Transcriptional Regulation by P53

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661 · see citing works

p21 is a universal inhibitor of cyclin kinases

Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691 · see citing works

The Role of Chromatin during Transcription

Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503 · see citing works

Blinded by the Light: The Growing Complexity of p53

Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163 · see citing works

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559 · see citing works

p53: puzzle and paradigm.Preprint

Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,338 · see citing works

Definition of a consensus binding site for p53

El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985 · see citing works

Transcriptional control of human p53-regulated genes

Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921 · see citing works

p53 function and dysfunction

Vogelstein, B. (1992) · Cell · doi:10.1016/0092-8674(92)90421-8 · Cited by 1,862 · see citing works

Modes of p53 regulation.

Kruse, J.-P., & Gu, W. (2009) · Cell · doi:10.1016/j.cell.2009.04.050 · Cited by 1,610 · cited 1× · see citing works

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

Toledo, F., & Wahl, G. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc2012 · Cited by 1,286 · see citing works

Post-translational modification of p53 in tumorigenesis

Bode, A. M., & Dong, Z. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1455 · Cited by 1,270 · see citing works

The IARC TP53 database: new online mutation analysis and recommendations to users

Olivier, M., Eeles, R., Hollstein, M., Khan, M. A., Harris, C. C., & Hainaut, P. (2002) · Human Mutation · doi:10.1002/humu.10081 · Cited by 1,248 · see citing works

DNA damage activates p53 through a phosphorylation–acetylation cascade

Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., & Appella, E. (1998) · Genes & Development · doi:10.1101/gad.12.18.2831 · Cited by 1,204 · see citing works

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00073-8 · Cited by 1,162 · see citing works

The Rb/E2F pathway: expanding roles and emerging paradigms

Harbour, J. W., & Dean, D. C. (2000) · Genes & Development · doi:10.1101/gad.813200 · Cited by 1,153 · see citing works

A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome

Wei, C.-L., Wu, Q., Vega, V. B., Chiu, K. P., Ng, P., Zhang, T., Shahab, A., Yong, H. C., Fu, Y., Weng, Z., et al. (2006) · Cell · doi:10.1016/j.cell.2005.10.043 · Cited by 1,141 · see citing works

The general transcription factors of RNA polymerase II.Preprint

Orphanides, G. M., Lagrange, T., & Reinberg, D. (1996) · Genes & Development · doi:10.1101/gad.10.21.2657 · Cited by 1,036 · see citing works

The General Transcription Machinery and General Cofactors

Thomas, M. C., & Chiang, C. (2006) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230600648736 · Cited by 923 · see citing works

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

Lin, T., Chao, C., Saito, S., Mazur, S. J., Murphy, M. E., Appella, E., & Xu, Y. (2004) · Nature Cell Biology · doi:10.1038/ncb1211 · Cited by 859 · see citing works

Acetylation Is Indispensable for p53 Activation

Tang, Y., Zhao, W., Chen, Y., Zhao, Y., & Gu, W. (2008) · Cell · doi:10.1016/j.cell.2008.03.025 · Cited by 838 · see citing works

Regulation of p53 activity through lysine methylation

Chuikov, S., Kurash, J. K., Wilson, J. R., Xiao, B., Justin, N., Ivanov, G. S., McKinney, K. M., Tempst, P., Prives, C. L., Gamblin, S. J., et al. (2004) · Nature · doi:10.1038/nature03117 · Cited by 820 · see citing works

p53 is regulated by the lysine demethylase LSD1

Huang, J. L., Sengupta, R., Espejo, A. B., Lee, M. G., Dorsey, J. A., Richter, M., Opravil, S., Shiekhattar, R., Bedford, M. T., Jenuwein, T., et al. (2007) · Nature · doi:10.1038/nature06092 · Cited by 820 · see citing works

p53 isoforms can regulate p53 transcriptional activity

Bourdon, J.-C., Fernandes, K., Murray-Zmijewski, F., Liu, G., Diot, A., Xirodimas, D. P., Saville, M. K., & Lane, D. P. (2005) · Genes & Development · doi:10.1101/gad.1339905 · Cited by 810 · see citing works

Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53

Hoffman, W. H., Biade, S., Zilfou, J. T., Chen, J., & Murphy, M. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106643200 · Cited by 794 · see citing works

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

Liu, L., Scolnick, D. M., Trievel, R. C., Zhang, H. B., Marmorstein, R., Halazonetis, T. D., & Berger, S. L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1202 · Cited by 776 · see citing works

Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

Sykes, S. M., Mellert, H. S., Holbert, M. A., Li, K., Marmorstein, R., Lane, W. S., & McMahon, S. B. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.026 · Cited by 752 · see citing works

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

Funk, W. D., Pak, D. T. S., Karas, R. H., Wright, W. E., & Shay, J. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2866 · Cited by 732 · see citing works

Effects of p21 Cip1/Waf1 at Both the G 1 /S and the G 2 /M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication

Niculescu, A. B., Chen, X., Smeets, M. F. M. A., Hengst, L., Prives, C. L., & Reed, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.629 · Cited by 725 · see citing works

Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

Tang, Y., Luo, J., Zhang, W., & Gu, W. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.021 · Cited by 724 · see citing works

Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

Barlev, N. A., Liu, L., Chehab, N. H., Mansfield, K., Harris, K. G., Halazonetis, T. D., & Berger, S. L. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00414-2 · Cited by 710 · see citing works

Elongation by RNA polymerase II: the short and long of itPreprint

Sims, R. J., Belotserkovskaya, R., & Reinberg, D. (2004) · Genes & Development · doi:10.1101/gad.1235904 · Cited by 709 · see citing works

Binding and modulation of p53 by p300/CBP coactivators

Lill, N. L., Grossman, S. R., Ginsberg, D., DeCaprio, J. A., & Livingston, D. M. (1997) · Nature · doi:10.1038/42981 · Cited by 693 · see citing works

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

Seoane, J., Le, H.-V., & Massagué, J. (2002) · Nature · doi:10.1038/nature01119 · Cited by 683 · see citing works

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

D’Orazi, G., Cecchinelli, B., Bruno, T., Manni, I., Higashimoto, Y., Saito, S., Gostissa, M., Coen, S., Marchetti, A., Sal, G. D., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb714 · Cited by 682 · see citing works

Recruitment of p300/CBP in p53-Dependent Signal Pathways

Avantaggiati, M. L., Ogryzko, V. V., Gardner, K., Giordano, A., Levine, A. S., & Kelly, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80304-9 · Cited by 668 · see citing works

ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

Samuels-Lev, Y., O'Connor, D. J., Bergamaschi, D., Trigiante, G., Hsieh, J.-K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., & Lu, X. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00367-7 · Cited by 664 · see citing works

Repression of p53 activity by Smyd2-mediated methylation

Huang, J. L., Perez-Burgos, L., Placek, B. J., Sengupta, R., Richter, M., Dorsey, J. A., Kubicek, S., Opravil, S., Jenuwein, T., & Berger, S. L. (2006) · Nature · doi:10.1038/nature05287 · Cited by 626 · see citing works

The mitochondrial p53 pathway

Vaseva, A. V., & Moll, U. M. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.10.005 · Cited by 618 · see citing works

MDM2–HDAC1-mediated deacetylation of p53 is required for its degradation

Ito, A., Kawaguchi, Y., Lai, C., Kovacs, J. J., Higashimoto, Y., Appella, E., & Yao, T. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf616 · Cited by 570 · see citing works

Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

Mirza, A., McGuirk, M., Hockenberry, T., Wu, Q. J., Ashar, H. R., Black, S., Wen, S. F., Wang, L., Kirschmeier, P. T., Bishop, W. R., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205353 · Cited by 530 · see citing works

Ordered Cooperative Functions of PRMT1, p300, and CARM1 in Transcriptional Activation by p53

An, W., Kim, J., & Roeder, R. G. (2004) · Cell · doi:10.1016/j.cell.2004.05.009 · Cited by 513 · see citing works

Wild-type p53 binds to the TATA-binding protein and represses transcription.

Seto, E., Usheva, A., Zambetti, G. P., Momand, J. A., Horikoshi, N., Weinmann, R. S., Levine, A. J., & Shenk, T. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.12028 · Cited by 504 · see citing works

Transcriptional regulation by p53: one protein, many possibilities

Laptenko, O., & Prives, C. L. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401916 · Cited by 500 · see citing works

BRCA1 physically associates with p53 and stimulates its transcriptional activity

Zhang, H., Somasundaram, K., Peng, Y., Tian, H., Zhang, H., Bi, D., Weber, B. L., & El‐Deiry, W. S. (1998) · Oncogene · doi:10.1038/sj.onc.1201932 · Cited by 492 · see citing works

Identification of redox/repair protein Ref-1 as a potent activator of p53.Preprint

