (BR)
  • Universidade Federal de São Paulo (BR)
Corresponding author
Ulrich, Henning
Venue
Frontiers in Pharmacology
Published
2018-04-10
Volume
9
Pages
325-325
ISSN
1663-9812 (ISSN-L)
OpenAlex
W2796748561
Cited by
50
References
317
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 8 · 2018: 3
FWCI
0.76
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Funders
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2012/50880-4, 2012/20685-5, 2013/25338-4, 2015/19478-3, 2015/14343-2)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (306429/2013-6, 141979/2014-3, 870458/1997-3)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
purinergic receptors, ATP as neurotransmitter, Parkinson's disease, motor neuron disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, restless legs syndrome, ataxia, neuroinflammation, excitotoxicity, apoptosis, calcium signaling, neurodegeneration, therapeutic target

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review