The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p
Open accessAbstract
Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding RNA urothelial carcinoma associated 1 (UCA1) in colorectal cancer (CRC). However, the in vivo functions and molecular mechanism of UCA1 in CRC remain unclear. Therefore, we investigated the detailed role and mechanism of UCA1 in CRC. We found that UCA1 was up-regulated in CRCs and negatively correlated with survival time in two CRC cohorts. Functional assays revealed the in vitro and in vivo growth-promoting function of UCA1 and revealed that UCA1 can decrease the sensitivity of CRC cells to 5-FU by attenuating apoptosis. Further mechanistic studies revealed that UCA1 could sponge endogenous miR-204-5p and inhibit its activity. We also identified CREB1 as a new target of miR-204-5p. The protein levels of CREB1 were significantly up-regulated in CRCs, negatively associated with survival time and positively correlated with the UCA1 expression. The present work provides the first evidence of a UCA1-miR-204-5p-CREB1/BCL2/RAB22A regulatory network in CRC and reveals that UCA1 and CREB1 are potential new oncogenes and prognostic factors for CRC.
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1 retracted
Ji, Q., Liu, X., Fu, X., Zhang, L., Sui, H., Zhou, L., Sun, J., Cai, J., Qin, J., Ren, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078700 · Cited by 354
Self-citationRetractedSiegel, R., Ma, J., Zou, Z., & Jemal, A. (2014) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21208 · Cited by 11,499
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. (2011) · Cell · doi:10.1016/j.cell.2011.07.014 · Cited by 7,262
Signet-Ring Cell Carcinoma of the Colon: A Case Report and Review of the Literature
Park, P. Y., Goldin, T., Chang, J., Markman, M., & Kundranda, M. N. (2015) · Case Reports in Oncology · doi:10.1159/000441772 · Cited by 5,273
Molecular Mechanisms of Long Noncoding RNAs
Wang, K. C., & Chang, H. Y. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.018 · Cited by 4,396
The multilayered complexity of ceRNA crosstalk and competition
Tay, Y., Rinn, J., & Pandolfi, P. P. (2014) · Nature · doi:10.1038/nature12986 · Cited by 3,910
Wang, X.-S., Zhang, Z., Wang, H.-C., Cai, J.-L., Xu, Q.-W., Li, M.-Q., Chen, Y.-C., Qian, X.-P., Lu, T.-J., Yu, L.-Z., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0134 · Cited by 480
LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer
Bhan, A., & Mandal, S. S. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.07.001 · Cited by 456
Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1)
Huang, J., Zhou, N., Watabe, K., Lu, Z., Wu, F., Xu, M., & Mo, Y.-Y. (2014) · Cell Death & Disease · doi:10.1038/cddis.2013.541 · Cited by 375
Fan, Y., Shen, B., Tan, M., Mu, X., Qin, Y., Zhang, F., & Liu, Y. (2014) · The FEBS Journal · doi:10.1111/febs.12737 · Cited by 370
Cited by
Xue, M., Chen, W., Xiang, A., Wang, R., Chen, H., Pan, J., Pang, H., An, H., Wang, X., Hou, H., et al. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0714-8 · Cited by 359
Yin, Y., Yao, S., Hu, Y., Feng, Y., Li, M., Bian, Z., Zhang, J., Qin, Y., Qi, X., Zhou, L., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1283 · Cited by 296
Self-citationGhafouri-Fard, S., Abak, A., Tondro Anamag, F., Shoorei, H., Fattahi, F., Javadinia, S. A., Basiri, A., & Taheri, M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.658636 · Cited by 193
An Integrated Three-Long Non-coding RNA Signature Predicts Prognosis in Colorectal Cancer Patients
Liu, Y., Liu, B., Jin, G., Zhang, J., Wang, X., Feng, Y., Bian, Z., Fei, B., Yin, Y., & Huang, Z. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01269 · Cited by 48
Metadata
- Authors
- Bian, Z., Jin, L., Zhang, J., Yin, Y., Quan, C., Hu, Y., Feng, Y., Liu, H., Fei, B., Mao, Y., Zhou, L., Qi, X., Huang, S., Hua, D., Xing, C., & Huang, Z.
- Venue
- Scientific Reports
- Published
- 2016-04-05
- Volume
- 6
- Issue
- 1
- Pages
- 23892-23892
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2324728011
- Cited by
- 363
- References
- 39
- FWCI
- 22.20
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bian, Z., Jin, L., Zhang, J., Yin, Y., Quan, C., Hu, Y., Feng, Y., Liu, H., Fei, B., Mao, Y., Zhou, L., Qi, X., Huang, S., Hua, D., Xing, C., & Huang, Z. (2016). LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p. Scientific Reports. https://doi.org/10.1038/srep23892
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