Jayaraman, L., Murthy, K. G. K., Zhu, C., Curran, T., Xanthoudakis, S., & Prives, C. L. (1997) · Genes & Development · doi:10.1101/gad.11.5.558 · Cited by 479 · see citing works

Arginine methylation regulates the p53 response

Jansson, M., Durant, S. T., Cho, E.-C., Sheahan, S., Edelmann, M. J., Kessler, B. M., & Thangue, N. B. L. (2008) · Nature Cell Biology · doi:10.1038/ncb1802 · Cited by 467 · see citing works

Modulation of p53 Function by SET8-Mediated Methylation at Lysine 382

Shi, X., Kachirskaia, I., Yamaguchi, H., West, L. E., Wen, H., Wang, E. W., Dutta, S. M., Appella, E., & Gozani, O. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.012 · Cited by 463 · see citing works

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3aPreprint

Murphy, M. E., Ahn, J., Walker, K. K., Hoffman, W. H., Evans, R. M., Levine, A. J., & George, D. L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2490 · Cited by 455 · see citing works

Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression

Godár, S., Ince, T. A., Bell, G. W., Feldser, D. M., Donaher, J. L., Bergh, J. C. S., Liu, A. Y., Miu, K., Watnick, R. S., Reinhardt, F., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.006 · Cited by 455 · see citing works

Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

Grossman, S. R., Deato, M. D. E., Brignone, C., Chan, H. M., Kung, A. L., Tagami, H., Nakatani, Y., & Livingston, D. M. (2003) · Science · doi:10.1126/science.1080386 · Cited by 454 · see citing works

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

Espinosa, J. M., & Emerson, B. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00283-0 · Cited by 440 · see citing works

p53 Transcriptional Activation Mediated by Coactivators TAF II 40 and TAF II 60

Thut, C. J., Chen, J.-L., Klemm, R. D., & Tjian, R. (1995) · Science · doi:10.1126/science.7809597 · Cited by 439 · see citing works

Phosphorylation of p53 Serine 15 Increases Interaction with CBP

Lambert, P. F., Kashanchi, F., Radonovich, M. F., Shiekhattar, R., & Brady, J. N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.33048 · Cited by 423 · see citing works

A complex barcode underlies the heterogeneous response of p53 to stress

Murray-Zmijewski, F., Slee, E. A., & Lu, X. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2451 · Cited by 420 · see citing works

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

Luo, J., Li, M., Tang, Y., Laszkowska, M., Roeder, R. G., & Gu, W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308762101 · Cited by 419 · see citing works

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

Grossman, S. R., Perez, M., Kung, A. L., Joseph, M., Mansur, C., Xiao, Z.-X., Kumar, S., Howley, P. M., & Livingston, D. M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80140-9 · Cited by 414 · see citing works

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

Zacchi, P., Gostissa, M., Uchida, T., Salvagno, C., Avolio, F., Volinia, S., Ronai, Z. A., Blandino, G., Schneider, C., & Sal, G. D. (2002) · Nature · doi:10.1038/nature01120 · Cited by 413 · see citing works

Structural Basis of DNA Recognition by p53 Tetramers

Kitayner, M., Rozenberg, H., Kessler, N., Rabinovich, D., Shaulov, L., Haran, T. E., & Shakked, Z. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.015 · Cited by 408 · see citing works

Slug Antagonizes p53-Mediated Apoptosis of Hematopoietic Progenitors by Repressing puma

Wu, W.-S., Heinrichs, S., Xu, D., Garrison, S. P., Zambetti, G. P., Adams, J. M., & Look, A. T. (2005) · Cell · doi:10.1016/j.cell.2005.09.029 · Cited by 398 · see citing works

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response

Zheng, H., You, H., Zhou, X. Z., Murray, S. A., Uchida, T., Wulf, G. M., Gu, L., Tang, X., Lu, K. P., & Xiao, Z. J. (2002) · Nature · doi:10.1038/nature01116 · Cited by 384 · see citing works

RNA polymerases I and III, growth control and cancer

White, R. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1551 · Cited by 330 · see citing works

p53-Dependent Transcriptional Repression of c-myc Is Required for G1 Cell Cycle Arrest

Ho, J. S. L., Ma, W., Mao, D. Y. L., & Benchimol, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7423-7431.2005 · Cited by 312 · see citing works

Allosteric activation of latent p53 tetramers

Hupp, T. R., & Lane, D. P. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00195-0 · Cited by 300 · see citing works

DYRK2 Is Targeted to the Nucleus and Controls p53 via Ser46 Phosphorylation in the Apoptotic Response to DNA Damage

