Cited by 339Immune Response and InflammationCardiac Fibrosis and RemodelingInflammasome and immune disorders

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The emerging role of Toll-like receptor 4 in myocardial inflammation

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Yang, Y, Lv, J, Jiang, S, Ma, Z, Wang, D, Hu, W, Deng, C, Fan, C, Di, S, Sun, Y, Yi, W·2016·Cell Death & Disease

DOI 10.1038/cddis.2016.140PMC PMC4917669

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Abstract

Toll-like receptors (TLRs) are a family of pattern recognition receptors involved in cardiovascular diseases. Notably, numerous studies have demonstrated that TLR4 activates the expression of several of pro-inflammatory cytokine genes that play pivotal roles in myocardial inflammation, particularly myocarditis, myocardial infarction, ischemia-reperfusion injury, and heart failure. In addition, TLR4 is an emerging target for anti-inflammatory therapies. Given the significance of TLR4, it would be useful to summarize the current literature on the molecular mechanisms and roles of TLR4 in myocardial inflammation. Thus, in this review, we first introduce the basic knowledge of the TLR4 gene and describe the activation and signaling pathways of TLR4 in myocardial inflammation. Moreover, we highlight the recent progress of research on the involvement of TLR4 in myocardial inflammation. The information reviewed here may be useful to further experimental research and to increase the potential of TLR4 as a therapeutic target.

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Authors: Yang, Y., Lv, J., Jiang, S., Ma, Z., Wang, D., Hu, W., Deng, C., Fan, C., Di, S., Sun, Y., & Yi, W.
Affiliations: Nanjing Drum Tower Hospital (CN)
Air Force Medical University (CN)
Tang Du Hospital (CN)
Xijing Hospital (CN)
Corresponding author: Sun, Y
ORCID: Yang, Y
Lv, J
Jiang, S
Deng, C
Fan, C
Yi, W
Venue: Cell Death & Disease
Publisher: Springer Science and Business Media LLC
Published: 2016-05-26
Volume: 7
Issue: 5
Pages: e2234-e2234
ISSN: 2041-4889 (ISSN-L)
DOI: 10.1038/cddis.2016.140
PMC: PMC4917669
OpenAlex: W2403031333
Cited by: 337
References: 89
Citations by year: 2026: 25 · 2025: 39 · 2024: 34 · 2023: 34 · 2022: 38 · 2021: 50 · 2020: 32 · 2019: 37 · 2018: 31 · 2017: 13 · 2016: 3
FWCI: 2.70
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Cell Death and Disease (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81500263, 81100081, 81422004, 2015M572681, 81470477, 81100137, 81470480)
China Postdoctoral Science Foundation (2015M572681, 81500263)
National Institute on Alcohol Abuse and Alcoholism (R00AA020514, K99AA020514, R01AA020919)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: TLR4, myocarditis, myocardial infarction, ischemia-reperfusion injury, heart failure, inflammatory cytokines, TLR4 signaling, anti-inflammatory therapy, pattern recognition receptors
MeSH terms: Animals, Cardiotonic Agents, Clinical Trials as Topic, Disaccharides, Gene Expression Regulation, Heart Failure, Humans, Metformin, Myocardial Infarction, Myocarditis, Myocardium, Sugar Phosphates, Signal Transduction, Reperfusion Injury, NF-kappa B, Follistatin, Toll-Like Receptor 4, Myeloid Differentiation Factor 88

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The emerging role of Toll-like receptor 4 in myocardial inflammation

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