The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Mechanisms of transcriptional regulation by p53
Open accessAbstract
p53 is a transcription factor that suppresses tumor growth through regulation of dozens of target genes with diverse biological functions. The activity of this master transcription factor is inactivated in nearly all tumors, either by mutations in the TP53 locus or by oncogenic events that decrease the activity of the wild-type protein, such as overexpression of the p53 repressor MDM2. However, despite decades of intensive research, our collective understanding of the p53 signaling cascade remains incomplete. In this review, we focus on recent advances in our understanding of mechanisms of p53-dependent transcriptional control as they relate to five key areas: (1) the functionally distinct N-terminal transactivation domains, (2) the diverse regulatory roles of its C-terminal domain, (3) evidence that p53 is solely a direct transcriptional activator, not a direct repressor, (4) the ability of p53 to recognize many of its enhancers across diverse chromatin environments, and (5) mechanisms that modify the p53-dependent transcriptional program in a context-dependent manner.
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“p53 protein functions primarily as a transcription factor, which regulates a wide variety of pathways, such as cell cycle arrest, DNA repair, cell apoptosis, autophagy, and metabolism”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [6]
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Cites
Regulation of p53 stability by Mdm2
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Blinded by the Light: The Growing Complexity of p53
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Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
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A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
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Census and evaluation of p53 target genes
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Wild-type p53 activates transcription in vitro
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Transcriptional Regulation by P53
Beckerman, R., & Prives, C. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000935 · Cited by 569
eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription
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Cited by
The multiple mechanisms that regulate p53 activity and cell fate
Hafner, A., Bulyk, M. L., Jambhekar, A., & Lahav, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0110-x · Cited by 1,129
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Kong, N., Tao, W., Ling, X., Wang, J., Xiao, Y., Shi, S., Ji, X., Shajii, A., Gan, S. T., Kim, N. Y., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw1565 · Cited by 314
Therapeutics targeting p53-MDM2 interaction to induce cancer cell death
Koo, N., Sharma, A. K., & Narayan, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095005 · Cited by 153
Regulation of Adult Neurogenesis in Mammalian Brain
Niklison-Chirou, M. V., Agostini, M., Amelio, I., & Melino, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144869 · Cited by 143
Metadata
- Authors
- Sullivan, K. D., Galbraith, M. D., Andrysik, Z., & Espinosa, J. M.
- Venue
- Cell Death & Differentiation
- Published
- 2017-11-10
- Volume
- 25
- Issue
- 1
- Pages
- 133-143
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W2767326431
- Cited by
- 446
- References
- 15
- FWCI
- 15.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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