Taira, N., Nihira, K., Yamaguchi, T., Miki, Y., & Yoshida, K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.007 · Cited by 299 · see citing works

A DNA Damage–Induced p53 Serine 392 Kinase Complex Contains CK2, hSpt16, and SSRP1

Keller, D. M., Zeng, X., Wang, Y., Zhang, Q. H., Kapoor, M., Shu, H., Goodman, R. H., Lozano, G., Zhao, Y., & Lu, H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00176-9 · Cited by 297 · see citing works

Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53

Zhai, W., & Comai, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5930-5938.2000 · Cited by 289 · see citing works

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate

Knights, C. D., Catania, J., Giovanni, S. D., Muratoglu, S. C., Perez, R. E., Swartzbeck, A., Quong, A. A., Zhang, X., Beerman, T. A., Pestell, R. G., et al. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200512059 · Cited by 284 · see citing works

The RNA Polymerase II Machinery

Woychik, N. A., & Hampsey, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00646-3 · Cited by 281 · see citing works

Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

Seo, Y. R., Kelley, M. R., & Smith, M. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212319799 · Cited by 280 · see citing works

Activation of AMP-activated Protein Kinase Induces p53-dependent Apoptotic Cell Death in Response to Energetic Stress

Okoshi, R., Ozaki, T., Yamamoto, H., Ando, K., Koida, N., Ono, S., Koda, T., Kamijo, T., Nakagawara, A., & Kizaki, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705232200 · Cited by 277 · see citing works

A Novel Human SRB/MED-Containing Cofactor Complex, SMCC, Involved in Transcription Regulation

Gu, W., Malik, S., Ito, M., Yuan, C., Fondell, J. D., Zhang, X., Martinez, E., Qin, J., & Roeder, R. G. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80178-1 · Cited by 276 · see citing works

A polymorphic microsatellite that mediates induction of PIG3 by p53

Contente, A., Dittmer, A., Koch, M. C., Roth, J., & Dobbelstein, M. (2002) · Nature Genetics · doi:10.1038/ng836 · Cited by 274 · see citing works

p21 transcription is regulated by differential localization of histone H2A.ZPreprint

Gévry, N. Y., Chan, H. M., Laflamme, L., Livingston, D. M., & Gaudreau, L. R. (2007) · Genes & Development · doi:10.1101/gad.1545707 · Cited by 267 · see citing works

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional programPreprint

Gomes, N. P., Bjerke, G. A., Llorente, B., Szostek, S. A., Emerson, B. M., & Espinosa, J. M. (2006) · Genes & Development · doi:10.1101/gad.1398206 · Cited by 266 · see citing works

p300/CBP/p53 interaction and regulation of the p53 response

Grossman, S. R. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02226.x · Cited by 264 · see citing works

MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation

Wang, C., Ivanov, A. V., Chen, L., Fredericks, W. J., Seto, E., Rauscher, F. J., & Chen, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600791 · Cited by 263 · see citing works

The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription

Liu, X. E., Miller, C. W., Koeffler, H. P., & Berk, A. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3291-3300.1993 · Cited by 260 · see citing works

How p53 binds DNA as a tetramer

McLure, K. G., & Lee, P. W. K. (1998) · The EMBO Journal · doi:10.1093/emboj/17.12.3342 · Cited by 260 · see citing works

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53

Bergamaschi, D., Samuels, Y., Sullivan, A., Zvelebil, M., Breyssens, H., Bisso, A., Sal, G. D., Syed, N., Smith, P. D., Gasco, M., et al. (2006) · Nature Genetics · doi:10.1038/ng1879 · Cited by 260 · see citing works

p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

Espinosa, J. M., Verdun, R. E., & Emerson, B. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00359-9 · Cited by 256 · see citing works

RB Regulates the Stability and the Apoptotic Function of p53 via MDM2

Hsieh, J.-K., Chan, F., O’Connor, D. J., Mittnacht, S., Zhong, S., & Lü, X. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80309-3 · Cited by 255 · see citing works

CDK8 Is a Stimulus-Specific Positive Coregulator of p53 Target Genes

Donner, A. J., Szostek, S. A., Hoover, J. M., & Espinosa, J. M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.026 · Cited by 253 · see citing works

E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation

Cam, L. L., Linares, L. K., Paul, C., Julien, E., Lacroix, M., Hatchi, E., Triboulet, R., Bossis, G., Shmueli, A., Rodríguez, M. S., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.031 · Cited by 241 · see citing works

