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miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer
Open accessAbstract
Micro RNAs (miRs) are small non-coding RNAs aberrantly expressed in human tumors. Here, we aim to identify miRs whose deregulated expression leads to the activation of oncogenic pathways in human gastric cancers (GCs). Thirty nine out of 123 tumoral and matched uninvolved peritumoral gastric specimens from three independent European subsets of patients were analyzed for the expression of 851 human miRs using Agilent Platform. The remaining 84 samples were used to validate miRs differentially expressed between tumoral and matched peritumoral specimens by qPCR. miR-204 falls into a group of eight miRs differentially expressed between tumoral and peritumoral samples. Downregulation of miR-204 has prognostic value and correlates with increased staining of Bcl-2 protein in tumoral specimens. Ectopic expression of miR-204 inhibited colony forming ability, migration and tumor engraftment of GC cells. miR-204 targeted Bcl-2 messenger RNA and increased responsiveness of GC cells to 5-fluorouracil and oxaliplatin treatment. Ectopic expression of Bcl-2 protein counteracted miR-204 pro-apoptotic activity in response to 5-fluorouracil. Altogether, these findings suggest that modulation of aberrant expression of miR-204, which in turn releases oncogenic Bcl-2 protein activity might hold promise for preventive and therapeutic strategies of GC.
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MicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
Cited by
Bian, Z., Jin, L., Zhang, J., Yin, Y., Quan, C., Hu, Y., Feng, Y., Liu, H., Fei, B., Mao, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep23892 · Cited by 363
MicroRNAs in apoptosis, autophagy and necroptosis
Su, Z., Yang, Z., Xu, Y., Chen, Y., & Yu, Q. (2015) · Oncotarget · doi:10.18632/oncotarget.3523 · Cited by 342
Metadata
- Authors
- Sacconi, A., Biagioni, F., Canu, V, Mori, F., Di Benedetto, A., Lorenzon, L., Ercolani, C., Di Agostino, S., Cambria, A. M., Germoni, S., Grasso, G., Blandino, R., Panebianco, V, Ziparo, V, Federici, O., Muti, P., Strano, S., Carboni, F., Mottolese, M., Diodoro, M., Pescarmona, E., Garofalo, A., & Blandino, G.
- Venue
- Cell Death & Disease
- Published
- 2012-11-15
- Volume
- 3
- Issue
- 11
- Pages
- e423-e423
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W1977485776
- Cited by
- 180
- References
- 2
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sacconi, A., Biagioni, F., Canu, V, Mori, F., Di Benedetto, A., Lorenzon, L., Ercolani, C., Di Agostino, S., Cambria, A. M., Germoni, S., Grasso, G., Blandino, R., Panebianco, V, Ziparo, V, Federici, O., Muti, P., Strano, S., Carboni, F., Mottolese, M., . . . Blandino, G. (2012). miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer. Cell Death & Disease. https://doi.org/10.1038/cddis.2012.160
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