The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
T-cell exhaustion in the tumor microenvironment
Open accessAbstract
T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to the failure of cancer elimination. Restoring exhausted T cells represents an inspiring strategy for cancer treatment, which has yielded promising results and become a significant breakthrough in the cancer immunotherapy. In this review, we overview the updated understanding on the exhausted T cells in cancer and their potential regulatory mechanisms and discuss current therapeutic interventions targeting exhausted T cells in clinical trials.
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Cites
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Cited by
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing
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“Interestingly, these T cells also manifested immuno-suppressive phenotypes of exhausted 39,40 or regulatory T cells 41 .”
Systemic Immunity Is Required for Effective Cancer Immunotherapy
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Immunosenescence: molecular mechanisms and diseases
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Metadata
- Authors
- Jiang, Y., Li, Y., & Zhu, B.
- Venue
- Cell Death & Disease
- Published
- 2015-06-18
- Volume
- 6
- Issue
- 6
- Pages
- e1792-e1792
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W1540592014
- Cited by
- 1,157
- References
- 108
- FWCI
- 21.32
- Type
- journal article
- Language
- en
- Open access
- gold
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- Jiang, Y., Li, Y., & Zhu, B. (2015). T-cell exhaustion in the tumor microenvironment. Cell Death & Disease. https://doi.org/10.1038/cddis.2015.162
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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