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

Funk, W. D., Pak, D. T. S., Karas, R. H., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2866-2871.1992 · Cited by 239 · see citing works

p21/CDKN1A Mediates Negative Regulation of Transcription by p53

Löhr, K., Möritz, C., Contente, A., & Dobbelstein, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212517200 · Cited by 227 · see citing works

CBP/p300 interact with and function as transcriptional coactivators of BRCA1

Pao, G. M., Janknecht, R., Ruffner, H., Hunter, T. R., & Verma, I. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1020 · Cited by 222 · see citing works

Comparative Binding of p53 to its Promoter and DNA Recognition Elements

Weinberg, R. L., Veprintsev, D. B., Bycroft, M., & Fersht, A. R. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.03.014 · Cited by 206 · see citing works

Methylation-Acetylation Interplay Activates p53 in Response to DNA Damage

Ivanov, G. S., Ivanova, T., Kurash, J. K., Ivanov, A. V., Chuikov, S., Gizatullin, F., Herrera-Medina, E. M., Rauscher, F. J., Reinberg, D., & Barlev, N. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00460-07 · Cited by 206 · see citing works

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

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Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G2/M Promoters

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p53 Linear Diffusion along DNA Requires Its C Terminus

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Tumor Suppressor p53 Slides on DNA with Low Friction and High Stability

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Kinetics of p53 Binding to Promoter Sites In Vivo

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p53-Mediated Repression of Alpha-Fetoprotein Gene Expression by Specific DNA Binding

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hCAS/CSE1L Associates with Chromatin and Regulates Expression of Select p53 Target Genes

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DNA Damage-Induced Downregulation of Cdc25C Is Mediated by p53 via Two Independent Mechanisms

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BRCA1-BARD1 Complexes Are Required for p53Ser-15 Phosphorylation and a G1/S Arrest following Ionizing Radiation-induced DNA Damage

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Transcriptional Repression by p53 through Direct Binding to a Novel DNA Element

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p53 represses ribosomal gene transcription

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Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

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The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

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Efficient Specific DNA Binding by p53 Requires both Its Central and C-Terminal Domains as Revealed by Studies with High-Mobility Group 1 Protein

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p53's double life: transactivation-independent repression of homologous recombination

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Control of E2F activity by p21Waf1/Cip1

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Regulation of p53 tumour suppressor target gene expression by the p52 NF‐κB subunit

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The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

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The Corepressor mSin3a Interacts with the Proline-Rich Domain of p53 and Protects p53 from Proteasome-Mediated Degradation

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p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting

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Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

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Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.Preprint

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A Chromatin-associated and Transcriptionally Inactive p53-Mdm2 Complex Occurs in mdm2 SNP309 Homozygous Cells

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KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis

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Acetylation of Mouse p53 at Lysine 317 Negatively Regulates p53 Apoptotic Activities after DNA Damage

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Mechanisms of regulatory diversity within the p53 transcriptional network

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p53 Inhibits RNA Polymerase III-Directed Transcription in a Promoter-Dependent Manner

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Functional Interaction between p53, the TATA-Binding Protein (TBP), and TBP-Associated Factors In Vivo

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PCAF is an HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia

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The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53

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Definition of the p53 Functional Domains Necessary for Inducing Apoptosis

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Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation

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Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

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General Transcription Factors for RNA Polymerase II1

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An Acetylation Switch in p53 Mediates Holo-TFIID Recruitment

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p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53

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A new p38 MAP kinase‐regulated transcriptional coactivator that stimulates p53‐dependent apoptosis

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Divergent Evolution of Human p53 Binding Sites: Cell Cycle Versus Apoptosis

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Murine Double Minute (MDM2) Blocks p53-coactivator Interaction, a New Mechanism for Inhibition of p53-dependent Gene Expression

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Y-box factor YB1 controls p53 apoptotic function

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DNA Bending Is Essential for the Site-specific Recognition of DNA Response Elements by the DNA Binding Domain of the Tumor Suppressor Protein p53

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A role for caspase 2 and PIDD in the process of p53-mediated apoptosis

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Tumor suppressor protein p53 binds preferentially to supercoiled DNA

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Specific Interaction of p53 with Target Binding Sites Is Determined by DNA Conformation and Is Regulated by the C-terminal Domain

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High-Affinity Binding of Tumor-Suppressor Protein p53 and HMGB1 to Hemicatenated DNA Loops

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Site-specific Acetylation of p53 Directs Selective Transcription Complex Assembly

