Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53 -deficient cancers to mTOR inhibition
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Redox-sensitive mRNA nanoparticles help kill tumors by restoring p53 expression.
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Restoration of the tumour suppressor gene TP53 can induce tumour cell apoptosis and sensitize tumour cells to chemotherapeutics in vivo.
“For example, restoration of the tumour suppressor gene TP53 can induce tumour cell apoptosis and sensitize tumour cells to chemotherapeutics in vivo118,218.”
From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [218]
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Ark floats gene therapy's boat, for now
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Challenges in the gene therapy commercial ecosystem
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Sorted by citations
Lipid nanoparticles for mRNA delivery
Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00358-0 · Cited by 4,076 · see citing works
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Self-citationmRNA-based cancer therapeutics
Liu, C., Shi, Q., Huang, X., Koo, S., Kong, N., & Tao, W. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-023-00586-2 · Cited by 500 · see citing works
Self-citationXie, H., Ma, K., Zhang, K., Zhou, J., Li, L., Yang, W., Gong, Y., Cai, L., & Gong, K. (2021) · Cell Death & Disease · doi:10.1038/s41419-020-03229-8 · Cited by 155 · see citing works
Nanomedicine-Based Approaches for mRNA Delivery
Uchida, S., Perche, F., Pichon, C., & Cabral, H. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00618 · Cited by 139 · see citing works
Nanoplatforms for mRNA Therapeutics
Meng, C., Chen, Z., Li, G., Welte, T., & Shen, H. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000099 · Cited by 130 · see citing works
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Small-molecule correctors and stabilizers to target p53
Fallatah, M. M. J., Law, F. V., Chow, W. A., & Kaiser, P. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.02.007 · Cited by 44 · see citing works
- Authors
- Kong, N., Tao, W., Ling, X., Wang, J., Xiao, Y., Shi, S., Ji, X., Shajii, A., Gan, S. T., Kim, N. Y., Duda, D. G., Xie, T., Farokhzad, O. C., & Shi, J.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Hangzhou Normal University (CN)
- Corresponding author
- Kong, Na
- Tao, Wei
- Xie, Tian
- Farokhzad, Omid C.
- Shi, Jinjun
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-12-18
- Volume
- 11
- Issue
- 523
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7024563
- OpenAlex
- W2994679067
- Cited by
- 314
- References
- 97
- Citations by year
- 2026: 39 · 2025: 60 · 2024: 52 · 2023: 48 · 2022: 38 · 2021: 48 · 2020: 29
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (CA200900)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- p53 restoration, mTOR inhibition, everolimus, hepatocellular carcinoma, non-small cell lung cancer, combination cancer therapy, cell cycle arrest, apoptosis, gene delivery
- MeSH terms
- Everolimus, Animals, Enzyme-Linked Immunosorbent Assay, Female, Fluorescent Antibody Technique, Humans, Mice, Inbred C57BL, Mice, Nude, Neoplasms, RNA, Messenger, Tumor Suppressor Protein p53, Cell Line, Tumor, Microscopy, Electron, Transmission, Nanoparticles, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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