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NIR is a novel INHAT repressor that modulates the transcriptional activity of p53Preprint

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CDK9 Phosphorylates p53 on Serine Residues 33, 315 and 392

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A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpointPreprint

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Architectural Accommodation in the Complex of Four p53 DNA Binding Domain Peptides with the p21/waf1/cip1 DNA Response Element

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Transcriptional Regulation of the Human DNA Polymerase δ Catalytic Subunit Gene POLD1 by p53 Tumor Suppressor and Sp1

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Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation

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Multivalent Binding of p53 to the STAGA Complex Mediates Coactivator Recruitment after UV Damage

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Chromatin Immunoprecipitation–on-Chip Reveals Stress-Dependent p53 Occupancy in Primary Normal Cells but Not in Established Cell Lines

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MDM2 Mediates p300/CREB-binding Protein-associated Factor Ubiquitination and Degradation

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Repression of hsp90β Gene by p53 in UV Irradiation-induced Apoptosis of Jurkat Cells

Zhang, Y., Wang, J., Chen, L., Zhang, Y., Cheng, X.-K., Heng, F.-Y., Wu, N., & Shen, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314213200 · Cited by 56 · see citing works

Activation of p53 Function by Human Transcriptional Coactivator PC4: Role of Protein-Protein Interaction, DNA Bending, and Posttranslational Modifications

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p53-Dependent p21 mRNA Elongation Is Impaired when DNA Replication Is Stalled

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p53 and translational control

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Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family

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Physical Interaction and Functional Antagonism between the RNA Polymerase II Elongation Factor ELL and p53

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Cdk9 phosphorylates p53 on serine 392 independently of CKII

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Excess HDM2 Impacts Cell Cycle and Apoptosis and Has a Selective Effect on p53-dependent Transcription

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Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

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Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain 1 1Edited by K. Yamamoto

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The p53 Tumor Suppressor Protein Represses Human snRNA Gene Transcription by RNA Polymerases II and III Independently of Sequence-Specific DNA Binding

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Mouse Double Minute 2 Associates with Chromatin in the Presence of p53 and Is Released to Facilitate Activation of Transcription

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Chromium-mediated apoptosis: Involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes

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Correction: Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

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p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core

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p53-Induced DNA Bending: The Interplay between p53−DNA and p53−p53 Interactions

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p18HamletMediates Different p53-Dependent Responses to DNA Damage Inducing Agents

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Sliding into home: facilitated p53 search for targets by the basic DNA binding domain

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Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21−/− HCT116 colon cancer cells

Hill, R., Leidal, A. M., Madureira, P. A., Gillis, L. D., Cochrane, H. K., Waisman, D. M., Chiu, A. O. S., & Lee, P. W. K. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.10.001 · Cited by 24 · see citing works

Transcriptional Regulation by p53 and p73Preprint

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Insights into Selective Activation of p53 DNA Binding by c-Abl

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p53 Stimulates TFIID-TFIIA-Promoter Complex Assembly, and p53-T Antigen Complex Inhibits TATA Binding Protein-TATA Interaction

Xing, J. W., Sheppard, H. M., Corneillie, S. I., & Liu, X. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3652-3661.2001 · Cited by 20 · see citing works

The tumor suppressor p53 associates with gene coding regions and co-traverses with elongating RNA polymerase II in an in vivo model

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Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53

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RP–MDM2–p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance

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Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression

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PTEN Interacts with Histone H1 and Controls Chromatin Condensation

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Crosstalk between p53 and TGF- β Signalling

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PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53

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Growth hormone is permissive for neoplastic colon growth

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Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment

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Quantifying transcription factor kinetics: At work or at play?

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mTORC1 and p53

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DNA Damage-induced Heterogeneous Nuclear Ribonucleoprotein K SUMOylation Regulates p53 Transcriptional Activation

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p53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA

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Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

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p53 at the Crossroads between Different Types of HDAC Inhibitor-Mediated Cancer Cell Death

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TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription

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Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity

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Clinical significance of p53 protein expression and TP53 variation status in colorectal cancer

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Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1

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A Versatile Platform to Analyze Low-Affinity and Transient Protein-Protein Interactions in Living Cells in Real Time

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Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis

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Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis

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Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion

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Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress

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Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice

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SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation

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p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells

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Whole-genome cartography of p53 response elements ranked on transactivation potential

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Apoptosis in inner ear sensory hair cells

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Transcriptional Activation by p53: Mechanisms and Targeted Genes

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